The SOS/ERK cascades are key signaling pathways that regulate cellular processes ranging from cellular proliferation,differentiation and apoptosis to tumor formation.However,the properties of these signaling pathways ...The SOS/ERK cascades are key signaling pathways that regulate cellular processes ranging from cellular proliferation,differentiation and apoptosis to tumor formation.However,the properties of these signaling pathways are not well understood.More importantly,how stochastic perturbations of internal and external cellular environment affect these pathways remains unanswered.To answer these questions,we,in this paper,propose a stochastic model according to the biochemical reaction processes of the SOS/ERK pathways,and,respectively,research the dynamical behaviors of this model under the four kinds of noises:Gaussian noise,colored noise,Lévy noise and fraction Brown noise.Some important results are found that Gaussian and colored noises have less effect on the stability of the system when the strength of the noise is small;Lévy and fractional Brownian noises significantly change the trajectories of the system.Power spectrum analysis shows that Lévy noise induces a system with quasi-periodic trajectories.Our results not only provide an understanding of the SOS/ERK pathway,but also show generalized rules for stochastic dynamical systems.展开更多
基金supported by 62066026,12071408,and 62363027 from NSF of Chinagrants PhD program of Entrepreneurship and Innovation of Jiangsu province,Jiangsu University"Blue Project"20224BAB202026 from NSF of Jiangxi province.
文摘The SOS/ERK cascades are key signaling pathways that regulate cellular processes ranging from cellular proliferation,differentiation and apoptosis to tumor formation.However,the properties of these signaling pathways are not well understood.More importantly,how stochastic perturbations of internal and external cellular environment affect these pathways remains unanswered.To answer these questions,we,in this paper,propose a stochastic model according to the biochemical reaction processes of the SOS/ERK pathways,and,respectively,research the dynamical behaviors of this model under the four kinds of noises:Gaussian noise,colored noise,Lévy noise and fraction Brown noise.Some important results are found that Gaussian and colored noises have less effect on the stability of the system when the strength of the noise is small;Lévy and fractional Brownian noises significantly change the trajectories of the system.Power spectrum analysis shows that Lévy noise induces a system with quasi-periodic trajectories.Our results not only provide an understanding of the SOS/ERK pathway,but also show generalized rules for stochastic dynamical systems.
