The skin serves as a crucial barrier against environmental threats,safeguarding against toxins,UV radiation,and pathogens while preventing fluid loss.This study aimed to investigate the reparative effects of Pediococc...The skin serves as a crucial barrier against environmental threats,safeguarding against toxins,UV radiation,and pathogens while preventing fluid loss.This study aimed to investigate the reparative effects of Pediococcus pentosaceus CCFM1402 on the skin barrier and elucidate its underlying molecular mechanisms.Our findings demonstrated that the postbiotic component of CCFM1402 significantly upregulated the mRNA expression of key barrier functional proteins(FLG,LOR,and IVL)and structural proteins(ZO-1,CLDN,and OCCLUDIN)in an SDS-injured HaCaT cell model.Additionally,oral administration of CCFM1402 enhanced skin barrier repair by increasing protein levels and reducing inflammatory responses in a DNFB-induced skin barrier disruption mouse model.Notably,CCFM1402 improved functional protein expression and immune response via the AHR-OVOL1 pathway and OX40 receptor regulation.These results provide valuable insights into probiotic and postbiotic therapies for skin health,underscoring the potential of P.pentosaceus CCFM1402 as a therapeutic agent for skin barrier repair.展开更多
基金supported by the Qinglan Project in Jiangsu Province,Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,and the Fundamental Research Funds for the Central Universities.
文摘The skin serves as a crucial barrier against environmental threats,safeguarding against toxins,UV radiation,and pathogens while preventing fluid loss.This study aimed to investigate the reparative effects of Pediococcus pentosaceus CCFM1402 on the skin barrier and elucidate its underlying molecular mechanisms.Our findings demonstrated that the postbiotic component of CCFM1402 significantly upregulated the mRNA expression of key barrier functional proteins(FLG,LOR,and IVL)and structural proteins(ZO-1,CLDN,and OCCLUDIN)in an SDS-injured HaCaT cell model.Additionally,oral administration of CCFM1402 enhanced skin barrier repair by increasing protein levels and reducing inflammatory responses in a DNFB-induced skin barrier disruption mouse model.Notably,CCFM1402 improved functional protein expression and immune response via the AHR-OVOL1 pathway and OX40 receptor regulation.These results provide valuable insights into probiotic and postbiotic therapies for skin health,underscoring the potential of P.pentosaceus CCFM1402 as a therapeutic agent for skin barrier repair.
