Carboxymethylated,phosphorylated and sulfated derivatives of SIP-IV,a polysaccharide derived from Sepia esculenta ink,were prepared and their antioxidant,anticoagulant and thrombolytic properties were evaluated.Data s...Carboxymethylated,phosphorylated and sulfated derivatives of SIP-IV,a polysaccharide derived from Sepia esculenta ink,were prepared and their antioxidant,anticoagulant and thrombolytic properties were evaluated.Data showed that sulfation and phosphorylation modification improved antioxidant activity of SIP-IV,but carboxymethylation impaired the property.In vitro data showed that SIP-IV and its three modified derivatives could significantly prolong activated partial thrombin time(APTT),prothrombin time(PT)and thrombin time(TT),and also exhibited thrombolysis activity.In vivo,these polymers alleviated chemotherapy-induced blood hypercoagulation by reversing abnormal levels of coagulation factors II and X,and antithrombin III in plasma,resulting in prolonged bleeding time.Moreover,the polysaccharides play an antagonistic role against chemotherapy-mediated liver oxidative stress.Sulfate-modified polysaccharide(S-SIP-IV)has the best anticoagulant,thrombolytic and antioxidant effects.展开更多
Because of graphene and phosphorene, two-dimensional （2D） layered materials of group IV and group V elements arouse great interest. However, group IV-V monolayers have not received due attention. In this work, three...Because of graphene and phosphorene, two-dimensional （2D） layered materials of group IV and group V elements arouse great interest. However, group IV-V monolayers have not received due attention. In this work, three types of SiP monolayers were computationally designed to explore their electronic structure and optical properties. Computations confirm the stability of these monolayers, which are all indirect-bandgap semiconductors with bandgaps in the range 1.38-2.21 eV. The bandgaps straddle the redox potentials of water at pH = 0, indicating the potential of the monolayers for use as water- splitting photocatalysts. The computed optical properties demonstrate that certain monolayers of SiP 2D materials axe absorbers of visible light and would serve as good candidates for optoelectronic devices.展开更多
基金supported by grants from Guangdong Basic and Applied Basic Research Foundation(2022A1515012091)the Project of Application-Based Talent Training Course from Guangdong Ocean University(570319017,571119165)Postgraduate Education Innovation Program of Guangdong Ocean University(521005022,040502122103).
文摘Carboxymethylated,phosphorylated and sulfated derivatives of SIP-IV,a polysaccharide derived from Sepia esculenta ink,were prepared and their antioxidant,anticoagulant and thrombolytic properties were evaluated.Data showed that sulfation and phosphorylation modification improved antioxidant activity of SIP-IV,but carboxymethylation impaired the property.In vitro data showed that SIP-IV and its three modified derivatives could significantly prolong activated partial thrombin time(APTT),prothrombin time(PT)and thrombin time(TT),and also exhibited thrombolysis activity.In vivo,these polymers alleviated chemotherapy-induced blood hypercoagulation by reversing abnormal levels of coagulation factors II and X,and antithrombin III in plasma,resulting in prolonged bleeding time.Moreover,the polysaccharides play an antagonistic role against chemotherapy-mediated liver oxidative stress.Sulfate-modified polysaccharide(S-SIP-IV)has the best anticoagulant,thrombolytic and antioxidant effects.
基金This work was supported by the National Science Foundation of China （Grant No. 21503195）, Natural Science Foundation of Shanxi Province （2015021044）, and Open Research Fund of Key Laboratory of Advanced Energy Materials Chemistry （Ministry of Education）, Nankai University in China.
文摘Because of graphene and phosphorene, two-dimensional （2D） layered materials of group IV and group V elements arouse great interest. However, group IV-V monolayers have not received due attention. In this work, three types of SiP monolayers were computationally designed to explore their electronic structure and optical properties. Computations confirm the stability of these monolayers, which are all indirect-bandgap semiconductors with bandgaps in the range 1.38-2.21 eV. The bandgaps straddle the redox potentials of water at pH = 0, indicating the potential of the monolayers for use as water- splitting photocatalysts. The computed optical properties demonstrate that certain monolayers of SiP 2D materials axe absorbers of visible light and would serve as good candidates for optoelectronic devices.
