The CAS Awards for S&T Progress and the CAS Awards for Inventions are two major awards issued by the Chinese Academy of Sciences to recognize major research results and inventions produced by CAS scientists that h...The CAS Awards for S&T Progress and the CAS Awards for Inventions are two major awards issued by the Chinese Academy of Sciences to recognize major research results and inventions produced by CAS scientists that have contributed greatly to the promotion of S&T progress, and social and economic development. In 1998, 12 research works won the CAS Awards for Inventions and 94 works won the CAS Awards for S&T Progress. The following are profiles of some of the prize-wining projects.展开更多
The CAS Awards for Natural Sciences and the CAS Awards for S&T Progress are two major awards issued by the Chinese Academy of Sciences. The former is to recognize the scientific findings and research results by wh...The CAS Awards for Natural Sciences and the CAS Awards for S&T Progress are two major awards issued by the Chinese Academy of Sciences. The former is to recognize the scientific findings and research results by which CAS scientists bring to light natural phenomena, laws and properties in their basic and applied basic research. The latter is to award major inventions or research results produced by CAS scientists that have contributed greatly to the promotion of S&T progress, and social and economic development. In 1997, 68 research projects won the CAS Awards for Natural Sciences, and 106 research works won CAS Awards for S&T Progress. The following are profiles of some of the prize-wining projects.展开更多
Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade ...Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade prizesrespectively at the 1994 CAS Awards for S&T Progress.A brief introduction of them is given as follows:展开更多
In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade pr...In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade prize and 28 first-grade prizes of the 1993 CAS Awards for S&T Progress respectively. A brief introduction to them is as follows: SPECIAL PRIZE (1 ITEM)展开更多
The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two ...The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two decades,we may reach the conclusion that a new technological revolution is taking shape.For both the developed and the developing countries,challenges and opportunities are close at hand.In the Decision to Speed up China’s S&T Progress Jointly Issued by the CPC Central Committee and the State Council.a developmen-展开更多
Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly ...Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.展开更多
On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyo...On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.展开更多
Coronavirus is an RNA virus that can infect both humans and animals,posing a significant threat to agriculture and public health.Although coronaviruses are highly host-specific,their ability to infect multiple hosts,c...Coronavirus is an RNA virus that can infect both humans and animals,posing a significant threat to agriculture and public health.Although coronaviruses are highly host-specific,their ability to infect multiple hosts,combined with the structure of their genome,gives them a high probability of genetic recombination and mutation,leading to the creation of novel viruses.In recent years,with the establishment and development of reverse genetic manipulation techniques,substantial technical support has been provided for studying the structure and function of the coronavirus genome,the development of novel vaccines and drugs and the construction of viral expression vectors.This paper briefly described the progress in research on coronaviruses and their reverse genetic system construction strategies,aiming to provide some references for future coronavirus research.展开更多
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas...AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge percep...Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.展开更多
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By...Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.展开更多
The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and pro...The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.展开更多
Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the ten...Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.展开更多
This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the ...This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.展开更多
Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the ri...Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.展开更多
AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:...AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:Totally 716 eyes of 716 patients with primary open angle glaucoma(POAG)with at least 5 reliable 24-2 test results and 2y of follow-up were selected.The functional GEE model was used to detect perimetric progression in the training dataset(501 eyes).In the testing dataset(215 eyes),progression was evaluated the functional GEE model,mean deviation(MD)and visual field index(VFI)rates of change,Advanced Glaucoma Intervention Study(AGIS)and Collaborative Initial Glaucoma Treatment Study(CIGTS)scores,and pointwise linear regression(PLR).RESULTS:The proposed method showed the highest proportion of eyes detected as progression(54.4%),followed by the VFI rate(34.4%),PLR(23.3%),and MD rate(21.4%).The CIGTS and AGIS scores had a lower proportion of eyes detected as progression(7.9%and 5.1%,respectively).The time to detection of progression was significantly shorter for the proposed method than that of other algorithms(adjusted P≤0.019).The VFI rate displayed moderate pairwise agreement with the proposed method(k=0.47).CONCLUSION:The functional GEE model shows the highest proportion of eyes detected as perimetric progression and the shortest time to detect perimetric progression in patients with POAG.展开更多
Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functiona...Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functional interplay in PC remain unclear.This study aimed to define the role of S100A14 in PC progression.Methods:Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes.Prognostic relevance was assessed via Kaplan-Meier and ROC analyses.Functional experiments were performed in PANC-1 and BxPC-3 cells,including qRT-PCR,CCK-8 assay,Western blotting,Transwell assay,and apoptosis assay.Co-immunoprecipitation(Co-IP)was used to verify S100A14-S100A16 interaction.CHX chase and dual-luciferase assays were employed to assess protein stability and transcriptional activity.Results:S100A14 was markedly upregulated in PC tissues and cell lines and identified as a key prognostic gene.Silencing S100A14 suppressed EMT,proliferation,invasion,and migration,while reversing S100A16-mediated p53 inhibition and enhancing apoptosis.Mechanistically,Co-IP assay confirmed the protein interaction between S100A14 and S100A16;S100A14 stabilized S100A16 protein through post-translational modification without transcriptional regulation;the S100A14/S100A16 axis reduced p53 protein stability and inhibited its transcriptional activity as well as the downstream p21 expression.Critically,knockdown of S100A14 abrogated the pro-metastatic phenotype of cancer cells.Conclusion:This study identifies S100A14 promotes PC progression by stabilizing S100A16 and suppressing the tumor-suppressive p53/p21 pathway;knockdown of S100A14 can reverse the above effects,restore p53 function,and enhance cancer cell apoptosis.Targeting the S100A14/S100A16/p53 regulatory axis could represent a promising therapeutic approach for PC.展开更多
Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities...Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities,defense capabilities,and composite national strength all reached new heights.”declared President Xi Jinping in his 2026 New Year message on De-By CHINA TODAY cember 31,2025,offering a succinct summary of China’s development over the past year,marked by resilience,progress,and renewed confidence as the country stands at the threshold of a new development phase.展开更多
文摘The CAS Awards for S&T Progress and the CAS Awards for Inventions are two major awards issued by the Chinese Academy of Sciences to recognize major research results and inventions produced by CAS scientists that have contributed greatly to the promotion of S&T progress, and social and economic development. In 1998, 12 research works won the CAS Awards for Inventions and 94 works won the CAS Awards for S&T Progress. The following are profiles of some of the prize-wining projects.
文摘The CAS Awards for Natural Sciences and the CAS Awards for S&T Progress are two major awards issued by the Chinese Academy of Sciences. The former is to recognize the scientific findings and research results by which CAS scientists bring to light natural phenomena, laws and properties in their basic and applied basic research. The latter is to award major inventions or research results produced by CAS scientists that have contributed greatly to the promotion of S&T progress, and social and economic development. In 1997, 68 research projects won the CAS Awards for Natural Sciences, and 106 research works won CAS Awards for S&T Progress. The following are profiles of some of the prize-wining projects.
文摘Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade prizesrespectively at the 1994 CAS Awards for S&T Progress.A brief introduction of them is given as follows:
文摘In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade prize and 28 first-grade prizes of the 1993 CAS Awards for S&T Progress respectively. A brief introduction to them is as follows: SPECIAL PRIZE (1 ITEM)
文摘The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two decades,we may reach the conclusion that a new technological revolution is taking shape.For both the developed and the developing countries,challenges and opportunities are close at hand.In the Decision to Speed up China’s S&T Progress Jointly Issued by the CPC Central Committee and the State Council.a developmen-
文摘Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.
文摘On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.
基金Supported by the National Natural Science Foundation of China Joint Foundation Programme(U22A20527)。
文摘Coronavirus is an RNA virus that can infect both humans and animals,posing a significant threat to agriculture and public health.Although coronaviruses are highly host-specific,their ability to infect multiple hosts,combined with the structure of their genome,gives them a high probability of genetic recombination and mutation,leading to the creation of novel viruses.In recent years,with the establishment and development of reverse genetic manipulation techniques,substantial technical support has been provided for studying the structure and function of the coronavirus genome,the development of novel vaccines and drugs and the construction of viral expression vectors.This paper briefly described the progress in research on coronaviruses and their reverse genetic system construction strategies,aiming to provide some references for future coronavirus research.
基金Supported by The Eye Hospital of Wenzhou Medical University(No.KYQD20220304)The Fifth Batch of Provincial Ten Thousand Personnel Program Outstanding Talents Funding(No.474092204)+1 种基金Innovative Talents and Teams(2024)-The Fifth Batch of Funding Funds for Scientific and Technological Innovation Leading Talents Under the Provincial Ten Thousand Personnel Program(No.4240924003G)The Key R&D Program of Zhejiang(No.2022C03112).
文摘AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金funded by Qinghai University Postgraduate Research and Practice Innovation Program of Funder,grant number 2025-GMKY-42.
文摘Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
文摘Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.
基金supported by the National Natural Science Foundation of China(Grant Nos.52225404 and 52404121)the Key Research and Development Program Projects of Xinjiang Uygur Autonomous Region(Grant No.2024B03017).
文摘The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.
基金supported by the Major Program of National Natural Science Foundation of China(Grant No.42090055)the National Key ScientificInstruments and Equipment Development Projects of China(Grant No.41827808)the National Nature Science Foundation of China(Grant No.42207216).
文摘Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.
文摘This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.
文摘Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.
基金Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(No.HR20C0026)the National Research Foundation of Korea(NRF)(No.RS-2023-00247504)the Patient-Centered Clinical Research Coordinating Center,funded by the Ministry of Health&Welfare,Republic of Korea(No.HC19C0276).
文摘AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:Totally 716 eyes of 716 patients with primary open angle glaucoma(POAG)with at least 5 reliable 24-2 test results and 2y of follow-up were selected.The functional GEE model was used to detect perimetric progression in the training dataset(501 eyes).In the testing dataset(215 eyes),progression was evaluated the functional GEE model,mean deviation(MD)and visual field index(VFI)rates of change,Advanced Glaucoma Intervention Study(AGIS)and Collaborative Initial Glaucoma Treatment Study(CIGTS)scores,and pointwise linear regression(PLR).RESULTS:The proposed method showed the highest proportion of eyes detected as progression(54.4%),followed by the VFI rate(34.4%),PLR(23.3%),and MD rate(21.4%).The CIGTS and AGIS scores had a lower proportion of eyes detected as progression(7.9%and 5.1%,respectively).The time to detection of progression was significantly shorter for the proposed method than that of other algorithms(adjusted P≤0.019).The VFI rate displayed moderate pairwise agreement with the proposed method(k=0.47).CONCLUSION:The functional GEE model shows the highest proportion of eyes detected as perimetric progression and the shortest time to detect perimetric progression in patients with POAG.
基金supported by the Yunnan Province Liu Liang Expert Workstation(No.202305AF150148)Famous Doctor Projects of Yunnan Province(No.XDYC-MY-2022-0032)+1 种基金Yunnan Health Training Project of High Level Talents(No.L-2024029)Innovation Team Special Program of Yunnan(No.202505AS350004).
文摘Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functional interplay in PC remain unclear.This study aimed to define the role of S100A14 in PC progression.Methods:Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes.Prognostic relevance was assessed via Kaplan-Meier and ROC analyses.Functional experiments were performed in PANC-1 and BxPC-3 cells,including qRT-PCR,CCK-8 assay,Western blotting,Transwell assay,and apoptosis assay.Co-immunoprecipitation(Co-IP)was used to verify S100A14-S100A16 interaction.CHX chase and dual-luciferase assays were employed to assess protein stability and transcriptional activity.Results:S100A14 was markedly upregulated in PC tissues and cell lines and identified as a key prognostic gene.Silencing S100A14 suppressed EMT,proliferation,invasion,and migration,while reversing S100A16-mediated p53 inhibition and enhancing apoptosis.Mechanistically,Co-IP assay confirmed the protein interaction between S100A14 and S100A16;S100A14 stabilized S100A16 protein through post-translational modification without transcriptional regulation;the S100A14/S100A16 axis reduced p53 protein stability and inhibited its transcriptional activity as well as the downstream p21 expression.Critically,knockdown of S100A14 abrogated the pro-metastatic phenotype of cancer cells.Conclusion:This study identifies S100A14 promotes PC progression by stabilizing S100A16 and suppressing the tumor-suppressive p53/p21 pathway;knockdown of S100A14 can reverse the above effects,restore p53 function,and enhance cancer cell apoptosis.Targeting the S100A14/S100A16/p53 regulatory axis could represent a promising therapeutic approach for PC.
文摘Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities,defense capabilities,and composite national strength all reached new heights.”declared President Xi Jinping in his 2026 New Year message on De-By CHINA TODAY cember 31,2025,offering a succinct summary of China’s development over the past year,marked by resilience,progress,and renewed confidence as the country stands at the threshold of a new development phase.
