AIMTo evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODSIn this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experime...AIMTo evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODSIn this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experimental groups, Paraquat alone and with different doses of Salep aqueous extract (40, 80, 160 and 320 mg/kg) was given intraperitoneal daily for 14 d. After that, liver biochemical parameter and histologic changes were analyzed and compared in different groups. RESULTSParaquat compared to control and sham groups, significantly (P CONCLUSIONSalep possesses remarkable hepatoprotection activity against Paraquat-induced hepatic injury by having antioxidant activity and reducing lipid peroxidation and oxidative stress.展开更多
基金Supported by The results described in this article are part of a Medical student,Sanaz Zarei’s dissertation that was financially supported by Jahrom University of Medical Sciences,Jahrom,Iran
文摘AIMTo evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODSIn this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experimental groups, Paraquat alone and with different doses of Salep aqueous extract (40, 80, 160 and 320 mg/kg) was given intraperitoneal daily for 14 d. After that, liver biochemical parameter and histologic changes were analyzed and compared in different groups. RESULTSParaquat compared to control and sham groups, significantly (P CONCLUSIONSalep possesses remarkable hepatoprotection activity against Paraquat-induced hepatic injury by having antioxidant activity and reducing lipid peroxidation and oxidative stress.
