With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light lim...With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their development.Sonodynamic therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue penetration.The soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of light.Therefore,many sonosensitizers are studied and applied to SDT-based therapy.Metal-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band structure.The representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is revealed.Syner-gistic effects of SDT in combination with other therapeutic modalities are mainly highlighted.At the same time,the critical and potential issues and future perspectives are addressed.展开更多
With the rise of live streaming on social media, platforms like Facebook, Instagram, and YouTube have become powerful business tools. They enable users to share live videos, fostering direct connections between busine...With the rise of live streaming on social media, platforms like Facebook, Instagram, and YouTube have become powerful business tools. They enable users to share live videos, fostering direct connections between businesses and their customers. This critical literature review paper explores the impact of live streaming on businesses, focusing on its role in attracting and satisfying consumers by promoting products tailored to their needs and wants. It emphasizes live streaming’s crucial role in engaging customers, a key to business growth. The study also provides viable strategies for businesses to leverage live streaming for growth and customer engagement, underscoring its importance in the business landscape.展开更多
Sonodynamic therapy(SDT)has emerged as a novel and highly researched advancement in the medical field.Traditional ultrasound contrast agents and novel bubble-shaped agents are used to stimulate cavitation and enhance ...Sonodynamic therapy(SDT)has emerged as a novel and highly researched advancement in the medical field.Traditional ultrasound contrast agents and novel bubble-shaped agents are used to stimulate cavitation and enhance SDT efficiency.However,the impact of artificially modified shell structures on the acoustic properties of microbubbles remains to be explored.Alternatively,in the absence of bubble-shaped agents,some clinically available organic sonosensitizers and advanced inorganic materials are also used to enhance the efficacy of SDT.Diagnostic and therapeutic ultrasound can also activate cavitation bubbles,which supply energy to sonosensitive agents,leading to the production of cytotoxic free radicals to achieve therapeutic effects.While inorganic materials often spark controversy in clinical applications,their relatively simple structure enables researchers to gain insight into the mechanism by which SDT produces various free radicals.Some organic-inorganic hybrid sonosensitive systems have also been reported,combining the benefits of inorganic and organic sonosensitive agents.Alternatively,by employing cell surface modification engineering to enable cells to perform functions such as immune escape,drug loading,gas loading,and sonosensitivity,cellular sonosensitizers have also been developed.However,further exploration is needed on the acoustic properties,ability to generate reactive oxygen species(ROS),and potential clinical application of this cellular sonosensitizer.This review offers a comprehensive analysis of vesical microbubbles and nanoscale sonocatalysts,including organic,inorganic,combined organic-inorganic sonosensitizers,and cellular sonosensitizers.This analysis will enhance our understanding of SDT and demonstrate its important potential in transforming medical applications.展开更多
文物监测数据具有结构单一、冗余性大、误差高容忍度的特点,使得无线传感器网络中现有的数据压缩算法在文物监测中显得计算复杂度高、计算能耗大.将轻计算量型的SDT(Swing Door Trending)算法应用到无线传感器网络的文物监测中并作了改...文物监测数据具有结构单一、冗余性大、误差高容忍度的特点,使得无线传感器网络中现有的数据压缩算法在文物监测中显得计算复杂度高、计算能耗大.将轻计算量型的SDT(Swing Door Trending)算法应用到无线传感器网络的文物监测中并作了改进,分析了大规模情况下数据压缩和网络能耗之间的关系,将改进的SDT算法与目前无线传感器网络中有代表性的分布式小波压缩算法进行比较.实验表明,改进的SDT计算能耗较分布式小波压缩算法的能耗少73%,在压缩率小于25%时,改进的SDT压缩算法性能可与分布式小波压缩算法媲美.在长期、大规模的文物监测下,改进的SDT算法更适合于无线传感器网络数据压缩.展开更多
基金This study was financially supported by the National Natural Science Foundation of China(Nos.22105116,51872030,51631001,51702016,51902023 and 21801015)Joint R&D Plan of Hongkong,Macao,Taiwan and Beijing(No.Z191100001619002)+1 种基金the Fundamental Research Funds for the Central Universities(No.2017CX01003)Beijing Institute of Technology Research Fund Program for Young Scholars.
文摘With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their development.Sonodynamic therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue penetration.The soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of light.Therefore,many sonosensitizers are studied and applied to SDT-based therapy.Metal-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band structure.The representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is revealed.Syner-gistic effects of SDT in combination with other therapeutic modalities are mainly highlighted.At the same time,the critical and potential issues and future perspectives are addressed.
文摘With the rise of live streaming on social media, platforms like Facebook, Instagram, and YouTube have become powerful business tools. They enable users to share live videos, fostering direct connections between businesses and their customers. This critical literature review paper explores the impact of live streaming on businesses, focusing on its role in attracting and satisfying consumers by promoting products tailored to their needs and wants. It emphasizes live streaming’s crucial role in engaging customers, a key to business growth. The study also provides viable strategies for businesses to leverage live streaming for growth and customer engagement, underscoring its importance in the business landscape.
基金supported by the National Natural Science Foundation of China(NSFC)(52100014 and 12274220)。
文摘Sonodynamic therapy(SDT)has emerged as a novel and highly researched advancement in the medical field.Traditional ultrasound contrast agents and novel bubble-shaped agents are used to stimulate cavitation and enhance SDT efficiency.However,the impact of artificially modified shell structures on the acoustic properties of microbubbles remains to be explored.Alternatively,in the absence of bubble-shaped agents,some clinically available organic sonosensitizers and advanced inorganic materials are also used to enhance the efficacy of SDT.Diagnostic and therapeutic ultrasound can also activate cavitation bubbles,which supply energy to sonosensitive agents,leading to the production of cytotoxic free radicals to achieve therapeutic effects.While inorganic materials often spark controversy in clinical applications,their relatively simple structure enables researchers to gain insight into the mechanism by which SDT produces various free radicals.Some organic-inorganic hybrid sonosensitive systems have also been reported,combining the benefits of inorganic and organic sonosensitive agents.Alternatively,by employing cell surface modification engineering to enable cells to perform functions such as immune escape,drug loading,gas loading,and sonosensitivity,cellular sonosensitizers have also been developed.However,further exploration is needed on the acoustic properties,ability to generate reactive oxygen species(ROS),and potential clinical application of this cellular sonosensitizer.This review offers a comprehensive analysis of vesical microbubbles and nanoscale sonocatalysts,including organic,inorganic,combined organic-inorganic sonosensitizers,and cellular sonosensitizers.This analysis will enhance our understanding of SDT and demonstrate its important potential in transforming medical applications.
文摘文物监测数据具有结构单一、冗余性大、误差高容忍度的特点,使得无线传感器网络中现有的数据压缩算法在文物监测中显得计算复杂度高、计算能耗大.将轻计算量型的SDT(Swing Door Trending)算法应用到无线传感器网络的文物监测中并作了改进,分析了大规模情况下数据压缩和网络能耗之间的关系,将改进的SDT算法与目前无线传感器网络中有代表性的分布式小波压缩算法进行比较.实验表明,改进的SDT计算能耗较分布式小波压缩算法的能耗少73%,在压缩率小于25%时,改进的SDT压缩算法性能可与分布式小波压缩算法媲美.在长期、大规模的文物监测下,改进的SDT算法更适合于无线传感器网络数据压缩.
