基于雷达数据的风暴体识别、追踪及预警方法是最早出现的临近预报技术,其中对风暴的准确识别是进行风暴体追踪和预警的前提。本文借鉴SCIT(Storm Cell Identification and Tracking)算法对强风暴进行识别,根据"宁短勿长,特征相似&q...基于雷达数据的风暴体识别、追踪及预警方法是最早出现的临近预报技术,其中对风暴的准确识别是进行风暴体追踪和预警的前提。本文借鉴SCIT(Storm Cell Identification and Tracking)算法对强风暴进行识别,根据"宁短勿长,特征相似"的原则匹配两时刻的风暴单体。通过风暴在过去两时刻的质心位置进行线性外推从而预报下一时刻风暴的位置。结果显示可以较好地识别强风暴并实现对识别出的风暴的大致跟踪。展开更多
Background:Allergen immunotherapy(AIT)has demonstrated clinical efficacy in patients with allergic asthma.However,there is little information on biomarkers to evaluate the effect of house dust mite(HDM)subcutaneous im...Background:Allergen immunotherapy(AIT)has demonstrated clinical efficacy in patients with allergic asthma.However,there is little information on biomarkers to evaluate the effect of house dust mite(HDM)subcutaneous immunotherapy(SCIT)on allergic asthma.Objective:To evaluate the association between clinical outcomes with pulmonary function and biomarkers in before and after HDM SCIT.Methods:139 patients with asthma sensitized to HDM were recruited,75 subjects received SCIT as an add-on therapy to drug treatment,and 64 subjects received drug treatment alone.Spirometry,fractional exhaled nitric oxide(FeNO),blood eosinophil counts,total IgE(TIgE),serum specific IgE for HDM,and frequency of exacerbations(ACT scores)were measured at baseline,6 months,and 12 months.The relationship between biomarkers and pulmonary function improvement was investigated.Results:SCIT demonstrated a significant reduction in FeNO,serum IL-25 and ACT scores at 6 months and significantly improved airflow limitation at 12 months compared to pharmacotherapy.The changes in FEV1 were dramatically correlated with changes in blood eosinophils(r=-0.35,P=0.002),FeNO(r=-0.57,P<0.0001),serum IL-25(r=-0.68,P<0.0001)and ACT scores(r=0.562,P<0.0001).The multivariate regression analysis revealed that the changes in serum IL-25 concentration and FeNO were independently associated with an increase in FEV1(r^(2)=0.514,P<0.05,respectively)in patients with allergic asthma treated with HDM SCIT.Conclusions:Adding HDM SCIT to pharmacotherapy reduced serum IL-25 and FeNO and improved pulmonary function in allergic asthma.Serum IL-25 and FeNO may be useful biomarkers for predicting HDM SCIT in allergic asthma,even in the absence of significant improvement in airflow limitation.展开更多
目的·探讨社会认知与互动训练(social cognition and interactive training,SCIT)对精神分裂症康复的有效性和可行性,拟建立一种新的社区康复模式。方法·选取上海市虹口区社区管理的60名精神分裂症患者,随机分成对照组和SCIT...目的·探讨社会认知与互动训练(social cognition and interactive training,SCIT)对精神分裂症康复的有效性和可行性,拟建立一种新的社区康复模式。方法·选取上海市虹口区社区管理的60名精神分裂症患者,随机分成对照组和SCIT组,每组30名。对照组予以常规社区管理,SCIT组在常规社区管理的基础上予以SCIT干预。干预前后用相关量表评估,采用SPSS 22.0软件进行方差分析,观察接受SCIT干预的患者的康复效果。结果·SCIT组执行面部情绪识别任务所用时间较对照组无显著性差异,但正确率明显提高。SCIT组模糊意向的敌意问卷各评分均显著降低,阳性与阴性症状量表总分及部分分量表分数、阴性症状评定量表总分及分量表分数、卡尔加里精神分裂症抑郁量表评分以及多伦多述情障碍量表评分均显著下降,个人与社会表现量表总分提高。根据患者在训练中的参与情况以及反馈表可以看出,SCIT有较高的接受度,得到了患者的积极肯定。结论·SCIT可以提高社区精神分裂症患者的社会认知和社会功能,对精神症状尤其是阴性症状、抑郁症状也有改善效果,且有较高的可行性和接受度,可在社区康复工作中推广。展开更多
文摘基于雷达数据的风暴体识别、追踪及预警方法是最早出现的临近预报技术,其中对风暴的准确识别是进行风暴体追踪和预警的前提。本文借鉴SCIT(Storm Cell Identification and Tracking)算法对强风暴进行识别,根据"宁短勿长,特征相似"的原则匹配两时刻的风暴单体。通过风暴在过去两时刻的质心位置进行线性外推从而预报下一时刻风暴的位置。结果显示可以较好地识别强风暴并实现对识别出的风暴的大致跟踪。
基金supported by the National Natural Science Foundation of China(grants 81800026)the National Key Research and Development Program of China(2016YFC1304400)the natural Science Foundation of Hubei Province of China(2021CFB308).
文摘Background:Allergen immunotherapy(AIT)has demonstrated clinical efficacy in patients with allergic asthma.However,there is little information on biomarkers to evaluate the effect of house dust mite(HDM)subcutaneous immunotherapy(SCIT)on allergic asthma.Objective:To evaluate the association between clinical outcomes with pulmonary function and biomarkers in before and after HDM SCIT.Methods:139 patients with asthma sensitized to HDM were recruited,75 subjects received SCIT as an add-on therapy to drug treatment,and 64 subjects received drug treatment alone.Spirometry,fractional exhaled nitric oxide(FeNO),blood eosinophil counts,total IgE(TIgE),serum specific IgE for HDM,and frequency of exacerbations(ACT scores)were measured at baseline,6 months,and 12 months.The relationship between biomarkers and pulmonary function improvement was investigated.Results:SCIT demonstrated a significant reduction in FeNO,serum IL-25 and ACT scores at 6 months and significantly improved airflow limitation at 12 months compared to pharmacotherapy.The changes in FEV1 were dramatically correlated with changes in blood eosinophils(r=-0.35,P=0.002),FeNO(r=-0.57,P<0.0001),serum IL-25(r=-0.68,P<0.0001)and ACT scores(r=0.562,P<0.0001).The multivariate regression analysis revealed that the changes in serum IL-25 concentration and FeNO were independently associated with an increase in FEV1(r^(2)=0.514,P<0.05,respectively)in patients with allergic asthma treated with HDM SCIT.Conclusions:Adding HDM SCIT to pharmacotherapy reduced serum IL-25 and FeNO and improved pulmonary function in allergic asthma.Serum IL-25 and FeNO may be useful biomarkers for predicting HDM SCIT in allergic asthma,even in the absence of significant improvement in airflow limitation.
