Objective: To study the effects of lipid emulsion (SMOF) intervention on stress hormones, inflammatory mediators and immune function after esophagus cancer operation. Methods:A total of 84 patients who received radica...Objective: To study the effects of lipid emulsion (SMOF) intervention on stress hormones, inflammatory mediators and immune function after esophagus cancer operation. Methods:A total of 84 patients who received radical operation for esophageal cancer in West China Hospital, Sichuan University between June 2015 and March 2017 were selected and randomly divided into two groups, SMOF group received parenteral nutrition configured by SMOF lipid emulsion, and control group received parenteral nutrition configured by long chain lipid emulsion. Before intervention as well as 3 d and 7 d after intervention, the levels of stress hormones and inflammatory mediators in serum and the mRNA expression of immune transcription factors in peripheral blood mononuclear cells were detected. Results: Serum NE, E, DA, Cor, SP-D, MIP-2 and TNF-α levels as well as peripheral blood GATA3 and Foxp3 mRNA expression of both groups of patients after intervention were higher than those before intervention while peripheral blood T-bet and RORγt mRNA expression were lower than those before intervention;serum NE, E, DA, Cor, SP-D, MIP-2 and TNF-α levels as well as peripheral blood GATA3 and Foxp3 mRNA expression of SMOF group after intervention were lower than those of control group while peripheral blood T-bet and RORγt mRNA expression were higher than those of control group. Conclusion: Lipid emulsion (SMOF) intervention can reduce the stress response and inflammatory response after esophageal cancer operation, and improve the immune response.展开更多
文摘Objective: To study the effects of lipid emulsion (SMOF) intervention on stress hormones, inflammatory mediators and immune function after esophagus cancer operation. Methods:A total of 84 patients who received radical operation for esophageal cancer in West China Hospital, Sichuan University between June 2015 and March 2017 were selected and randomly divided into two groups, SMOF group received parenteral nutrition configured by SMOF lipid emulsion, and control group received parenteral nutrition configured by long chain lipid emulsion. Before intervention as well as 3 d and 7 d after intervention, the levels of stress hormones and inflammatory mediators in serum and the mRNA expression of immune transcription factors in peripheral blood mononuclear cells were detected. Results: Serum NE, E, DA, Cor, SP-D, MIP-2 and TNF-α levels as well as peripheral blood GATA3 and Foxp3 mRNA expression of both groups of patients after intervention were higher than those before intervention while peripheral blood T-bet and RORγt mRNA expression were lower than those before intervention;serum NE, E, DA, Cor, SP-D, MIP-2 and TNF-α levels as well as peripheral blood GATA3 and Foxp3 mRNA expression of SMOF group after intervention were lower than those of control group while peripheral blood T-bet and RORγt mRNA expression were higher than those of control group. Conclusion: Lipid emulsion (SMOF) intervention can reduce the stress response and inflammatory response after esophageal cancer operation, and improve the immune response.
