Objective To study the apoptosis of cultured rabbit smooth muscle cells (SMCs) by low dose 32Pperfused in balloon catheter and its doseresponse relationship differences. Methods Liquid 32P isotope wasinfused directly ...Objective To study the apoptosis of cultured rabbit smooth muscle cells (SMCs) by low dose 32Pperfused in balloon catheter and its doseresponse relationship differences. Methods Liquid 32P isotope wasinfused directly into the balloon of PTCA catheter, to irradiate the SMCs with various doses. Light microscope,electron microscope, agarose gel electrophoreses and flow Cytometry(FCM) were used to detect the apoptosis ofSMCs after 24h irradiation. Results The irradiated SMCs showed condensation of the cytoplasm, chromatincondensation, chromosal clumping and margination, apoptotic body and the nuclear DNA degradation on agarose,the amount of SMC opoptosis was positively correlated with the different doses in FCM. Conclusion Our dataidentified irradiation with 32P isotopefilled balloon can be the induction of SMCs apoptosis. Further study isrequired to determine potential value of this method about prevention of restenosis resulting from decreasing ofSMCs proliferation.展开更多
On 15 February 2025,the IEEE Systems,Man,and Cybernetics Society(SMCS)convened its Artificial Intelligence(AI)Executive Workshop in Santa Monica,California,USA.Held at the Huntley Hotel upon the recommendation of SMCS...On 15 February 2025,the IEEE Systems,Man,and Cybernetics Society(SMCS)convened its Artificial Intelligence(AI)Executive Workshop in Santa Monica,California,USA.Held at the Huntley Hotel upon the recommendation of SMCS President Adrian Stoica,the intensive,one-day workshop adopted a hybrid format,accommodating both in-person and online participation.The event was strategically scheduled to precede the SMCS Executive Committee(ExCom)meeting(Fig.1).展开更多
软磁复合材料(Soft Magnetic Composites,SMCs)作为高频电力电子器件的核心材料,需同时满足高饱和磁化强度、低损耗及高频稳定性等要求,而传统软磁材料已难以适应这一需求。通过综述近年来SMCs在高性能化方向的研究进展,重点探讨表面处...软磁复合材料(Soft Magnetic Composites,SMCs)作为高频电力电子器件的核心材料,需同时满足高饱和磁化强度、低损耗及高频稳定性等要求,而传统软磁材料已难以适应这一需求。通过综述近年来SMCs在高性能化方向的研究进展,重点探讨表面处理、粉末优化、制备工艺创新及高频损耗机制解析等关键技术。研究表明,通过复合涂层纳米化设计(如磷酸盐/有机硅树脂包覆、六方氮化硼绝缘层)、增材制造驱动的成分调控(如中熵合金激光3D打印)、温压与低温氮化工艺优化,可显著提升SMCs的电阻率、磁导率及高频适应性。此外,多物理场耦合模型与涡流-磁滞损耗机制的深化研究为工程应用提供了理论支撑。未来需突破超薄绝缘涂层、环保制备技术及GHz频段损耗预测等挑战,以推动SMCs在5G通信、新能源等领域的更高效应用。展开更多
目的:探讨染色体结构维持蛋白1A(structural maintenance of chromosome 1A,SMC1A)在乳腺癌中的表达情况,分析其与临床病理特征的相关性以及对乳腺癌细胞凋亡的影响。方法:利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析S...目的:探讨染色体结构维持蛋白1A(structural maintenance of chromosome 1A,SMC1A)在乳腺癌中的表达情况,分析其与临床病理特征的相关性以及对乳腺癌细胞凋亡的影响。方法:利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析SMC1A m RNA在乳腺癌及正常乳腺组织中的表达差异及其与乳腺癌预后的相关性。收集南京医科大学第一附属医院2023年1—12月间48例乳腺癌患者手术切除的癌组织和癌旁组织标本,采用实时荧光定量聚合酶链反应和免疫组织化学分析SMC1A的表达,并评估其与患者临床病理指标的关系。通过下调乳腺癌细胞系MCF-7中SMC1A表达,检测其凋亡相关蛋白的变化。结果:对TCGA相关转录组测序数据分析提示,SMC1A m RNA在乳腺癌组织中的表达显著高于正常乳腺组织,并与乳腺癌的预后紧密相关。临床样本验证也表明,SMC1A的表达水平在乳腺癌组织中显著高于癌旁组织,并与TNM分期、淋巴结转移及病理分化程度相关。siRNA介导的SMC1A下调在MCF-7细胞中显著提升了Cleaved-caspase-3、Cleaved-caspase-9及Bax的表达,降低了Bcl2的表达。结论:SMC1A在乳腺癌组织中高表达,并与乳腺癌的进展及病理分化有关。初步机制研究表明,SMC1A的表达调控可能对促进乳腺癌细胞凋亡具有重要作用。展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
文摘Objective To study the apoptosis of cultured rabbit smooth muscle cells (SMCs) by low dose 32Pperfused in balloon catheter and its doseresponse relationship differences. Methods Liquid 32P isotope wasinfused directly into the balloon of PTCA catheter, to irradiate the SMCs with various doses. Light microscope,electron microscope, agarose gel electrophoreses and flow Cytometry(FCM) were used to detect the apoptosis ofSMCs after 24h irradiation. Results The irradiated SMCs showed condensation of the cytoplasm, chromatincondensation, chromosal clumping and margination, apoptotic body and the nuclear DNA degradation on agarose,the amount of SMC opoptosis was positively correlated with the different doses in FCM. Conclusion Our dataidentified irradiation with 32P isotopefilled balloon can be the induction of SMCs apoptosis. Further study isrequired to determine potential value of this method about prevention of restenosis resulting from decreasing ofSMCs proliferation.
文摘On 15 February 2025,the IEEE Systems,Man,and Cybernetics Society(SMCS)convened its Artificial Intelligence(AI)Executive Workshop in Santa Monica,California,USA.Held at the Huntley Hotel upon the recommendation of SMCS President Adrian Stoica,the intensive,one-day workshop adopted a hybrid format,accommodating both in-person and online participation.The event was strategically scheduled to precede the SMCS Executive Committee(ExCom)meeting(Fig.1).
文摘软磁复合材料(Soft Magnetic Composites,SMCs)作为高频电力电子器件的核心材料,需同时满足高饱和磁化强度、低损耗及高频稳定性等要求,而传统软磁材料已难以适应这一需求。通过综述近年来SMCs在高性能化方向的研究进展,重点探讨表面处理、粉末优化、制备工艺创新及高频损耗机制解析等关键技术。研究表明,通过复合涂层纳米化设计(如磷酸盐/有机硅树脂包覆、六方氮化硼绝缘层)、增材制造驱动的成分调控(如中熵合金激光3D打印)、温压与低温氮化工艺优化,可显著提升SMCs的电阻率、磁导率及高频适应性。此外,多物理场耦合模型与涡流-磁滞损耗机制的深化研究为工程应用提供了理论支撑。未来需突破超薄绝缘涂层、环保制备技术及GHz频段损耗预测等挑战,以推动SMCs在5G通信、新能源等领域的更高效应用。
文摘目的:探讨染色体结构维持蛋白1A(structural maintenance of chromosome 1A,SMC1A)在乳腺癌中的表达情况,分析其与临床病理特征的相关性以及对乳腺癌细胞凋亡的影响。方法:利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析SMC1A m RNA在乳腺癌及正常乳腺组织中的表达差异及其与乳腺癌预后的相关性。收集南京医科大学第一附属医院2023年1—12月间48例乳腺癌患者手术切除的癌组织和癌旁组织标本,采用实时荧光定量聚合酶链反应和免疫组织化学分析SMC1A的表达,并评估其与患者临床病理指标的关系。通过下调乳腺癌细胞系MCF-7中SMC1A表达,检测其凋亡相关蛋白的变化。结果:对TCGA相关转录组测序数据分析提示,SMC1A m RNA在乳腺癌组织中的表达显著高于正常乳腺组织,并与乳腺癌的预后紧密相关。临床样本验证也表明,SMC1A的表达水平在乳腺癌组织中显著高于癌旁组织,并与TNM分期、淋巴结转移及病理分化程度相关。siRNA介导的SMC1A下调在MCF-7细胞中显著提升了Cleaved-caspase-3、Cleaved-caspase-9及Bax的表达,降低了Bcl2的表达。结论:SMC1A在乳腺癌组织中高表达,并与乳腺癌的进展及病理分化有关。初步机制研究表明,SMC1A的表达调控可能对促进乳腺癌细胞凋亡具有重要作用。
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
