Editor-in-Chief:Xinhe Bao Professor,President of University of Science and Technology of China,Academician of Chinese Academy of Sciences(CAS),Academician of The World Academy of Sciences(TWAS),Honorary Fellow ofthe R...Editor-in-Chief:Xinhe Bao Professor,President of University of Science and Technology of China,Academician of Chinese Academy of Sciences(CAS),Academician of The World Academy of Sciences(TWAS),Honorary Fellow ofthe Royal Society of Chemistry(HonFRSC).展开更多
On November 13,King Maha Vajiralongkorn and Queen Suthida of Thailand began a five-day state visit to China.It was the king’s first visit to the country and the first time a Thai monarch has set foot on Chinese soil ...On November 13,King Maha Vajiralongkorn and Queen Suthida of Thailand began a five-day state visit to China.It was the king’s first visit to the country and the first time a Thai monarch has set foot on Chinese soil since the founding of the People’s Republic of China in 1949,before establishment of diplomatic relations between the two countries in 1975.展开更多
1 The Fair Isle sweater,a timeless fashion element,continues to charm the world.This comfortable,colorful knit has grown from a practical workwear piece into a high-fashion item beloved by the royal family,celebrities...1 The Fair Isle sweater,a timeless fashion element,continues to charm the world.This comfortable,colorful knit has grown from a practical workwear piece into a high-fashion item beloved by the royal family,celebrities and even the latest fashion designers.Despite its long history,the Fair Isle sweater remains popular,especially as winter approaches.展开更多
Royal jelly(RJ)is rich in various nutrients with multiple health-promoting properties.This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice.Male C57BL/6J mice drank RJ soluti...Royal jelly(RJ)is rich in various nutrients with multiple health-promoting properties.This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice.Male C57BL/6J mice drank RJ solution daily for 9 months.Determination of serum lipids and pathological analysis exhibited that triglycerides,serum cholesterol,and low-density lipoprotein cholesterol were decreased by 31.15%,9.96%,and 22.58%,respectively,the morphology of brain nerve cells was also effectively recovered after RJ intervention.Lipidomic analysis showed that RJ could improve the levels of different kinds of lipids in aging mice brain,especially by increasing the content of antioxidant ether ester,and that the ratio of monounsaturated fatty acid to polyunsaturated fatty acid was up by 23.46%,which could alleviate oxidative stress.Moreover,the metabolism of glycerol phospholipids,glycerols,and fatty acids in aging mice could be regulated by RJ.RJ intervention can effectively improve lipid metabolism disorders caused by aging.展开更多
Keratinocytes,the major cell types of the epidermis,proliferate and migrate during wound healing to restore the epithelial barrier.Royal jelly is a traditional remedy used in wound repair.Our previous study found that...Keratinocytes,the major cell types of the epidermis,proliferate and migrate during wound healing to restore the epithelial barrier.Royal jelly is a traditional remedy used in wound repair.Our previous study found that the mixture of major royal jelly protein(MRJP)2,3 and 7 exhibited in vitro wound healing-promoting effects;however,the exact functional constituents and the associated underlying mechanisms of action are still largely unknown.In this study,a partial fragment of MRJP3 was recombinantly expressed as a fusion protein MRJP3-C113-Fc which promoted wound healing in vitro and in vivo.By employing protein inhibitors and immunoblots technology,it was initially found that the wound-repairing mechanisms of MRJP3-C113-Fc were correlated to the activation of EGFR/AKT/m TOR signaling pathway in keratinocytes(Ha Ca T cells).LC-MS/MS-based proteomic analysis demonstrated that the proteins present in the MRJP3-C113-Fc-treated Ha Ca T cells were different from the untreated ones,in which rhomboid 5 homolog 2(RHBDF2)might be the potential regulator for the EGFR/AKT/m TOR signaling pathway.Silencing of RHBDF2 diminished the proproliferative and-migratory effectiveness of MRJP3-C113-Fc on Ha Ca T cells,as well as the phosphorylation of EGFR/AKT/m TOR,suggesting that the wound healing-promoting efficacy was attributable to the RHBDF2-mediated activation of EGFR/AKT/m TOR signaling pathway.Hence,this study is the first to discover the single fragment of MRJPs possessing pro-healing properties,and also the first to disclose the regulatory role of RHBDF2 in EGFR/AKT/m TOR signaling pathway-modulated wound healing.It will facilitate the development of MRJP3-C113-based therapeutic agent for skin wounds,and provide a novel target for treating cutaneous trauma.展开更多
On 12 March 2025,the Exchange Event“Reading China in Cambodia”under the Action Plan on Silk Road People-to-People Connectivity was held at the Cambodia 21st Century Maritime Silk Road Research Centre of the Royal Un...On 12 March 2025,the Exchange Event“Reading China in Cambodia”under the Action Plan on Silk Road People-to-People Connectivity was held at the Cambodia 21st Century Maritime Silk Road Research Centre of the Royal University of Phnom Penh(RUPP).Through sharing their views and cases,participants jointly discussed upon the rich connotation of the whole-process democracy of China.展开更多
1876年,英国皇家植物园邱园（The Royal Botanic Gardens,Kew,简称邱园）将三叶橡胶（Hevea brasiliensis）幼苗送至英国在南亚、东南亚的殖民地试种,这些幼苗是邱园用从南美洲引种获得的种子繁殖出来的。橡胶在东南亚试种获得成功后,...1876年,英国皇家植物园邱园（The Royal Botanic Gardens,Kew,简称邱园）将三叶橡胶（Hevea brasiliensis）幼苗送至英国在南亚、东南亚的殖民地试种,这些幼苗是邱园用从南美洲引种获得的种子繁殖出来的。橡胶在东南亚试种获得成功后,发展成为庞大的橡胶产业,对全世界的工业、农业、交通运输、经济、社会乃至政治产生了极大的影响,也使得橡胶成为一种＂改变世界历史进程＂的植物。展开更多
2014年6月7日～14日,笔者至伦敦参加由英国剧场技术协会主办的2014年国际剧场工程及建筑会议（ITEAC2014）。其间,笔者受邀作了一场关于中国现代剧场的舞台发展报告,并作为五位主要嘉宾之一参加了＂未来剧场的20个想法＂的讨论会;会后,...2014年6月7日～14日,笔者至伦敦参加由英国剧场技术协会主办的2014年国际剧场工程及建筑会议（ITEAC2014）。其间,笔者受邀作了一场关于中国现代剧场的舞台发展报告,并作为五位主要嘉宾之一参加了＂未来剧场的20个想法＂的讨论会;会后,重点访问英国皇家歌剧院（Royal Opera House）、皇家节日音乐厅（Royal Festival Hall）、阿德菲剧场（Adelphi Theatre）和天普剧场（Temple Studio）等4个剧场。这几个剧场的规模、类型、舞台形式及配置都有很大的差异,体现出英国剧场的多样性，和其作为世界表演艺术中心的价值。展开更多
1989年初,挪威皇家科学与工业研究院(The Royal Norwegian Council for Scientific andIndustrial Research,简写为NTNF)提出了一项关于海上石油与天然气浮式生产系统的研究计划FPS—2000,为期三年,总经费七千万挪威克朗(约合一千万美...1989年初,挪威皇家科学与工业研究院(The Royal Norwegian Council for Scientific andIndustrial Research,简写为NTNF)提出了一项关于海上石油与天然气浮式生产系统的研究计划FPS—2000,为期三年,总经费七千万挪威克朗(约合一千万美元),经费的一半由NTNF自身负担,另一半由各大石油公司提供,整个研究计划有极为强烈的经济效益方面的考虑。NTNF提出该计划的主要目标是:“在可以接受的安全标准所允许的范围内,降低在挪威大陆架上油气开采的成本,帮助海事工业领域内的挪威公司在世界市场上竞争”。展开更多
Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigment...Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations.展开更多
文摘Editor-in-Chief:Xinhe Bao Professor,President of University of Science and Technology of China,Academician of Chinese Academy of Sciences(CAS),Academician of The World Academy of Sciences(TWAS),Honorary Fellow ofthe Royal Society of Chemistry(HonFRSC).
文摘On November 13,King Maha Vajiralongkorn and Queen Suthida of Thailand began a five-day state visit to China.It was the king’s first visit to the country and the first time a Thai monarch has set foot on Chinese soil since the founding of the People’s Republic of China in 1949,before establishment of diplomatic relations between the two countries in 1975.
文摘1 The Fair Isle sweater,a timeless fashion element,continues to charm the world.This comfortable,colorful knit has grown from a practical workwear piece into a high-fashion item beloved by the royal family,celebrities and even the latest fashion designers.Despite its long history,the Fair Isle sweater remains popular,especially as winter approaches.
基金supported by the Science and Technology Department of Jiangxi Province(20212AEI91010)National Natural Science Foundation of China(31772067)+1 种基金Jiangxi Agriculture Research System(JXARS-14)Research Project of State Key Laboratory of Food Science and Technology(SKFL-ZZB-2)。
文摘Royal jelly(RJ)is rich in various nutrients with multiple health-promoting properties.This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice.Male C57BL/6J mice drank RJ solution daily for 9 months.Determination of serum lipids and pathological analysis exhibited that triglycerides,serum cholesterol,and low-density lipoprotein cholesterol were decreased by 31.15%,9.96%,and 22.58%,respectively,the morphology of brain nerve cells was also effectively recovered after RJ intervention.Lipidomic analysis showed that RJ could improve the levels of different kinds of lipids in aging mice brain,especially by increasing the content of antioxidant ether ester,and that the ratio of monounsaturated fatty acid to polyunsaturated fatty acid was up by 23.46%,which could alleviate oxidative stress.Moreover,the metabolism of glycerol phospholipids,glycerols,and fatty acids in aging mice could be regulated by RJ.RJ intervention can effectively improve lipid metabolism disorders caused by aging.
基金supported by the grants from the Natural Science Foundation of Fujian Province(2023J01490,2019J01408)the Central Guidance on Local Science and Technology Development Fund of Fujian Province(2024L3006)+3 种基金the Science and Technology Innovation Special Fund of Fujian Agriculture and Forestry University(KFb22071XA)the Outstanding Young Scientist Program of Fujian Agriculture and Forestry University(xjq201916)the National Natural Science Foundation of China(32272938)the China Agriculture Research System of MOF,and MARA(CARS-44)。
文摘Keratinocytes,the major cell types of the epidermis,proliferate and migrate during wound healing to restore the epithelial barrier.Royal jelly is a traditional remedy used in wound repair.Our previous study found that the mixture of major royal jelly protein(MRJP)2,3 and 7 exhibited in vitro wound healing-promoting effects;however,the exact functional constituents and the associated underlying mechanisms of action are still largely unknown.In this study,a partial fragment of MRJP3 was recombinantly expressed as a fusion protein MRJP3-C113-Fc which promoted wound healing in vitro and in vivo.By employing protein inhibitors and immunoblots technology,it was initially found that the wound-repairing mechanisms of MRJP3-C113-Fc were correlated to the activation of EGFR/AKT/m TOR signaling pathway in keratinocytes(Ha Ca T cells).LC-MS/MS-based proteomic analysis demonstrated that the proteins present in the MRJP3-C113-Fc-treated Ha Ca T cells were different from the untreated ones,in which rhomboid 5 homolog 2(RHBDF2)might be the potential regulator for the EGFR/AKT/m TOR signaling pathway.Silencing of RHBDF2 diminished the proproliferative and-migratory effectiveness of MRJP3-C113-Fc on Ha Ca T cells,as well as the phosphorylation of EGFR/AKT/m TOR,suggesting that the wound healing-promoting efficacy was attributable to the RHBDF2-mediated activation of EGFR/AKT/m TOR signaling pathway.Hence,this study is the first to discover the single fragment of MRJPs possessing pro-healing properties,and also the first to disclose the regulatory role of RHBDF2 in EGFR/AKT/m TOR signaling pathway-modulated wound healing.It will facilitate the development of MRJP3-C113-based therapeutic agent for skin wounds,and provide a novel target for treating cutaneous trauma.
文摘On 12 March 2025,the Exchange Event“Reading China in Cambodia”under the Action Plan on Silk Road People-to-People Connectivity was held at the Cambodia 21st Century Maritime Silk Road Research Centre of the Royal University of Phnom Penh(RUPP).Through sharing their views and cases,participants jointly discussed upon the rich connotation of the whole-process democracy of China.
文摘1876年,英国皇家植物园邱园（The Royal Botanic Gardens,Kew,简称邱园）将三叶橡胶（Hevea brasiliensis）幼苗送至英国在南亚、东南亚的殖民地试种,这些幼苗是邱园用从南美洲引种获得的种子繁殖出来的。橡胶在东南亚试种获得成功后,发展成为庞大的橡胶产业,对全世界的工业、农业、交通运输、经济、社会乃至政治产生了极大的影响,也使得橡胶成为一种＂改变世界历史进程＂的植物。
文摘2014年6月7日～14日,笔者至伦敦参加由英国剧场技术协会主办的2014年国际剧场工程及建筑会议（ITEAC2014）。其间,笔者受邀作了一场关于中国现代剧场的舞台发展报告,并作为五位主要嘉宾之一参加了＂未来剧场的20个想法＂的讨论会;会后,重点访问英国皇家歌剧院（Royal Opera House）、皇家节日音乐厅（Royal Festival Hall）、阿德菲剧场（Adelphi Theatre）和天普剧场（Temple Studio）等4个剧场。这几个剧场的规模、类型、舞台形式及配置都有很大的差异,体现出英国剧场的多样性，和其作为世界表演艺术中心的价值。
文摘1989年初,挪威皇家科学与工业研究院(The Royal Norwegian Council for Scientific andIndustrial Research,简写为NTNF)提出了一项关于海上石油与天然气浮式生产系统的研究计划FPS—2000,为期三年,总经费七千万挪威克朗(约合一千万美元),经费的一半由NTNF自身负担,另一半由各大石油公司提供,整个研究计划有极为强烈的经济效益方面的考虑。NTNF提出该计划的主要目标是:“在可以接受的安全标准所允许的范围内,降低在挪威大陆架上油气开采的成本,帮助海事工业领域内的挪威公司在世界市场上竞争”。
基金supported by grants from Fundación Séneca,Agencia de Cienciay Tecnología Región de Murcia,No.19881/GERM/15(to MVS)Spanish Ministry of Economy and Competitiveness,Instituto de Salud Carlos Ⅲ,Fondo Europeo de Desarrollo Regional ‘‘Una 30 Manera de Hacer Europa’’,No.SAF2015-67643-P(to MVS),PI16/00380(to MPVP),RD16/0008/0026(to MPVP),PI16/00031(to MAB)
文摘Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations.
