This paper deals with the boundedness and compactness of the compositionintegral type operators T g, from F (p, q, s) spaces to(little) Bloch-type spaces in the unit ball of C n , where Tg,φf(z) =∫01fφ(tz)Rg(tz)(dt...This paper deals with the boundedness and compactness of the compositionintegral type operators T g, from F (p, q, s) spaces to(little) Bloch-type spaces in the unit ball of C n , where Tg,φf(z) =∫01fφ(tz)Rg(tz)(dt)/t , z ∈ B, g ∈ H(B) and φ∈H(B, B).展开更多
This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to ...This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to Bers-type spaces Hv^∞（ or little Bers-type spaces Hv,o∞ ）, where v is normal.展开更多
The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh p...The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh pathway components— Patched1(PTCH1) and Gli1 in 40 human primary NB samples.Western blotting and RT-PCR were used to examine the protein expression and mRNA levels of PTCH1 and Gli1 in three kinds of S-type NB cell lines(SK-N-AS,SK-N-SH and SHEP1),respectively.Exogenous Shh was administrated to activate Shh signaling pathway while cyclopamine was used as a selective antagonist of Shh pathway.S-type NB cell lines were treated with different concentrations of Shh or/and cyclopamine for different durations.Cell viability was measured by using MTT method.Apoptosis rate and cell cycle were assayed by flow cytometry.The xenograft experiments were used to evaluate the role of Shh pathway in tumor growth in immunodeficient mice.High-level expression of PTCH1 and Gli1 was detected in both NB samples and S-type NB cell lines.Cyclopamine decreased the survival rate of the three cell lines while Shh increased it,and the inhibition effects of cyclopamine could be partially reversed by shh pre-treatment.Cyclopamine induced the cell apoptosis and the cell cycle arrest in G0/G1 phase,while Shh induced the reverse effects and could partially prevent effects of cyclopamine.Cyclopamine could also inhibit the growth of NB in vivo.Our studies revealed that activation of the Shh pathway is important for survival and proliferation of S-type NB cells in vivo and in vitro through affecting cell apoptosis and cell cycle,suggesting a new therapeutic approach to NB.展开更多
A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some resul...A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some results on the related Jacobi interpolation are established. A pseudospectral scheme is proposed for the Kuramoto-Sivashisky equation. A skew symmetric decomposition is used for dealing with the nonlinear convection term. The stability and convergence of the proposed scheme are proved. The error estimates are obtained. Numerical results show the efficiency of this approach.展开更多
The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical ind...The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).展开更多
基金Supported by the NNSF of China(10771064, 11101139)Supported by the NSF of Zhejiang Province(Y7080197, Y6090036, Y6100219)Supported by the Foundation of Creative Group in Colleges and Universities of Zhejiang Province(T200924)
文摘This paper deals with the boundedness and compactness of the compositionintegral type operators T g, from F (p, q, s) spaces to(little) Bloch-type spaces in the unit ball of C n , where Tg,φf(z) =∫01fφ(tz)Rg(tz)(dt)/t , z ∈ B, g ∈ H(B) and φ∈H(B, B).
基金Supported by the National Natural Science Foundation of China (10771064)the Natural Science Foundation of Zhejiang province (Y6090036+1 种基金Y7080197,Y606197)the Foundation of Department of Education of Zhejiang Province (20070482)
文摘This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to Bers-type spaces Hv^∞（ or little Bers-type spaces Hv,o∞ ）, where v is normal.
基金supported by a grant from the National Natural Sciences Foundation of China (No.30600189)
文摘The effects of Sonic hedgehog(Shh) signaling pathway activation on S-type neuroblastoma(NB) cell lines and its role in NB tumorigenesis were investigated.Immunohistochemistry was used to detect the expression of Shh pathway components— Patched1(PTCH1) and Gli1 in 40 human primary NB samples.Western blotting and RT-PCR were used to examine the protein expression and mRNA levels of PTCH1 and Gli1 in three kinds of S-type NB cell lines(SK-N-AS,SK-N-SH and SHEP1),respectively.Exogenous Shh was administrated to activate Shh signaling pathway while cyclopamine was used as a selective antagonist of Shh pathway.S-type NB cell lines were treated with different concentrations of Shh or/and cyclopamine for different durations.Cell viability was measured by using MTT method.Apoptosis rate and cell cycle were assayed by flow cytometry.The xenograft experiments were used to evaluate the role of Shh pathway in tumor growth in immunodeficient mice.High-level expression of PTCH1 and Gli1 was detected in both NB samples and S-type NB cell lines.Cyclopamine decreased the survival rate of the three cell lines while Shh increased it,and the inhibition effects of cyclopamine could be partially reversed by shh pre-treatment.Cyclopamine induced the cell apoptosis and the cell cycle arrest in G0/G1 phase,while Shh induced the reverse effects and could partially prevent effects of cyclopamine.Cyclopamine could also inhibit the growth of NB in vivo.Our studies revealed that activation of the Shh pathway is important for survival and proliferation of S-type NB cells in vivo and in vitro through affecting cell apoptosis and cell cycle,suggesting a new therapeutic approach to NB.
文摘A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some results on the related Jacobi interpolation are established. A pseudospectral scheme is proposed for the Kuramoto-Sivashisky equation. A skew symmetric decomposition is used for dealing with the nonlinear convection term. The stability and convergence of the proposed scheme are proved. The error estimates are obtained. Numerical results show the efficiency of this approach.
文摘The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).
