Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid ...Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.展开更多
With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a va...With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a variety of dermoscopic lesion images.This paper aims to develop and ne-tune a deep learning architecture to diagnose different skin cancer grades based on dermatoscopic images.Fine-tuning is a powerful method to obtain enhanced classication results by the customized pre-trained network.Regularization,batch normalization,and hyperparameter optimization are performed for ne-tuning the proposed deep network.The proposed ne-tuned ResNet50 model successfully classied 7-respective classes of dermoscopic lesions using the publicly available HAM10000 dataset.The developed deep model was compared against two powerful models,i.e.,InceptionV3 and VGG16,using the Dice similarity coefcient(DSC)and the area under the curve(AUC).The evaluation results show that the proposed model achieved higher results than some recent and robust models.展开更多
A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused ...A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate labeling.To mitigate these issues,an improved training framework has been proposed.In this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model performance.Notably,this enhancement is primarily attributed to the coupling effect of the soft labels and correction mechanism.This improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a disruption.It presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.展开更多
Medical images are used as a diagnostic tool, so protecting theirconfidentiality has long been a topic of study. From this, we propose aResnet50-DCT-based zero watermarking algorithm for use with medicalimages. To beg...Medical images are used as a diagnostic tool, so protecting theirconfidentiality has long been a topic of study. From this, we propose aResnet50-DCT-based zero watermarking algorithm for use with medicalimages. To begin, we use Resnet50, a pre-training network, to draw out thedeep features of medical images. Then the deep features are transformedby DCT transform and the perceptual hash function is used to generatethe feature vector. The original watermark is chaotic scrambled to get theencrypted watermark, and the watermark information is embedded into theoriginal medical image by XOR operation, and the logical key vector isobtained and saved at the same time. Similarly, the same feature extractionmethod is used to extract the deep features of the medical image to be testedand generate the feature vector. Later, the XOR operation is carried outbetween the feature vector and the logical key vector, and the encryptedwatermark is extracted and decrypted to get the restored watermark;thenormalized correlation coefficient (NC) of the original watermark and therestored watermark is calculated to determine the ownership and watermarkinformation of the medical image to be tested. After calculation, most ofthe NC values are greater than 0.50. The experimental results demonstratethe algorithm’s robustness, invisibility, and security, as well as its ability toaccurately extract watermark information. The algorithm also shows goodresistance to conventional attacks and geometric attacks.展开更多
Brain tumor is one of the most common tumors with high mortality.Early detection is of great significance for the treatment and rehabilitation of patients.The single channel convolution layer and pool layer of traditi...Brain tumor is one of the most common tumors with high mortality.Early detection is of great significance for the treatment and rehabilitation of patients.The single channel convolution layer and pool layer of traditional convolutional neural network(CNN)structure can only accept limited local context information.And most of the current methods only focus on the classification of benign and malignant brain tumors,multi classification of brain tumors is not common.In response to these shortcomings,considering that convolution kernels of different sizes can extract more comprehensive features,we put forward the multi-size convolutional kernel module.And considering that the combination of average-pooling with max-pooling can realize the complementary of the high-dimensional information extracted by the two structures,we proposed the dual-channel pooling layer.Combining the two structures with ResNet50,we proposed an improved ResNet50 CNN for the applications in multi-category brain tumor classification.We used data enhancement before training to avoid model over fitting and used five-fold cross-validation in experiments.Finally,the experimental results show that the network proposed in this paper can effectively classify healthy brain,meningioma,diffuse astrocytoma,anaplastic oligodendroglioma and glioblastoma.展开更多
While the internet has a lot of positive impact on society,there are negative components.Accessible to everyone through online platforms,pornography is,inducing psychological and health related issues among people of ...While the internet has a lot of positive impact on society,there are negative components.Accessible to everyone through online platforms,pornography is,inducing psychological and health related issues among people of all ages.While a difficult task,detecting pornography can be the important step in determining the porn and adult content in a video.In this paper,an architecture is proposed which yielded high scores for both training and testing.This dataset was produced from 190 videos,yielding more than 19 h of videos.The main sources for the content were from YouTube,movies,torrent,and websites that hosts both pornographic and non-pornographic contents.The videos were from different ethnicities and skin color which ensures the models can detect any kind of video.A VGG16,Inception V3 and Resnet 50 models were initially trained to detect these pornographic images but failed to achieve a high testing accuracy with accuracies of 0.49,0.49 and 0.78 respectively.Finally,utilizing transfer learning,a convolutional neural network was designed and yielded an accuracy of 0.98.展开更多
基金funded by the National Key Research and Development Program of China(No.2022YFC2804101)the Guangdong Provincial Key R&D Program(No.2023B1111050011)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010432)the Guangzhou Basic and Applied Basic Research Foundation(No.202201010305)the High-Level Talents Special Program of Zhejiang(No.2022R52036)。
文摘Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.
文摘With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a variety of dermoscopic lesion images.This paper aims to develop and ne-tune a deep learning architecture to diagnose different skin cancer grades based on dermatoscopic images.Fine-tuning is a powerful method to obtain enhanced classication results by the customized pre-trained network.Regularization,batch normalization,and hyperparameter optimization are performed for ne-tuning the proposed deep network.The proposed ne-tuned ResNet50 model successfully classied 7-respective classes of dermoscopic lesions using the publicly available HAM10000 dataset.The developed deep model was compared against two powerful models,i.e.,InceptionV3 and VGG16,using the Dice similarity coefcient(DSC)and the area under the curve(AUC).The evaluation results show that the proposed model achieved higher results than some recent and robust models.
基金supported by National Natural Science Foundation of China(Nos.12175277 and 11975271)the National Key R&D Program of China(No.2022YFE 03050003)。
文摘A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate labeling.To mitigate these issues,an improved training framework has been proposed.In this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model performance.Notably,this enhancement is primarily attributed to the coupling effect of the soft labels and correction mechanism.This improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a disruption.It presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.
基金supported in part by the Natural Science Foundation of China under Grants 62063004the Key Research Project of Hainan Province under Grant ZDYF2021SHFZ093+1 种基金the Hainan Provincial Natural Science Foundation of China under Grants 2019RC018 and 619QN246the postdoctor research from Zhejiang Province under Grant ZJ2021028.
文摘Medical images are used as a diagnostic tool, so protecting theirconfidentiality has long been a topic of study. From this, we propose aResnet50-DCT-based zero watermarking algorithm for use with medicalimages. To begin, we use Resnet50, a pre-training network, to draw out thedeep features of medical images. Then the deep features are transformedby DCT transform and the perceptual hash function is used to generatethe feature vector. The original watermark is chaotic scrambled to get theencrypted watermark, and the watermark information is embedded into theoriginal medical image by XOR operation, and the logical key vector isobtained and saved at the same time. Similarly, the same feature extractionmethod is used to extract the deep features of the medical image to be testedand generate the feature vector. Later, the XOR operation is carried outbetween the feature vector and the logical key vector, and the encryptedwatermark is extracted and decrypted to get the restored watermark;thenormalized correlation coefficient (NC) of the original watermark and therestored watermark is calculated to determine the ownership and watermarkinformation of the medical image to be tested. After calculation, most ofthe NC values are greater than 0.50. The experimental results demonstratethe algorithm’s robustness, invisibility, and security, as well as its ability toaccurately extract watermark information. The algorithm also shows goodresistance to conventional attacks and geometric attacks.
基金This paper is supported by the National Youth Natural Science Foundation of China(61802208)the National Natural Science Foundation of China(61873131)+5 种基金the Natural Science Foundation of Anhui(1908085MF207 and 1908085QE217)the Key Research Project of Anhui Natural Science(KJ2020A1215 and KJ2020A1216)the Excellent Youth Talent Support Foundation of Anhui(gxyqZD2019097)the Postdoctoral Foundation of Jiangsu(2018K009B)the Higher Education Quality Project of Anhui(2019sjjd81,2018mooc059,2018kfk009,2018sxzx38 and 2018FXJT02)the Fuyang Normal University Doctoral Startup Foundation(2017KYQD0008).
文摘Brain tumor is one of the most common tumors with high mortality.Early detection is of great significance for the treatment and rehabilitation of patients.The single channel convolution layer and pool layer of traditional convolutional neural network(CNN)structure can only accept limited local context information.And most of the current methods only focus on the classification of benign and malignant brain tumors,multi classification of brain tumors is not common.In response to these shortcomings,considering that convolution kernels of different sizes can extract more comprehensive features,we put forward the multi-size convolutional kernel module.And considering that the combination of average-pooling with max-pooling can realize the complementary of the high-dimensional information extracted by the two structures,we proposed the dual-channel pooling layer.Combining the two structures with ResNet50,we proposed an improved ResNet50 CNN for the applications in multi-category brain tumor classification.We used data enhancement before training to avoid model over fitting and used five-fold cross-validation in experiments.Finally,the experimental results show that the network proposed in this paper can effectively classify healthy brain,meningioma,diffuse astrocytoma,anaplastic oligodendroglioma and glioblastoma.
文摘While the internet has a lot of positive impact on society,there are negative components.Accessible to everyone through online platforms,pornography is,inducing psychological and health related issues among people of all ages.While a difficult task,detecting pornography can be the important step in determining the porn and adult content in a video.In this paper,an architecture is proposed which yielded high scores for both training and testing.This dataset was produced from 190 videos,yielding more than 19 h of videos.The main sources for the content were from YouTube,movies,torrent,and websites that hosts both pornographic and non-pornographic contents.The videos were from different ethnicities and skin color which ensures the models can detect any kind of video.A VGG16,Inception V3 and Resnet 50 models were initially trained to detect these pornographic images but failed to achieve a high testing accuracy with accuracies of 0.49,0.49 and 0.78 respectively.Finally,utilizing transfer learning,a convolutional neural network was designed and yielded an accuracy of 0.98.
