Eva Hoffman’s Lost in Translation:A life in a New Language is prominent in that it spares no effort elaborating on the author’s personal experience in acquiring her second language(L2)English from the view of sociol...Eva Hoffman’s Lost in Translation:A life in a New Language is prominent in that it spares no effort elaborating on the author’s personal experience in acquiring her second language(L2)English from the view of sociolinguistics.In this vein,by in vestigating the underlined relationship between language learners’cultural identity and language identity from the perspective of sociolinguistics,the paper aims to explore the possibilities of assisting L2 learners reach a balance in their biological,cultural,so cial,and psychological domains of life.展开更多
The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased i...The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased in daily practice and now it is not uncommon to see patients surviving kidney cancer for more than four to five years. Once treatment fails with the first line targeted therapy, head to head comparisons have shown that cabozantinib, nivolumab and the combination of lenvatinib plus everolimus are more effective than everolimus alone and that axitinib is more active than sorafenib. Unfortunately, it is very unlikely that we will ever have prospective data comparing the activity of axitinib, cabozantinib, lenvatinib or nivolumab. It is frustrating to observe the lack of biomarkers that we have in this field, thus there is no firm recommendation about the optimal sequence of treatment in the second line. In the absence of reliable biomarkers, there are several clinical endpoints that can help physicians to make decisions for an individual patient, such as the tumor burden, the expected response rate and the time to achieve the response to each agent, the prior response to the agent administered, the toxicity profile of the different compounds and patient preference. Here, we propose the introduction of the tumor-growth rate(TGR) during first-line treatment as a new tool to be used to select the second line strategy in m RCC. The rapidness of TGR before the onset of the treatment reflects the variability between patients in terms of tumor growth kinetics and it could be a surrogate marker of tumor aggressiveness that may guide treatment decisions.展开更多
In this article we study the two-dimensional completeλ-translators immersed in the Euclidean space R^3 and Minkovski space R1^ 3.We obtain two classification theorems:one for two-dimensional completeλ-translators x:...In this article we study the two-dimensional completeλ-translators immersed in the Euclidean space R^3 and Minkovski space R1^ 3.We obtain two classification theorems:one for two-dimensional completeλ-translators x:M 2→R^3 and one for two-dimensional complete space-likeλ-translators x:M 2→R1^3,with a second fundamental form of constant length.展开更多
GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSEA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-o...GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSEA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community sincethe previous International Conference HSLA Steels’85 was held in Beijing,The aim of the conference isto review and to consolidate the scientific,metallurgical,and economical results and to assessthe future trend of development in the fields.展开更多
General Information The Chinese Society of Metals ispleased to announce that The SecondInternational Conference on HSLA Steels(HSLA ’90) will be held in Beijing, Chinain October, 1990. Much progress in researchand de...General Information The Chinese Society of Metals ispleased to announce that The SecondInternational Conference on HSLA Steels(HSLA ’90) will be held in Beijing, Chinain October, 1990. Much progress in researchand development of HSLA steels has beenachieved by the world’s metallurgical andmaterials community since the previousInternational Conference HSLA Steels ’85展开更多
二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提...二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提升;二语写作研究领域暂未形成明显的核心作者和机构的合作网络;研究主题主要聚焦二语写作教学方法的多元化、二语写作反馈的多焦点、二语写作评估与测试的科学化,以及学习者个体差异的多维影响等方面。基于此,提出未来该领域发展需加强学者、机构之间的相互合作;关注个体学习者写作过程的认知特征与情感因素,尤其重视青少年二语学习过程的研究;扩大二语写作纵向研究规模,推动研究的深入发展。展开更多
Motivation is one of the most important factors that affect foreign language learning.As it is affected by various factors,it becomes very complicated. Therefore, it is of great significance for foreign language teach...Motivation is one of the most important factors that affect foreign language learning.As it is affected by various factors,it becomes very complicated. Therefore, it is of great significance for foreign language teachers to explore how to motivate their students to become autonomous learners based on the overview of motivation studies in foreign language learning. This paper analyzes motivation factors on influencing learners in foreign language learning and explores some suggestions for motivating learner's learning.展开更多
In all convective heat transfer situations, losses occur in the flow field （by dissipation） as well as in the temperature field （by conduction）. Typically these losses are more or less quantified by the friction f...In all convective heat transfer situations, losses occur in the flow field （by dissipation） as well as in the temperature field （by conduction）. Typically these losses are more or less quantified by the friction factorfwith respect to losses in the flow field, and the Nusselt number Nu for the heat transfer quality. Assessing the process of convective heat transfer as a whole, then becomes problematic because two different non-dimensional quantities, f and Nu, have to be combined somehow. From a thermodynamics point of view, there is a reasonable alternative： Since all losses become manifest in corresponding entropy generation rates, these rates are determined in the velocity as well as in the temperature field. Based on the integration of the entropy generation fields, an energy devaluation number is introduced. It basically determines how much oftbe so-called entropic potential of the energy involved in a convective heat transfer process is used within it. This approach is called SLA （second law analysis）.展开更多
GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels (HSLA’90) will be held in Beijing,China inOctober 1990.Much progress in research and devel...GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels (HSLA’90) will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community since展开更多
GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSLA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-o...GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSLA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community since展开更多
When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,whi...When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.展开更多
Input theory as a theoretical foundation in language teaching plays an important role in SLA.Though a wealth of re⁃search has been done by linguists to demonstrate the importance of language input in SLA,little has be...Input theory as a theoretical foundation in language teaching plays an important role in SLA.Though a wealth of re⁃search has been done by linguists to demonstrate the importance of language input in SLA,little has been written about the type and amount of language input for successful SLA,especially its processing model while acquiring a second language.This paper first discusses the Krashen’s input hypothesis in language learning,and then an introduction to Chaudron’s processing model of in⁃put is made.In the final part,the author explains the acquisition process based on word acquisition and grammar acquisition and concludes that in the process of acquiring a second language,the language learners reconstruct a new cognitive model by taking in consistent comprehensible language input.展开更多
Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects o...Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, the more severe the pain. 4) Scar condition: Scar formation was evaluated 1, 3, and 6 months after wound healing using the VAS scale, with a total score of 15 points. The higher the score, the more severe the scar. 5) Detect the expression of AGEs in wound tissue. Results: The wound healed 14.03 ± 2.28 days after eschar removal, with a cure rate of 97.8%. No infection occurred in the wound after eschar removal in all patients. The wound healing time ranged from 9 to 23 days, with an average healing time of 28.41 ± 1.45 days. The healing quality was satisfactory. The Vancouver Scar Scale scored the wound healing scar as 0.81 ± 0.73 points. Western blot was used to detect the expression of AGEs, (receptor for advanced glycation end products) RAGE, and protein in the wound tissue. Results After 7, 14, and 28 days of medication, the wounds of diabetic patients healed well. The drug treatment efficacy and hydroxyproline content showed an upward trend, and the expression levels of AGEs, RAGE, and HIF-1a proteins showed a downward trend. Compared with day 0, the hydroxyproline content of the wound granulation tissue on days 7, 14, and 28 was significantly increased (P< 0.01), and the expression levels of AGEs, RAGE, and HIF-1α proteins were significantly downregulated (P< 0.05 or P< 0.01). Conclusion: Monitoring the expression levels of AGEs and RAGE can reflect the wound-healing effect of patients with second-degree burns, and the prognosis of the wound is closely related to the expression levels of AGEs, RAGE, and scab abrasion. In the treatment of second-degree burn wounds, scab abrasion can grasp the level of necrotic scab removal, can achieve “relatively accurate” removal of necrotic tissue, maximally protect the ecological tissue between wounds and retaining normal tissue, and can play a positive role in promoting the healing process of burn wounds;at the same time, nanosilver dressings have good antibacterial properties and high safety, and mussel mucin has anti-inflammatory and antioxidant activities and the characteristics of blocking nerve endings, which can effectively relieve the burning, stinging, and itching of sensitive skin and effectively promote wound healing.展开更多
The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue a...The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.展开更多
Higher-order band topology not only enriches our understanding of topological phases but also unveils pioneering lower-dimensional boundary states,which harbors substantial potential for next-generation device applica...Higher-order band topology not only enriches our understanding of topological phases but also unveils pioneering lower-dimensional boundary states,which harbors substantial potential for next-generation device applications.The distinct electronic configurations and tunable attributes of two-dimensional materials position them as a quintessential platform for the realization of second-order topological insulators(SOTIs).This article provides an overview of the research progress in SOTIs within the field of two-dimensional electronic materials,focusing on the characterization of higher-order topological properties and the numerous candidate materials proposed in theoretical studies.These endeavors not only enhance our understanding of higher-order topological states but also highlight potential material systems that could be experimentally realized.展开更多
Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was ...Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.展开更多
The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex...The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex beams for various applications.In this work,the second harmonic(SH)optical vortex beams generated from nonlinear fork gratings under Gaussian beam illumination are numerically investigated.The far-field intensity and phase distributions,as well as the orbital angular momentum(OAM)spectra of the SH beams,are analyzed for different structural topological charges and diffraction orders.Results reveal that higher-order diffraction and larger structural topological charges lead to angular interference patterns and non-uniform intensity distributions,deviating from the standard vortex profile.To optimize the SH vortex quality,the effects of the fundamental wave beam waist,crystal thickness,and grating duty cycle are explored.It is shown that increasing the beam waist can effectively suppress diffraction order interference and improve the beam’s quality.This study provides theoretical guidance for enhancing the performance of nonlinear optical devices based on NPCs.展开更多
We consider the space and time decays of certain problems within the second gradient thermal law.Notably,for this thermal theory,the exponential time decay is precluded.First,the time estimates of polynomial type are ...We consider the space and time decays of certain problems within the second gradient thermal law.Notably,for this thermal theory,the exponential time decay is precluded.First,the time estimates of polynomial type are obtained for both the thermal equation and the one-dimensional thermoelastic system,where the impossibility of localization with respect to time is also established.Then,the space estimates are deduced for the multidimensional thermoelastic problem,which allow to show the exponential decay of the energy.展开更多
文摘Eva Hoffman’s Lost in Translation:A life in a New Language is prominent in that it spares no effort elaborating on the author’s personal experience in acquiring her second language(L2)English from the view of sociolinguistics.In this vein,by in vestigating the underlined relationship between language learners’cultural identity and language identity from the perspective of sociolinguistics,the paper aims to explore the possibilities of assisting L2 learners reach a balance in their biological,cultural,so cial,and psychological domains of life.
文摘The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased in daily practice and now it is not uncommon to see patients surviving kidney cancer for more than four to five years. Once treatment fails with the first line targeted therapy, head to head comparisons have shown that cabozantinib, nivolumab and the combination of lenvatinib plus everolimus are more effective than everolimus alone and that axitinib is more active than sorafenib. Unfortunately, it is very unlikely that we will ever have prospective data comparing the activity of axitinib, cabozantinib, lenvatinib or nivolumab. It is frustrating to observe the lack of biomarkers that we have in this field, thus there is no firm recommendation about the optimal sequence of treatment in the second line. In the absence of reliable biomarkers, there are several clinical endpoints that can help physicians to make decisions for an individual patient, such as the tumor burden, the expected response rate and the time to achieve the response to each agent, the prior response to the agent administered, the toxicity profile of the different compounds and patient preference. Here, we propose the introduction of the tumor-growth rate(TGR) during first-line treatment as a new tool to be used to select the second line strategy in m RCC. The rapidness of TGR before the onset of the treatment reflects the variability between patients in terms of tumor growth kinetics and it could be a surrogate marker of tumor aggressiveness that may guide treatment decisions.
基金Foundation of Natural Sciences of China(11671121,11871197 and 11971153)。
文摘In this article we study the two-dimensional completeλ-translators immersed in the Euclidean space R^3 and Minkovski space R1^ 3.We obtain two classification theorems:one for two-dimensional completeλ-translators x:M 2→R^3 and one for two-dimensional complete space-likeλ-translators x:M 2→R1^3,with a second fundamental form of constant length.
文摘GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSEA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community sincethe previous International Conference HSLA Steels’85 was held in Beijing,The aim of the conference isto review and to consolidate the scientific,metallurgical,and economical results and to assessthe future trend of development in the fields.
文摘General Information The Chinese Society of Metals ispleased to announce that The SecondInternational Conference on HSLA Steels(HSLA ’90) will be held in Beijing, Chinain October, 1990. Much progress in researchand development of HSLA steels has beenachieved by the world’s metallurgical andmaterials community since the previousInternational Conference HSLA Steels ’85
文摘二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提升;二语写作研究领域暂未形成明显的核心作者和机构的合作网络;研究主题主要聚焦二语写作教学方法的多元化、二语写作反馈的多焦点、二语写作评估与测试的科学化,以及学习者个体差异的多维影响等方面。基于此,提出未来该领域发展需加强学者、机构之间的相互合作;关注个体学习者写作过程的认知特征与情感因素,尤其重视青少年二语学习过程的研究;扩大二语写作纵向研究规模,推动研究的深入发展。
文摘Motivation is one of the most important factors that affect foreign language learning.As it is affected by various factors,it becomes very complicated. Therefore, it is of great significance for foreign language teachers to explore how to motivate their students to become autonomous learners based on the overview of motivation studies in foreign language learning. This paper analyzes motivation factors on influencing learners in foreign language learning and explores some suggestions for motivating learner's learning.
文摘In all convective heat transfer situations, losses occur in the flow field （by dissipation） as well as in the temperature field （by conduction）. Typically these losses are more or less quantified by the friction factorfwith respect to losses in the flow field, and the Nusselt number Nu for the heat transfer quality. Assessing the process of convective heat transfer as a whole, then becomes problematic because two different non-dimensional quantities, f and Nu, have to be combined somehow. From a thermodynamics point of view, there is a reasonable alternative： Since all losses become manifest in corresponding entropy generation rates, these rates are determined in the velocity as well as in the temperature field. Based on the integration of the entropy generation fields, an energy devaluation number is introduced. It basically determines how much oftbe so-called entropic potential of the energy involved in a convective heat transfer process is used within it. This approach is called SLA （second law analysis）.
文摘GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels (HSLA’90) will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community since
文摘GENERAL INFORMATIONThe Chinese Society of Metals is pleased to announcethat The Second International Conference on HSLASteels(HSLA’90)will be held in Beijing,China inOctober 1990.Much progress in research and devel-opment of HSLA steels has been achieved by theworld’s metallurgical and materials community since
文摘When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.
文摘Input theory as a theoretical foundation in language teaching plays an important role in SLA.Though a wealth of re⁃search has been done by linguists to demonstrate the importance of language input in SLA,little has been written about the type and amount of language input for successful SLA,especially its processing model while acquiring a second language.This paper first discusses the Krashen’s input hypothesis in language learning,and then an introduction to Chaudron’s processing model of in⁃put is made.In the final part,the author explains the acquisition process based on word acquisition and grammar acquisition and concludes that in the process of acquiring a second language,the language learners reconstruct a new cognitive model by taking in consistent comprehensible language input.
文摘Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, the more severe the pain. 4) Scar condition: Scar formation was evaluated 1, 3, and 6 months after wound healing using the VAS scale, with a total score of 15 points. The higher the score, the more severe the scar. 5) Detect the expression of AGEs in wound tissue. Results: The wound healed 14.03 ± 2.28 days after eschar removal, with a cure rate of 97.8%. No infection occurred in the wound after eschar removal in all patients. The wound healing time ranged from 9 to 23 days, with an average healing time of 28.41 ± 1.45 days. The healing quality was satisfactory. The Vancouver Scar Scale scored the wound healing scar as 0.81 ± 0.73 points. Western blot was used to detect the expression of AGEs, (receptor for advanced glycation end products) RAGE, and protein in the wound tissue. Results After 7, 14, and 28 days of medication, the wounds of diabetic patients healed well. The drug treatment efficacy and hydroxyproline content showed an upward trend, and the expression levels of AGEs, RAGE, and HIF-1a proteins showed a downward trend. Compared with day 0, the hydroxyproline content of the wound granulation tissue on days 7, 14, and 28 was significantly increased (P< 0.01), and the expression levels of AGEs, RAGE, and HIF-1α proteins were significantly downregulated (P< 0.05 or P< 0.01). Conclusion: Monitoring the expression levels of AGEs and RAGE can reflect the wound-healing effect of patients with second-degree burns, and the prognosis of the wound is closely related to the expression levels of AGEs, RAGE, and scab abrasion. In the treatment of second-degree burn wounds, scab abrasion can grasp the level of necrotic scab removal, can achieve “relatively accurate” removal of necrotic tissue, maximally protect the ecological tissue between wounds and retaining normal tissue, and can play a positive role in promoting the healing process of burn wounds;at the same time, nanosilver dressings have good antibacterial properties and high safety, and mussel mucin has anti-inflammatory and antioxidant activities and the characteristics of blocking nerve endings, which can effectively relieve the burning, stinging, and itching of sensitive skin and effectively promote wound healing.
基金Supported by National Natural Science Foundation of China(81874059 and 82102105)the Natural Science Foundation of Zhejiang Province(LQ22H160017)the China Postdoctoral Science Foundation(2021M702825).
文摘The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.
基金supported by the National Natu-ral Science Foundation of China(Grants No.12174220 and No.12074217)the Shandong Provincial Science Foundation for Excellent Young Scholars(Grant No.ZR2023YQ001)+1 种基金the Taishan Young Scholar Program of Shandong Provincethe Qilu Young Scholar Pro-gram of Shandong University.
文摘Higher-order band topology not only enriches our understanding of topological phases but also unveils pioneering lower-dimensional boundary states,which harbors substantial potential for next-generation device applications.The distinct electronic configurations and tunable attributes of two-dimensional materials position them as a quintessential platform for the realization of second-order topological insulators(SOTIs).This article provides an overview of the research progress in SOTIs within the field of two-dimensional electronic materials,focusing on the characterization of higher-order topological properties and the numerous candidate materials proposed in theoretical studies.These endeavors not only enhance our understanding of higher-order topological states but also highlight potential material systems that could be experimentally realized.
基金Supported by the National Natural Science Foundation of China(42302141).
文摘Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.
基金supported by the National Nat-ural Science Foundation of China(Nos.12192251,12174185,92163216,and 62288101).
文摘The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex beams for various applications.In this work,the second harmonic(SH)optical vortex beams generated from nonlinear fork gratings under Gaussian beam illumination are numerically investigated.The far-field intensity and phase distributions,as well as the orbital angular momentum(OAM)spectra of the SH beams,are analyzed for different structural topological charges and diffraction orders.Results reveal that higher-order diffraction and larger structural topological charges lead to angular interference patterns and non-uniform intensity distributions,deviating from the standard vortex profile.To optimize the SH vortex quality,the effects of the fundamental wave beam waist,crystal thickness,and grating duty cycle are explored.It is shown that increasing the beam waist can effectively suppress diffraction order interference and improve the beam’s quality.This study provides theoretical guidance for enhancing the performance of nonlinear optical devices based on NPCs.
基金part of the project“Qualitative and numerical analyses of some thermomechanics problems(ACUANUTER)”(Ref.PID2024-156827NB-I00)。
文摘We consider the space and time decays of certain problems within the second gradient thermal law.Notably,for this thermal theory,the exponential time decay is precluded.First,the time estimates of polynomial type are obtained for both the thermal equation and the one-dimensional thermoelastic system,where the impossibility of localization with respect to time is also established.Then,the space estimates are deduced for the multidimensional thermoelastic problem,which allow to show the exponential decay of the energy.
