In recent years,our understanding of photoaging and photoprotection has significantly advanced,with photoaging now widely recognized as a key factor affecting both the health and aesthetic quality of the skin.This pap...In recent years,our understanding of photoaging and photoprotection has significantly advanced,with photoaging now widely recognized as a key factor affecting both the health and aesthetic quality of the skin.This paper explores the underlying mechanisms of skin damage caused by various bands of the light spectrum,along with the classical biological targets associated with photoaging.It proposes innovative strategies for effective photoprotection,including:(1)broadening protection beyond the ultraviolet(UV)spectrum;(2)tailoring sunscreen formulations to match different skin phototypes;and(3)adopting a comprehensive photoprotective approach that integrates prevention,defense,and repair.These strategies offer a theoretical foundation for the development of next-generation photoprotective products,contributing to the mitigation of photoaging and the maintenance of skin health.展开更多
Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,worldwide.Although the antitumor activity of chalcones has been extensively studied,the m...Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,worldwide.Although the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well understood.In this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner.TEC induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in vivo.Moreover,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 pathways.TEC triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 axis.The mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.展开更多
皮肤衰老是衰老研究领域的一个分支,生物标志物可用于客观评价皮肤衰老程度,包括了特定蛋白基因、信号通路的激活以及一系列细胞分泌因子。本文概述了皮肤衰老相关分泌表型(skin aging related secretion phenotype,SASP)的组成及其生...皮肤衰老是衰老研究领域的一个分支,生物标志物可用于客观评价皮肤衰老程度,包括了特定蛋白基因、信号通路的激活以及一系列细胞分泌因子。本文概述了皮肤衰老相关分泌表型(skin aging related secretion phenotype,SASP)的组成及其生理功能、SASP在皮肤衰老过程中的变化,以及针对SASP为功效靶点设计的化妆品功效测试组合方法,旨在对基于SASP靶点的相关功效化妆品研究有一个更加全面深刻的认识。展开更多
近日,中国科学院上海营养与健康研究所孙宇研究组在《自然-代谢》(Nature Metabolism)上,在线发表了题为“PDK4-dependent hypercatabolism and lactate production of senescence cells promotes cancer malignancy”的研究论文。该研...近日,中国科学院上海营养与健康研究所孙宇研究组在《自然-代谢》(Nature Metabolism)上,在线发表了题为“PDK4-dependent hypercatabolism and lactate production of senescence cells promotes cancer malignancy”的研究论文。该研究揭示了衰老相关分泌表型(SASP)广谱表达的同时,一种关键代谢因子-丙酮酸脱氢酶激酶4(PDK4)在衰老细胞中显著上调,后者可以介导衰老细胞代谢重编程并使其呈现一种葡萄糖高分解代谢的特性。该研究解析了细胞衰老、乳酸生成、器官退行和增龄相关疾病之间的关联,并开创了相应的干预策略。展开更多
文摘In recent years,our understanding of photoaging and photoprotection has significantly advanced,with photoaging now widely recognized as a key factor affecting both the health and aesthetic quality of the skin.This paper explores the underlying mechanisms of skin damage caused by various bands of the light spectrum,along with the classical biological targets associated with photoaging.It proposes innovative strategies for effective photoprotection,including:(1)broadening protection beyond the ultraviolet(UV)spectrum;(2)tailoring sunscreen formulations to match different skin phototypes;and(3)adopting a comprehensive photoprotective approach that integrates prevention,defense,and repair.These strategies offer a theoretical foundation for the development of next-generation photoprotective products,contributing to the mitigation of photoaging and the maintenance of skin health.
基金funded by the National Natural Science Foundation of China(82003879)Project of Science and Technology Department of Sichuan Province(2023NSFSC1928,2023NSFSC1992)+3 种基金Young Elite Scientists Sponsorship Program China Association for Science and Technology(CACM-2020-QNRC1-01)Project of State Administration of Traditional Chinese Medicine of China(ZYYCXTD-D-202209)Project of Undergraduate Training Programs for Innovation and Entrepreneurship(S202310610637)the Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM202205).
文摘Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,worldwide.Although the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well understood.In this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner.TEC induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in vivo.Moreover,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 pathways.TEC triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 axis.The mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.
文摘皮肤衰老是衰老研究领域的一个分支,生物标志物可用于客观评价皮肤衰老程度,包括了特定蛋白基因、信号通路的激活以及一系列细胞分泌因子。本文概述了皮肤衰老相关分泌表型(skin aging related secretion phenotype,SASP)的组成及其生理功能、SASP在皮肤衰老过程中的变化,以及针对SASP为功效靶点设计的化妆品功效测试组合方法,旨在对基于SASP靶点的相关功效化妆品研究有一个更加全面深刻的认识。
文摘近日,中国科学院上海营养与健康研究所孙宇研究组在《自然-代谢》(Nature Metabolism)上,在线发表了题为“PDK4-dependent hypercatabolism and lactate production of senescence cells promotes cancer malignancy”的研究论文。该研究揭示了衰老相关分泌表型(SASP)广谱表达的同时,一种关键代谢因子-丙酮酸脱氢酶激酶4(PDK4)在衰老细胞中显著上调,后者可以介导衰老细胞代谢重编程并使其呈现一种葡萄糖高分解代谢的特性。该研究解析了细胞衰老、乳酸生成、器官退行和增龄相关疾病之间的关联,并开创了相应的干预策略。
