Long non-coding RNAs(lnc RNAs) are widely involved in a variety of biological processes, including epithelial-mesenchymal transition(EMT). In the current study, we found that lnc RNA small nucleolar RNA host gene 8(SN...Long non-coding RNAs(lnc RNAs) are widely involved in a variety of biological processes, including epithelial-mesenchymal transition(EMT). In the current study, we found that lnc RNA small nucleolar RNA host gene 8(SNHG8) was tightly correlated with EMT-associated gene signatures, and was down-regulated by Zinc finger E-box-binding homeobox 1(ZEB1) during EMT progress. Functionally, knockdown of SNHG8 induced EMT in epithelial cells, through destabilizing the CDH1 m RNA dependent on a 17-nucleotide sequence shared by SNHG8 and CDH1. In addition, analysis with public database showed that SNHG8 tended to be down-regulated in different cancer types and the lower expression of SNHG8 predicted poorer prognosis.Taken together, our study reports a ZEB1-repressed lnc RNA SNHG8 which is important for stabilizing CDH1 m RNA, thereby maintaining the epithelial status of epithelial cells.展开更多
Digestive tract tumors,ranging from esophageal to colorectal cancers(CRCs),pose a substantial challenge in oncology because of their high global incidence and mortality.1,2 The heterogeneity of these malignancies unde...Digestive tract tumors,ranging from esophageal to colorectal cancers(CRCs),pose a substantial challenge in oncology because of their high global incidence and mortality.1,2 The heterogeneity of these malignancies underscores the complexity of their etiology,which is influenced by a combination of genetic,epigenetic,and environmental factors.3 Unraveling the molecular complexities and clinical implications of these tumors is of growing importance,as they provide insights that can inform the development of more effective diagnostic,therapeutic,and preventative approaches.The Special Issue,titled“Basic research and clinical practice on gastrointestinal cancer”,aims to highlight the recent advances in molecular mechanisms and clinical research in the field of digestive tract oncology.We hope that by presenting these findings we can foster collaboration and dialog among experts in the field,ultimately leading to innovative perspectives on the diagnosis and treatment of these cancers.展开更多
基金This work was supported by the National Natural Science Foundation of China(82022053,81830091,91853206,and 81972583)the National Key Research and Development Program of China(2020YFA0803403)+1 种基金CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-051)the Fundamental Research Funds for the Central Universities.
文摘Long non-coding RNAs(lnc RNAs) are widely involved in a variety of biological processes, including epithelial-mesenchymal transition(EMT). In the current study, we found that lnc RNA small nucleolar RNA host gene 8(SNHG8) was tightly correlated with EMT-associated gene signatures, and was down-regulated by Zinc finger E-box-binding homeobox 1(ZEB1) during EMT progress. Functionally, knockdown of SNHG8 induced EMT in epithelial cells, through destabilizing the CDH1 m RNA dependent on a 17-nucleotide sequence shared by SNHG8 and CDH1. In addition, analysis with public database showed that SNHG8 tended to be down-regulated in different cancer types and the lower expression of SNHG8 predicted poorer prognosis.Taken together, our study reports a ZEB1-repressed lnc RNA SNHG8 which is important for stabilizing CDH1 m RNA, thereby maintaining the epithelial status of epithelial cells.
基金the Beijing Xisike Clinical Oncology Research Foundation(No.Y-xsk2021-0004).
文摘Digestive tract tumors,ranging from esophageal to colorectal cancers(CRCs),pose a substantial challenge in oncology because of their high global incidence and mortality.1,2 The heterogeneity of these malignancies underscores the complexity of their etiology,which is influenced by a combination of genetic,epigenetic,and environmental factors.3 Unraveling the molecular complexities and clinical implications of these tumors is of growing importance,as they provide insights that can inform the development of more effective diagnostic,therapeutic,and preventative approaches.The Special Issue,titled“Basic research and clinical practice on gastrointestinal cancer”,aims to highlight the recent advances in molecular mechanisms and clinical research in the field of digestive tract oncology.We hope that by presenting these findings we can foster collaboration and dialog among experts in the field,ultimately leading to innovative perspectives on the diagnosis and treatment of these cancers.
