A kind of PH gradient microfluidic chips through soft-lithography microfabrication for isoelectric focusing(IEF)and high performance liquid chromatography(HPLC)is introduced here.These pH gradient chips have the advan...A kind of PH gradient microfluidic chips through soft-lithography microfabrication for isoelectric focusing(IEF)and high performance liquid chromatography(HPLC)is introduced here.These pH gradient chips have the advan-tages such as easy fabrication,controllable pH range and precision,isoelectric focusing and separation at the same time,low voltage for isoelectric focusing,and time stable pH gradient.This method has potential application to sample preparation,separation and analysis of microfluidic chips.展开更多
A new kind of organic-inorganic hybrid HfO2/SiO2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating...A new kind of organic-inorganic hybrid HfO2/SiO2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating （LPWG） filter, whose parameters were optimized and designed by using finite difference time domain （FDTD） simulations. The LPWG filter, a periodic rectangle-corrugated grating structure, was easily fabricated with soft-lithography technique. At a temperature range from 19~C to 70~C, the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/~C and a wide linear tunable temperature range of 51℃, so that it can be used as a precise thermometer. Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions.展开更多
Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics.We report on establishing ...Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics.We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane(PDMS)-based materials.This trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects,called geometry-induced electrostatic(GIE)trapping.With gold nanoparticles as probes,we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps,and compare the results with numerical simulations.When trapping 100 nm particles,we observe potential depths of up to Q≅24 k_(B)T that provide stable trapping for many days.Taking advantage of the soft material properties of PDMS,we actively tune the trapping strength and potential depth by elastically reducing the device channel height,which boosts the potential depth up to Q~200 k_(B)T,providing practically permanent contactfree trapping.Due to a high-throughput and low-cost fabrication process,ease of use,and excellent trapping performance,our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids.展开更多
文摘A kind of PH gradient microfluidic chips through soft-lithography microfabrication for isoelectric focusing(IEF)and high performance liquid chromatography(HPLC)is introduced here.These pH gradient chips have the advan-tages such as easy fabrication,controllable pH range and precision,isoelectric focusing and separation at the same time,low voltage for isoelectric focusing,and time stable pH gradient.This method has potential application to sample preparation,separation and analysis of microfluidic chips.
基金supported by the Natural Science Foundation of Guangdong Province,China (Grant Nos. 8251063101000007,10151063101000009 and 9451063101002082)the Scientific & Technological Plan of Guangdong Province (Grant Nos. 2008B010200004,2010B010600030 and 2009B011100003)+4 种基金the National Natural Science Foundation of China (Grant Nos. 61078046 and 10904042)the Key Project of Chinese Ministry of Education (Grant No. 210157)the Scientific & Technological Project of Education Department of Hubei Province (Grant No. D20101104)the Fundamental Research Funds for the Central Universities (Grant No. HUST 2010MS069)Program for New Century Excellent Talents in University,China (Grant No. 07-0319)
文摘A new kind of organic-inorganic hybrid HfO2/SiO2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating （LPWG） filter, whose parameters were optimized and designed by using finite difference time domain （FDTD） simulations. The LPWG filter, a periodic rectangle-corrugated grating structure, was easily fabricated with soft-lithography technique. At a temperature range from 19~C to 70~C, the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/~C and a wide linear tunable temperature range of 51℃, so that it can be used as a precise thermometer. Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions.
基金This work was funded by the Swiss Nanoscience Institute in Basel,Switzerland(SNI PhD graduate school,Project P1202).
文摘Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics.We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane(PDMS)-based materials.This trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects,called geometry-induced electrostatic(GIE)trapping.With gold nanoparticles as probes,we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps,and compare the results with numerical simulations.When trapping 100 nm particles,we observe potential depths of up to Q≅24 k_(B)T that provide stable trapping for many days.Taking advantage of the soft material properties of PDMS,we actively tune the trapping strength and potential depth by elastically reducing the device channel height,which boosts the potential depth up to Q~200 k_(B)T,providing practically permanent contactfree trapping.Due to a high-throughput and low-cost fabrication process,ease of use,and excellent trapping performance,our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids.
