Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupunc...Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupuncture （EA） sensations. Methods Twenty one volunteers received EA. According to the tissue specificities of acupoints, 5 acupoint pairs were selected, named Zúsānlǐ （足三里 ST 36） vs Yánglíngquán （阳陵泉 GB 34, different meridians）, Nèiguān （内关 PC 6） vs Dàlíng （大陵 PC 7, different tissues）, Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28, different nerve segments）, Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12, different nerve segments）, and Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4, different meridians, tissues and nerve segments）. The electric frequency was 15 Hz. The electric current was under the subject’s tolerance without sharp pain induced. EA lasted 90 s with 3 discontinuities. The sensations, such as soreness, numbness, fullness/distention, heaviness, tingling, pressure, dull pain, hotness and coldness were recorded as well as the current flow output in association with the needling sensations. The differences in the frequency, intensity and current flow output relevant with the needling sensations were compared among the different acupoint pairs. Results There were no significant differences in the frequency of the needling sensations among the different acupoint pairs （all P〉0.05）. Of 9 different sensations of EA, fullness/distention, numbness and soreness presented the most commonly and remarkably; heaviness, pressure and tingling were on the second top; dull pain, hotness and coldness occurred at the lower frequency. There were the differences in the intensity of some needling sensations among the acupoint pairs, in which, the intensity of soreness, fullness/distention and heaviness was stronger at Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28） （all P〈0.05）; the intensity of fullness / distention, and numbness was stronger at Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4） （P〈0.01）; the intensity of fullness/distention was stronger at Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12） （P〈0.05）. The current flow output of EA was similar among the acupoint pairs （all P〉0.05）. Conclusion In the situation that there is no obvious difference in the current flow output associated with EA sensations, the frequency of EA sensations does not relevant apparently with the different tissues. The difference in the intensity of the needling sensations among the different acupoints is probably relevant with the nerve segments at the acupoint locations. The frequency and the intensity of the different needling sensations at the same acupoint are relatively stable at the different times of EA.展开更多
To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out whe...To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out when a single body part is thermally stimulated.Cooling airflow is sent to seven body parts,respectively.Totally 94 samples are tested.To eliminate the obvious multicollinearity of thermal sensation among different body parts,the principal component regression approach is adopted to obtain the principal components for the body parts under different experimental conditions.Through regression and analysis of principal components,the weighting factors of the seven body parts are obtained.A predictive model on whole-body thermal sensation is obtained based on the weighting factors.The results show that the different characteristics of trunk and limbs are clearly seen.The weighting factors of local thermal sensation are integrated values,and there is little difference among values of different body parts.展开更多
To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a...To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a nozzle height of 4 m in the occupied zone are obtained.Then,the numerical simulation under the test condition is carried out by the computational fluid dynamics（CFD）method.The calculation results of the indoor vertical temperature and the draft sensation distribution are validated by the test data.Simulations with different nozzle heights are conducted.The satisfactory air supply condition is determined by analyzing the draft sensations and the temperatures in the occupied zone under three conditions.The simulation results show that the optimal draft sensation distribution and the uniform temperature and velocity fields can be obtained at a nozzle height of 5 m.展开更多
It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function....It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the （neurobiological） mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective ＆ cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut （brain- gut axis） will be briefly outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted.展开更多
Propagated sensation along the meridian can occur when acupoints are stimulated by acupuncture or electrical impulses. In this study, participants with notable propagated sensation along the me- ridian were given elec...Propagated sensation along the meridian can occur when acupoints are stimulated by acupuncture or electrical impulses. In this study, participants with notable propagated sensation along the me- ridian were given electro-acupuncture at the Jianyu （LI15） acupoint of the large intestine meridian. When participants stated that the sensation reached the back of their hand, reguJar nervous system action discharge was examined using a physiological recording electrode placed on the superficial branch of the radial nerve. The topographical maps of brain-evoked potential in the primary cortical somatosensory area were also detected. When Guangming （GB37） acupoint in the lower limb and Hegu （LI4） acupoint in the upper limb were stimulated, subjects without propagated sensation along the meridian exhibited a high potential reaction in the corresponding area of the brain cortical somatosensory area. For subjects with a notable propagated sensation along the meridian, the re- action area was larger and extended into the face representative area. These electrophysiological measures directly prove the existence of propagated sensation along the meridian, and the periph- eral stimulated site is consistent with the corresponding primary cortical somatosensory area, which presents a high potential reaction.展开更多
AIM:To determine the association between Helicobacter pylori(H.pylori)and globus sensation(GS)in the patients with cervical inlet patch. METHODS:Sixty-eight patients with esophageal inlet patches were identified from ...AIM:To determine the association between Helicobacter pylori(H.pylori)and globus sensation(GS)in the patients with cervical inlet patch. METHODS:Sixty-eight patients with esophageal inlet patches were identified from 6760 consecutive patients undergoing upper gastrointestinal endoscopy prospectively.In these 68 patients with cervical inlet patches, symptoms of globus sensation(lump in the throat), hoarseness,sore throat,frequent clearing of the throat,cough,dysphagia,odynophagia of at least 3 mo duration was questioned prior to endoscopy. RESULTS:Cervical heterotopic gastric mucosa(CHGM) was found in 68 of 6760 patients.The endoscopic prevalence of CHGM was determined to be 1%.H.pylori was identified in 16(23.5%)of 68 patients with inlet patch.53 patients were classified as CHGMⅡ.This group included 48 patients with globus sensation,4 patients with chronic cough and 1 patient with hoarseness.All the patients who were H.pylori(+)in cervical inlet patches had globus sensation.CONCLUSION:Often patients with CHGM have a long history of troublesome throat symptoms.We speculate that disturbances in globus sensation are like non-ulcer dyspepsia.展开更多
Objective:To investigate the short-term efficacy difference between sensation of transmission along meridian acupuncture and non-sensation of transmission along meridian acupuncture in the treatment of chronic nonbact...Objective:To investigate the short-term efficacy difference between sensation of transmission along meridian acupuncture and non-sensation of transmission along meridian acupuncture in the treatment of chronic nonbacterial prostatitis.Methods:A randomized,controlled,and single-blind clinical study was performed to collect 63 patients with chronic nonbacterial prostatitis who met the inclusion criteria and were randomly assigned to a transmission sensation group(31 patients)and a non-transmission sensation group(32 patients).The two groups of patients took the same acupuncture points.When they were lying down on their backs,Guānyuán(关元 CV4),Zhōngjí(中极 CV3)and Dàhè(大赫 K112)were taken.When they were lying down on their stomachs,Shènshū(肾俞 BL 23),Cìliáo(次髎 BL32)and Huìyáng(会阳 BL35)were taken.Among them,the transmission sensation group was treated with transmission sensation along meridian to apply deep needling to the lower abdomen and lumbosacral acupuncture points with lifting,thrusting,and twirling method,so that the needling sensation was transmitted to the bladder,perineum and urethra.The non-transmission sensation group was treated with non-transmission sensation along meridian,and the acupuncture points were treated with conventional acupuncture until the patient felt soreness and distending etc.and the arrival of qi.Both groups of patients were treated with electro-acupuncture during acupuncture,and the sparse-dense wave(sparse wave 4 Hz,dense wave 20 Hz),and the needle retention continued for 20 min.All patients were treated for 3 times with once every other day,and the treatment lasted for one week.The CV4,CV3 and KI12 were used in the first and third treatments,and the BL23,BL32 and BL35 were used in the second treatment.The National Institute of Health chronic prostatitis syndrome index(NIH-CPSI)and Hamilton Anxiety Rating Scale(HAMA)were observed,and the clinical efficacies of the patient were observed.Results:After treatment,the NIH-CPSI scores(18.29±1.25,21.56±1.28)and HAMA scores(10.29±1.16,11.25±1.14)in the transmission sensation group and non-transmission sensation group were all lower than the pre-treatment NIH-CPSI score(24.90±1.45,24.94±1.25)and HAMA(14.10±1.53,14.47±1.22)in the transmission sensation group and non-transmission sensation group,the differences were statistically significant(all P<0.05).The difference value between the pre-treatment and post-treatment NIH-CPSI scores of the transmission sensation group(6.61±0.97)was higher than that of the nontransmission sensation group(3.48±0.59),and the difference was statistically significant(P<0.05).The difference value between the pre-treatment and post-treatment HAMA scores of the transmission sensation group(3.81±0.81)was higher than that of the non-transmission sensation group(2.77±0.54).The total effective rate of the transmission sensation group(35.48%)was higher than that of the nontransmission sensation group(12.50%),and the difference was statistically significant(P<0.05).Conclusions:Both the method of transmission sensation along meridian and the method of nontransmission sensation along meridian can effectively relieve the clinical symptoms and anxiety symptoms of patients with chronic nonbacterial prostatitis,improve the quality of life,and the method of transmission sensation along meridian had a more advantageous effect.展开更多
The peripheral driver stimulating theory states that as a driver passes along a certain meridian during acupuncture; the driver provokes nerve sense devices along the meridian, resulting in the nerve impulse entering ...The peripheral driver stimulating theory states that as a driver passes along a certain meridian during acupuncture; the driver provokes nerve sense devices along the meridian, resulting in the nerve impulse entering the central nervous system. Accordingly, volunteers have reported propagated sensations along the meridians （PSM）. The present study was designed to utilize a cortical somatosensory-evoked potential （CSEP） topographic map for determining whether stimulation expansion occurs in somatosensory area I when sensation was provoked in individuals with obvious PSM. The sensation was blocked by mechanical compression, and the sensation was imitated in individuals without PSM. Results revealed a red, high-potential signal in the representative area of the lower limbs in individuals with obvious PSM symptoms when the Gall Bladder Meridian （GBM） sensation passed to the head and face. This representative area was near the middle line of the CSEP topographic map, and a red, high-potential signal, which jumps over the representative area of the upper limbs, also appeared in the representative face area, which was at the external region of the CSEP topographic map. However, in individuals exhibiting no PSM, only a red high-potential signal appeared in the representative lower limb area. When Hegu （LI 4） was stimulated in individuals without PSM, an obvious evoked response appeared only in the representative upper limb area. However, when Hegu was stimulated in individuals exhibiting PSM, the response area was larger in the representative upper limb area and extended to the representative face area. When Guangrning （GB 37） was stimulated in PSM individuals, the face representation response disappeared and was confined to a foot representation of the somatosensory area I when PSM was blocked by mechanical pressure. Results suggested that mechanical compression blocked PSM, and corresponding changes were exhibited in the CSEP topographic map. These results provide compelling evidence for the hypothesis that peripheral driver stimulation is the key element in producing PSM.展开更多
A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-rela...A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be determined.Here,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone loss.However,Acan-associated Z24 depletion caused only trabecular bone loss.Single-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)mice.Both premature SSPC populations exhibited apoptotic signaling pathway activation and decreased mechanosensation.Physical exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone mass.This study identified two populations of SSPCs that are responsible for premature aging-related bone loss.The impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging.展开更多
Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured wit...Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured without interfering the air gap state. It was discussed the effect of different air gap size on subjective clothing sensation. At the same time, taken the subjective sensations of moisture, adhesiveness and mugginess from the lower back as example, the relationship among the subjective evaluation, the air gap size and the clothing surface temperature were analyzed.展开更多
Tobacco smoking is considered to be one of the main risk factors in the development of chronic pain.Long-term chronic exposure to nicotine and other forms of tobacco have been shown to be associated with an increased ...Tobacco smoking is considered to be one of the main risk factors in the development of chronic pain.Long-term chronic exposure to nicotine and other forms of tobacco have been shown to be associated with an increased incidence of pain.Studies have shown that acupuncture can help smokers to reduce their desire to smoke,reduce their withdrawal symptoms,and avoid a relapse after treatment.However,little has been reported about the effects of acupuncture on pain sensitivity caused by long-term smoking.Models of hyperalgesia were established in rats exposed to nicotine for 6 weeks.After 6 weeks of continuous nicotine exposure,electroacupuncture at bilateral acupoints Zusanli(ST36)and Taichong(LR3)was performed 20 minutes per day for 6 days at a continuous wave with a frequency of 2 Hz and a stimulus intensity of 1 m A.The results revealed that electroacupuncture treatment increased the mechanical response threshold of hind paw of nicotine-dependent rats with hyperalgesia and up-regulated the protein expression of pain-related factorsμ-opioid receptor,β-endorphin and glutamic acid decarboxylase 65 in the spinal cord and midbrain periaqueductal gray and the protein expression of glutamic acid decarboxylase 67 in the spinal cord.These findings suggest that electroacupuncture treatment has positive analgesic effects on pain sensitivity caused by long-term chronic nicotine exposure.One possible mechanism for the improved analgesia is that electroacupuncture increases the expression of painrelated factors in the spinal cord and midbrain periaqueductal gray.This study was approved by Institutional Animal Care and Use Committee(IACUC)of the University of Miami(#18-167)on December 12,2018.展开更多
Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate mu...Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.展开更多
基金Supported by National Natural Science Fund Project: 30870668NIH/NCCAM subsidized project: F 05 AT 03022-01-04
文摘Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupuncture （EA） sensations. Methods Twenty one volunteers received EA. According to the tissue specificities of acupoints, 5 acupoint pairs were selected, named Zúsānlǐ （足三里 ST 36） vs Yánglíngquán （阳陵泉 GB 34, different meridians）, Nèiguān （内关 PC 6） vs Dàlíng （大陵 PC 7, different tissues）, Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28, different nerve segments）, Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12, different nerve segments）, and Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4, different meridians, tissues and nerve segments）. The electric frequency was 15 Hz. The electric current was under the subject’s tolerance without sharp pain induced. EA lasted 90 s with 3 discontinuities. The sensations, such as soreness, numbness, fullness/distention, heaviness, tingling, pressure, dull pain, hotness and coldness were recorded as well as the current flow output in association with the needling sensations. The differences in the frequency, intensity and current flow output relevant with the needling sensations were compared among the different acupoint pairs. Results There were no significant differences in the frequency of the needling sensations among the different acupoint pairs （all P〉0.05）. Of 9 different sensations of EA, fullness/distention, numbness and soreness presented the most commonly and remarkably; heaviness, pressure and tingling were on the second top; dull pain, hotness and coldness occurred at the lower frequency. There were the differences in the intensity of some needling sensations among the acupoint pairs, in which, the intensity of soreness, fullness/distention and heaviness was stronger at Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28） （all P〈0.05）; the intensity of fullness / distention, and numbness was stronger at Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4） （P〈0.01）; the intensity of fullness/distention was stronger at Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12） （P〈0.05）. The current flow output of EA was similar among the acupoint pairs （all P〉0.05）. Conclusion In the situation that there is no obvious difference in the current flow output associated with EA sensations, the frequency of EA sensations does not relevant apparently with the different tissues. The difference in the intensity of the needling sensations among the different acupoints is probably relevant with the nerve segments at the acupoint locations. The frequency and the intensity of the different needling sensations at the same acupoint are relatively stable at the different times of EA.
基金The National Natural Science Foundation of China(No.50678030)
文摘To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out when a single body part is thermally stimulated.Cooling airflow is sent to seven body parts,respectively.Totally 94 samples are tested.To eliminate the obvious multicollinearity of thermal sensation among different body parts,the principal component regression approach is adopted to obtain the principal components for the body parts under different experimental conditions.Through regression and analysis of principal components,the weighting factors of the seven body parts are obtained.A predictive model on whole-body thermal sensation is obtained based on the weighting factors.The results show that the different characteristics of trunk and limbs are clearly seen.The weighting factors of local thermal sensation are integrated values,and there is little difference among values of different body parts.
基金The National Natural Science Foundation of China(No.50478113)the Leading Academic Discipline Project of Shanghai Municipal Education Commission(No.J50502)
文摘To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a nozzle height of 4 m in the occupied zone are obtained.Then,the numerical simulation under the test condition is carried out by the computational fluid dynamics（CFD）method.The calculation results of the indoor vertical temperature and the draft sensation distribution are validated by the test data.Simulations with different nozzle heights are conducted.The satisfactory air supply condition is determined by analyzing the draft sensations and the temperatures in the occupied zone under three conditions.The simulation results show that the optimal draft sensation distribution and the uniform temperature and velocity fields can be obtained at a nozzle height of 5 m.
文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the （neurobiological） mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective ＆ cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut （brain- gut axis） will be briefly outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted.
基金supported by the General Project of the National Natural Science Foundation of China,No.30973720the Natural Science Foundation of Fujian Province in China,No.2011J01192Free Topics of Fujian Provincial Science & Technology Ministry in China,No.2012fjzyyk-6
文摘Propagated sensation along the meridian can occur when acupoints are stimulated by acupuncture or electrical impulses. In this study, participants with notable propagated sensation along the me- ridian were given electro-acupuncture at the Jianyu （LI15） acupoint of the large intestine meridian. When participants stated that the sensation reached the back of their hand, reguJar nervous system action discharge was examined using a physiological recording electrode placed on the superficial branch of the radial nerve. The topographical maps of brain-evoked potential in the primary cortical somatosensory area were also detected. When Guangming （GB37） acupoint in the lower limb and Hegu （LI4） acupoint in the upper limb were stimulated, subjects without propagated sensation along the meridian exhibited a high potential reaction in the corresponding area of the brain cortical somatosensory area. For subjects with a notable propagated sensation along the meridian, the re- action area was larger and extended into the face representative area. These electrophysiological measures directly prove the existence of propagated sensation along the meridian, and the periph- eral stimulated site is consistent with the corresponding primary cortical somatosensory area, which presents a high potential reaction.
文摘AIM:To determine the association between Helicobacter pylori(H.pylori)and globus sensation(GS)in the patients with cervical inlet patch. METHODS:Sixty-eight patients with esophageal inlet patches were identified from 6760 consecutive patients undergoing upper gastrointestinal endoscopy prospectively.In these 68 patients with cervical inlet patches, symptoms of globus sensation(lump in the throat), hoarseness,sore throat,frequent clearing of the throat,cough,dysphagia,odynophagia of at least 3 mo duration was questioned prior to endoscopy. RESULTS:Cervical heterotopic gastric mucosa(CHGM) was found in 68 of 6760 patients.The endoscopic prevalence of CHGM was determined to be 1%.H.pylori was identified in 16(23.5%)of 68 patients with inlet patch.53 patients were classified as CHGMⅡ.This group included 48 patients with globus sensation,4 patients with chronic cough and 1 patient with hoarseness.All the patients who were H.pylori(+)in cervical inlet patches had globus sensation.CONCLUSION:Often patients with CHGM have a long history of troublesome throat symptoms.We speculate that disturbances in globus sensation are like non-ulcer dyspepsia.
基金Supported by Scientific Research Project of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine:2018YJ12Innovation and entrepreneurship training program for Post-graduates of Shanghai University of Traditional Chinese Medicine:Y201825
文摘Objective:To investigate the short-term efficacy difference between sensation of transmission along meridian acupuncture and non-sensation of transmission along meridian acupuncture in the treatment of chronic nonbacterial prostatitis.Methods:A randomized,controlled,and single-blind clinical study was performed to collect 63 patients with chronic nonbacterial prostatitis who met the inclusion criteria and were randomly assigned to a transmission sensation group(31 patients)and a non-transmission sensation group(32 patients).The two groups of patients took the same acupuncture points.When they were lying down on their backs,Guānyuán(关元 CV4),Zhōngjí(中极 CV3)and Dàhè(大赫 K112)were taken.When they were lying down on their stomachs,Shènshū(肾俞 BL 23),Cìliáo(次髎 BL32)and Huìyáng(会阳 BL35)were taken.Among them,the transmission sensation group was treated with transmission sensation along meridian to apply deep needling to the lower abdomen and lumbosacral acupuncture points with lifting,thrusting,and twirling method,so that the needling sensation was transmitted to the bladder,perineum and urethra.The non-transmission sensation group was treated with non-transmission sensation along meridian,and the acupuncture points were treated with conventional acupuncture until the patient felt soreness and distending etc.and the arrival of qi.Both groups of patients were treated with electro-acupuncture during acupuncture,and the sparse-dense wave(sparse wave 4 Hz,dense wave 20 Hz),and the needle retention continued for 20 min.All patients were treated for 3 times with once every other day,and the treatment lasted for one week.The CV4,CV3 and KI12 were used in the first and third treatments,and the BL23,BL32 and BL35 were used in the second treatment.The National Institute of Health chronic prostatitis syndrome index(NIH-CPSI)and Hamilton Anxiety Rating Scale(HAMA)were observed,and the clinical efficacies of the patient were observed.Results:After treatment,the NIH-CPSI scores(18.29±1.25,21.56±1.28)and HAMA scores(10.29±1.16,11.25±1.14)in the transmission sensation group and non-transmission sensation group were all lower than the pre-treatment NIH-CPSI score(24.90±1.45,24.94±1.25)and HAMA(14.10±1.53,14.47±1.22)in the transmission sensation group and non-transmission sensation group,the differences were statistically significant(all P<0.05).The difference value between the pre-treatment and post-treatment NIH-CPSI scores of the transmission sensation group(6.61±0.97)was higher than that of the nontransmission sensation group(3.48±0.59),and the difference was statistically significant(P<0.05).The difference value between the pre-treatment and post-treatment HAMA scores of the transmission sensation group(3.81±0.81)was higher than that of the non-transmission sensation group(2.77±0.54).The total effective rate of the transmission sensation group(35.48%)was higher than that of the nontransmission sensation group(12.50%),and the difference was statistically significant(P<0.05).Conclusions:Both the method of transmission sensation along meridian and the method of nontransmission sensation along meridian can effectively relieve the clinical symptoms and anxiety symptoms of patients with chronic nonbacterial prostatitis,improve the quality of life,and the method of transmission sensation along meridian had a more advantageous effect.
基金the National Natural Science Foundation of China, No.30973720the Science Research Foundation of Ministry of Health & United Fujian Provincial Health and Education Project for Tackling the Key Research of China, No.WKJ2005-2-004
文摘The peripheral driver stimulating theory states that as a driver passes along a certain meridian during acupuncture; the driver provokes nerve sense devices along the meridian, resulting in the nerve impulse entering the central nervous system. Accordingly, volunteers have reported propagated sensations along the meridians （PSM）. The present study was designed to utilize a cortical somatosensory-evoked potential （CSEP） topographic map for determining whether stimulation expansion occurs in somatosensory area I when sensation was provoked in individuals with obvious PSM. The sensation was blocked by mechanical compression, and the sensation was imitated in individuals without PSM. Results revealed a red, high-potential signal in the representative area of the lower limbs in individuals with obvious PSM symptoms when the Gall Bladder Meridian （GBM） sensation passed to the head and face. This representative area was near the middle line of the CSEP topographic map, and a red, high-potential signal, which jumps over the representative area of the upper limbs, also appeared in the representative face area, which was at the external region of the CSEP topographic map. However, in individuals exhibiting no PSM, only a red high-potential signal appeared in the representative lower limb area. When Hegu （LI 4） was stimulated in individuals without PSM, an obvious evoked response appeared only in the representative upper limb area. However, when Hegu was stimulated in individuals exhibiting PSM, the response area was larger in the representative upper limb area and extended to the representative face area. When Guangrning （GB 37） was stimulated in PSM individuals, the face representation response disappeared and was confined to a foot representation of the somatosensory area I when PSM was blocked by mechanical pressure. Results suggested that mechanical compression blocked PSM, and corresponding changes were exhibited in the CSEP topographic map. These results provide compelling evidence for the hypothesis that peripheral driver stimulation is the key element in producing PSM.
基金supported by the National Natural Science Foundation of China (NSFC) (82230082,81991512 to W.Z.,82202742 to J.S.,82070108 to R.Y.)the National Key Research and Development Program of China (2022YFA0806600 to W.Z.,2022YFA1103200 to R.Y.)CAS Project for Young Scientists in Basic Research (YSBR077 to W.Z.)。
文摘A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be determined.Here,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone loss.However,Acan-associated Z24 depletion caused only trabecular bone loss.Single-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)mice.Both premature SSPC populations exhibited apoptotic signaling pathway activation and decreased mechanosensation.Physical exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone mass.This study identified two populations of SSPCs that are responsible for premature aging-related bone loss.The impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging.
基金Supported by Shanghai Science and Technology Ministry Phosphor Project (No.05QMX1402)
文摘Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured without interfering the air gap state. It was discussed the effect of different air gap size on subjective clothing sensation. At the same time, taken the subjective sensations of moisture, adhesiveness and mugginess from the lower back as example, the relationship among the subjective evaluation, the air gap size and the clothing surface temperature were analyzed.
基金supported by a grant from Department of Anesthesiology,Perioperative Medicine and Pain Management,University of Miami Miller School of Medicine,USA。
文摘Tobacco smoking is considered to be one of the main risk factors in the development of chronic pain.Long-term chronic exposure to nicotine and other forms of tobacco have been shown to be associated with an increased incidence of pain.Studies have shown that acupuncture can help smokers to reduce their desire to smoke,reduce their withdrawal symptoms,and avoid a relapse after treatment.However,little has been reported about the effects of acupuncture on pain sensitivity caused by long-term smoking.Models of hyperalgesia were established in rats exposed to nicotine for 6 weeks.After 6 weeks of continuous nicotine exposure,electroacupuncture at bilateral acupoints Zusanli(ST36)and Taichong(LR3)was performed 20 minutes per day for 6 days at a continuous wave with a frequency of 2 Hz and a stimulus intensity of 1 m A.The results revealed that electroacupuncture treatment increased the mechanical response threshold of hind paw of nicotine-dependent rats with hyperalgesia and up-regulated the protein expression of pain-related factorsμ-opioid receptor,β-endorphin and glutamic acid decarboxylase 65 in the spinal cord and midbrain periaqueductal gray and the protein expression of glutamic acid decarboxylase 67 in the spinal cord.These findings suggest that electroacupuncture treatment has positive analgesic effects on pain sensitivity caused by long-term chronic nicotine exposure.One possible mechanism for the improved analgesia is that electroacupuncture increases the expression of painrelated factors in the spinal cord and midbrain periaqueductal gray.This study was approved by Institutional Animal Care and Use Committee(IACUC)of the University of Miami(#18-167)on December 12,2018.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFB1307201)the National Natural Science Foundation of China(Grant Nos.51875120,91948302,U1813209).
文摘Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.
