In translation initiation,eIF2 is responsible for delivering initiator tRNA to ribosome,and such delivery only occurs when GTP is bound to eIF2.eIF2B,a guanine nucleotide exchange factor,is required for the conversion...In translation initiation,eIF2 is responsible for delivering initiator tRNA to ribosome,and such delivery only occurs when GTP is bound to eIF2.eIF2B,a guanine nucleotide exchange factor,is required for the conversion of eIF2·GDP to eIF2·GTP.eIF2B is a heteropentameric protein complex containing two subcomplexes,a regulatory subcomplex composed of eIF2Bα,βandδand a catalysis subcomplex composed of eIF2Bγandε.展开更多
文摘In translation initiation,eIF2 is responsible for delivering initiator tRNA to ribosome,and such delivery only occurs when GTP is bound to eIF2.eIF2B,a guanine nucleotide exchange factor,is required for the conversion of eIF2·GDP to eIF2·GTP.eIF2B is a heteropentameric protein complex containing two subcomplexes,a regulatory subcomplex composed of eIF2Bα,βandδand a catalysis subcomplex composed of eIF2Bγandε.
