One novel metal-organic framework [Cu2（L）（μ3-OH）]n（1, H3L = [1,1＇：3＇,1＇＇-terphenyl]-4,4＇＇,5＇-tricarboxylic acid） has been synthesized and characterized by single-crystal powder X-ray diffraction, IR and...One novel metal-organic framework [Cu2（L）（μ3-OH）]n（1, H3L = [1,1＇：3＇,1＇＇-terphenyl]-4,4＇＇,5＇-tricarboxylic acid） has been synthesized and characterized by single-crystal powder X-ray diffraction, IR and thermogravimetric analyses. Complex 1 crystallizes in orthorhombic crystal system, space group Pbca with a = 21.573（19）, b = 5.404（5）, c = 33.78（3） ？, C21H（12）O7Cu2, Mr = 503.39, V = 3938（6） A^3, Z = 8, Dc = 1.698 g·cm^-3, μ = 2.202 mm^-1, F（000） = 2016, 1.531〈θ〈25.009°, λ（Mo Kα） = 0.71073 A, T = 293（2） K, the final R = 0.0448 and wR = 0.1002. The structure of complex 1 is a three-dimensional（3D） framework based on infinite rod-shaped secondary building units and can be simplified as kgd topology. The gas adsorption measurements for N2, CO2, H2O, CH3OH and CH3CH2OH have been done. Fortunately, the selective sorption of CO2 over N2 was found at 195 K.展开更多
A series of main chain liquid crystal aromatic copolyesters with X-shaped and rod-shaped mesogenic units were synthesized via solution condensation polymerizations of 4,4'-(alpha,omega-octanedioyloxy)-dibenzoyl di...A series of main chain liquid crystal aromatic copolyesters with X-shaped and rod-shaped mesogenic units were synthesized via solution condensation polymerizations of 4,4'-(alpha,omega-octanedioyloxy)-dibenzoyl dichlorides with 2,5-bis(p-octanoxy benzoyloxy)-hydroquinone and diphenol. All of the copolyesters showed thermotropic liquid crystalline behaviors through observations using DSC, polarized microscopy and X-ray diffraction. The melting point (T-m) and the isotropization temperature (T-i) change regularly with varying the content of diphenol unit in the copolymers.展开更多
By establishing the finite element models and corresponding calculation methods for the target board and rod-shaped fragment, the penetration effect of the high-velocity rod-shaped fragments＇ impact on the LY- 12cz t...By establishing the finite element models and corresponding calculation methods for the target board and rod-shaped fragment, the penetration effect of the high-velocity rod-shaped fragments＇ impact on the LY- 12cz thin sheet is analyzed by analog calculation. The variation rules of the residual velocity and residual mass of fragments, chock mass and crevasse shape are obtained when the fragment penetrates target board with different incidence velocities and attack angles. Corresponding fitting computation formulas are concluded from the above calculating data. The conclusions are helpful to analyzing the destructivity of fragment and protective ability of aircraft structure. In addition, they can guide the research for battle damage mode and assessment effectively.展开更多
The cross section of photonic crystal fiber (PCF) is a two dimensional photonic crystal. The rods formed in PCF are not exact cylinders, the shape of rods will affect the eigenmode formed in two dimensional photonic c...The cross section of photonic crystal fiber (PCF) is a two dimensional photonic crystal. The rods formed in PCF are not exact cylinders, the shape of rods will affect the eigenmode formed in two dimensional photonic crystals around a defect. Based on the relations between the defect eigenmodes and the radius of dielectric cylinders, the defect eigenmodes in photonic crystals in which the ellipse rods take the place of cylinders are studied by numerical calculation. The analysis of the relation between the eigenfrequency and the minor axis radius of ellipse rods show that the defect eigenfrequency is controlled by the cross section area of rods and the distribution of electromagnetic field around the defect is also affected by the cross section shape of rods. It provides a better way to modify the distribution of electromagnetic fields in photonic crystal and keeps the eigenfrequency unchanged.展开更多
Local delivery of nanomedicines holds therapeutic promise for colorectal cancer(CRC).However,it presents tremendous challenges due to the existence of multiple physiological barriers,especially intracellular obstacles...Local delivery of nanomedicines holds therapeutic promise for colorectal cancer(CRC).However,it presents tremendous challenges due to the existence of multiple physiological barriers,especially intracellular obstacles,including intracellular trafficking,subcellular accumulation,and drug release.Herein,we report a multifunctional nanoparticle(CMSNR)by wrapping the mesoporous silica nanorod with cell membrane derived from CRC cells for improved chemotherapy.Compared with their naked counterparts,the cell membrane endowed CMSNR with homotypic targeting and improved cellular uptake capacities.Due to the rod-like shape,CMSNR achieved superior colorectal mucus permeability,enhanced tumor accumulation,and boosted cellular uptake than their spherical counterparts.Moreover,the internalized CMSNR underwent robust intracellular trafficking and gained augmented motility toward the nucleus,leading to efficient perinuclear accumulation and a subsequent 5.6-fold higher nuclear accumulation of loaded drug than that of nanospheres.In the orthotopic colorectal tumor-bearing nude mice,rectally administrated mefuparib hydrochloride(MPH)-loaded CMSNR traversed the colorectal mucus,penetrated the tumor tissue,and successfully aggregated in the perinuclear region of cancer cells,thus exhibiting significantly improved antitumor outcomes.Our findings highlight the shape-based design of cell membranecoated nanoparticles that can address sequential drug delivery barriers has a promising future in cancer nanomedicine.展开更多
The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite （HA） scaffolds was investigated by sintering the mixture of rod-shaped HA （r-HA） and spherical HA （s-HA） with polyac...The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite （HA） scaffolds was investigated by sintering the mixture of rod-shaped HA （r-HA） and spherical HA （s-HA） with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of oorous HA scaffolds.展开更多
The objective is to present exact analytical solutions of longitudinal impact analysis for slender conical rods struck by a particle and a new method is proposed for conical rod-particle impact analysis, in which the ...The objective is to present exact analytical solutions of longitudinal impact analysis for slender conical rods struck by a particle and a new method is proposed for conical rod-particle impact analysis, in which the superposition method is used and the response of the rod is presented. These analytical results are exact and can be used to validate the numerical methods or other analytical results. The numerical example shows that one of the advantages of the present method is that the analytical form is very simple. The result is that mass ratio and some variables describing the geometrical shape of rods such as taper, length and radius play an important role in impact dynamic system.展开更多
基金Supported by the Natural Science Foundation of Shandong Province(No.ZR2016BL01)the Talent Introduction Project of Dezhou University(No.320116)
文摘One novel metal-organic framework [Cu2（L）（μ3-OH）]n（1, H3L = [1,1＇：3＇,1＇＇-terphenyl]-4,4＇＇,5＇-tricarboxylic acid） has been synthesized and characterized by single-crystal powder X-ray diffraction, IR and thermogravimetric analyses. Complex 1 crystallizes in orthorhombic crystal system, space group Pbca with a = 21.573（19）, b = 5.404（5）, c = 33.78（3） ？, C21H（12）O7Cu2, Mr = 503.39, V = 3938（6） A^3, Z = 8, Dc = 1.698 g·cm^-3, μ = 2.202 mm^-1, F（000） = 2016, 1.531〈θ〈25.009°, λ（Mo Kα） = 0.71073 A, T = 293（2） K, the final R = 0.0448 and wR = 0.1002. The structure of complex 1 is a three-dimensional（3D） framework based on infinite rod-shaped secondary building units and can be simplified as kgd topology. The gas adsorption measurements for N2, CO2, H2O, CH3OH and CH3CH2OH have been done. Fortunately, the selective sorption of CO2 over N2 was found at 195 K.
基金The work was supported by the National Natural Science Foundation of China.
文摘A series of main chain liquid crystal aromatic copolyesters with X-shaped and rod-shaped mesogenic units were synthesized via solution condensation polymerizations of 4,4'-(alpha,omega-octanedioyloxy)-dibenzoyl dichlorides with 2,5-bis(p-octanoxy benzoyloxy)-hydroquinone and diphenol. All of the copolyesters showed thermotropic liquid crystalline behaviors through observations using DSC, polarized microscopy and X-ray diffraction. The melting point (T-m) and the isotropization temperature (T-i) change regularly with varying the content of diphenol unit in the copolymers.
基金Sponsored by the Ministerial Level Advanced Research Foundation(2164K)
文摘By establishing the finite element models and corresponding calculation methods for the target board and rod-shaped fragment, the penetration effect of the high-velocity rod-shaped fragments＇ impact on the LY- 12cz thin sheet is analyzed by analog calculation. The variation rules of the residual velocity and residual mass of fragments, chock mass and crevasse shape are obtained when the fragment penetrates target board with different incidence velocities and attack angles. Corresponding fitting computation formulas are concluded from the above calculating data. The conclusions are helpful to analyzing the destructivity of fragment and protective ability of aircraft structure. In addition, they can guide the research for battle damage mode and assessment effectively.
文摘The cross section of photonic crystal fiber (PCF) is a two dimensional photonic crystal. The rods formed in PCF are not exact cylinders, the shape of rods will affect the eigenmode formed in two dimensional photonic crystals around a defect. Based on the relations between the defect eigenmodes and the radius of dielectric cylinders, the defect eigenmodes in photonic crystals in which the ellipse rods take the place of cylinders are studied by numerical calculation. The analysis of the relation between the eigenfrequency and the minor axis radius of ellipse rods show that the defect eigenfrequency is controlled by the cross section area of rods and the distribution of electromagnetic field around the defect is also affected by the cross section shape of rods. It provides a better way to modify the distribution of electromagnetic fields in photonic crystal and keeps the eigenfrequency unchanged.
基金the financial support from the National Natural Science Foundation of China(Nos.82073773,82104078)the Major International Joint Research Project of Chinese Academy of Sciences(No.153631KYSB20190020)。
文摘Local delivery of nanomedicines holds therapeutic promise for colorectal cancer(CRC).However,it presents tremendous challenges due to the existence of multiple physiological barriers,especially intracellular obstacles,including intracellular trafficking,subcellular accumulation,and drug release.Herein,we report a multifunctional nanoparticle(CMSNR)by wrapping the mesoporous silica nanorod with cell membrane derived from CRC cells for improved chemotherapy.Compared with their naked counterparts,the cell membrane endowed CMSNR with homotypic targeting and improved cellular uptake capacities.Due to the rod-like shape,CMSNR achieved superior colorectal mucus permeability,enhanced tumor accumulation,and boosted cellular uptake than their spherical counterparts.Moreover,the internalized CMSNR underwent robust intracellular trafficking and gained augmented motility toward the nucleus,leading to efficient perinuclear accumulation and a subsequent 5.6-fold higher nuclear accumulation of loaded drug than that of nanospheres.In the orthotopic colorectal tumor-bearing nude mice,rectally administrated mefuparib hydrochloride(MPH)-loaded CMSNR traversed the colorectal mucus,penetrated the tumor tissue,and successfully aggregated in the perinuclear region of cancer cells,thus exhibiting significantly improved antitumor outcomes.Our findings highlight the shape-based design of cell membranecoated nanoparticles that can address sequential drug delivery barriers has a promising future in cancer nanomedicine.
基金supported by the National Natural Science Foundation of China (Nos. 11532004 and 31370946)the National Science and Technology Support Program of China (No. 2012BAI17B03-4)+1 种基金the Development of Strategic Emerging Industries of Shenzhen Project (Nos. JCYJ20140417113430596 and CXZZ201404171134 30716)the Science and Technology Project of Guangdong Province (No. 2015A010105021)
文摘The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite （HA） scaffolds was investigated by sintering the mixture of rod-shaped HA （r-HA） and spherical HA （s-HA） with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of oorous HA scaffolds.
基金Project supported by the National Natural Science Foundation of China (Nos. 10372084 and 10572119) Program for New Century Excellent Talents of Education Ministry of China (No.NCET-04-0958) and the Open Foundation of State Key Laboratory of Structural Analysis of Industrial Equipment
文摘The objective is to present exact analytical solutions of longitudinal impact analysis for slender conical rods struck by a particle and a new method is proposed for conical rod-particle impact analysis, in which the superposition method is used and the response of the rod is presented. These analytical results are exact and can be used to validate the numerical methods or other analytical results. The numerical example shows that one of the advantages of the present method is that the analytical form is very simple. The result is that mass ratio and some variables describing the geometrical shape of rods such as taper, length and radius play an important role in impact dynamic system.
