Two new compounds, senarguines A and B, were isolated from Senecio argunensis. They were respectively identified as （Z）-3- ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro [4.4] nonane-5,8-dione （1） and 3,6,6-trimeth...Two new compounds, senarguines A and B, were isolated from Senecio argunensis. They were respectively identified as （Z）-3- ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro [4.4] nonane-5,8-dione （1） and 3,6,6-trimethyl 6,7,8-tetrahydronaphtha-[1,2b] furan （2） on the basis of spectral data.展开更多
Objective:To investigate activity-guided isolation and identification of anti-Staphylococcus aures components from Senecio tenuifolius Burm.F.(S.tenuifolius).Methods:Hexane,chloroform,ethyl acetate,methanol and aqueou...Objective:To investigate activity-guided isolation and identification of anti-Staphylococcus aures components from Senecio tenuifolius Burm.F.(S.tenuifolius).Methods:Hexane,chloroform,ethyl acetate,methanol and aqueous extracts of S.tenuifolius were prepared by soxilation for antimicrobial activity against one registered Staphylococcus aureus(S.aureus)(ATCC No:25923)and two clinical isolates,methicillin resistant and methicillin sensitive S.aureus.NCCL standard methods were followed for antibacterial activity.GC-MS was performed to identify the chemical composition of bio active fraction.Results:Among all solvent extracts,methanol extract significantly reduced the growth of S.aureus(ATCC No:25923),methicillin resistant and methicillin sensitive S.aureus with the best zone of inhibition at 16.23,14.06 and 15.23mm and minimum inhibition concentration(MIC)values at 426.16,683.22 and 512.12μg/mL,respectively.In order to detect the active component in methanol extract,it was further purified by column chromatography,which yielded four fractions(St1,St2,St3,and St4).Among these four fractions,St3 was effective against the tested strains of S.aures,with the best zone of inhibition at 15.09,13.25 and 14.12 mm and with best MIC values at 88.16,128.11 and 116.12μg/mL,respectively.Effective fraction partially purified from S.tenuifolius(St3)yielded MIC's that were at least 20 fold less when compared to crude extract.GC-MS analysis of St3 revealed the presence of 3-[methyl-6,7-dihydro benzofuran-4(5H)-one],1,2-benzenedicarboxylic acid,hydroquinone,methyl ester and 3 unknown compounds.Conclusions:The study provides scientific evidence for traditional and folklore medicinal use of S.tenuifolius in skin infections treatment.展开更多
A new Eremophilanoid sesquiterpene (1) was isolated from the whole plant of Senecio oldhamianus. Its structure was elucidated as 7? 11-epoxy-9? 10?epoxy-8-oxoeremophilane using spectroscopic methords and X-ray analysis.
Invasive alien species threaten global biodiversity and ecosystems.Understanding the context-dependency of invasion dynamics is crucial for uncovering the processes driving the establishment and spread of alien specie...Invasive alien species threaten global biodiversity and ecosystems.Understanding the context-dependency of invasion dynamics is crucial for uncovering the processes driving the establishment and spread of alien species.This study investigates how abiotic(soil characteristics)and biotic factors(resident vegetation diversity and similarity to the invader)affect the invasion success of Senecio inaequidens(South African ragwort)across high-and low-productivity habitats in northern Italy.Our results revealed that abiotic and biotic factors affect S.inaequidens success.We found evidence of biotic resistance from resident plant communities,driven mainly by diversity and cover.However,a negative relationship between S.inaequidens performance and both phylogenetic and functional similarity to resident species was found,indicating better performance when growing with more similar species.We additionally observed stronger resistance in more nutrient-rich environments,highlighting the context-dependent nature of such relationships.Our results suggest that S.inaequidens is more susceptible to competition than adverse abiotic conditions,making it as a good colonizer rather than a strong competitor.These findings emphasize the complexity of invasion dynamics and the importance of considering both biotic and abiotic factors in developing management strategies for invaded ecosystems.展开更多
Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. T...Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids(PAs)has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.Methods: In this study, a simple but specific UHPLC-QTOF-MS method for the determination of toxic PAs was developed, based on the characteristic fragment ions specific to different types of PAs. It was successfully applied for the identification and distinguishing of PAs present in Qianliguang and related Senecio species growing in different locations of China.Results: Significant diversity of the PA types and quantities were revealed among the samples tested. The estimated total amounts of toxic PAs in three of the samples exceed the toxic limits of PA intake restricted by WHO, demonstrating the timely and highly demand for regulating both types and quantities of PAs present in Qianliguang.Conclusions: This study provides the methodology for simultaneous identification and quantification of PAs present in herbs without requiring corresponding standards, which could be further used for more systematic investigations of the PA distribution in Qianliguang and other PA-containing herbs.展开更多
The use of plant species to cleanse groundwater with excessive concentrations of arsenic(As)derived from contact with weathered materials has become a valuable option to treat it.The aim of this work was to analyze th...The use of plant species to cleanse groundwater with excessive concentrations of arsenic(As)derived from contact with weathered materials has become a valuable option to treat it.The aim of this work was to analyze the bioaccumulation capacity of As of Senecio bonariensis(Asteraceae)through controlled laboratory tests and uncontrolled trials in the field in order to generate a low cost method applicable in rural areas that do not have systems of water treatments.Plants collected from the natural environment were arranged in hydroponic crops under controlled and uncontrolled conditions,in the first case with increasing concentrations of As for 45 days,and in the second,with a constant concentration of As for a period in a range between 45 and 90 days.The plants were processed and dried for the measurement of As.In both tests,in all the samples there was a noticeable accumulation of As,generally greater in roots than in leaves.Under controlled conditions the plants accumulated more As in relation to greater concentration of this element in the water.In all the trials a high bioaccumulation of As was found,which turns the plant into a hyperaccumulator.Due to the ability of S.bonariensis to accumulate As,and even more because of the great biomass produced by this species,it becomes an excellent one to be used for the remediation of arsenical waters.展开更多
基金partially supported by a grant from the National High Technology Research and Development Program of PR China(863 Program)(No.2004AA2Z3730-15).
文摘Two new compounds, senarguines A and B, were isolated from Senecio argunensis. They were respectively identified as （Z）-3- ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro [4.4] nonane-5,8-dione （1） and 3,6,6-trimethyl 6,7,8-tetrahydronaphtha-[1,2b] furan （2） on the basis of spectral data.
文摘From Senecio saluenensis, a novel eremophilanolide Saluenolide A was isolated. Its structure was elucidated by 2D-NMR technique and X-ray diffraction.
基金Supported by the Department of Riotechnology.Government of Indiafor funding(DBT-Sanction No.102/IFD/SAN/PR0313)
文摘Objective:To investigate activity-guided isolation and identification of anti-Staphylococcus aures components from Senecio tenuifolius Burm.F.(S.tenuifolius).Methods:Hexane,chloroform,ethyl acetate,methanol and aqueous extracts of S.tenuifolius were prepared by soxilation for antimicrobial activity against one registered Staphylococcus aureus(S.aureus)(ATCC No:25923)and two clinical isolates,methicillin resistant and methicillin sensitive S.aureus.NCCL standard methods were followed for antibacterial activity.GC-MS was performed to identify the chemical composition of bio active fraction.Results:Among all solvent extracts,methanol extract significantly reduced the growth of S.aureus(ATCC No:25923),methicillin resistant and methicillin sensitive S.aureus with the best zone of inhibition at 16.23,14.06 and 15.23mm and minimum inhibition concentration(MIC)values at 426.16,683.22 and 512.12μg/mL,respectively.In order to detect the active component in methanol extract,it was further purified by column chromatography,which yielded four fractions(St1,St2,St3,and St4).Among these four fractions,St3 was effective against the tested strains of S.aures,with the best zone of inhibition at 15.09,13.25 and 14.12 mm and with best MIC values at 88.16,128.11 and 116.12μg/mL,respectively.Effective fraction partially purified from S.tenuifolius(St3)yielded MIC's that were at least 20 fold less when compared to crude extract.GC-MS analysis of St3 revealed the presence of 3-[methyl-6,7-dihydro benzofuran-4(5H)-one],1,2-benzenedicarboxylic acid,hydroquinone,methyl ester and 3 unknown compounds.Conclusions:The study provides scientific evidence for traditional and folklore medicinal use of S.tenuifolius in skin infections treatment.
基金This work was financially supported by the National Nature Science Foundation of China (NO. 29972017) and the Foundation of Ministry of Education of China for Doctoral Program (NO. 98073003).
文摘A new Eremophilanoid sesquiterpene (1) was isolated from the whole plant of Senecio oldhamianus. Its structure was elucidated as 7? 11-epoxy-9? 10?epoxy-8-oxoeremophilane using spectroscopic methords and X-ray analysis.
基金funded by the Italian National Recovery and Resilience Plan(NRRP),Mission 4 Component 2 Investment 1.4-Call for tender No.3138 of 16 December 2021,rectified by Decree n.3175 of 18 December 2021 of the Italian Ministry of University and Research,funded by the European Union-NextGenerationEU.Award Number:Project code CN_00000033,Concession Decree No.1034 of 17 June 2022adopted by the Italian Ministry of University and Research,CUP,H43C22000530001,Project title“National Biodiversity Future Center-NBFC”.
文摘Invasive alien species threaten global biodiversity and ecosystems.Understanding the context-dependency of invasion dynamics is crucial for uncovering the processes driving the establishment and spread of alien species.This study investigates how abiotic(soil characteristics)and biotic factors(resident vegetation diversity and similarity to the invader)affect the invasion success of Senecio inaequidens(South African ragwort)across high-and low-productivity habitats in northern Italy.Our results revealed that abiotic and biotic factors affect S.inaequidens success.We found evidence of biotic resistance from resident plant communities,driven mainly by diversity and cover.However,a negative relationship between S.inaequidens performance and both phylogenetic and functional similarity to resident species was found,indicating better performance when growing with more similar species.We additionally observed stronger resistance in more nutrient-rich environments,highlighting the context-dependent nature of such relationships.Our results suggest that S.inaequidens is more susceptible to competition than adverse abiotic conditions,making it as a good colonizer rather than a strong competitor.These findings emphasize the complexity of invasion dynamics and the importance of considering both biotic and abiotic factors in developing management strategies for invaded ecosystems.
基金Research Grant Council of Hong Kong(GRF Grants no.471310 and 469712)CUHK Direct Grant(2041744)
文摘Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids(PAs)has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.Methods: In this study, a simple but specific UHPLC-QTOF-MS method for the determination of toxic PAs was developed, based on the characteristic fragment ions specific to different types of PAs. It was successfully applied for the identification and distinguishing of PAs present in Qianliguang and related Senecio species growing in different locations of China.Results: Significant diversity of the PA types and quantities were revealed among the samples tested. The estimated total amounts of toxic PAs in three of the samples exceed the toxic limits of PA intake restricted by WHO, demonstrating the timely and highly demand for regulating both types and quantities of PAs present in Qianliguang.Conclusions: This study provides the methodology for simultaneous identification and quantification of PAs present in herbs without requiring corresponding standards, which could be further used for more systematic investigations of the PA distribution in Qianliguang and other PA-containing herbs.
基金VPC and ERP are Research Members of the National Research Council(CONICET)and ME is Researcher of CIC(Bs.As).This work was funded by Universidad Nacional del Sur(UNS)under grant numbers PMADS 24/MA01,PGI 24/B234 and PIO UNS-CONICET 20720150100019CO.
文摘The use of plant species to cleanse groundwater with excessive concentrations of arsenic(As)derived from contact with weathered materials has become a valuable option to treat it.The aim of this work was to analyze the bioaccumulation capacity of As of Senecio bonariensis(Asteraceae)through controlled laboratory tests and uncontrolled trials in the field in order to generate a low cost method applicable in rural areas that do not have systems of water treatments.Plants collected from the natural environment were arranged in hydroponic crops under controlled and uncontrolled conditions,in the first case with increasing concentrations of As for 45 days,and in the second,with a constant concentration of As for a period in a range between 45 and 90 days.The plants were processed and dried for the measurement of As.In both tests,in all the samples there was a noticeable accumulation of As,generally greater in roots than in leaves.Under controlled conditions the plants accumulated more As in relation to greater concentration of this element in the water.In all the trials a high bioaccumulation of As was found,which turns the plant into a hyperaccumulator.Due to the ability of S.bonariensis to accumulate As,and even more because of the great biomass produced by this species,it becomes an excellent one to be used for the remediation of arsenical waters.
