Do you spend manyhours oftheday sitting?When you sit,you use less energy than you do when you are active.Sittingtoo much hurts your back,and it's bad for your heart.It causesyou to gain weight and may even increas...Do you spend manyhours oftheday sitting?When you sit,you use less energy than you do when you are active.Sittingtoo much hurts your back,and it's bad for your heart.It causesyou to gain weight and may even increase your risk of cancer.展开更多
1 Do you spend many hours of the day sitting?When you sit,you use less energy than you do when you are active.Sitting too much hurts your back,and It's bad for your heart.It causes you to gain weight and may even ...1 Do you spend many hours of the day sitting?When you sit,you use less energy than you do when you are active.Sitting too much hurts your back,and It's bad for your heart.It causes you to gain weight and may even increase your risk of cancer、How can you avoid sitting too much?展开更多
Detecting sitting posture abnormalities in wheelchair users enables early identification of changes in their functional status.To date,this detection has relied on in-person observation by medical specialists.However,...Detecting sitting posture abnormalities in wheelchair users enables early identification of changes in their functional status.To date,this detection has relied on in-person observation by medical specialists.However,given the challenges faced by health specialists to carry out continuous monitoring,the development of an intelligent anomaly detection system is proposed.Unlike other authors,where they use supervised techniques,this work proposes using unsupervised techniques due to the advantages they offer.These advantages include the lack of prior labeling of data,and the detection of anomalies previously not contemplated,among others.In the present work,an individualized methodology consisting of two phases is developed:characterizing the normal sitting pattern and determining abnormal samples.An analysis has been carried out between different unsupervised techniques to study which ones are more suitable for postural diagnosis.It can be concluded,among other aspects,that the utilization of dimensionality reduction techniques leads to improved results.Moreover,the normality characterization phase is deemed necessary for enhancing the system’s learning capabilities.Additionally,employing an individualized approach to the model aids in capturing the particularities of the various pathologies present among subjects.展开更多
Do you spend many hours of he day sitting?When you sit,"you use less energy than you do when you are active.Sitting too much hurts your back,and it's tad for your heart.it causes you to gain weight and may ev...Do you spend many hours of he day sitting?When you sit,"you use less energy than you do when you are active.Sitting too much hurts your back,and it's tad for your heart.it causes you to gain weight and may even increase your risk of cancer.How can you avoid sitting too much?展开更多
Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting dis...Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting disrupts the circulation of qi and blood,damages muscles,impairs spleen function,and ultimately leads to diseases.Modern biomedical evidence shows that sedentary behavior,including prolonged sitting,affects endocrine,metabolic,and physiological functions,increasing the risk of chronic diseases.This article systematically reviews TCM records of the health impacts of long-time sitting and biomedical findings,to explore the pathophysiological mechanisms underlying the health risks of prolonged sitting.By integrating TCM's preventative philosophy,namely Zhi Wei Bing(治未病preventing a disease before it arises),with modern preventive medicine,this study offers insights into strategies for mitigating the health risks associated with sedentary behavior.展开更多
Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investi...Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.展开更多
Situs inversus totalis(SIT)is a rare homozygous recessive disease caused by the mutation in PKD1L1,which is required for normal interaction with PKD2 and leads to different complications such as respiratory disorders,...Situs inversus totalis(SIT)is a rare homozygous recessive disease caused by the mutation in PKD1L1,which is required for normal interaction with PKD2 and leads to different complications such as respiratory disorders,brain disorders and even obesity.The present study was designed to find out the mutational effect on the binding of PKD2 with mutated PKD1L1,which leads to SIT.The three-dimensional(3D)structure of wild type and mutated PKD1L1 was predicted with>90%confidence using different online tools.The different online tools that were employed were SWISS-MODEL,Phyre2(normal&intensive)and i-TASSER.To compute the physiochemical properties of PKD1L1(wild&mutated)and PKD2 in silico approaches were employed using the ExPASy ProtParam tool.Physicochemical properties such as molecular weight,isoelectric point,the total number of negatively and positively charged residues,extinction coefficient,half-life,instability and aliphatic index,grand average of hydropathicity,and amino acid percentage were calculated.A lot of variability was observed in these parameters among PKD1L1 and PKD2,which accounted for diversification in their functional properties.The theoretical pI points showed that PKD1L1(whole)is more basic with 6.64 pI compared to its first chain TOPO_DOM(amino acids from 1–1748)has a pI of 5.62 which means it is basic while PKD2 have the lowest pI point of 5.34.Docking was performed using the PatchDock and ClusPro online tools.展开更多
Do you spend many hours of the day siting?When you sit,you use less energy than you do when you are active.Siting toomuch hurts yourback,and it's bad for your heart it causes you to gain weight and may even increa...Do you spend many hours of the day siting?When you sit,you use less energy than you do when you are active.Siting toomuch hurts yourback,and it's bad for your heart it causes you to gain weight and may even increase your risk of cancer.How can you avoid siting too much?Every 30minutes,move and stretch.Better on thephone orwatch TV.展开更多
Background:While the relationship between sedentary time and adiposity markers may be independent of moderate-to-vigorous intensity physical activity(MVPA) among adolescents,little is known about the role of light-int...Background:While the relationship between sedentary time and adiposity markers may be independent of moderate-to-vigorous intensity physical activity(MVPA) among adolescents,little is known about the role of light-intensity physical activity(LIPA) in this relationship.The aim of this cross-sectional study was to examine whether device-measured LIPA and MVPA moderate the associations between objectively measured sitting time and adiposity markers(body mass index(BMI)) and waist circumference(WC)) among adolescents.Methods:This study included accelerometer and inclinometer data obtained from 219 adolescents(age=14.9±1.6 years,mean± SD),collected during 2014 and 2015 in Melbourne,Australia.ActiGraph GT3 X accelerometers were used to determine time spent in total-LIPA(101 counts/min to 3.99 metabolic equivalents(METs)) was dichotomized into low-LIPA(101-799 counts/min) and high LIPA(800 counts/min to 3.99 METs),and MVPA(> 4 METs).The average time spent sitting was obtained from activPAL inclinometers.Anthropometric measures were assessed by trained staff.Interactions between sitting and total-LIPA,low-LIPA,high-LIPA,and MVPA on BMI z-score(zBMI) and WC z-score(zWC),respectively,were examined using linear regression,adjusting for age and sex;and moderation by total-LIPA,low-LIPA,high-LIPA,and MVPA were examined by adding interaction terms.Significant interaction effects were probed by comparing associations at the mean and at 1 SD below and above the mean.Results:Total-LIPA significantly moderated the association between sitting time and zBMI,and low-LIPA significantly moderated the association between sitting time and zBMI and zWC.No other associations were found for total-LIPA,high-LIPA,or MVPA.Specifically,at high levels of total-LIPA(+1 SD),there is a negative association between sitting time and zBMI.In addition,at high levels of low-LIPA(+1 SD),there is a negative association between sitting time and zBMI and zWC.Conclusion:Associations between sitting and adiposity depended on time spent in total-LIPA and low-LIPA,but not high-LIPA or MVPA.Results suggest that increasing time spent in LIP A may provide protection from the deleterious effects of sitting on adiposity markers among adolescents.Experimental evidence is needed to support these conclusions.展开更多
Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evide...Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evidence of posterior semicircular canal(P-SCC)cupula stimulation on sitting-up was described and named sitting-up vertigo BPPV.A periampullar restricted P-SCC canalolithiasis was proposed as a causal mechanism.Objective:To describe new mechanisms of action for the sitting-up vertigo BPPV variant.Methods:Eighteen patients with sitting-up vertigo BPPV were examined with a pre-established set of positional maneuvers and follow-up until they resolved their symptoms and clinical findings.Results:All patients showed up-beating torsional nystagmus(UBTN)and vestibular symptoms on coming up from either Dix-Hallpike(DHM)or straight head-hanging maneuver.Sixteen out of 18 patients presented a sustained UBTN with an ipsitorsional component to the tested side on half-Hallpike maneuver(HH).A slower persistent contratorsional down-beating nystagmus was found in eleven out18 patients tested on nose down position(ND).Conclusions:Persistent direction changing positional nystagmus on HH and ND positions indicative of PSCC heavy cupula was found in 11 patients.A sustained UBTN on HH with the absence of findings on ND,which is suggestive of the presence of P-SCC short arm canalolithiasis,was found on 5 patients.All patients were treated with canalith repositioning maneuvers without success,but they resolved their findings by means of Brandt-Daroff exercises.We propose P-SCC heavy cupula and P-SCC short arm canalolithiasis as two new putative mechanisms for the sitting-up vertigo BPPV variant.展开更多
文摘Do you spend manyhours oftheday sitting?When you sit,you use less energy than you do when you are active.Sittingtoo much hurts your back,and it's bad for your heart.It causesyou to gain weight and may even increase your risk of cancer.
文摘1 Do you spend many hours of the day sitting?When you sit,you use less energy than you do when you are active.Sitting too much hurts your back,and It's bad for your heart.It causes you to gain weight and may even increase your risk of cancer、How can you avoid sitting too much?
基金FEDER/Ministry of Science and Innovation-State Research Agency/Project PID2020-112667RB-I00 funded by MCIN/AEI/10.13039/501100011033the Basque Government,IT1726-22+2 种基金by the predoctoral contracts PRE_2022_2_0022 and EP_2023_1_0015 of the Basque Governmentpartially supported by the Italian MIUR,PRIN 2020 Project“COMMON-WEARS”,N.2020HCWWLP,CUP:H23C22000230005co-funding from Next Generation EU,in the context of the National Recovery and Resilience Plan,through the Italian MUR,PRIN 2022 Project”COCOWEARS”(A framework for COntinuum COmputing WEARable Systems),N.2022T2XNJE,CUP:H53D23003640006.
文摘Detecting sitting posture abnormalities in wheelchair users enables early identification of changes in their functional status.To date,this detection has relied on in-person observation by medical specialists.However,given the challenges faced by health specialists to carry out continuous monitoring,the development of an intelligent anomaly detection system is proposed.Unlike other authors,where they use supervised techniques,this work proposes using unsupervised techniques due to the advantages they offer.These advantages include the lack of prior labeling of data,and the detection of anomalies previously not contemplated,among others.In the present work,an individualized methodology consisting of two phases is developed:characterizing the normal sitting pattern and determining abnormal samples.An analysis has been carried out between different unsupervised techniques to study which ones are more suitable for postural diagnosis.It can be concluded,among other aspects,that the utilization of dimensionality reduction techniques leads to improved results.Moreover,the normality characterization phase is deemed necessary for enhancing the system’s learning capabilities.Additionally,employing an individualized approach to the model aids in capturing the particularities of the various pathologies present among subjects.
文摘Do you spend many hours of he day sitting?When you sit,"you use less energy than you do when you are active.Sitting too much hurts your back,and it's tad for your heart.it causes you to gain weight and may even increase your risk of cancer.How can you avoid sitting too much?
基金financed by the grants from the Zhejiang Province Higher Education Research Fund Program(NO.JG20220766)National Natural Science Foundation of China(No.71774147)Innovation and Entrepreneurship Training Program for College Students in Zhejiang Province(No.S202010344012)。
文摘Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting disrupts the circulation of qi and blood,damages muscles,impairs spleen function,and ultimately leads to diseases.Modern biomedical evidence shows that sedentary behavior,including prolonged sitting,affects endocrine,metabolic,and physiological functions,increasing the risk of chronic diseases.This article systematically reviews TCM records of the health impacts of long-time sitting and biomedical findings,to explore the pathophysiological mechanisms underlying the health risks of prolonged sitting.By integrating TCM's preventative philosophy,namely Zhi Wei Bing(治未病preventing a disease before it arises),with modern preventive medicine,this study offers insights into strategies for mitigating the health risks associated with sedentary behavior.
文摘Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.
文摘Situs inversus totalis(SIT)is a rare homozygous recessive disease caused by the mutation in PKD1L1,which is required for normal interaction with PKD2 and leads to different complications such as respiratory disorders,brain disorders and even obesity.The present study was designed to find out the mutational effect on the binding of PKD2 with mutated PKD1L1,which leads to SIT.The three-dimensional(3D)structure of wild type and mutated PKD1L1 was predicted with>90%confidence using different online tools.The different online tools that were employed were SWISS-MODEL,Phyre2(normal&intensive)and i-TASSER.To compute the physiochemical properties of PKD1L1(wild&mutated)and PKD2 in silico approaches were employed using the ExPASy ProtParam tool.Physicochemical properties such as molecular weight,isoelectric point,the total number of negatively and positively charged residues,extinction coefficient,half-life,instability and aliphatic index,grand average of hydropathicity,and amino acid percentage were calculated.A lot of variability was observed in these parameters among PKD1L1 and PKD2,which accounted for diversification in their functional properties.The theoretical pI points showed that PKD1L1(whole)is more basic with 6.64 pI compared to its first chain TOPO_DOM(amino acids from 1–1748)has a pI of 5.62 which means it is basic while PKD2 have the lowest pI point of 5.34.Docking was performed using the PatchDock and ClusPro online tools.
文摘Do you spend many hours of the day siting?When you sit,you use less energy than you do when you are active.Siting toomuch hurts yourback,and it's bad for your heart it causes you to gain weight and may even increase your risk of cancer.How can you avoid siting too much?Every 30minutes,move and stretch.Better on thephone orwatch TV.
基金funded by the National Institutes for Health (NIH) (R01 HL 111378)AMCA is supported by a Deakin University Postgraduate Research Scholarship (DUPRS)+5 种基金JS was supported by a NHMRC Principal Research Fellowship (APP1026216) during this researchDWD is supported by an NHMRC Senior Research Fellowship (APP1078360)the Victorian Government’s Operational Infrastructure Support ProgramLA is supported by an Alfred Deakin Postdoctoral Research Fellowshipsupported by a National Heart Foundation of Australia Future Leader Fellowship (Award ID 100046) during this researchJS,DWD,and AT received funding support from an NHMRC Centre for Research Excellence Grant (APP1057608)。
文摘Background:While the relationship between sedentary time and adiposity markers may be independent of moderate-to-vigorous intensity physical activity(MVPA) among adolescents,little is known about the role of light-intensity physical activity(LIPA) in this relationship.The aim of this cross-sectional study was to examine whether device-measured LIPA and MVPA moderate the associations between objectively measured sitting time and adiposity markers(body mass index(BMI)) and waist circumference(WC)) among adolescents.Methods:This study included accelerometer and inclinometer data obtained from 219 adolescents(age=14.9±1.6 years,mean± SD),collected during 2014 and 2015 in Melbourne,Australia.ActiGraph GT3 X accelerometers were used to determine time spent in total-LIPA(101 counts/min to 3.99 metabolic equivalents(METs)) was dichotomized into low-LIPA(101-799 counts/min) and high LIPA(800 counts/min to 3.99 METs),and MVPA(> 4 METs).The average time spent sitting was obtained from activPAL inclinometers.Anthropometric measures were assessed by trained staff.Interactions between sitting and total-LIPA,low-LIPA,high-LIPA,and MVPA on BMI z-score(zBMI) and WC z-score(zWC),respectively,were examined using linear regression,adjusting for age and sex;and moderation by total-LIPA,low-LIPA,high-LIPA,and MVPA were examined by adding interaction terms.Significant interaction effects were probed by comparing associations at the mean and at 1 SD below and above the mean.Results:Total-LIPA significantly moderated the association between sitting time and zBMI,and low-LIPA significantly moderated the association between sitting time and zBMI and zWC.No other associations were found for total-LIPA,high-LIPA,or MVPA.Specifically,at high levels of total-LIPA(+1 SD),there is a negative association between sitting time and zBMI.In addition,at high levels of low-LIPA(+1 SD),there is a negative association between sitting time and zBMI and zWC.Conclusion:Associations between sitting and adiposity depended on time spent in total-LIPA and low-LIPA,but not high-LIPA or MVPA.Results suggest that increasing time spent in LIP A may provide protection from the deleterious effects of sitting on adiposity markers among adolescents.Experimental evidence is needed to support these conclusions.
文摘Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evidence of posterior semicircular canal(P-SCC)cupula stimulation on sitting-up was described and named sitting-up vertigo BPPV.A periampullar restricted P-SCC canalolithiasis was proposed as a causal mechanism.Objective:To describe new mechanisms of action for the sitting-up vertigo BPPV variant.Methods:Eighteen patients with sitting-up vertigo BPPV were examined with a pre-established set of positional maneuvers and follow-up until they resolved their symptoms and clinical findings.Results:All patients showed up-beating torsional nystagmus(UBTN)and vestibular symptoms on coming up from either Dix-Hallpike(DHM)or straight head-hanging maneuver.Sixteen out of 18 patients presented a sustained UBTN with an ipsitorsional component to the tested side on half-Hallpike maneuver(HH).A slower persistent contratorsional down-beating nystagmus was found in eleven out18 patients tested on nose down position(ND).Conclusions:Persistent direction changing positional nystagmus on HH and ND positions indicative of PSCC heavy cupula was found in 11 patients.A sustained UBTN on HH with the absence of findings on ND,which is suggestive of the presence of P-SCC short arm canalolithiasis,was found on 5 patients.All patients were treated with canalith repositioning maneuvers without success,but they resolved their findings by means of Brandt-Daroff exercises.We propose P-SCC heavy cupula and P-SCC short arm canalolithiasis as two new putative mechanisms for the sitting-up vertigo BPPV variant.
