Artificial intelligence(AI)is reshaping financial systems and services,as intelligent AI agents increasingly form the foundation of autonomous,goal-driven systems capable of reasoning,learning,and action.This review s...Artificial intelligence(AI)is reshaping financial systems and services,as intelligent AI agents increasingly form the foundation of autonomous,goal-driven systems capable of reasoning,learning,and action.This review synthesizes recent research and developments in the application of AI agents across core financial domains.Specifically,it covers the deployment of agent-based AI in algorithmic trading,fraud detection,credit risk assessment,roboadvisory,and regulatory compliance(RegTech).The review focuses on advanced agent-based methodologies,including reinforcement learning,multi-agent systems,and autonomous decision-making frameworks,particularly those leveraging large language models(LLMs),contrasting these with traditional AI or purely statistical models.Our primary goals are to consolidate current knowledge,identify significant trends and architectural approaches,review the practical efficiency and impact of current applications,and delineate key challenges and promising future research directions.The increasing sophistication of AI agents offers unprecedented opportunities for innovation in finance,yet presents complex technical,ethical,and regulatory challenges that demand careful consideration and proactive strategies.This review aims to provide a comprehensive understanding of this rapidly evolving landscape,highlighting the role of agent-based AI in the ongoing transformation of the financial industry,and is intended to serve financial institutions,regulators,investors,analysts,researchers,and other key stakeholders in the financial ecosystem.展开更多
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po...Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.展开更多
BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithel...BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithelial cells has a causal role leading to infiltration of neutrophils into the colonic mucosa and subsequent development of UC.This evidence-based mechanism identifies hydrogen peroxide as a therapeutic target for reducing agents in the treatment of UC.CASE SUMMARY Presented is a 41-year-old female with a 26-year history of refractory UC.Having developed steroid dependence and never achieving complete remission on treatment by conventional and advanced therapies,she began treatment with oral R-dihydrolipoic acid(RDLA),a lipid-soluble reducing agent with intracellular site of action.Within a week,rectal bleeding ceased.She was asymptomatic for three years until a highly stressful experience,when she noticed blood in her stool.RDLA was discontinued,and she began treatment with oral sodium thiosulfate pentahydrate(STS),a reducing agent with extracellular site of action.After a week,rectal bleeding ceased,and she resumed oral RDLA and discontinued STS.To date,she remains asymptomatic with normal stool calprotectin while on RDLA.CONCLUSION STS and RDLA are reducing agents that serve as highly effective and safe therapy for the induction and maintenance of remission in UC,even in patients refractory or poorly controlled by conventional and advanced therapies.Should preliminary findings be validated by subsequent clinical trials,the use of reducing agents could potentially prevent thousands of colectomies and represent a paradigm shift in the treatment of UC.展开更多
This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with ...This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.展开更多
【Objectives】Si and microbial application could relieve the crop replanting problems(CRPs).We further studied the change of key microorganisms that are related to the beneficial effects,aiming at provide reference fo...【Objectives】Si and microbial application could relieve the crop replanting problems(CRPs).We further studied the change of key microorganisms that are related to the beneficial effects,aiming at provide reference for the manufacture and application of both microbial agents and Si fertilizer in food lily production.【Methods】A field experiment was conducted over a three-year period,from March 2019 to March 2022.The experimental field had been continuously cultivated with lily for 9 years.Three treatments were established:silicon fertilizer(SF),microbial agents(“Special 8^(TM)”,MF),and combined application of silicon fertilizer and microbial agents(SMF).A control group with blank soil(CK)was also included.At seedling stage of Lanzhou lilies in 2020 and 2021,the shoot and bulb dry weight,and the plant height and stem diameter of Lanzhou lilies were investigated for calculation of seedling index.In July 2020,20 plants were selected in each plot,and root zone soils were sampled at a depth of 20 cm,10 cm away from the roots,and then mixed to form a composite sample.The soil available Si and organic matter content were analyzed,and the fungal community structure and some specific microbial groups in soils were determined with high-throughput sequencing of ITS.【Results】All the three treatments significantly enhanced the lily plant growth and the seedling index,compared to CK.Besides,SF and MF treatments increased the relative abundances(RA)and diversity of fungal communities,and altered the community structures.The RA of some specific groups were found to be significantly correlated with the seedling index and/or soil available Si.Of them,the RA of the genera Fusarium,Dactylonectria,Humicola,Stilbella,and the species Humicola_grisea showed a positive correlation,while that of the genera Mortierella,Stilbella,Holtermanniella,and the species Mortierella_fatshederae showed a negative correlation with seedling index.The genera Fusarium,Stilbella,the species Humicola_grisea,and Dactylonectria_estremocensis showed a positive correlation,while the genura Stilbella,and the species Mortierella fatshederae showed a negative correlation with available Si content.In the co-occurence network of top twenty fungal genera and top sixteen bacterial genera(RA>0.2%),Holtermanniella was the only genus that interacted with the bacteria and negatively correlated with bacterial genus Blastococcus.Holtermanniella was also the most densely connected genera,followed by the genus Fusarium,Didymella and Humicola.In addition,the genus Holtermanniella was the key species connecting fungal and bacterial community in soil.Fungal functional prediction revealed that SF,MF and SMF treatments decreased plant pathogens guilds and increased the beneficial guilds Ectomycorrhizal,plant saprophyte,leaf saprophyte,and arbuscular mycorrhizal compared to CK.【Conclusions】Combined application of silicon fertilizer and microbial agents can alleviate continuous replanting problems of Lanzhou lilies through restoring the fungal community diversity,and promoting plant residue depredation,thus reducing soil born disease incidence.The beneficial genus Humicola and its one species H.grisea acts as bioconversion,and the genus Acremonium acts as plant pathogen inhibitor.展开更多
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.展开更多
Given that the citrus psyllid is the primary vector of citrus Huanglongbing(HLB),there is an urgent need to control this pest to mitigate the spread of the disease.This paper reviews the current research on two predom...Given that the citrus psyllid is the primary vector of citrus Huanglongbing(HLB),there is an urgent need to control this pest to mitigate the spread of the disease.This paper reviews the current research on two predominant control strategies:chemical control and biological control agents,in managing the citrus psyllid.It emphasizes the mechanisms of action,efficacy,and application advancements of these control methods.Finally,the paper analyzes the principal challenges associated with the sustainable management of citrus psyllids and offers perspectives for future research.展开更多
Domain randomization is a widely adopted technique in deep reinforcement learning(DRL)to improve agent generalization by exposing policies to diverse environmental conditions.This paper investigates the impact of diff...Domain randomization is a widely adopted technique in deep reinforcement learning(DRL)to improve agent generalization by exposing policies to diverse environmental conditions.This paper investigates the impact of different reset strategies,normal,non-randomized,and randomized,on agent performance using the Deep Deterministic Policy Gradient(DDPG)and Twin Delayed DDPG(TD3)algorithms within the CarRacing-v2 environment.Two experimental setups were conducted:an extended training regime with DDPG for 1000 steps per episode across 1000 episodes,and a fast execution setup comparing DDPG and TD3 for 30 episodes with 50 steps per episode under constrained computational resources.A step-based reward scaling mechanism was applied under the randomized reset condition to promote broader state exploration.Experimental results showthat randomized resets significantly enhance learning efficiency and generalization,with DDPG demonstrating superior performance across all reset strategies.In particular,DDPG combined with randomized resets achieves the highest smoothed rewards(reaching approximately 15),best stability,and fastest convergence.These differences are statistically significant,as confirmed by t-tests:DDPG outperforms TD3 under randomized(t=−101.91,p<0.0001),normal(t=−21.59,p<0.0001),and non-randomized(t=−62.46,p<0.0001)reset conditions.The findings underscore the critical role of reset strategy and reward shaping in enhancing the robustness and adaptability of DRL agents in continuous control tasks,particularly in environments where computational efficiency and training stability are crucial.展开更多
Clinical pharmacy is on the cusp of exponential change powered by artificial intelligence agents,automation,data analytics,and robotics.Blockchain will enhance data integrity and transparency,and Augmented and Virtual...Clinical pharmacy is on the cusp of exponential change powered by artificial intelligence agents,automation,data analytics,and robotics.Blockchain will enhance data integrity and transparency,and Augmented and Virtual Reality technologies will revolutionise training,patient education,and simulation-based care planning.Clinical pharmacists need to be ready and upskill to prepare for emerging technologies.The ethical,regulatory,and educational frameworks surrounding artificial intelligence and precision medicine will require constant attention,but the potential benefits for patient outcomes are unprecedented.Clinical pharmacists are in a prime position to design a new era in precision medicine,where technology works hand in hand with humans to transform healthcare.展开更多
Steganography is a technology that discreetly embeds secret information into the redundant space of a carrier,enabling covert communication.As generative models continue to advance,steganography has evolved from tradi...Steganography is a technology that discreetly embeds secret information into the redundant space of a carrier,enabling covert communication.As generative models continue to advance,steganography has evolved from traditional modification-based methods to generative steganography,which includes generative linguistic and image based forms.However,while large model agents are rapidly emerging,no method has exploited the stable redundant space in their action processes.Inspired by this insightful observation,we propose a steganographic method leveraging large model agents,employing their actions to conceal secret messages.In this paper,we introduce StegoAgent,a generative steganography framework based on graphical user interface(GUI)agents,which effectively demonstrates the remarkable potential and effectiveness of large model agent-based steganographic methods.展开更多
All maritime industries are plagued by marine biofouling pollution,which causes large economic and environmental costs.Therefore,there is an urgent need for ecofriendly alternatives that can effectively reduce the neg...All maritime industries are plagued by marine biofouling pollution,which causes large economic and environmental costs.Therefore,there is an urgent need for ecofriendly alternatives that can effectively reduce the negative consequences of biofouling pollution.This study aimed to produce novel capsaicin-inspired amide derivatives(CIADs)with multifunctional antifouling features by introducing amide compounds to aromatic compounds via a Friedel-Crafts alkylation reaction.The structure of the CIADs was characterized using FTIR,1H NMR,13C NMR,and HRMS,and the comprehensive antifouling capacity was determined by thermal stability,anti-ultraviolet,antibacterial,anti-algal,and marine field experiments.CIADs showed good thermal stability and did not show obvious weight loss before 226°C.2,4-dihydroxy-3,5-diphenylimidemet-hylbenzophenone(DDB)had an excellent ultraviolet absorption effect,which was even better than that of 2-hydroxy-4-(octyloxy)benzophenone.The antibacterial and anti-algal rates of N-(2,4-dimethyl-3-chloro-5-benzamide-methyl-6-hydroxybenzyl)benzamide(NDCBHB)were more than 99.5%and 64.0%,respectively,and the surface of antifouling coating with NDCBHB(NDCBHB-AC)was covered with only a small amount of sludge and biofilm,its antifouling effect was better than that of chlorothalonil.The above work provides a reference for preparing green and multifunctional antifouling agents.展开更多
This paper discusses the importance of standards in the fire extinguishing agent industry,and highlights the vital role of the standards in promoting technological innovation.China’s standards for fire extinguishing ...This paper discusses the importance of standards in the fire extinguishing agent industry,and highlights the vital role of the standards in promoting technological innovation.China’s standards for fire extinguishing agent products have evolved significantly,aligning with industrial development,market demands,regulatory requirements,to respond to the great impact of international competition in the industry.The paper analyzes the current state of China’s standards,including their composition and integration with industry growth,green development strategies,and international harmonization.Future development strategies for the standards framework should focus on valid period estimation,fire test model development,and raw material selection guidelines.By implementing these strategies,China’s fire protection industry can enhance product quality,contribute to public safety,and maintain a competitive edge in the global market.展开更多
Dengue virus(DENV)is a mosquito-borne pathogen responsible for a spectrum of illnesses,including dengue fever,dengue hemorrhagic fever,and dengue shock syndrome.Nearly half of the global population is at risk of DENV ...Dengue virus(DENV)is a mosquito-borne pathogen responsible for a spectrum of illnesses,including dengue fever,dengue hemorrhagic fever,and dengue shock syndrome.Nearly half of the global population is at risk of DENV infection,making it a pressing public health issue worldwide.The limited cross-protection among the four DENV serotypes(DENV1-4)and the phenomenon of antibody-dependent enhancement(ADE)have posed significant challenges to the development of effective dengue vaccines.Furthermore,there are currently no specific antiviral treatments available.This review provides an overview of DENV's key characteristics,clinical manifestations,and recent advancements in antiviral drug development-including the repurposing of approved drugs,peptidebased antiviral agents,therapeutic antibodies,natural products with antiviral potential,and host factor inhibitors-aiming to offer critical insights to inform strategies for managing and preventing dengue outbreaks.展开更多
Using maize varieties including Zhengdan 958,Xianyu 335,Yudan 132,Xundan 20,Lianchuang 808,and Dingyou 163 as experimental materials,this study investigated the effects of two ethephon compound agents on the lodging r...Using maize varieties including Zhengdan 958,Xianyu 335,Yudan 132,Xundan 20,Lianchuang 808,and Dingyou 163 as experimental materials,this study investigated the effects of two ethephon compound agents on the lodging resistance and yield of different maize varieties across various ecological regions.The results demonstrated that the lodging resistance of maize was significantly enhanced after the application of the two chemical control agents.Specifically,the lodging rate of Xundan 20 was reduced by 6.1 percentage points following treatment with benzylaminopurine(6-BA)·ethephon(ETH),while the lodging rate of Zhengdan 958 was decreased by 6.2 percentage points after treatment with diethyl aminoethyl hexanoate(DTA-6)·ETH.In the Shangqiu area,treatment of Lianchuang 808 with DTA-6·ETH reduced its ear height coefficient by 9.8 percentage points,whereas in the Zhumadian area,treatment of Dingyou 163 with 6-BA·ETH lowered its ear height coefficient by 11.3 percentage points.Additionally,both ethephon compound agents improved the stalk puncture strength of maize.For the same maize variety,phenotypic traits such as ear length,ear diameter,and number of kernel rows showed no significant differences under different chemical control treatments.However,traits including kernel number per row,1000-kernel weight,and yield exhibited significant variations across treatments and years.Moreover,the yield performance of maize varieties after chemical control treatment varied by region.In Hebi,Zhoukou,and Zhumadian areas,the yield under the DTA-6·ETH treatment surpassed that under the 6-BA·ETH treatment,with average yield increases of 4.22%,8.41%,and 5.67%compared to the clear water control(CK),respectively.Conversely,in Shangqiu,Nanyang,and Changge areas,the 6-BA·ETH treatment outperformed DTA-6·ETH,resulting in average yield increases of 6.96%,7.54%,and 5.56%relative to CK.展开更多
COMPUTATIONAL experiments method is an essential tool for analyzing,designing,managing,and integrating complex systems.However,a significant challenge arises in constructing agents with human-like characteristics to f...COMPUTATIONAL experiments method is an essential tool for analyzing,designing,managing,and integrating complex systems.However,a significant challenge arises in constructing agents with human-like characteristics to form an AI society.Agent modeling typically encompasses four levels:1)The autonomy features of agents,e.g.,perception,behavior,and decision-making;2)The evolutionary features of agents,e.g.,bounded rationality,heterogeneity,and learning evolution;3)The social features of agents,e.g.,interaction,cooperation,and competition;4)The emergent features of agents,e.g.,gaming with environments or regulatory strategies.Traditional modeling techniques primarily derive from ABMs(Agent-based Models)and incorporate various emerging technologies(e.g.,machine learning,big data,and social networks),which can enhance modeling capabilities,while amplifying the complexity[1].展开更多
Surfactants play a critical role in enhanced oil recovery(EOR) applications;however,their performance is often compromised in harsh reservoir conditions,such as high temperature and high salinity,due to precipitation ...Surfactants play a critical role in enhanced oil recovery(EOR) applications;however,their performance is often compromised in harsh reservoir conditions,such as high temperature and high salinity,due to precipitation caused by interactions with multivalent metal ions.Chelating agents were introduced into oilfields for various purposes due to their ability to sequester metal ions.In this work,we conducted a comprehensive investigation about chelating agent-surfactant(CS) flooding for carbonate reservoirs,as an alternative to the well-established alkaline surfactant(AS) flooding used in sandstone.The tested surfactants include sodium dodecyl sulfate(anionic)(SDS),dodecyltrimethylammonium bromide(cationic)(DTAB),Triton X100(nonionic),and a locally synthesized zwitterionic surfactant.The tested chelating agents include diethylenetriaminepentaacetic acid(DTPA),ethylenediaminetetraacetic acid,and glutamic acid N,N-diacetic acid.pH and temperature,as dominant factors in chelating agent solubility and brine stability,were modified to test chelating agent solutions of different concentrations and their mixtures with surfactants.Interfacial tension reduction by chelating agents alone,surfactants alone,and their mixtures were measured.Wettability alteration brought by chelating agents and surfactants on carbonate rock surfaces was evaluated using the static contact angle method.Based on the obtained results,chelating agents can be applied as low-cost additives for surfactant stabilization in high salinity conditions.The addition of chelating agents significantly improved the stability of SDS and DTAB in salt solutions and seawater.At a relatively low concentration(0.25 wt%),DTPA was able to stabilize DTAB of 1.00 wt% in seawater at high temperature(90℃).DTPA,among the tested three chelating agents,exhibited a stronger stabilization effect on surfactants of different ion types.When chelating agents are to be applied in brine,an optimal applicable pH range of 5-9 is recommended so not to induce solubility issue of chelating agents or stability issues of metal ions.In this range,IFT reduction is more significant at high pH,while wettability alteration is more significant at low pH.The combination of a cationic surfactant with a chelating agent forms a low adsorption wettability modifier which can change strongly oil-wet rock to water-wet conditions,thus significantly increasing the residual oil recovery from oil-wet carbonate formations.Zwitterionic and nonionic surfactants are also applicable to combine with a chelating agent for EOR purposes.Anionic surfactant SDS,however,showed a growing inhibition on the wettability alteration effect induced by EDTA as the concentration of SDS increased.展开更多
Natural products are the important sources in cardiovascular drug development.In this study,twenty-nine buthutin derivatives were designed,synthesized,and evaluated for their NHE-1 inhibition and protective effects on...Natural products are the important sources in cardiovascular drug development.In this study,twenty-nine buthutin derivatives were designed,synthesized,and evaluated for their NHE-1 inhibition and protective effects on cardiomyo-cyte injury.The structure of the newly synthesized compounds had been confirmed by 1H-NMR,13C-NMR,and HR-ESI-MS spectra.Among all target compounds at 1μM,compounds 9d,9f,9k,9m,and 9n,with a protection ratio exceeding 30%,exerted stronger protective effects on H9c2 cardiomyocyte than positive control dexrazoxane and buthutin A.Meanwhile,compounds 9k,9m,and 9o showed the significant NHE-1 inhibitory activities on H9c2 cardiomyocyte,all with a dpHi/min value less than 0.23.What is more,compounds 9k,9m,9o and buthutin A all exhibited the specificity on NHE-1 inhibition.Molecular modelling studies suggested the ability of compounds 9m and 9o to establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1,but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A.The structure-activity relationship(SAR)studies suggested that the presences of amide group,four-carbon linker,and para hydroxyl benzene ring were advantageous pharmacophores for above two pharmacological actions.This research would open new avenues for developing amide-guanidine-based cardioprotective agents.展开更多
基金supported by the Ministry of Education and Science of the Republic of North Macedonia through the project“Utilizing AI and National Large Language Models to Advance Macedonian Language Capabilties”。
文摘Artificial intelligence(AI)is reshaping financial systems and services,as intelligent AI agents increasingly form the foundation of autonomous,goal-driven systems capable of reasoning,learning,and action.This review synthesizes recent research and developments in the application of AI agents across core financial domains.Specifically,it covers the deployment of agent-based AI in algorithmic trading,fraud detection,credit risk assessment,roboadvisory,and regulatory compliance(RegTech).The review focuses on advanced agent-based methodologies,including reinforcement learning,multi-agent systems,and autonomous decision-making frameworks,particularly those leveraging large language models(LLMs),contrasting these with traditional AI or purely statistical models.Our primary goals are to consolidate current knowledge,identify significant trends and architectural approaches,review the practical efficiency and impact of current applications,and delineate key challenges and promising future research directions.The increasing sophistication of AI agents offers unprecedented opportunities for innovation in finance,yet presents complex technical,ethical,and regulatory challenges that demand careful consideration and proactive strategies.This review aims to provide a comprehensive understanding of this rapidly evolving landscape,highlighting the role of agent-based AI in the ongoing transformation of the financial industry,and is intended to serve financial institutions,regulators,investors,analysts,researchers,and other key stakeholders in the financial ecosystem.
基金supported by the National Natural Science Foundation of China(No.22176200)the Industrial Innovation Entrepreneurial Team Project of Ordos 2021.
文摘Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.
文摘BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithelial cells has a causal role leading to infiltration of neutrophils into the colonic mucosa and subsequent development of UC.This evidence-based mechanism identifies hydrogen peroxide as a therapeutic target for reducing agents in the treatment of UC.CASE SUMMARY Presented is a 41-year-old female with a 26-year history of refractory UC.Having developed steroid dependence and never achieving complete remission on treatment by conventional and advanced therapies,she began treatment with oral R-dihydrolipoic acid(RDLA),a lipid-soluble reducing agent with intracellular site of action.Within a week,rectal bleeding ceased.She was asymptomatic for three years until a highly stressful experience,when she noticed blood in her stool.RDLA was discontinued,and she began treatment with oral sodium thiosulfate pentahydrate(STS),a reducing agent with extracellular site of action.After a week,rectal bleeding ceased,and she resumed oral RDLA and discontinued STS.To date,she remains asymptomatic with normal stool calprotectin while on RDLA.CONCLUSION STS and RDLA are reducing agents that serve as highly effective and safe therapy for the induction and maintenance of remission in UC,even in patients refractory or poorly controlled by conventional and advanced therapies.Should preliminary findings be validated by subsequent clinical trials,the use of reducing agents could potentially prevent thousands of colectomies and represent a paradigm shift in the treatment of UC.
基金023 Zhejiang Provincial Department of Education General Project:Research on an interdisciplinary teaching model to promote the development of computational thinking in the context of the new curriculum standards[Grant NO:Y202351596]Key Project of Zhejiang Provincial Education Science Planning:Research on an interdisciplinary teaching model to promote students’computational thinking from multiple analytical perspectives[Grant NO:2025SB103].
文摘This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.
基金Key Research project of Gansu Province of China(22YF7NA108)National Natural Science Foundation of China(31860549)+1 种基金Industry Supporting Project from Education Department of Gansu Province(2023CYZC-49)Major Science and Technology project of Gansu province(24ZDNA006)。
文摘【Objectives】Si and microbial application could relieve the crop replanting problems(CRPs).We further studied the change of key microorganisms that are related to the beneficial effects,aiming at provide reference for the manufacture and application of both microbial agents and Si fertilizer in food lily production.【Methods】A field experiment was conducted over a three-year period,from March 2019 to March 2022.The experimental field had been continuously cultivated with lily for 9 years.Three treatments were established:silicon fertilizer(SF),microbial agents(“Special 8^(TM)”,MF),and combined application of silicon fertilizer and microbial agents(SMF).A control group with blank soil(CK)was also included.At seedling stage of Lanzhou lilies in 2020 and 2021,the shoot and bulb dry weight,and the plant height and stem diameter of Lanzhou lilies were investigated for calculation of seedling index.In July 2020,20 plants were selected in each plot,and root zone soils were sampled at a depth of 20 cm,10 cm away from the roots,and then mixed to form a composite sample.The soil available Si and organic matter content were analyzed,and the fungal community structure and some specific microbial groups in soils were determined with high-throughput sequencing of ITS.【Results】All the three treatments significantly enhanced the lily plant growth and the seedling index,compared to CK.Besides,SF and MF treatments increased the relative abundances(RA)and diversity of fungal communities,and altered the community structures.The RA of some specific groups were found to be significantly correlated with the seedling index and/or soil available Si.Of them,the RA of the genera Fusarium,Dactylonectria,Humicola,Stilbella,and the species Humicola_grisea showed a positive correlation,while that of the genera Mortierella,Stilbella,Holtermanniella,and the species Mortierella_fatshederae showed a negative correlation with seedling index.The genera Fusarium,Stilbella,the species Humicola_grisea,and Dactylonectria_estremocensis showed a positive correlation,while the genura Stilbella,and the species Mortierella fatshederae showed a negative correlation with available Si content.In the co-occurence network of top twenty fungal genera and top sixteen bacterial genera(RA>0.2%),Holtermanniella was the only genus that interacted with the bacteria and negatively correlated with bacterial genus Blastococcus.Holtermanniella was also the most densely connected genera,followed by the genus Fusarium,Didymella and Humicola.In addition,the genus Holtermanniella was the key species connecting fungal and bacterial community in soil.Fungal functional prediction revealed that SF,MF and SMF treatments decreased plant pathogens guilds and increased the beneficial guilds Ectomycorrhizal,plant saprophyte,leaf saprophyte,and arbuscular mycorrhizal compared to CK.【Conclusions】Combined application of silicon fertilizer and microbial agents can alleviate continuous replanting problems of Lanzhou lilies through restoring the fungal community diversity,and promoting plant residue depredation,thus reducing soil born disease incidence.The beneficial genus Humicola and its one species H.grisea acts as bioconversion,and the genus Acremonium acts as plant pathogen inhibitor.
文摘Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.
基金Supported by National Undergraduate Training Programs for Innovation and Entrepreneurship(202510580009)Special Project for Promoting the Coordinated Development of Urban and Rural Areas and Regions by Introducing Scientific and Technological Achievements of Guangdong Province into Counties and Towns(2025B0202010051)Project of High-quality Development in Hundred Counties,Thousands Towns and Ten Thousand Villages of Guangdong Provincial Department of Science and Technology:Key Dispatch Project for Rural Science and Technology Commissioners(KTP20240704).
文摘Given that the citrus psyllid is the primary vector of citrus Huanglongbing(HLB),there is an urgent need to control this pest to mitigate the spread of the disease.This paper reviews the current research on two predominant control strategies:chemical control and biological control agents,in managing the citrus psyllid.It emphasizes the mechanisms of action,efficacy,and application advancements of these control methods.Finally,the paper analyzes the principal challenges associated with the sustainable management of citrus psyllids and offers perspectives for future research.
基金supported by the Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia(Project No.MoE-IF-UJ-R2-22-04220773-1).
文摘Domain randomization is a widely adopted technique in deep reinforcement learning(DRL)to improve agent generalization by exposing policies to diverse environmental conditions.This paper investigates the impact of different reset strategies,normal,non-randomized,and randomized,on agent performance using the Deep Deterministic Policy Gradient(DDPG)and Twin Delayed DDPG(TD3)algorithms within the CarRacing-v2 environment.Two experimental setups were conducted:an extended training regime with DDPG for 1000 steps per episode across 1000 episodes,and a fast execution setup comparing DDPG and TD3 for 30 episodes with 50 steps per episode under constrained computational resources.A step-based reward scaling mechanism was applied under the randomized reset condition to promote broader state exploration.Experimental results showthat randomized resets significantly enhance learning efficiency and generalization,with DDPG demonstrating superior performance across all reset strategies.In particular,DDPG combined with randomized resets achieves the highest smoothed rewards(reaching approximately 15),best stability,and fastest convergence.These differences are statistically significant,as confirmed by t-tests:DDPG outperforms TD3 under randomized(t=−101.91,p<0.0001),normal(t=−21.59,p<0.0001),and non-randomized(t=−62.46,p<0.0001)reset conditions.The findings underscore the critical role of reset strategy and reward shaping in enhancing the robustness and adaptability of DRL agents in continuous control tasks,particularly in environments where computational efficiency and training stability are crucial.
文摘Clinical pharmacy is on the cusp of exponential change powered by artificial intelligence agents,automation,data analytics,and robotics.Blockchain will enhance data integrity and transparency,and Augmented and Virtual Reality technologies will revolutionise training,patient education,and simulation-based care planning.Clinical pharmacists need to be ready and upskill to prepare for emerging technologies.The ethical,regulatory,and educational frameworks surrounding artificial intelligence and precision medicine will require constant attention,but the potential benefits for patient outcomes are unprecedented.Clinical pharmacists are in a prime position to design a new era in precision medicine,where technology works hand in hand with humans to transform healthcare.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.62472398 and U2336206.
文摘Steganography is a technology that discreetly embeds secret information into the redundant space of a carrier,enabling covert communication.As generative models continue to advance,steganography has evolved from traditional modification-based methods to generative steganography,which includes generative linguistic and image based forms.However,while large model agents are rapidly emerging,no method has exploited the stable redundant space in their action processes.Inspired by this insightful observation,we propose a steganographic method leveraging large model agents,employing their actions to conceal secret messages.In this paper,we introduce StegoAgent,a generative steganography framework based on graphical user interface(GUI)agents,which effectively demonstrates the remarkable potential and effectiveness of large model agent-based steganographic methods.
基金supported by the Scientific Research Project funded by the Qingdao Postdoctoral Science Foundation(No.QDBSH20230102075)the China Postdoctoral Science Foundation(No.2023M733337)the National Natural Science Foundation of China(No.U2141251).
文摘All maritime industries are plagued by marine biofouling pollution,which causes large economic and environmental costs.Therefore,there is an urgent need for ecofriendly alternatives that can effectively reduce the negative consequences of biofouling pollution.This study aimed to produce novel capsaicin-inspired amide derivatives(CIADs)with multifunctional antifouling features by introducing amide compounds to aromatic compounds via a Friedel-Crafts alkylation reaction.The structure of the CIADs was characterized using FTIR,1H NMR,13C NMR,and HRMS,and the comprehensive antifouling capacity was determined by thermal stability,anti-ultraviolet,antibacterial,anti-algal,and marine field experiments.CIADs showed good thermal stability and did not show obvious weight loss before 226°C.2,4-dihydroxy-3,5-diphenylimidemet-hylbenzophenone(DDB)had an excellent ultraviolet absorption effect,which was even better than that of 2-hydroxy-4-(octyloxy)benzophenone.The antibacterial and anti-algal rates of N-(2,4-dimethyl-3-chloro-5-benzamide-methyl-6-hydroxybenzyl)benzamide(NDCBHB)were more than 99.5%and 64.0%,respectively,and the surface of antifouling coating with NDCBHB(NDCBHB-AC)was covered with only a small amount of sludge and biofilm,its antifouling effect was better than that of chlorothalonil.The above work provides a reference for preparing green and multifunctional antifouling agents.
基金supported by the specialized fund project for the fundamental research operation of central-level public welfare scientific research institutes,titled“Research on the International Standards System Construction and Updates in the Field of Fire Protection(Project No.2023SJ09)”.
文摘This paper discusses the importance of standards in the fire extinguishing agent industry,and highlights the vital role of the standards in promoting technological innovation.China’s standards for fire extinguishing agent products have evolved significantly,aligning with industrial development,market demands,regulatory requirements,to respond to the great impact of international competition in the industry.The paper analyzes the current state of China’s standards,including their composition and integration with industry growth,green development strategies,and international harmonization.Future development strategies for the standards framework should focus on valid period estimation,fire test model development,and raw material selection guidelines.By implementing these strategies,China’s fire protection industry can enhance product quality,contribute to public safety,and maintain a competitive edge in the global market.
基金funded by National Natural Science Foundation of China(92578123)Shenzhen High-level Hospital Construction Fund(23250G1001)+3 种基金the Sanming Project of Medicine in Shenzhen(SZSM202311033)National Key Research and Development Program of China(2023YFC2606004)National Natural Science Foundation of China(32501262)Beijing Institute of Technology Research Fund Program for Young Scholars(6120220072).
文摘Dengue virus(DENV)is a mosquito-borne pathogen responsible for a spectrum of illnesses,including dengue fever,dengue hemorrhagic fever,and dengue shock syndrome.Nearly half of the global population is at risk of DENV infection,making it a pressing public health issue worldwide.The limited cross-protection among the four DENV serotypes(DENV1-4)and the phenomenon of antibody-dependent enhancement(ADE)have posed significant challenges to the development of effective dengue vaccines.Furthermore,there are currently no specific antiviral treatments available.This review provides an overview of DENV's key characteristics,clinical manifestations,and recent advancements in antiviral drug development-including the repurposing of approved drugs,peptidebased antiviral agents,therapeutic antibodies,natural products with antiviral potential,and host factor inhibitors-aiming to offer critical insights to inform strategies for managing and preventing dengue outbreaks.
基金Supported by Hebi Comprehensive Experimental Station Project of Henan Maize Industry Technology System(Z2010-02-07)Henan Science and Technology Research Project-Creating Maize Germplasm and New Varieties Resistant to Southern Rust Suitable for the Huang-Huai-Hai Ecological Region Based on RppC Gene(242102110236)+1 种基金Henan Science and Technology Research Project-Targeted Improvement Breeding Application of ZmREX4 in Regulating Kernel Length(232102110172)Henan Key Research and Development Special Project-Breeding and Industrialization Demonstration of New Varieties of Advantageous Characteristic Crops and Aquatic Products in Henan Province(241111114300).
文摘Using maize varieties including Zhengdan 958,Xianyu 335,Yudan 132,Xundan 20,Lianchuang 808,and Dingyou 163 as experimental materials,this study investigated the effects of two ethephon compound agents on the lodging resistance and yield of different maize varieties across various ecological regions.The results demonstrated that the lodging resistance of maize was significantly enhanced after the application of the two chemical control agents.Specifically,the lodging rate of Xundan 20 was reduced by 6.1 percentage points following treatment with benzylaminopurine(6-BA)·ethephon(ETH),while the lodging rate of Zhengdan 958 was decreased by 6.2 percentage points after treatment with diethyl aminoethyl hexanoate(DTA-6)·ETH.In the Shangqiu area,treatment of Lianchuang 808 with DTA-6·ETH reduced its ear height coefficient by 9.8 percentage points,whereas in the Zhumadian area,treatment of Dingyou 163 with 6-BA·ETH lowered its ear height coefficient by 11.3 percentage points.Additionally,both ethephon compound agents improved the stalk puncture strength of maize.For the same maize variety,phenotypic traits such as ear length,ear diameter,and number of kernel rows showed no significant differences under different chemical control treatments.However,traits including kernel number per row,1000-kernel weight,and yield exhibited significant variations across treatments and years.Moreover,the yield performance of maize varieties after chemical control treatment varied by region.In Hebi,Zhoukou,and Zhumadian areas,the yield under the DTA-6·ETH treatment surpassed that under the 6-BA·ETH treatment,with average yield increases of 4.22%,8.41%,and 5.67%compared to the clear water control(CK),respectively.Conversely,in Shangqiu,Nanyang,and Changge areas,the 6-BA·ETH treatment outperformed DTA-6·ETH,resulting in average yield increases of 6.96%,7.54%,and 5.56%relative to CK.
基金supported in part by National Key Research and Development Program of China(2021YFF0900800)National Natural Science Foundation of China(62472306,62441221,62206116)+2 种基金Tianjin University’s 2024 Special Project on Disciplinary Development(XKJS-2024-5-9)Tianjin University Talent Innovation Reward Program for Literature&Science Graduate Student(C1-2022-010)Shanxi Province Social Science Foundation(2020F002).
文摘COMPUTATIONAL experiments method is an essential tool for analyzing,designing,managing,and integrating complex systems.However,a significant challenge arises in constructing agents with human-like characteristics to form an AI society.Agent modeling typically encompasses four levels:1)The autonomy features of agents,e.g.,perception,behavior,and decision-making;2)The evolutionary features of agents,e.g.,bounded rationality,heterogeneity,and learning evolution;3)The social features of agents,e.g.,interaction,cooperation,and competition;4)The emergent features of agents,e.g.,gaming with environments or regulatory strategies.Traditional modeling techniques primarily derive from ABMs(Agent-based Models)and incorporate various emerging technologies(e.g.,machine learning,big data,and social networks),which can enhance modeling capabilities,while amplifying the complexity[1].
基金supported by the College of Petroleum Engineering&Geoscience (CPG) at King Fahd University of Petroleum and Minerals (KFUPM)。
文摘Surfactants play a critical role in enhanced oil recovery(EOR) applications;however,their performance is often compromised in harsh reservoir conditions,such as high temperature and high salinity,due to precipitation caused by interactions with multivalent metal ions.Chelating agents were introduced into oilfields for various purposes due to their ability to sequester metal ions.In this work,we conducted a comprehensive investigation about chelating agent-surfactant(CS) flooding for carbonate reservoirs,as an alternative to the well-established alkaline surfactant(AS) flooding used in sandstone.The tested surfactants include sodium dodecyl sulfate(anionic)(SDS),dodecyltrimethylammonium bromide(cationic)(DTAB),Triton X100(nonionic),and a locally synthesized zwitterionic surfactant.The tested chelating agents include diethylenetriaminepentaacetic acid(DTPA),ethylenediaminetetraacetic acid,and glutamic acid N,N-diacetic acid.pH and temperature,as dominant factors in chelating agent solubility and brine stability,were modified to test chelating agent solutions of different concentrations and their mixtures with surfactants.Interfacial tension reduction by chelating agents alone,surfactants alone,and their mixtures were measured.Wettability alteration brought by chelating agents and surfactants on carbonate rock surfaces was evaluated using the static contact angle method.Based on the obtained results,chelating agents can be applied as low-cost additives for surfactant stabilization in high salinity conditions.The addition of chelating agents significantly improved the stability of SDS and DTAB in salt solutions and seawater.At a relatively low concentration(0.25 wt%),DTPA was able to stabilize DTAB of 1.00 wt% in seawater at high temperature(90℃).DTPA,among the tested three chelating agents,exhibited a stronger stabilization effect on surfactants of different ion types.When chelating agents are to be applied in brine,an optimal applicable pH range of 5-9 is recommended so not to induce solubility issue of chelating agents or stability issues of metal ions.In this range,IFT reduction is more significant at high pH,while wettability alteration is more significant at low pH.The combination of a cationic surfactant with a chelating agent forms a low adsorption wettability modifier which can change strongly oil-wet rock to water-wet conditions,thus significantly increasing the residual oil recovery from oil-wet carbonate formations.Zwitterionic and nonionic surfactants are also applicable to combine with a chelating agent for EOR purposes.Anionic surfactant SDS,however,showed a growing inhibition on the wettability alteration effect induced by EDTA as the concentration of SDS increased.
基金supported by the National Natural Science Foundation of China(NSFC)Youth Project(No.82204397).
文摘Natural products are the important sources in cardiovascular drug development.In this study,twenty-nine buthutin derivatives were designed,synthesized,and evaluated for their NHE-1 inhibition and protective effects on cardiomyo-cyte injury.The structure of the newly synthesized compounds had been confirmed by 1H-NMR,13C-NMR,and HR-ESI-MS spectra.Among all target compounds at 1μM,compounds 9d,9f,9k,9m,and 9n,with a protection ratio exceeding 30%,exerted stronger protective effects on H9c2 cardiomyocyte than positive control dexrazoxane and buthutin A.Meanwhile,compounds 9k,9m,and 9o showed the significant NHE-1 inhibitory activities on H9c2 cardiomyocyte,all with a dpHi/min value less than 0.23.What is more,compounds 9k,9m,9o and buthutin A all exhibited the specificity on NHE-1 inhibition.Molecular modelling studies suggested the ability of compounds 9m and 9o to establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1,but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A.The structure-activity relationship(SAR)studies suggested that the presences of amide group,four-carbon linker,and para hydroxyl benzene ring were advantageous pharmacophores for above two pharmacological actions.This research would open new avenues for developing amide-guanidine-based cardioprotective agents.
