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水稻SBP基因家族的全基因组鉴定与生物信息学分析
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作者 王志成 何勇 +5 位作者 刘之恩 程碧云 王廷宝 邱东峰 张再君 田志宏 《分子植物育种》 北大核心 2026年第2期353-365,共13页
鳞状芽孢子启动子结合蛋白(squamosa promoter binding protein,SBP)基因家族是植物特有的一类转录因子,它所有成员均含有1个功能相似且由80个左右氨基酸残基构成的保守结构域,主要参与植物生长发育、生理生化过程。为探究水稻(Oryza sa... 鳞状芽孢子启动子结合蛋白(squamosa promoter binding protein,SBP)基因家族是植物特有的一类转录因子,它所有成员均含有1个功能相似且由80个左右氨基酸残基构成的保守结构域,主要参与植物生长发育、生理生化过程。为探究水稻(Oryza sativa)SBP基因家族的生物学功能,本研究从水稻基因组数据库中通过NCBI BLAST及HMMsearch等生信手段对水稻SBP基因家族所含成员进行鉴定,并分析这些成员编码蛋白的理化性质、基因结构、基因在染色体上的定位、蛋白保守结构域、同源关系。研究表明,共获得20个水稻SBP基因,分布在除10号和12号染色体外的水稻染色体上,编码蛋白亚细胞定位均在细胞核上,有13个成员的等电点大于7,推测该家族蛋白多为碱性基因;该家族成员有5个成员存在跨膜现象,其中有3个存在跨膜结构域;该家族成员均无信号肽;该基因家族编码蛋白平均疏水性均小于0,推测均为亲水蛋白;二级结构以α-螺旋和无规卷曲为主;水稻、拟南芥(Arabidopsis thaliana)、玉米(Zea mays)、高粱(Sorghum bicolor)、大麦(Hordeum vulgare)5种研究较为透彻的物种,它们SBP基因的系统进化树可分为9个亚族,且每个亚族均含有拟南芥SBP基因,推测SBP基因家族在单双子叶植物分化前就存在;共线性分析表明大片段复制是水稻SBP基因家族扩张的主要模式。本研究为明确水稻SBP基因家族的功能提供了一定的参考。 展开更多
关键词 水稻 sbp 基因家族 生物信息学 基因结构
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一维准晶波动方程系数矩阵对称化及其SBP-SAT模拟
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作者 刘泰玉 周月娥 +2 位作者 蒋关希曦 张剑伟 孙铖 《应用数学和力学》 北大核心 2026年第3期367-380,共14页
研究波在准晶中的传播对深入理解准晶体的独特物理特性具有重要价值,但其数值模拟面临较大挑战.通过对波动方程系数矩阵进行对称化,可以有效整合不同类别的波动方程并降低波传播模拟的难度.研究推导了一维准晶波动方程的系数矩阵对称形... 研究波在准晶中的传播对深入理解准晶体的独特物理特性具有重要价值,但其数值模拟面临较大挑战.通过对波动方程系数矩阵进行对称化,可以有效整合不同类别的波动方程并降低波传播模拟的难度.研究推导了一维准晶波动方程的系数矩阵对称形式,并应用迎风格式SBP-SAT差分方法对波动方程进行了离散化,同时通过能量法评估了其稳定性.数值仿真结果表明,所提出的离散框架具有较高的整合度、良好的稳定性及较强的拓展性.此外,该方法能够稳定模拟曲线域中的波传播,降低实现成本,显示了波动方程系数矩阵对称化及其离散框架在波传播模拟中的广泛应用前景. 展开更多
关键词 准晶波动方程 系数矩阵对称式 sbp-SAT 有限差分方法 能量法
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Design and Exploration of Intelligent Software Testing Course
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作者 Depeng Gao Rui Wu +1 位作者 Shihan Xiao Shuxi Chen 《计算机教育》 2026年第3期47-53,共7页
With the rapid development of artificial intelligence,the intelligence level of software is increasingly improving.Intelligent software,which is widely applied in crucial fields such as autonomous driving,intelligent ... With the rapid development of artificial intelligence,the intelligence level of software is increasingly improving.Intelligent software,which is widely applied in crucial fields such as autonomous driving,intelligent customer service,and medical diagnosis,is constructed based on complex technologies like machine learning and deep learning.Its uncertain behavior and data dependence pose unprecedented challenges to software testing.However,existing software testing courses mainly focus on conventional contents and are unable to meet the requirements of intelligent software testing.Therefore,this work deeply analyzed the relevant technologies of intelligent software testing,including reliability evaluation indicator system,neuron coverage,and test case generation.It also systematically designed an intelligent software testing course,covering teaching objectives,teaching content,teaching methods,and a teaching case.Verified by the practical teaching in four classes,this course has achieved remarkable results,providing practical experience for the reform of software testing courses. 展开更多
关键词 Intelligent software testing Intelligent software software testing Course design
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OSSerCopilot:An LLM-driven Tutoring System for Fostering Open Source Competency in Software Engineering Education
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作者 Xin Tan Jingyi Tan +4 位作者 Weimiao Ren Keqing Fan Xiao Long Fang Liu Li Zhang 《计算机教育》 2026年第3期119-129,共11页
In the context of large language model(LLM)reshaping software engineering education,this paper presents OSSerCopilot,a LLM-based tutoring system designed to address the critical challenge faced by newcomers(especially... In the context of large language model(LLM)reshaping software engineering education,this paper presents OSSerCopilot,a LLM-based tutoring system designed to address the critical challenge faced by newcomers(especially student contributors)in open source software(OSS)communities.Leveraging natural language processing,code semantic understanding,and learner profiling,the system functions as an intelligent tutor to scaffold three core competency domains:contribution guideline interpretation,project architecture comprehension,and personalized task matching.By transforming traditional onboarding barriers-such as complex contribution documentation and opaque project structures-into interactive learning journeys,OSSerCopilot enables newcomers to complete their first OSS contribution more easily and confidently.This paper highlights how LLM technologies can redefine software engineering education by bridging the gap between theoretical knowledge and practical OSS participation,offering implications for curriculum design,competency assessment,and sustainable OSS ecosystem cultivation.A demonstration video of the system is available at https://figshare.com/articles/media/OSSerCopilot_Introduction_mp4/29510276. 展开更多
关键词 software engineering education Open source software education Intelligent tutoring systems Newcomer onboarding Large language models AI-driven educational tools OSS contribution
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Software and layout optimization of HIRFL-CSR external-target experiment
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作者 Jian-Wang Hong Chen-Lu Hu +29 位作者 Yu-Hong Yu Nu Xu Zhi-Yu Sun Hao Qiu Zhi-Gang Xiao Ming Shao Li-Min Duan Xiong-Hong He Zhi-Hui Xu Yi Wang Dong Han Zi-Xuan Chen Feng-Yi Zhao He-Run Yang Xiang-Lun Wei Rong-Jiang Hu Feng Liu Hua Pei Ya-Ping Wang Ye Tian Zhi Qin Dong-Dong Hu Guo-Dong Shen Li-Jun Mao Wei Wu Wei You Yu-Quan Chen Peng Yang De-Qing Fang Ya-Peng Zhang 《Nuclear Science and Techniques》 2026年第5期289-297,共9页
Heavy-ion collisions(HICs)is a unique experimental tool for investigating the properties of nuclear matter under extreme conditions in the laboratory.At HIRFL-CSR energies,HICs can create nuclear matter with 2-3 times... Heavy-ion collisions(HICs)is a unique experimental tool for investigating the properties of nuclear matter under extreme conditions in the laboratory.At HIRFL-CSR energies,HICs can create nuclear matter with 2-3 times the saturation density(ρ_(0)).The HIRFL-CSR external-target experiment(CEE)is a large-acceptance spectrometer designed to explore frontier topics in high-energy nuclear physics,such as the QCD phase structure and nuclear matter equation of states.In this letter,we introduce simulation and analysis software for the CEE experiment(CeeROOT).Based on the CEE conceptual design and CeeROOT software,the configurations of its subdetectors were optimized by considering foreseeable physical constraints.The final detector layout of the CEE spectrometer and its acceptances were validated through simulations of U+U collisions at 500 MeV/u and pp collisions at 2.8 GeV,which demonstrated that the CEE experiment will serve as a detector with wide acceptance and multi-particle identification capabilities for studying high-energy nuclear physics topics at HIRFL-CSR energies with pp,pA,and A A collisions. 展开更多
关键词 CEE experiment Simulation software OPTIMIZATION HIRFL-CSR
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Statistical Inference for Software Reliability Constrained by the Shape of the Mean Value Function
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作者 CHEN Kangan LIU Jian +1 位作者 HU Qingpei XIE Min 《Journal of Systems Science & Complexity》 2026年第1期334-362,共29页
While parametric Software Reliability Growth Models(SRGMs)serve as a cornerstone in software reliability assessment,their reliance on known fault-detection time distributions often presents a significant limitation in... While parametric Software Reliability Growth Models(SRGMs)serve as a cornerstone in software reliability assessment,their reliance on known fault-detection time distributions often presents a significant limitation in practical software testing.In this study,the authors develop a novel shaperestricted spline estimator for quantifying software reliability.Compared with parametric SRGMs,the proposed estimator not only shares a key characteristic with parametric SRGMs,but also obviates the need for specifying fault-detection time distributions.More importantly,it effectively utilizes the critical shape information of the mean value function(MVF)of fault-detection process,a detail seldom considered in prior work.Moreover,the authors investigate the predictive performance of the proposed methods by employing the so-called one-step look-ahead prediction method.Furthermore,the authors show that under certain conditions,the shape-restricted spline estimator will attain the point-wise convergence rate O_P(n~(-3/7)).In numerical experiment,the authors show that spline estimators under restriction demonstrate competitive performance compared to parametric and certain non-parametric models. 展开更多
关键词 Penalize regression spline shape restriction software reliability
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Enhancing Code Quality with LLM in Software Static Analysis
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作者 Niu Zhi Dong Luming 《ZTE Communications》 2026年第1期65-71,共7页
In the modern era of ubiquitous and highly interconnected information technology,cybersecurity threats stemming from software code vulnerabilities have become increasingly severe,posing significant risks to the confid... In the modern era of ubiquitous and highly interconnected information technology,cybersecurity threats stemming from software code vulnerabilities have become increasingly severe,posing significant risks to the confidentiality,integrity,and availability of modern information systems.To enhance software code quality,enterprises often integrate static code analysis tools into Continuous Integration(CI) pipelines.However,the high rates of false positives and false negatives remain a challenge.The advent of large language models(LLMs),such as ChatGPT,presents a new opportunity to address these challenges.In this paper,we propose AI-SCDF,a framework that utilizes the custombuilt Nebula-Coder AI model for detecting and fixing code security issues in real time during the developer ' s personal build process.We construct a static code checking rule knowledge base through summarizing and classifying Common Weakness Enumeration(CWE) code security problems identified by security and quality assurance teams.The rule knowledge base is combined with CodeFuse-processed code contexts to serve as input for an AI code security detection microservice,which assists in identifying code quality and security issues.If any abnormalities are detected,they are addressed by an AI code security patching microservice,which alerts the developer and requests confirmation before committing the code into the repository.Experimental results show that our approach effectively improves code quality.We also develop a VS Code plugin for code alert detection and fix based on LLMs,which facilitates test shift-left and lowers the risk of software development. 展开更多
关键词 software static analysis LLM CWE knowledge base
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Research and Practice of a New Training Model for Software Engineering Courses Based on Generative AI and OBE Concepts
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作者 Shengshai Zhang Xiaodong Yu +1 位作者 Jianhui Jiang Lixiao Zhang 《计算机教育》 2026年第3期139-147,共9页
With the advent of the AI era,how can students effectively utilize generative AI large models to assist in course learning?At the same time,how can teachers utilize generative AI tools and the teaching concept of OBE ... With the advent of the AI era,how can students effectively utilize generative AI large models to assist in course learning?At the same time,how can teachers utilize generative AI tools and the teaching concept of OBE to stimulate students’innovative consciousness and teamwork ability,enabling students to identify some problems in a certain industry or field and creatively propose feasible solutions,and truly achieve the cultivation of new models in software engineering course teaching with the assistance of generative AI tools?This paper presents research and practice on a new model for cultivating software engineering courses that integrates generative AI and OBE,introduces the specific process of teaching reform and practice,and finally explains the achievements of teaching reform. 展开更多
关键词 Generative AI OBE software engineering Teaching reform
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Developing Innovation Capacity in Graduate Software Engineering Practice Through Newquality Productive Forces
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作者 Ting Cai Tianyuan Yin +2 位作者 Yuxin Wu Shan Lin Zhiwei Ye 《计算机教育》 2026年第3期220-229,共10页
The rapid development of new-quality productive forces(NQPF)has intensified the demand for high-level innovative talent.As a representative of NQPF,generative artificial intelligence(GenAI)offers powerful tools to res... The rapid development of new-quality productive forces(NQPF)has intensified the demand for high-level innovative talent.As a representative of NQPF,generative artificial intelligence(GenAI)offers powerful tools to reshape talent cultivation but also presents significant challenges,including skill hollowing,ethical risks,and a growing disconnect between education and industry needs.Currently,graduate-level software engineering education struggles with outdated curricula and insufficient alignment with practical demands.In this paper,we propose a dual-core collaborative framework driven by“GenAI technology”and“industry demand”.Under this framework,we design a four-dimensional capability development path to enhance graduate students’innovation in software engineering practice.This path focuses on①scientific research innovation,②engineering problem-solving,③cross-domain collaborative evolution,and④ethical risk governance.The proposed approach promotes a shift from traditional knowledge transfer to human-machine collaborative innovation,aligning talent cultivation with the demands of the NQPF. 展开更多
关键词 New-quality productive forces GenAI Graduate student software engineering Innovation ability
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Exploring Reform Strategies for Software Engineering Talent Development Models in the AI Era
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作者 Linying Jiang Guibing Guo +1 位作者 Jianzhe Zhao Xiaochun Yang 《计算机教育》 2026年第3期95-100,共6页
The rapid development of artificial intelligence(AI)has placed significant pressure on universities to rethink how they train software engineering students.Tools like GitHub Copilot can now generate basic code in seco... The rapid development of artificial intelligence(AI)has placed significant pressure on universities to rethink how they train software engineering students.Tools like GitHub Copilot can now generate basic code in seconds.This raises important questions:What is the value of traditional programming education?What role should instructors play when AI becomes a powerful teaching assistant?How should the goals of software engineering programs change as companies increasingly use AI to handle coding tasks?This paper explores the key challenges AI brings to software engineering education and proposes practical strategies for updating talent development models to meet these changes. 展开更多
关键词 Artificial intelligence software engineering education Talent development Reform strategies
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GranuSAS:Software of rapid particle size distribution analysis from small angle scattering data
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作者 Qiaoyu Guo Fei Xie +3 位作者 Xuefei Feng Zhe Sun Changda Wang Xuechen Jiao 《Chinese Physics B》 2026年第2期216-225,共10页
Small angle x-ray scattering(SAXS)is an advanced technique for characterizing the particle size distribution(PSD)of nanoparticles.However,the ill-posed nature of inverse problems in SAXS data analysis often reduces th... Small angle x-ray scattering(SAXS)is an advanced technique for characterizing the particle size distribution(PSD)of nanoparticles.However,the ill-posed nature of inverse problems in SAXS data analysis often reduces the accuracy of conventional methods.This article proposes a user-friendly software for PSD analysis,GranuSAS,which employs an algorithm that integrates truncated singular value decomposition(TSVD)with the Chahine method.This approach employs TSVD for data preprocessing,generating a set of initial solutions with noise suppression.A high-quality initial solution is subsequently selected via the L-curve method.This selected candidate solution is then iteratively refined by the Chahine algorithm,enforcing constraints such as non-negativity and improving physical interpretability.Most importantly,GranuSAS employs a parallel architecture that simultaneously yields inversion results from multiple shape models and,by evaluating the accuracy of each model's reconstructed scattering curve,offers a suggestion for model selection in material systems.To systematically validate the accuracy and efficiency of the software,verification was performed using both simulated and experimental datasets.The results demonstrate that the proposed software delivers both satisfactory accuracy and reliable computational efficiency.It provides an easy-to-use and reliable tool for researchers in materials science,helping them fully exploit the potential of SAXS in nanoparticle characterization. 展开更多
关键词 small angle x-ray scattering data analysis software particle size distribution inverse problem
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A Hybrid Approach to Software Testing Efficiency:Stacked Ensembles and Deep Q-Learning for Test Case Prioritization and Ranking
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作者 Anis Zarrad Thomas Armstrong Jaber Jemai 《Computers, Materials & Continua》 2026年第3期1726-1746,共21页
Test case prioritization and ranking play a crucial role in software testing by improving fault detection efficiency and ensuring software reliability.While prioritization selects the most relevant test cases for opti... Test case prioritization and ranking play a crucial role in software testing by improving fault detection efficiency and ensuring software reliability.While prioritization selects the most relevant test cases for optimal coverage,ranking further refines their execution order to detect critical faults earlier.This study investigates machine learning techniques to enhance both prioritization and ranking,contributing to more effective and efficient testing processes.We first employ advanced feature engineering alongside ensemble models,including Gradient Boosted,Support Vector Machines,Random Forests,and Naive Bayes classifiers to optimize test case prioritization,achieving an accuracy score of 0.98847 and significantly improving the Average Percentage of Fault Detection(APFD).Subsequently,we introduce a deep Q-learning framework combined with a Genetic Algorithm(GA)to refine test case ranking within priority levels.This approach achieves a rank accuracy of 0.9172,demonstrating robust performance despite the increasing computational demands of specialized variation operators.Our findings highlight the effectiveness of stacked ensemble learning and reinforcement learning in optimizing test case prioritization and ranking.This integrated approach improves testing efficiency,reduces late-stage defects,and improves overall software stability.The study provides valuable information for AI-driven testing frameworks,paving the way for more intelligent and adaptive software quality assurance methodologies. 展开更多
关键词 software testing test case prioritization test case ranking machine learning reinforcement learning deep Q-learning
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Exploration and Practice of School-Enterprise Cooperation Model of Software Engineering Majors from Multi-Perspectives
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作者 Linpeng Zhong Yong Liao 《计算机教育》 2026年第3期38-46,共9页
Promoting the integration of industry and education and deepening school-enterprise cooperation in talent cultivation and collaborative innovation are long-term goals of higher education.This paper systematically anal... Promoting the integration of industry and education and deepening school-enterprise cooperation in talent cultivation and collaborative innovation are long-term goals of higher education.This paper systematically analyzes the multiple perspectives,practical challenges,and implementation paths of in-depth school-enterprise cooperation.Based on the typical case of school-enterprise cooperation at the School of Information and Software Engineering,University of Electronic Science and Technology of China(UESTC),this paper explores the innovative practices of in-depth school-enterprise cooperation in talent cultivation,scientific research,and faculty construction.It also explores a multi-party collaborative mechanism from the perspectives of universities,enterprises,students,and the government.By policy guidance,resource integration,and benefit sharing,this mechanism achieves in-depth integration of industry and education,providing references and examples for further development of school-enterprise cooperation in the new era. 展开更多
关键词 software engineering School-enterprise cooperation Integration of industry and education Collaborative talent cultivation Multi-perspective analysis
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Exploration and Practice in Building a Diversified Faculty Team for Specialized Software Talent Cultivation
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作者 Fangshi Wang Weiwei Xing +1 位作者 Wei Lu Shunli Zhang 《计算机教育》 2026年第3期67-73,共7页
Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial t... Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial to build a faculty team with knowledge in industry application fields and experience in domestic software development.This paper first analyzes the new requirements for the faculty imposed by the cultivation of specialized software talents and the existing problems in the current faculty.Then,in response to these issues,it introduces the reforms and explorations carried out by the School of Software Engineering at Beijing Jiaotong University in the construction of the faculty for cultivating specialized software talents.The aim is to build a high-caliber and diversified faculty that boasts strong political qualities,interdisciplinary integration,complementary advantages between full-time and part-time faculty,and in-depth integration of industry and education. 展开更多
关键词 Specialized software talents Diversified faculty team Interdisciplinary integration Integration of industry and education
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Research and Implementation of the Academic Development Monitoring System for High-quality Software Engineering Talents
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作者 Kun Niu Kaiyang Zhang +5 位作者 Tan Yang Hui Gao Hongfeng Gu Ting Diao Jing Li Honglin Fu 《计算机教育》 2026年第3期199-209,共11页
Traditional grade-centered evaluation models are inadequate for high-quality software engineering talents in the digital and AI era.This study develops an academic development monitoring system to address shortcomings... Traditional grade-centered evaluation models are inadequate for high-quality software engineering talents in the digital and AI era.This study develops an academic development monitoring system to address shortcomings in dynamics,interdisciplinary integration,and industry adaptability.It builds a multi-dimensional dynamic model covering seven core dimensions with quantitative scoring,non-linear weighting,and DivClust grouping.An intelligent platform with real-time monitoring,early warning,and personalized recommendations integrates AI like multi-modal fusion and large-model diagnosis.The“monitoring-warning-improvement”loop helps optimize training programs,support personalized planning,and bridge talent-industry gaps,enabling digital transformation in software engineering education evaluation. 展开更多
关键词 software engineering talents Academic development monitoring Multi-dimensional dynamic evaluation Intelligent monitoring platform AI-driven evaluation Industry adaptability
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糜子SBP基因家族鉴定及在籽粒稃壳色形成中的表达分析 被引量:1
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作者 郝子义 刘天鹏 +6 位作者 何继红 董孔军 任瑞玉 张磊 韦恒 李亚伟 杨天育 《甘肃农业大学学报》 北大核心 2025年第4期65-77,共13页
【目的】了解糜子SBP基因家族及在其籽粒稃壳色形成中的表达特征。【方法】采用生物信息学方法,全基因组鉴定了含有SBP结构域的SBP基因家族成员,并进一步分析了其染色体分布、蛋白理化性质、系统进化关系、基因结构、保守结构域、启动... 【目的】了解糜子SBP基因家族及在其籽粒稃壳色形成中的表达特征。【方法】采用生物信息学方法,全基因组鉴定了含有SBP结构域的SBP基因家族成员,并进一步分析了其染色体分布、蛋白理化性质、系统进化关系、基因结构、保守结构域、启动子区域的顺式作用元件及在糜子白、黄、褐籽粒稃壳色形成中的表达特征。【结果】糜子含有38个SBP基因,不均匀的分布在18条染色体上,PmSBP蛋白的氨基酸序列长度为122-1109aa,等电点为5.49-10.32,家族成员含有1-11个外显子,亚细胞定位于细胞核、叶绿体中。糜子38个SBP基因的蛋白聚类分析显示,该蛋白家族可分为Ⅰ、Ⅱ、Ⅲ、Ⅳ和Ⅴ5个亚家族,亚家族Ⅲ成员具有相对复杂的结构。顺式作用元件分析显示,在糜子SBP家族基因存在共同的顺式作用元件,如光响应、激素响应、分生组织表达和调控种子特异性等。白、黄、褐色籽粒品种晋黍8号、陇糜12号和张778稃壳色形成期转录组及qRT-PCR分析显示,糜子SBP基因家族成员中PmSBP33、PmSBP8、PmSBP17、PmSBP37、PmSBP12、PmSBP14、PmSBP1、PmSBP7、PmSBP23和PmSBP16在3个品种籽粒中的表达量较高,且品种间表达量差异显著。通过与谷子、拟南芥和水稻同源基因比对,推测PmSBP1和PmSBP7与糜子籽粒发育相关。【结论】鉴定出38个糜子SBP基因家族成员,在糜子籽粒稃壳中的表达量差异明显,且PmSBP1和PmSBP7与糜子籽粒形态建成密切相关。 展开更多
关键词 糜子 sbp基因家族 转录因子 生物信息学分析 表达特征
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鼓槌石斛SBP基因家族全基因组鉴定与生物信息学分析
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作者 董蓉娇 李泽生 +4 位作者 姚志军 贾敏 罗凯 高燕 李桂琳 《西南农业学报》 北大核心 2025年第9期1822-1831,共10页
【目的】鉴定和分析鼓槌石斛全基因组中SBP转录因子家族,为后续深入研究SBP转录因子的生物学功能奠定基础。【方法】利用生物信息学方法从鼓槌石斛全基因组中筛选鉴定出SBP基因家族成员,并对其蛋白理化特性、亚细胞定位、蛋白质空间结... 【目的】鉴定和分析鼓槌石斛全基因组中SBP转录因子家族,为后续深入研究SBP转录因子的生物学功能奠定基础。【方法】利用生物信息学方法从鼓槌石斛全基因组中筛选鉴定出SBP基因家族成员,并对其蛋白理化特性、亚细胞定位、蛋白质空间结构、蛋白磷酸化修饰位点、染色体定位、保守结构域与保守基序、系统发育树、启动子顺式作用元件等进行系统分析。【结果】鼓槌石斛基因组中鉴定出15个SBP基因,不均匀分布在10条染色体上,氨基酸数量为219~1086 aa,等电点为5.37~9.63,相对分子质量为24480.53~119978.42 Da,不稳定系数为44.54~74.10,脂肪系数为52.65~81.42,总平均亲水性为-0.787~0.575。亚细胞定位预测结果显示,基因家族成员中3个定位在细胞质上,15个定位在细胞核上;蛋白质二级结构以规则的α-螺旋和松散的无规则卷曲为主要构成,而三级结构整体相似度较低,空间构象更复杂;蛋白磷酸化修饰位点为21~134个;家族成员均具备高度保守的SBP结构域,由2个锌指结构模块和1个核定位信号序列构成;不同SBP基因家族成员之间所含基序(Motif)不同,聚类关系较近基因的基序相似,基序数量为2~7个;鼓槌石斛、拟南芥和水稻51个SBP蛋白被划分为11个亚族,15个鼓槌石斛SBP蛋白分布于8个亚族中;SBP基因启动子区域检测到光响应、激素响应及逆境胁迫响应等22类不同顺式作用元件;SBP基因在鼓槌石斛根和茎中表达量相对较低,在叶片和花中表达量相对较高,同一亚族基因表达模式相似。【结论】SBP基因家族成员理化性质差异较大,划分为8个系统发育亚族,同一亚族结构域和基序保守性极强,启动子区主要包含光响应、激素类响应及逆境胁迫响应等顺式作用元件,SBP基因在不同组织中差异化表达,可能在鼓槌石斛叶片和花器官生长发育方面发挥重要作用。 展开更多
关键词 鼓槌石斛 sbp 基因家族 生物信息学 保守结构域
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3种栗属植物SBP基因家族生物信息学与表达分析
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作者 付丽枝 杨涌 +3 位作者 于克妍 于立洋 王旋 张海娥 《山东农业科学》 北大核心 2025年第5期36-45,共10页
SBP蛋白是一类广泛参与调节生长发育过程的植物特有转录因子。本研究从3种栗属植物中鉴定到58个SBP基因家族成员,并利用生物信息学方法对其染色体定位、蛋白理化性质、共线性关系等方面进行了分析。结果发现,所有栗属植物SBP基因家族成... SBP蛋白是一类广泛参与调节生长发育过程的植物特有转录因子。本研究从3种栗属植物中鉴定到58个SBP基因家族成员,并利用生物信息学方法对其染色体定位、蛋白理化性质、共线性关系等方面进行了分析。结果发现,所有栗属植物SBP基因家族成员在染色体上呈非均匀分布,其中3个SBP基因未被组装到染色体的大片段中。进化树分析发现栗属植物SBP基因家族可以分为7个小组,小组5中发生了基因的丢失和扩增。Motif分析发现所有SBP基因家族成员都包含保守的Motif1或Motif2。共线性基因对的Ka/Ks分析发现,SBP基因家族成员在栗属植物基因组内及组间正在经历纯化选择。转录组数据分析发现CmSBP基因家族在不同时期中国板栗芽与果实中的表达量变化明显。本研究结果可为后续栗属植物SBP基因功能研究提供理论基础。 展开更多
关键词 栗属植物 sbp基因家族 选择压力 生物信息学分析 表达分析
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When Software Security Meets Large Language Models:A Survey 被引量:4
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作者 Xiaogang Zhu Wei Zhou +3 位作者 Qing-Long Han Wanlun Ma Sheng Wen Yang Xiang 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期317-334,共18页
Software security poses substantial risks to our society because software has become part of our life. Numerous techniques have been proposed to resolve or mitigate the impact of software security issues. Among them, ... Software security poses substantial risks to our society because software has become part of our life. Numerous techniques have been proposed to resolve or mitigate the impact of software security issues. Among them, software testing and analysis are two of the critical methods, which significantly benefit from the advancements in deep learning technologies. Due to the successful use of deep learning in software security, recently,researchers have explored the potential of using large language models(LLMs) in this area. In this paper, we systematically review the results focusing on LLMs in software security. We analyze the topics of fuzzing, unit test, program repair, bug reproduction, data-driven bug detection, and bug triage. We deconstruct these techniques into several stages and analyze how LLMs can be used in the stages. We also discuss the future directions of using LLMs in software security, including the future directions for the existing use of LLMs and extensions from conventional deep learning research. 展开更多
关键词 Large language models(LLMs) software analysis software security software testing
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双相介质波动方程系数矩阵对称化及其SBP-SAT差分模拟
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作者 孙铖 刘泰玉 +2 位作者 蒋关希曦 张剑伟 杨在林 《振动与冲击》 北大核心 2025年第16期108-118,共11页
波动方程系数矩阵对称化是整合不同类别波动方程、降低波传播模拟难度的有效方法,目前已成功应用于声波方程、各向同性与各向异性介质弹性波动方程。该研究将推导出双项介质波动方程的系数矩阵对称式;随后,引入多轴完全匹配层,采用迎风... 波动方程系数矩阵对称化是整合不同类别波动方程、降低波传播模拟难度的有效方法,目前已成功应用于声波方程、各向同性与各向异性介质弹性波动方程。该研究将推导出双项介质波动方程的系数矩阵对称式;随后,引入多轴完全匹配层,采用迎风格式分部求和-一致逼近项(summation by parts-simultaneous approximation terms,SBP-SAT)有限差分方法离散波动方程,并通过能量法进行稳定性评估。通过数值仿真,表明所提出的离散框架具有整合度高,稳定性好和拓展性强等特点。此外,该方法可以稳定模拟曲线域中的波传播并降低其实现成本,表明了波动方程系数矩阵对称化方法及其离散框架在波传播模拟领域具有广泛的应用前景。 展开更多
关键词 双相介质波动方程 系数矩阵对称式 分部求和-一致逼近项(sbp-SAT) 有限差分方法 能量法
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