目的系统评价阿戈美拉汀治疗首发抑郁障碍患者的效果和安全性,以期为抑郁障碍的药物治疗提供参考。方法检索PubMed、Web of Science、中国学术期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库中关于阿戈美拉汀治疗首发抑郁障碍患者...目的系统评价阿戈美拉汀治疗首发抑郁障碍患者的效果和安全性,以期为抑郁障碍的药物治疗提供参考。方法检索PubMed、Web of Science、中国学术期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库中关于阿戈美拉汀治疗首发抑郁障碍患者的临床随机对照研究,提取阿戈美拉汀与SSRIs/SNRIs类抗抑郁药物在治疗首发抑郁障碍的效果和安全性的数据,采用RevMan 5.3进行Meta分析。结果共纳入12篇文章,其中中文10篇,英文2篇。Meta分析结果显示,治疗后阿戈美拉汀组与对照组HAMD-17评分差异有统计学意义(SMD=-1.31,95%CI:-1.55^-1.07,Z=10.77,P<0.01)。由于研究间异质性较大(I2=83%,P<0.01),根据对照组所采用抗抑郁药种类进行亚组分析,分别以氟西汀(SMD=-1.22,95%CI:-1.66^-0.77,Z=5.30,P<0.01)、度洛西汀(SMD=-0.88,95%CI:-1.26^-0.50,Z=4.49,P<0.01)为对照的研究治疗后HAMD-17评分与阿戈美拉汀组差异均有统计学意义。关于副作用的Meta分析显示,阿戈美拉汀组与对照组之间差异有统计学意义(RR=0.63,95%CI:0.49~0.80,Z=3.73,P<0.01)。结论阿戈美拉汀治疗首发抑郁障碍的疗效优于SSRIs/SNRIs类抗抑郁药物或与其疗效相当,副作用小于SSRIs/SNRIs类抗抑郁药物。展开更多
A generalized approach for narrowband interference （NBI） suppression in direct sequence spread spectrum （DSSS） communication systems using adaptive infinite impulse response （IIR） filter is presented. The excisi...A generalized approach for narrowband interference （NBI） suppression in direct sequence spread spectrum （DSSS） communication systems using adaptive infinite impulse response （IIR） filter is presented. The excision filter coefficients depend on both the jammer power and its instantaneous frequency. The dependency of the filter construction on the jammer power is significant as it allows optimal tradeoff between interference removal and signal distortion by maximizing the receiver signal to noise ratio improvement（SNRI）. Instead of traditional adaptive line enhancer （ALE） estimator, a preferable NBI estimator-Fourier interpolation estimator （FIE） is proposed. Closed-form expressions of the SNR improvement and theoretical bit error rate （BER） based on the assumption that the output of the correlator is Gaussian distributed are both derived. Performance results obtained by numerical simulation are also presented and compared with theoretical results.展开更多
<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> It is not well analyze...<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of major monopolar depression (MMD). </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Ultra high-speed </span></span><span style="font-family:""><span style="font-family:Verdana;">liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive </span><span><span style="font-family:Verdana;">patients. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> There are no significant differences between plasma levels of TRP between HC and MMD. Plasma levels of TRP of HC are higher in young men, young women, old men, and old women in this order. Serotonin (5-HT) levels are higher in MMD than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are higher than those of young men and old women. Plasma levels of KYN are higher in old women and young men of MMD than those of HC. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Plasma levels of 5-HT are higher in patients of MMD than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation may increase plasma levels of 5-HT in MMD.展开更多
RTT girls suffer periods of abnormal behavior from early infancy, including irritability and sleep disorders or anxiety in the first years of life, and a more depressed mood after adolescence, all of which influences ...RTT girls suffer periods of abnormal behavior from early infancy, including irritability and sleep disorders or anxiety in the first years of life, and a more depressed mood after adolescence, all of which influences their quality of life. An association between emotional and behavioral disorders and various neurochemical changes in the synapses of cortical and subcortical brain regions has been established;also, cortisol levels in the blood vary during stress. The main purpose of this study was to improve mood and behavior disorders in RTT patients with venlafaxine (SNRI), and compare the results with citalopram (SSRIs) during 6 - 8 weeks, to determine which drug offered greater efficacy and fewer side effects, as well as to compare them to risperidone, and to correlate cortisol levels in saliva with stress and drug response. Eleven patients, aged 5 to 26 years old, agreed to participate in this study;neuropsychological tests (Mullen and Vineland scales), quality of life and quality of sleep scales, blood tests, EKG and EEG were performed before and after treatment. Only 2 patients completed the three months trial. Improvement in mood and behavior was not statistically significant for patients;differences in neurodevelopment and quality of life or sleep scales were not significant either;no serious adverse effects were observed. Cortisol levels in saliva decreased in 50% of the patients after the first month of treatment, although this was not statistically significant.展开更多
Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra ...Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.展开更多
Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry...Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.展开更多
文摘目的系统评价阿戈美拉汀治疗首发抑郁障碍患者的效果和安全性,以期为抑郁障碍的药物治疗提供参考。方法检索PubMed、Web of Science、中国学术期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库中关于阿戈美拉汀治疗首发抑郁障碍患者的临床随机对照研究,提取阿戈美拉汀与SSRIs/SNRIs类抗抑郁药物在治疗首发抑郁障碍的效果和安全性的数据,采用RevMan 5.3进行Meta分析。结果共纳入12篇文章,其中中文10篇,英文2篇。Meta分析结果显示,治疗后阿戈美拉汀组与对照组HAMD-17评分差异有统计学意义(SMD=-1.31,95%CI:-1.55^-1.07,Z=10.77,P<0.01)。由于研究间异质性较大(I2=83%,P<0.01),根据对照组所采用抗抑郁药种类进行亚组分析,分别以氟西汀(SMD=-1.22,95%CI:-1.66^-0.77,Z=5.30,P<0.01)、度洛西汀(SMD=-0.88,95%CI:-1.26^-0.50,Z=4.49,P<0.01)为对照的研究治疗后HAMD-17评分与阿戈美拉汀组差异均有统计学意义。关于副作用的Meta分析显示,阿戈美拉汀组与对照组之间差异有统计学意义(RR=0.63,95%CI:0.49~0.80,Z=3.73,P<0.01)。结论阿戈美拉汀治疗首发抑郁障碍的疗效优于SSRIs/SNRIs类抗抑郁药物或与其疗效相当,副作用小于SSRIs/SNRIs类抗抑郁药物。
基金Sponsored by the Beijing Municipal Natural Science Foundation(4052024)
文摘A generalized approach for narrowband interference （NBI） suppression in direct sequence spread spectrum （DSSS） communication systems using adaptive infinite impulse response （IIR） filter is presented. The excision filter coefficients depend on both the jammer power and its instantaneous frequency. The dependency of the filter construction on the jammer power is significant as it allows optimal tradeoff between interference removal and signal distortion by maximizing the receiver signal to noise ratio improvement（SNRI）. Instead of traditional adaptive line enhancer （ALE） estimator, a preferable NBI estimator-Fourier interpolation estimator （FIE） is proposed. Closed-form expressions of the SNR improvement and theoretical bit error rate （BER） based on the assumption that the output of the correlator is Gaussian distributed are both derived. Performance results obtained by numerical simulation are also presented and compared with theoretical results.
文摘<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of major monopolar depression (MMD). </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Ultra high-speed </span></span><span style="font-family:""><span style="font-family:Verdana;">liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive </span><span><span style="font-family:Verdana;">patients. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> There are no significant differences between plasma levels of TRP between HC and MMD. Plasma levels of TRP of HC are higher in young men, young women, old men, and old women in this order. Serotonin (5-HT) levels are higher in MMD than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are higher than those of young men and old women. Plasma levels of KYN are higher in old women and young men of MMD than those of HC. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Plasma levels of 5-HT are higher in patients of MMD than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation may increase plasma levels of 5-HT in MMD.
文摘RTT girls suffer periods of abnormal behavior from early infancy, including irritability and sleep disorders or anxiety in the first years of life, and a more depressed mood after adolescence, all of which influences their quality of life. An association between emotional and behavioral disorders and various neurochemical changes in the synapses of cortical and subcortical brain regions has been established;also, cortisol levels in the blood vary during stress. The main purpose of this study was to improve mood and behavior disorders in RTT patients with venlafaxine (SNRI), and compare the results with citalopram (SSRIs) during 6 - 8 weeks, to determine which drug offered greater efficacy and fewer side effects, as well as to compare them to risperidone, and to correlate cortisol levels in saliva with stress and drug response. Eleven patients, aged 5 to 26 years old, agreed to participate in this study;neuropsychological tests (Mullen and Vineland scales), quality of life and quality of sleep scales, blood tests, EKG and EEG were performed before and after treatment. Only 2 patients completed the three months trial. Improvement in mood and behavior was not statistically significant for patients;differences in neurodevelopment and quality of life or sleep scales were not significant either;no serious adverse effects were observed. Cortisol levels in saliva decreased in 50% of the patients after the first month of treatment, although this was not statistically significant.
文摘Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.
文摘Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.
