近年来学术界和工业界推出了大量的多主体系统开发环境(MASDE:Multi-Agent System DevelopmentEnvironment)。如何评价已有的各种MASDE,帮助软件开发人员从大量、异构和多样化的MASDE中选择“合适”的MASDE以及促进MASDE的标准化和集成...近年来学术界和工业界推出了大量的多主体系统开发环境(MASDE:Multi-Agent System DevelopmentEnvironment)。如何评价已有的各种MASDE,帮助软件开发人员从大量、异构和多样化的MASDE中选择“合适”的MASDE以及促进MASDE的标准化和集成化是目前人们面临的一项重要研究课题。本文从工程实践的角度提出了一个结构化的MASDE评价框架SEF;并对一组典型的MASDE作了深入的分析和评价,得到了一系列重要的评价结果。与已有工作相比较,SEF具有多视角、身于操作、可扩展以及独立于应用等特点,能较好地用于描述、分析和展示MASDE的基本特征、发现其优势和不足。展开更多
Interleukin-17 （IL-17 or IL-17A） production is a hallmark of TH17 cells, a new unique lineage of CD4^＋ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor...Interleukin-17 （IL-17 or IL-17A） production is a hallmark of TH17 cells, a new unique lineage of CD4^＋ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor （IL-17R or IL-17RA） is essential for IL-17 biological activity. Emerging data suggest that the formation of a heteromeric and/or homomeric receptor complex is required for IL-17 signaling. Here we show that the orphan receptor IL-17RD （Sef, similar expression to FGF genes or IL-17RLM） is associated and colocalized with IL-17R. Importantly, IL-17RD mediates IL-17 signaling, as evaluated using a luciferase reporter driven by the native promoter of 24p3, an IL-17 target gene. In addition, an IL-17RD mutant lacking the intraeellnlar domain dominant-negatively suppresses IL-17R- mediated IL-17 signaling. Moreover, IL-17RD as well as IL-17R is associated with TRAF6, an IL-17R downstream molecule. These results indicate that IL-17RD is a part of the IL-17 receptor signaling complex, therefore providing novel evidence for IL-17 signaling through a heteromeric and/or homomeric receptor complex.展开更多
文摘近年来学术界和工业界推出了大量的多主体系统开发环境(MASDE:Multi-Agent System DevelopmentEnvironment)。如何评价已有的各种MASDE,帮助软件开发人员从大量、异构和多样化的MASDE中选择“合适”的MASDE以及促进MASDE的标准化和集成化是目前人们面临的一项重要研究课题。本文从工程实践的角度提出了一个结构化的MASDE评价框架SEF;并对一组典型的MASDE作了深入的分析和评价,得到了一系列重要的评价结果。与已有工作相比较,SEF具有多视角、身于操作、可扩展以及独立于应用等特点,能较好地用于描述、分析和展示MASDE的基本特征、发现其优势和不足。
文摘Interleukin-17 （IL-17 or IL-17A） production is a hallmark of TH17 cells, a new unique lineage of CD4^＋ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor （IL-17R or IL-17RA） is essential for IL-17 biological activity. Emerging data suggest that the formation of a heteromeric and/or homomeric receptor complex is required for IL-17 signaling. Here we show that the orphan receptor IL-17RD （Sef, similar expression to FGF genes or IL-17RLM） is associated and colocalized with IL-17R. Importantly, IL-17RD mediates IL-17 signaling, as evaluated using a luciferase reporter driven by the native promoter of 24p3, an IL-17 target gene. In addition, an IL-17RD mutant lacking the intraeellnlar domain dominant-negatively suppresses IL-17R- mediated IL-17 signaling. Moreover, IL-17RD as well as IL-17R is associated with TRAF6, an IL-17R downstream molecule. These results indicate that IL-17RD is a part of the IL-17 receptor signaling complex, therefore providing novel evidence for IL-17 signaling through a heteromeric and/or homomeric receptor complex.
