In this article,an efficient,simple and environmentally friendly approach to the synthesis of diacetals(diketals) pentaerythritol using SOH-functionalized ionic liquids(ILs) as catalysts was reported.The ILs show high...In this article,an efficient,simple and environmentally friendly approach to the synthesis of diacetals(diketals) pentaerythritol using SOH-functionalized ionic liquids(ILs) as catalysts was reported.The ILs show high catalytic activity and reusability with good to excellent yields of the desired products.Hammett method has been used to determine the acidity order of these ionic liquids and the results are consistent with the catalytic activities observed in acetalization reaction.Maximum product yield of 93%was observed on using[PSPy][OTf]as catalyst and it can be reused at least 8 times without obvious activity loss.展开更多
In this article, series of novel bi-SOaH-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammer method had been used to determine the acidity order of these ionic liquids, and the a...In this article, series of novel bi-SOaH-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammer method had been used to determine the acidity order of these ionic liquids, and the acidifies of bi-SOaH-functionalized ILs were stronger than that of traditional single-SOaH-functionalized ILs. Their catalytic activities in the synthesis of N-（3-phenyl）-3- oxo-1-（phenylpropyl）acetamide were investigated and they were consistent with their acidities.展开更多
A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hy...A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hydrogen generation via Na BH4hydrolysis through dual activation pathways.Theoretical predictions based on d-band center analysis and electron transfer calculations suggest that introducing-OH functional groups induce charge redistribution,enhancing charge concentration on alk-Ti_(3)C_(2)and facilitating the adsorption and activation of dual active species,H2O molecules and BH4-anion.Inspired by these predictions,the optimized alk-Ti_(3)C_(2)/Ru Oxcatalyst demonstrates the highest catalytic activity,achieving a hydrogen generation rate(HGR)of 9468 m L min^(-1)gcat.^(-1).Both experimental data and theoretical analyses confirm that the-OH functional groups promote charge enrichment on alk-Ti_(3)C_(2),optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,and reducing the dissociation energy barrier of the*OH–H-TS intermediate.This dual activation pathways mechanism lowers the activation energy for Na BH4hydrolysis,significantly enhancing the HGR performance.These findings,guided by theoretical insights,establish alk-Ti_(3)C_(2)/Ru Oxas an efficient catalyst for Na BH4hydrolysis and provide a strong foundation for future hydrogen generation catalyst designs.展开更多
背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献...背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献,为后续以叉头框转录因子O3为靶点治疗骨疾病的研究提供参考。方法:以“(SU=FoxO3a OR SU=Foxo3 OR SU=Forkhead box O3 OR SU=叉头框转录因子O3)AND SU=骨”为检索句在中国知网进行检索,以“主题:(“FoxO3a”)OR主题:(“Foxo3”)OR主题:(“Forkhead box O3”)OR主题:(“叉头框转录因子O3”)AND主题:(“骨”)”为检索句在万方医学数据库进行检索;以“((FoxO3a)OR(Foxo3)OR(Forkhead box O3))AND((bone)OR(Skeleton))”为检索句在PubMed数据库进行检索,排除陈旧、重复、质量较差以及不相关的文献,最终纳入56篇文献进行综述分析。结果与结论:①叉头框转录因子O3与骨髓间充质干细胞:叉头框转录因子O3能够促进成骨谱系的形成,还可通过激活自噬促进早期成骨分化。同时,叉头框转录因子O3在骨髓间充质干细胞中体现抗氧化特性,保护细胞免受氧化应激诱导的衰老。②叉头框转录因子O3与成骨细胞:叉头框转录因子O3在成骨细胞中能通过干扰Wnt/β-连环蛋白通路抑制成骨,同时能激活抗氧化酶保护成熟成骨细胞。叉头框转录因子O3能促进成骨祖细胞的增殖,并通过激活自噬促进成骨分化。③叉头框转录因子O3与破骨细胞:叉头框转录因子O3表达可抵抗氧化应激和激活自噬抑制破骨细胞生成。④叉头框转录因子O3与骨细胞:叉头框转录因子O3可通过抗氧化作用保护骨细胞,还可通过抑制p16和p53信号通路和抑制衰老相关分泌表型来减少骨流失。⑤叉头框转录因子O3与软骨细胞:叉头框转录因子O3在骨关节炎中对软骨细胞起到保护作用,抑制软骨细胞分解或凋亡,促进软骨细胞外基质合成,可抑制软骨细胞肥大;然而,叉头框转录因子O3与Runt相关转录因子1在软骨细胞中高度共表达却会促进软骨祖细胞的早期软骨形成和终末肥大。⑥叉头框转录因子O3通过参与氧化应激抵抗与调控自噬等过程影响骨代谢,参与多类骨相关疾病的病理进程。展开更多
基金supported by National 863 High-Tech Research and Development Program of China(No. 2007AA05Z101)
文摘In this article,an efficient,simple and environmentally friendly approach to the synthesis of diacetals(diketals) pentaerythritol using SOH-functionalized ionic liquids(ILs) as catalysts was reported.The ILs show high catalytic activity and reusability with good to excellent yields of the desired products.Hammett method has been used to determine the acidity order of these ionic liquids and the results are consistent with the catalytic activities observed in acetalization reaction.Maximum product yield of 93%was observed on using[PSPy][OTf]as catalyst and it can be reused at least 8 times without obvious activity loss.
基金the National Natural Science Foundation ofChina(Nos.21003049,21073064)the Fundamental Research Funds for the Central Universities for financial support
文摘In this article, series of novel bi-SOaH-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammer method had been used to determine the acidity order of these ionic liquids, and the acidifies of bi-SOaH-functionalized ILs were stronger than that of traditional single-SOaH-functionalized ILs. Their catalytic activities in the synthesis of N-（3-phenyl）-3- oxo-1-（phenylpropyl）acetamide were investigated and they were consistent with their acidities.
基金supported by the Hebei province Natural Science Foundation(No.B2023108012)the Science Research Project of Hebei Education Department(No.BJK2024137)+2 种基金the S&T Program of Xingtai(No.2023ZZ096)the National Natural Science Foundation of China(No.62004143)the Key R&D Program of Hubei Province(No.2022BAA084)。
文摘A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hydrogen generation via Na BH4hydrolysis through dual activation pathways.Theoretical predictions based on d-band center analysis and electron transfer calculations suggest that introducing-OH functional groups induce charge redistribution,enhancing charge concentration on alk-Ti_(3)C_(2)and facilitating the adsorption and activation of dual active species,H2O molecules and BH4-anion.Inspired by these predictions,the optimized alk-Ti_(3)C_(2)/Ru Oxcatalyst demonstrates the highest catalytic activity,achieving a hydrogen generation rate(HGR)of 9468 m L min^(-1)gcat.^(-1).Both experimental data and theoretical analyses confirm that the-OH functional groups promote charge enrichment on alk-Ti_(3)C_(2),optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,and reducing the dissociation energy barrier of the*OH–H-TS intermediate.This dual activation pathways mechanism lowers the activation energy for Na BH4hydrolysis,significantly enhancing the HGR performance.These findings,guided by theoretical insights,establish alk-Ti_(3)C_(2)/Ru Oxas an efficient catalyst for Na BH4hydrolysis and provide a strong foundation for future hydrogen generation catalyst designs.
文摘背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献,为后续以叉头框转录因子O3为靶点治疗骨疾病的研究提供参考。方法:以“(SU=FoxO3a OR SU=Foxo3 OR SU=Forkhead box O3 OR SU=叉头框转录因子O3)AND SU=骨”为检索句在中国知网进行检索,以“主题:(“FoxO3a”)OR主题:(“Foxo3”)OR主题:(“Forkhead box O3”)OR主题:(“叉头框转录因子O3”)AND主题:(“骨”)”为检索句在万方医学数据库进行检索;以“((FoxO3a)OR(Foxo3)OR(Forkhead box O3))AND((bone)OR(Skeleton))”为检索句在PubMed数据库进行检索,排除陈旧、重复、质量较差以及不相关的文献,最终纳入56篇文献进行综述分析。结果与结论:①叉头框转录因子O3与骨髓间充质干细胞:叉头框转录因子O3能够促进成骨谱系的形成,还可通过激活自噬促进早期成骨分化。同时,叉头框转录因子O3在骨髓间充质干细胞中体现抗氧化特性,保护细胞免受氧化应激诱导的衰老。②叉头框转录因子O3与成骨细胞:叉头框转录因子O3在成骨细胞中能通过干扰Wnt/β-连环蛋白通路抑制成骨,同时能激活抗氧化酶保护成熟成骨细胞。叉头框转录因子O3能促进成骨祖细胞的增殖,并通过激活自噬促进成骨分化。③叉头框转录因子O3与破骨细胞:叉头框转录因子O3表达可抵抗氧化应激和激活自噬抑制破骨细胞生成。④叉头框转录因子O3与骨细胞:叉头框转录因子O3可通过抗氧化作用保护骨细胞,还可通过抑制p16和p53信号通路和抑制衰老相关分泌表型来减少骨流失。⑤叉头框转录因子O3与软骨细胞:叉头框转录因子O3在骨关节炎中对软骨细胞起到保护作用,抑制软骨细胞分解或凋亡,促进软骨细胞外基质合成,可抑制软骨细胞肥大;然而,叉头框转录因子O3与Runt相关转录因子1在软骨细胞中高度共表达却会促进软骨祖细胞的早期软骨形成和终末肥大。⑥叉头框转录因子O3通过参与氧化应激抵抗与调控自噬等过程影响骨代谢,参与多类骨相关疾病的病理进程。
