The fluorination reaction involving a β-ketosulfones by Selectfluor^TM was efficiently promoted by the ionic liquid, [Hbim]BF4 （IL） as a reaction medium with methanol as co-solvent at room temperature under ultraso...The fluorination reaction involving a β-ketosulfones by Selectfluor^TM was efficiently promoted by the ionic liquid, [Hbim]BF4 （IL） as a reaction medium with methanol as co-solvent at room temperature under ultrasonic irradiation to afford the corresponding mono and difluoro-β-ketosulfones in excellent yields. The advantages of this method include among others the use of a recyclable, non-volatile ionic liquid, which promotes this protocol under room temperature without the requirement of any added catalyst under ultrasonic irradiation.展开更多
An expedient and mild strategy for the synthesis of unconventional 2-（dimethylamino）-3,3-difluorochroman-4-one derivatives from o-hydroxyarylenaminones and Selectfluor was developed at room temperature under catalys...An expedient and mild strategy for the synthesis of unconventional 2-（dimethylamino）-3,3-difluorochroman-4-one derivatives from o-hydroxyarylenaminones and Selectfluor was developed at room temperature under catalyst-free conditions. This method showed excellent chemoselectivity and great functional groups tolerance.展开更多
A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerate...A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerated,providing a mild and simple method for the synthesis of C2-hydroxyalkylated2 H-benzothiazoles in moderate to good yields.Besides,ethers were also compatible in this reaction,leading to corresponding C2 ether-substituted 2 H-benzothiazoles with high regioselectivity.展开更多
Metal-free direct α-C(sp^(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor is described.This novel strategy provides a facile and efficient method to access important 1,3-ben...Metal-free direct α-C(sp^(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor is described.This novel strategy provides a facile and efficient method to access important 1,3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields.展开更多
A novel and facile preparation of l,l-difluoroallyl substituted five-membered lactones or pyrrolidines in mod- erate yields through direct double electrophilic fluorination of 4,5-allenoic acids or tosylamides with Se...A novel and facile preparation of l,l-difluoroallyl substituted five-membered lactones or pyrrolidines in mod- erate yields through direct double electrophilic fluorination of 4,5-allenoic acids or tosylamides with SelectfluorTM F-TEAD-BF4 is described.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.21772176,21372201)the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology,Zhejiang University of Technology~~
基金Project supported by the National Natural Science Foundation of China(No.21502076)the Natural Science Foundation of Jiangxi Province(No.20161BAB213068)+1 种基金the Hundred-Talent Program(Hefei)the Outstanding Young Talent Program of Jiangxi Province(No.20171BCB23039)~~
文摘The fluorination reaction involving a β-ketosulfones by Selectfluor^TM was efficiently promoted by the ionic liquid, [Hbim]BF4 （IL） as a reaction medium with methanol as co-solvent at room temperature under ultrasonic irradiation to afford the corresponding mono and difluoro-β-ketosulfones in excellent yields. The advantages of this method include among others the use of a recyclable, non-volatile ionic liquid, which promotes this protocol under room temperature without the requirement of any added catalyst under ultrasonic irradiation.
基金Financial support from the Recruitment Program of Global Experts (1000 Talents Plan)the Natural Science Foundation of Fujian Province (No. 2016J01064)+1 种基金Fujian Hundred Talents Plan, Program of Innovative Research Team of Huaqiao University (No. Z14X0047)Subsidized Project for Cultivating Postgraduates’ Innovative Ability in Scientific Research of Huaqiao University (for Z. Kuang) are gratefully acknowledged
文摘An expedient and mild strategy for the synthesis of unconventional 2-（dimethylamino）-3,3-difluorochroman-4-one derivatives from o-hydroxyarylenaminones and Selectfluor was developed at room temperature under catalyst-free conditions. This method showed excellent chemoselectivity and great functional groups tolerance.
基金the financial support by the National Natural Science Foundation of China(No.30900959)the Natural Science Foundation of Zhejiang Province(No.LY17C140003)。
文摘A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerated,providing a mild and simple method for the synthesis of C2-hydroxyalkylated2 H-benzothiazoles in moderate to good yields.Besides,ethers were also compatible in this reaction,leading to corresponding C2 ether-substituted 2 H-benzothiazoles with high regioselectivity.
基金the financial support from the National Natural Science Foundation of China(Nos.21572026,21702019)Advanced Catalysis and Green Manufacturing Collaborative Innovation Center,Changzhou University。
文摘Metal-free direct α-C(sp^(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor is described.This novel strategy provides a facile and efficient method to access important 1,3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields.
基金Project supported by the National Natural Science Foundation of China （Nos. 21032006, 20172064）, and the QT Program, Shanghai Natural Science Council.
文摘A novel and facile preparation of l,l-difluoroallyl substituted five-membered lactones or pyrrolidines in mod- erate yields through direct double electrophilic fluorination of 4,5-allenoic acids or tosylamides with SelectfluorTM F-TEAD-BF4 is described.
