An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothi...An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothiocyanates,amines and cyclic ethers.This methodology features simple operation,mild reaction conditions,favorable functional group tolerance,easily available starting materials and high efficiency.展开更多
Twelve S-substituted 7-mercapto-4-methylcoumarin analogs were synthesized and evaluated for the inhibition to HBV in HepG2 2.2.1.5 cell. Among them, ten compounds exhibited potent inhibition to HBsAg and/or HBeAg with...Twelve S-substituted 7-mercapto-4-methylcoumarin analogs were synthesized and evaluated for the inhibition to HBV in HepG2 2.2.1.5 cell. Among them, ten compounds exhibited potent inhibition to HBsAg and/or HBeAg with the IC50 values of sub μmol/L level. The ICso of anti-HBsAg activities of 5c and 5j reached 0.01 μmol/L respectively which were 16 fold more potent than that of 3TC. Compounds 3, 5e, 5g, 5h and 5i showed admirable inhibitory activity to both HBsAg and HBeAg. The bioassay results indicated the S-substituted 7-mercapto-4-methylcoumarin analogs merit attention as novel anti-HBV agents.展开更多
Developing polymers that can be chemically recycled signifies a considerable prospect to polymer scientists to tackle the increasing plastic crises but is still plagued with certain limitations in architecture/perform...Developing polymers that can be chemically recycled signifies a considerable prospect to polymer scientists to tackle the increasing plastic crises but is still plagued with certain limitations in architecture/performance diversity and depolymerization activity.Polythioesters synthesized through ring-opening polymerization(ROP)of cyclic thioesters monomers are captivating materials owing to the labile thioester bonds in polymer chains and the low ring strain energy of thiolactone monomers.In this brief review,the latest advancements in the ring-opening polymerization of dithiolactone and monothiodilactone monomers to prepare chemically recycled polythioesters are summarized.Moreover,the feasibility and challenges in future practical applications of chemically recyclable polythioesters derived from dithiolactone and monothiodilactone will be discussed.展开更多
基金financially supported by Natural Science Foundation of Shandong Province(No.ZR2021MB065)the major innovation fund of Shandong Province(No.2021ZDSYS_(2)3)the National Natural Science Foundation of China(Nos.21976105,22101237).
文摘An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothiocyanates,amines and cyclic ethers.This methodology features simple operation,mild reaction conditions,favorable functional group tolerance,easily available starting materials and high efficiency.
基金a grant from National Science Foundation of China(No.20272010 and 30200348)awarded to P.Xia and Y.Chert,respectively.
文摘Twelve S-substituted 7-mercapto-4-methylcoumarin analogs were synthesized and evaluated for the inhibition to HBV in HepG2 2.2.1.5 cell. Among them, ten compounds exhibited potent inhibition to HBsAg and/or HBeAg with the IC50 values of sub μmol/L level. The ICso of anti-HBsAg activities of 5c and 5j reached 0.01 μmol/L respectively which were 16 fold more potent than that of 3TC. Compounds 3, 5e, 5g, 5h and 5i showed admirable inhibitory activity to both HBsAg and HBeAg. The bioassay results indicated the S-substituted 7-mercapto-4-methylcoumarin analogs merit attention as novel anti-HBV agents.
基金supported by grants from the National Science Fund for Distinguished Young Scholars(22325108)National Natural Science Foundation of China(91856113,U21A2089 and 52273015)+2 种基金the National Key Research and Development Program of China(2022YFE0130500)the State Key Laboratory of Catalytic Materials and Reaction Engineering(RIPP,SINOPEC,PR20232038)Jilin Province and CAS(2022SYHZ0034).
文摘Developing polymers that can be chemically recycled signifies a considerable prospect to polymer scientists to tackle the increasing plastic crises but is still plagued with certain limitations in architecture/performance diversity and depolymerization activity.Polythioesters synthesized through ring-opening polymerization(ROP)of cyclic thioesters monomers are captivating materials owing to the labile thioester bonds in polymer chains and the low ring strain energy of thiolactone monomers.In this brief review,the latest advancements in the ring-opening polymerization of dithiolactone and monothiodilactone monomers to prepare chemically recycled polythioesters are summarized.Moreover,the feasibility and challenges in future practical applications of chemically recyclable polythioesters derived from dithiolactone and monothiodilactone will be discussed.
