Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition...Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of Xinyi San were got, and the target genes of rhinitis of Xinyi San were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.展开更多
Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease t...Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease targets through GeneCards database. We constructed “disease-single drug-component-target” network through software Cytoscape 3.7.2 and constructed PPI network through STRING database. GO function and KEGG pathway enrichment were analyzed to predict its mechanism. Results: We got 162 components, 69 therapeutic targets, 88 GO items and 135 pathways. The main pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, Kaposi sarcoma-associated herpesvirus infection, Hepatitis B, Human cytomegalovirus infection, etc. Conclusion: This study preliminarily revealed the active components, targets and pathways of Xinyi San in treating nasal polyposis.展开更多
Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xin...Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xinyi San were collected by TCMSP. The targets of senile rhinitis were collected by the Genecards database. The potential target of Xinyi San in the treatment of senile rhinitis was obtained by Venn analysis. Cytoscape 3.7.2 the software constructs the relationship network model of “disease-single drug-active ingredient-action target”. Protein protein interaction (PPI) network was constructed by using a string database. R4.1.1 software was used for GO function enrichment analysis and KEGG pathway enrichment analysis. Results: In this study, we obtained 158 active ingredients, 40 potential therapeutic targets, 74 GO projects, and 99 pathways. Major pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways of neurodegeneration-multiple diseases, etc. Conclusion: Xinyi San has the characteristics of multi-component, multi-target, and multi-channel in the treatment of senile rhinitis. This study provides a basis for the in-depth study of Xinyi San.展开更多
Short Retraction Notice The paper does not meet the standards of “Chinese Medicine ". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE&#...Short Retraction Notice The paper does not meet the standards of “Chinese Medicine ". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Editor guiding this retraction: Prof. Maythem Saeed (EiC of CM) The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".展开更多
传统数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重不足。我院采用SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系统具有良好的可用性、可扩充性、可维护性。从而实现医...传统数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重不足。我院采用SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系统具有良好的可用性、可扩充性、可维护性。从而实现医院的统一数据存储平台,保障医院网络业务的高效、正常运行。展开更多
Both the requirement of the application and the development of the technology invoke the research of the new networking technology in network storage, currently the IP -based SAN has become the new focus. The main net...Both the requirement of the application and the development of the technology invoke the research of the new networking technology in network storage, currently the IP -based SAN has become the new focus. The main networking technology used in the IP -based SAN is: iSCSI, FCIP, iFCP, mFCP. These protocols all implement the transmitting of SCSI block I/O over the TCP/IP. To understand the protocols deeply, this paper analyzes and compares the protocols intensively.展开更多
随着互联网技术的快速发展,数据的爆炸式增长,存储系统的软硬件紧耦合设计严重地限制了存储技术的发展,也越来越无法满足移动互联网和大数据时代下对存储系统快速、多变的需求.软件定义网络(storage defined network,SDN)作为一种新的...随着互联网技术的快速发展,数据的爆炸式增长,存储系统的软硬件紧耦合设计严重地限制了存储技术的发展,也越来越无法满足移动互联网和大数据时代下对存储系统快速、多变的需求.软件定义网络(storage defined network,SDN)作为一种新的网络架构,更适合下一代数据中心的发展.在SDN思想基础上,提出了一种基于控制中心的新型SAN架构(controller-based SAN,CSN),该架构分离FC交换机的协议控制面和数据面,将FC协议的控制功能和分布式服务功能部署在控制器中,随后详细阐述了该架构的控制器设计、通信机制和整体机制的设计与实现.在CSN基础上,又提出了按需可用带宽优先路由协议.最后,通过实际开发环境验证该架构的可行性.通过实验测试,得出CSN下服务器能够更快地与存储服务器建立连接,并且存储网络具有更高的吞吐量、更快的收敛性、更好的可靠性和可扩展性,此外,还对中心控制器的CPU、内存和带宽进行压力测试.展开更多
With the increasing explosively of data in network,more and more people pay attention to the networked storage ,currently the main technology of networked storage is NAS ( Network Attached Storage )and SAN ( Storage A...With the increasing explosively of data in network,more and more people pay attention to the networked storage ,currently the main technology of networked storage is NAS ( Network Attached Storage )and SAN ( Storage Area Network ). They are different ,and they are not competed but complement ,they are used in different occasion.To reduce the TOC (total of cost),people hope to merges the two technology :design a united storage network,it can supply the virtues and overcome the drawbacks of the NAS and SAN. This paper analysis and discuss the topic.展开更多
随着医院信息资源和数字资源的飞速增长,传统的数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重问题。昌吉州人民医院采用了SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系...随着医院信息资源和数字资源的飞速增长,传统的数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重问题。昌吉州人民医院采用了SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系统具有良好的可用性、可扩充性、可维护性,从而实现了统一数据存储平台,保障了网络业务的高效、正常运行。展开更多
文摘Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of Xinyi San were got, and the target genes of rhinitis of Xinyi San were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.
文摘Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease targets through GeneCards database. We constructed “disease-single drug-component-target” network through software Cytoscape 3.7.2 and constructed PPI network through STRING database. GO function and KEGG pathway enrichment were analyzed to predict its mechanism. Results: We got 162 components, 69 therapeutic targets, 88 GO items and 135 pathways. The main pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, Kaposi sarcoma-associated herpesvirus infection, Hepatitis B, Human cytomegalovirus infection, etc. Conclusion: This study preliminarily revealed the active components, targets and pathways of Xinyi San in treating nasal polyposis.
文摘Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xinyi San were collected by TCMSP. The targets of senile rhinitis were collected by the Genecards database. The potential target of Xinyi San in the treatment of senile rhinitis was obtained by Venn analysis. Cytoscape 3.7.2 the software constructs the relationship network model of “disease-single drug-active ingredient-action target”. Protein protein interaction (PPI) network was constructed by using a string database. R4.1.1 software was used for GO function enrichment analysis and KEGG pathway enrichment analysis. Results: In this study, we obtained 158 active ingredients, 40 potential therapeutic targets, 74 GO projects, and 99 pathways. Major pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways of neurodegeneration-multiple diseases, etc. Conclusion: Xinyi San has the characteristics of multi-component, multi-target, and multi-channel in the treatment of senile rhinitis. This study provides a basis for the in-depth study of Xinyi San.
文摘Short Retraction Notice The paper does not meet the standards of “Chinese Medicine ". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Editor guiding this retraction: Prof. Maythem Saeed (EiC of CM) The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".
文摘传统数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重不足。我院采用SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系统具有良好的可用性、可扩充性、可维护性。从而实现医院的统一数据存储平台,保障医院网络业务的高效、正常运行。
文摘Both the requirement of the application and the development of the technology invoke the research of the new networking technology in network storage, currently the IP -based SAN has become the new focus. The main networking technology used in the IP -based SAN is: iSCSI, FCIP, iFCP, mFCP. These protocols all implement the transmitting of SCSI block I/O over the TCP/IP. To understand the protocols deeply, this paper analyzes and compares the protocols intensively.
文摘随着互联网技术的快速发展,数据的爆炸式增长,存储系统的软硬件紧耦合设计严重地限制了存储技术的发展,也越来越无法满足移动互联网和大数据时代下对存储系统快速、多变的需求.软件定义网络(storage defined network,SDN)作为一种新的网络架构,更适合下一代数据中心的发展.在SDN思想基础上,提出了一种基于控制中心的新型SAN架构(controller-based SAN,CSN),该架构分离FC交换机的协议控制面和数据面,将FC协议的控制功能和分布式服务功能部署在控制器中,随后详细阐述了该架构的控制器设计、通信机制和整体机制的设计与实现.在CSN基础上,又提出了按需可用带宽优先路由协议.最后,通过实际开发环境验证该架构的可行性.通过实验测试,得出CSN下服务器能够更快地与存储服务器建立连接,并且存储网络具有更高的吞吐量、更快的收敛性、更好的可靠性和可扩展性,此外,还对中心控制器的CPU、内存和带宽进行压力测试.
文摘With the increasing explosively of data in network,more and more people pay attention to the networked storage ,currently the main technology of networked storage is NAS ( Network Attached Storage )and SAN ( Storage Area Network ). They are different ,and they are not competed but complement ,they are used in different occasion.To reduce the TOC (total of cost),people hope to merges the two technology :design a united storage network,it can supply the virtues and overcome the drawbacks of the NAS and SAN. This paper analysis and discuss the topic.
文摘随着医院信息资源和数字资源的飞速增长,传统的数据存储以服务器上的磁盘空间为主,或者后端连接着共享SCSI阵列,存在严重问题。昌吉州人民医院采用了SAN(Storage Area Network)为核心的智能化网络存储系统,存储、整合数据,使网络存储系统具有良好的可用性、可扩充性、可维护性,从而实现了统一数据存储平台,保障了网络业务的高效、正常运行。
