Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de...Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.展开更多
A composite Air Health Index(AHI)is helpful for separately emphasizing the health risks of multiple stimuli and communicating the overall risks of an adverse atmospheric environment to the public.We aimed to establish...A composite Air Health Index(AHI)is helpful for separately emphasizing the health risks of multiple stimuli and communicating the overall risks of an adverse atmospheric environment to the public.We aimed to establish a new AHI by integrating daily mortality risks due to air pollution with those due to non-optimum temperature in China.Based on the exposure-response(E-R)coefficients obtained from time-series models,the new AHI was constructed as the sum of excess mortality risk associated with air pollutants and non-optimum temperature in 272 Chinese cities from 2013 to 2015.We examined the association between the“total AHI”(based on total mortality)and total mortality,and further compared the ability of the“total AHI”to predict specific cardiopulmonary mortality with that of“specific AHIs”(based on specific mortalities).On average,air pollution and non-optimum temperature were associated with 28.23%of daily excess mortality,of which 23.47%was associated with non-optimum temperature while the remainder was associated with fine particulate matter(PM2.5)(1.12%),NO2(2.29%,),and O3(2.29%).The new AHI uses a 10-point scale and shows an average across all 272 cities of 6 points.The E-R curve for AHI and mortality is approximately linear,without any thresholds.Each one unit increase in“total AHI”is associated with a 0.84%increase in all-cause mortality and 1.01%,0.98%,1.02%,1.66%,and 1.71%increases in cardiovascular disease,coronary heart disease,stroke,respiratory diseases,and chronic obstructive pulmonary disease mortality,respectively.Cause-specific mortality risk estimates using the“total AHI”are similar to those predicted by“specific AHIs.”In conclusion,the“total AHI”proposed herein could be a promising tool for communicating health risks related to exposure to the ambient environment to the public.展开更多
Nitrate contamination of groundwater is a worldwide problem, particularly in agricultural countries. Exposure to high levels of nitrates in groundwater can have adverse effects on the health of residents who use groun...Nitrate contamination of groundwater is a worldwide problem, particularly in agricultural countries. Exposure to high levels of nitrates in groundwater can have adverse effects on the health of residents who use groundwater for drinking. This study aims to assess the health risk associated with the ingestion of nitrates in well water in the town of M’bahiakro. Health risk maps were created on the basis of hazard quotients (HQ) using the US Environmental Protection Agency (USEPA) health risk assessment model. The results indicate that residents of the Koko, Dougouba and Baoulekro neighbourhoods, whatever their age, are potentially exposed to the toxic effects of NO3−during their daily intake of nitrate-contaminated well water, with reference to hazard quotients (HQ) greater than 1. Nitrate concentrations in the groundwater should therefore be controlled in order to prevent their harmful effects on the health of the population and guarantee its use in rice-growing activities in M’Bahiakro.展开更多
The complexity of coupled risks,which refer to the compounded effects of interacting uncertainties across multiple interdependent objectives,is inherent to cities functioning as dynamic,interdependent systems.A disrup...The complexity of coupled risks,which refer to the compounded effects of interacting uncertainties across multiple interdependent objectives,is inherent to cities functioning as dynamic,interdependent systems.A disruption in one domain ripples across various urban systems,often with unforeseen consequences.Central to this complexity are people,whose behaviors,needs,and vulnerabilities shape risk evolution and response effectiveness.Realizing cities as complex systems centered on human needs and behaviors is essential to understanding the complexities of coupled urban risks.This paper adopts a complex systems perspective to examine the intricacies of coupled urban risks,emphasizing the critical role of human decisions and behavior in shaping these dynamics.We focus on two key dimensions:cascading hazards in urban environments and cascading failures across interdependent exposed systems in cities.Existing risk assessment models often fail to capture the complexity of these processes,particularly when factoring in human decision-making.To tackle these challenges,we advocate for a standardized taxonomy of cascading hazards,urban components,and their interactions.At its core is a people-centric perspective,emphasizing the bidirectional interactions between people and the systems that serve them.Building on this foundation,we argue the need for an integrated,people-centric risk assessment framework that evaluates event impacts in relation to the hierarchical needs of people and incorporates their preparedness and response capacities.By leveraging real-time data,advanced simulations,and innovative validation methods,this framework aims to enhance the accuracy of coupled urban risk modeling.To effectively manage coupled urban risks,cities can draw from proven strategies in real complex systems.However,given the escalating uncertainties and complexities associated with climate change,prioritizing people-centric strategies is crucial.This approach will empower cities to build resilience not only against known hazards but also against evolving and unforeseen challenges in an increasingly uncertain world.展开更多
A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiag...A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiagu.The objective is to address two key unresolved issues:the evolution of detached glacier materials into debris flows or debris floods and the amplification of the impact range and threats.A comprehensive framework is developed that considers the impacts of near-field and far-field hazards.Numerical modeling,remote sensing,and field investigations were integrated to understand the interactions,transformations,and amplifications of hazards in the glacier hazard chain.The results indicate that extensive,nearly saturated sediments on the glacier valley floor,when entrained,amplify the magnitude of the mass flow.The topography plays a crucial role.When the valley outlet is perpendicular to the river course,topographic obstacles cause immediate halting,resulting in the formation of high barrier dams.Conversely,when the glacier valley aligns nearly parallel to the river course,the mass flow can travel a much longer distance upon entering the river,causing an enlarged affected area.The barrier dams can breach rapidly,causing breaching floods that amplify the downstream impact from several kilometers to hundreds of kilometers.Our analysis reveals that the overall impacts remain spatially limited.Specifically,downstream areas along the Yarlung Zangbo-Brahmaputra River are unlikely to face greater threats from the upstream floods than local monsoon floods.Our findings provide the foundation for the management of glacier hazard chains.展开更多
Fifty agricultural soil samples collected from Fuzhou,southeast China,were first investigated for the occurrence,distribution,and potential risks of twelve organophosphate esters(OPEs).The total concentration of OPEs(...Fifty agricultural soil samples collected from Fuzhou,southeast China,were first investigated for the occurrence,distribution,and potential risks of twelve organophosphate esters(OPEs).The total concentration of OPEs(ΣOPEs)in soil ranged from 1.33 to 96.5 ng/g dry weight(dw),with an average value of 17.1 ng/g dw.Especially,halogenated-OPEs were the predominant group with amean level of 9.75 ng/g dw,and tris(1-chloro-2-propyl)phosphate(TCIPP)was the most abundant OPEs,accounting for 51.1%ofΣOPEs.The concentrations of TCIPP andΣOPEs were found to be significantly higher(P<0.05)in soils of urban areas than those in suburban areas.In addition,the use of agricultural plastic films and total organic carbon had a positive effect on the occurrence of OPE in this study.The positive matrix factorization model suggested complex sources of OPEs in agricultural soils from Fuzhou.The ecological risk assessment demonstrated that tricresyl phosphate presented a medium risk to land-based organisms(0.1≤risk quotient<1.0).Nevertheless,the carcinogenic and noncarcinogenic risks for human exposure to OPEs through soil ingestion and dermal absorption were negligible.These findings would facilitate further investigations into the pollution management and risk control of OPEs.展开更多
With the continuous control of anthropogenic emissions,China’s air quality has improved significantly in recent years.Given this background,research on how the short-term exposure risks caused by air pollution in Chi...With the continuous control of anthropogenic emissions,China’s air quality has improved significantly in recent years.Given this background,research on how the short-term exposure risks caused by air pollution in China have changed is insufficient.This study utilized hourly concentration data from ground observation stations and the official air quality guidelines of the Ministry of Ecology and Environment of China and the World Health Organization as standards to systematically investigate the spatiotemporal characteristics and short-term exposure risks of air pollution in China from 2015 to 2022.The results indicate that various atmospheric pollutants except for ozone showed a decreasing trend yearly.Nationwide,both single pollutant air pollution days(SAPDs)and multiple pollutant air pollution days(MAPDs)showed varying degrees of reduction within 15 and 25 days,respectively.SAPD was dominated mainly by excessive PM_(2.5)and PM_(10)pollutants,while MAPD was dominated mainly by excessive pollutant combinations,including PM_(2.5)+PM_(10),CO+PM_(2.5)+PM_(10),and SO_(2)+PM_(2.5)+PM_(10).As the concentration of atmospheric pollutants decreased,the total excess risk(ER)decreased yearly from 2015 to 2022,but there were significant regional differences.Now,the ER is less than 0.25%in southern China,in the range of 0.25%-0.5%in the North China Plain and some cities in the northeast,and higher than 1%in the northwest.Particulate matter is currently the primary pollutant posing short-term exposure risk in China,especially due to the impact of sandstorm weather.This study indicates that China’s atmospheric cleaning action is significantly beneficial for reducing health risks.展开更多
Agricultural soil is related to food security and human health,antibiotics and heavy metals(HMs),as two typical pollutants,possess a high coexistence rate in the environmental medium,which is extremely prone to induci...Agricultural soil is related to food security and human health,antibiotics and heavy metals(HMs),as two typical pollutants,possess a high coexistence rate in the environmental medium,which is extremely prone to inducing antibiotic-HMs combined pollution.Recently,frequent human activities have led to more prominent antibiotics-HMs combined contamination in agricultural soils,especially the production and spread of antibiotic resistance genes(ARGs),heavy metal resistance genes(MRGs),antibiotic resistant bacteria(ARB),and antibiotics-HMs complexes(AMCs),which seriously threaten soil ecology and human health.This review describes the main sources(Intrinsic and manmade sources),composite mechanisms(co-selective resistance,oxidative stress,and Joint toxicity mechanism),environmental fate and the potential risks(soil ecological and human health risks)of antibiotics and HMs in agricultural soils.Finally,the current effective source blocking,transmission control,and attenuation strategies are classified for discussion,such as the application of additives and barrier materials,as well as plant and animal remediation and bioremediation,etc.,pointing out that future research should focus on the whole chain process of“source-processterminal”,intending to provide a theoretical basis and decision-making reference for future research.展开更多
Ideological and political education is crucial for implementing the fundamental task of fostering virtue through education.Colleges and universities,as the main front,shoulder the important responsibility of cultivati...Ideological and political education is crucial for implementing the fundamental task of fostering virtue through education.Colleges and universities,as the main front,shoulder the important responsibility of cultivating talent.At present,with the exchange and collision of Eastern and Western cultures,it is necessary to accelerate the effective integration of excellent traditional Chinese culture with ideological and political education in colleges and universities.Firstly,based on college classrooms,excavate the ideological and political elements of traditional culture and integrate them into courses;Secondly,carry out practical activities,such as traditional culture themed lectures and experience activities,to enhance students’cultural identity;Thirdly,build a“Internet+”new system,use new media platforms to spread traditional culture,and strengthen the leading role of ideological and political education,to help build a cultural power.展开更多
Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors suc...Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors such as genetic diversity and the impacts of climate and land-use changes,hindering effective conservation planning.To address these limitations,we developed an enhanced extinction risk assessment framework using Diploderma lizards as a model.This framework incorporates long-term field surveys,environmental data,and land-use information to predict distributional changes for 10 recently described Diploderma species on the Qinghai-Xizang Plateau,which hold ecological significance but remain underassessed in conservation assessment.By integrating the distribution data and genetically inferred effective population sizes(Ne),we conducted scenario analyses and used a rank-sum approach to calculate Risk ranking scores(RRS)for each species.This approach revealed significant discrepancies with the IUCN Red List assessments.Notably,D.yangi and D.qilin were identified as facing the highest extinction risk.Furthermore,D.vela,D.batangense,D.flaviceps,D.dymondi,D.yulongense,and D.laeviventre,currently classified as“Least Concern”,were found to warrant reclassification as“Vulnerable”due to considerable threat from projected range contractions.Exploring the relationship between morphology and RRS revealed that traits such as snout-vent length and relative tail length could serve as potential predictors of extinction risk,offering preliminary metrics for assessing species vulnerability when comprehensive data are unavailable.This study enhances the precision of extinction risk assessment frameworks and demonstrates their capacity to refine and update risk assessments,especially for lesser-known taxa.展开更多
Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabi...Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabits a large population on the floodplains.Many floodplain management modes have been presented,but implementation effects of these management modes have not been evaluated correctly.An integrated model was first proposed to evaluate the flood risks to people’s life and property,covering an improved module of two-dimensional(2D)morphodynamic processes and a module of flood risk evaluation for people,buildings and crops on the floodplains.Two simulation cases were then conducted to validate the model accuracy,including the hyperconcentrated flood event and dike-breach induced flood event occurring in the LYR.Finally,the integrated model was applied to key floodplains in the LYR,and the effects of different floodplain management modes were quantified on the risks to people’s life and property under an extreme flood event.Results indicate that:①Satisfactory accuracy was achieved in the simulation of these two flood events.The maximum sediment concentration was just underestimated by 9%,and the simulated inundation depth agreed well with the field record;②severe inundation was predicted to occur in most domains under the current topography(SchemeⅠ),which would be alleviated after implementing different floodplain management modes,with the area in slight inundation degree accounting for a large proportion under the mode of“construction of protection embankment”(SchemeⅡ)and the area in medium inundation degree occupying a high ratio under the mode of“floodplain partition harnessing”(SchemeⅢ);and③compared with SchemeⅠ,the high-risk area for people’s life and property would reduce by 21%–49%under SchemeⅡ,and by 35%–93%under SchemeⅢ.展开更多
To assess the effect of mining activity on heavy metal pollution and associated health risks in tin mining regions,water and soil sampling was conducted near a tin mining site in Hunan Province.The content and distrib...To assess the effect of mining activity on heavy metal pollution and associated health risks in tin mining regions,water and soil sampling was conducted near a tin mining site in Hunan Province.The content and distribution of heavy metals were determined.Pollution,ecological risks,and potential health hazards were evaluated using the ground accumulation index,potential ecological risk index,and health risk assessment models,respectively.The results indicated elevated levels of heavy metals in water and soil samples compared to acceptable background values.Ground accumulation index assessment revealed extreme pollution of soil with As and Cd and moderate pollution with Cu,Pb,and Zn.Cr and Hg were categorized as non-pollutants.Water samples exhibited extreme pollution levels of Hg,Cr,Cd,and As;moderate pollution levels of Pb;and moderate to high pollution levels of Cu and Zn.The tin mining area demonstrated a significantly high level of potential ecological risk,where As and Cd were the primary risk elements in soil,whereas Cr,Cd,and As contributed predominantly to water ecological risk.The human health risk assessment highlighted As,Cd,Cr,Hg,Pb,and Cu in water and As and Pb in soil as the principal non-carcinogenic factors.The primary carcinogenic factors were As,Cr,and Cd in water and As in soil,with As posing the greatest risk for non-carcinogenic and carcinogenic effects.Furthermore,oral intake was the primary exposure route,with children being particularly vulnerable to the adverse effects of heavy metal pollution.展开更多
Introduction Gender and sex are related to important quality and safety issues in scientific,health,and clinical research.Sex refers to biological characteristics,while gender encompasses the sociocultural norms,ident...Introduction Gender and sex are related to important quality and safety issues in scientific,health,and clinical research.Sex refers to biological characteristics,while gender encompasses the sociocultural norms,identities,and relationships that shape communities and organizations,as well as influence actions,behaviors,contexts,and knowledge.Both gender and sex intersect with other social categories.In this context,in addition to sex or gender,the intersectionality refers to overlapping or interdependent systems of discrimination by more than one factor,such as age,disability,ethnicity,geographic location,socioeconomic status,and sexuality,among others.展开更多
Non-obstructive azoospermia is a common condition associated with significant health risks,including increased mortality,cancer,and chronic diseases such as metabolic and cardiovascular disorders.This review aims to h...Non-obstructive azoospermia is a common condition associated with significant health risks,including increased mortality,cancer,and chronic diseases such as metabolic and cardiovascular disorders.This review aims to highlight the potential health challenges faced by men with this condition compared to fertile counterparts.Through a comprehensive bibliographic search on PubMed,using the following algorithm:(“infertility,male”[MeSH Terms]OR“azoospermia”[MeSH Terms])AND(“mortality”[MeSH Terms]OR“neoplasms”[MeSH Terms]OR“chronic disease”[MeSH Terms]OR“diabetes mellitus”[MeSH Terms]OR“heart diseases”[MeSH Terms]),we analyzed existing literature to explore the associations between infertility,specifically azoospermia,and adverse health outcomes.Findings indicate that infertile men are at a higher risk of death,various cancers(particularly testicular cancer),metabolic syndrome,diabetes,hypogonadism,and cardiovascular disease.Although research specifically addressing azoospermia is limited,available studies support the notion that men with this condition may experience heightened health vulnerabilities.Given these risks,it is imperative for healthcare professionals,especially urologists,to conduct thorough health assessments for men diagnosed with azoospermia.Informing patients of these potential health issues and integrating comprehensive evaluations into their care can facilitate early detection and intervention for life-threatening conditions.Ultimately,men with azoospermia should receive ongoing monitoring to address their specific health concerns,thus improving their long-term health outcomes.展开更多
Against the backdrop of the new era,artificial intelligence(AI),as a key driver for industrial transformation and upgrading,is accelerating innovation and development in the field of education.Obviously,it undoubtedly...Against the backdrop of the new era,artificial intelligence(AI),as a key driver for industrial transformation and upgrading,is accelerating innovation and development in the field of education.Obviously,it undoubtedly brings new challenges to university governance.Based on this,this paper mainly conducts relevant analysis and research on the risks and countermeasures of AI empowering university governance.The purpose is to further promote the digital development of universities,thereby providing students with better education and management services,and hoping to offer some references for peers.展开更多
Co-branding,as an innovative consumer model,is increasingly favored by“Generation Z”consumers and has become a preferred strategy for many brands to expand their market reach and achieve widespread recognition.Howev...Co-branding,as an innovative consumer model,is increasingly favored by“Generation Z”consumers and has become a preferred strategy for many brands to expand their market reach and achieve widespread recognition.However,with the rapid growth of the co-branding economy,trademark infringement issues related to co-branded products have become more prevalent,posing significant obstacles to the successful execution of co-branding marketing activities.Based on the different legal statuses of trademarks,this study systematically analyzes the various infringement risks that may arise in the use of trademarks within co-branding practices and explores corresponding risk prevention measures.The objective is to provide strong support for the healthy and sustainable development of the co-branding economy.展开更多
Excessive concentrations of toxic metals are a global threat to aquatic systems.Taking a typical tributary(Zijiang River,ZR)of the midstream of the Yangtze River as the research area,the concentration distribution and...Excessive concentrations of toxic metals are a global threat to aquatic systems.Taking a typical tributary(Zijiang River,ZR)of the midstream of the Yangtze River as the research area,the concentration distribution and chemical fractions occurrence characteristics of five toxic metals(Cd,Cr,Cu,Pb,and Zn)were analyzed,their potential sources were explored,and their contamination and ecological risk was assessed.In the surface waters and sediments,there were high concentrations of Zn,a low concentration of Cd,and small spatial differences in concentration among the upstream,midstream,and downstream.In terms of speciation,Cd mainly existed in the acid-soluble fraction,Pb mainly existed in the reducible fraction,and Cr,Cu,and Zn mainly existed in the residue fraction.The potential sources in surface waters and sediments were determined to be industrial emissions and agricultural non-point sources through the absolute principal component scores–multiple linear regression model(APCS–MLR).Based on the assessment results of total concentration and speciation,Cd was the typical contamination element in ZR sediments.In addition,the secondary phase enrichment factor(SPEF)based on speciation underestimates the degree of Pb contamination,and the ecological risk of Zn assessed by the ratio of secondary phase and primary phase(RSP)and the risk assessment code(RAC)was higher than that of Cr,which was inconsistent with the results based on total concentrations.SOM and Al/Fe/Mn cycles in sediments influenced the geochemical behavior of toxic metals.展开更多
Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regi...Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored.Here we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian Amazon.We studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian population.No significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain.The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption.This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological concern.Furthermore,carcinogenic risks may be expected due to the continued exposure to Cr and As.The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled.Moreover,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.展开更多
Objective:To identify predictive factors for brucellosis by analyzing cases with and without focal involvement.Methods:This single-center retrospective study included adults(≥18 years)diagnosed with brucellosis at Ağ...Objective:To identify predictive factors for brucellosis by analyzing cases with and without focal involvement.Methods:This single-center retrospective study included adults(≥18 years)diagnosed with brucellosis at AğrıTraining and Research Hospital between January 1,2022 and December 31,2024.Patients were evaluated for organ involvement based on localized symptoms and classified accordingly.Logistic regression analysis was performed to identify demographic,clinical,and laboratory predictors of organ involvement.Results:A total of 210 cases were analyzed including 115 females(54.8%)and 95 males(45.2%).Among patients with focal involvement,the proportion of males was higher(54.4%),and comorbidities were also more common(34.4%).Days of complaints before hospital admission was significantly longer in patients with focal involvement(median 31 days)compared to those without focal involvement(median 20 days)(P=0.004).Lower back pain and testicular pain were more common in focal cases,with elevated levels of leukocytes,neutrophils,monocytes,C-reactive protein,and erythrocyte sedimentation rate(ESR).Osteoarticular involvement was found in 61/90 cases(67.7%).Logistic regression identified male sex(OR 2.56;95%CI 1.29-5.04),subacute(OR 3.74;95%CI 1.36-10.32)or chronic presentation(OR 29.01;95%CI 2.96-284.20),and elevated ESR(OR 1.03;95%CI 1.01-1.05)as independent risk factors for focal involvement.The model explained 33.9%of the variance,with 74.3%accuracy.Conclusions:Male sex,subacute or chronic brucellosis,and elevated ESR are key risk factors for focal brucellosis.展开更多
Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied w...Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied worldwide.However,their occurrence and potential risks in aquatic environments remain largely unknown.This work investigated 11 HMW SPAs and 3 LAC parabens in the river and treated industrial wastewater samples along the Yangtze River,the largest river and most important source water in China.For convenience of comparison,6 short alkyl chain(SAC)parabens were also included.In 15 industrial wastewater treatment plant effluents(effluent-IWTPs)and 34 surface water monitoring sections along the river,19 out of 20 target compounds were detected with total concentrations(TCs)from 152.5 to 1955.5 ng/L and 141.3 to 1364.9 ng/L in effluent-IWTPs and surface water,respectively.HMW SPAs 1,3,5-tris-[(3,5-di–tert–butyl–4-hydroxyphenyl)methyl]-1,3,5-triazinane-2,4,6-trione(AO3114)and octadecyl 3-(3,5-di–tert–butyl–4-hydroxyphenyl)propionate(AO1076)were the dominant ones.HMWSPAs bis(3–tert–butyl–4–hydroxy-5-methylphenyl)propionate(AO245)and 4,4'-sulfanediylbis(2–tert–butyl–5-methylphenol)(AO-TBM6)and SAC parabens propylparaben(PrP)and butylparaben(BuP)posed medium to high potential ecological risks in 27 surface water monitoring sections.Additionally,AO-TBM6 also exhibited potential health risks in 2 out of 11 drinking water sources.Though the ecotoxicity data are very limited,the ubiquitous presence of the LAC parabens including hexylparaben(HeP)and octylparaben(OcP)in surface water should be of concern since these compounds usually exhibit stronger estrogen potencies than the SAC ones.Finally,kernel density analysis revealed that regulation of industrial discharges is necessary to mitigate the HMW SPA and paraben contamination.展开更多
基金funded by China Law Society 2025 Annual Legal Research,Project grant number:CLS(2025)Y04.
文摘Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.
基金the National Natural Science Foun-dation of China(92043301,82030103,and 91843302)the Research Program of the Shanghai Meteorological Service(ZD201904).
文摘A composite Air Health Index(AHI)is helpful for separately emphasizing the health risks of multiple stimuli and communicating the overall risks of an adverse atmospheric environment to the public.We aimed to establish a new AHI by integrating daily mortality risks due to air pollution with those due to non-optimum temperature in China.Based on the exposure-response(E-R)coefficients obtained from time-series models,the new AHI was constructed as the sum of excess mortality risk associated with air pollutants and non-optimum temperature in 272 Chinese cities from 2013 to 2015.We examined the association between the“total AHI”(based on total mortality)and total mortality,and further compared the ability of the“total AHI”to predict specific cardiopulmonary mortality with that of“specific AHIs”(based on specific mortalities).On average,air pollution and non-optimum temperature were associated with 28.23%of daily excess mortality,of which 23.47%was associated with non-optimum temperature while the remainder was associated with fine particulate matter(PM2.5)(1.12%),NO2(2.29%,),and O3(2.29%).The new AHI uses a 10-point scale and shows an average across all 272 cities of 6 points.The E-R curve for AHI and mortality is approximately linear,without any thresholds.Each one unit increase in“total AHI”is associated with a 0.84%increase in all-cause mortality and 1.01%,0.98%,1.02%,1.66%,and 1.71%increases in cardiovascular disease,coronary heart disease,stroke,respiratory diseases,and chronic obstructive pulmonary disease mortality,respectively.Cause-specific mortality risk estimates using the“total AHI”are similar to those predicted by“specific AHIs.”In conclusion,the“total AHI”proposed herein could be a promising tool for communicating health risks related to exposure to the ambient environment to the public.
文摘Nitrate contamination of groundwater is a worldwide problem, particularly in agricultural countries. Exposure to high levels of nitrates in groundwater can have adverse effects on the health of residents who use groundwater for drinking. This study aims to assess the health risk associated with the ingestion of nitrates in well water in the town of M’bahiakro. Health risk maps were created on the basis of hazard quotients (HQ) using the US Environmental Protection Agency (USEPA) health risk assessment model. The results indicate that residents of the Koko, Dougouba and Baoulekro neighbourhoods, whatever their age, are potentially exposed to the toxic effects of NO3−during their daily intake of nitrate-contaminated well water, with reference to hazard quotients (HQ) greater than 1. Nitrate concentrations in the groundwater should therefore be controlled in order to prevent their harmful effects on the health of the population and guarantee its use in rice-growing activities in M’Bahiakro.
基金jointly supported by the National Natural Science Foundation of China(71821001,72371109,72071088,72074089,and 51938004)Strategic Study Project of Chinese Academy of Engineering(2022-JB-02)Project of Interdisciplinary Research Support Program in Huazhong University of Science and Technology(2023-32)。
文摘The complexity of coupled risks,which refer to the compounded effects of interacting uncertainties across multiple interdependent objectives,is inherent to cities functioning as dynamic,interdependent systems.A disruption in one domain ripples across various urban systems,often with unforeseen consequences.Central to this complexity are people,whose behaviors,needs,and vulnerabilities shape risk evolution and response effectiveness.Realizing cities as complex systems centered on human needs and behaviors is essential to understanding the complexities of coupled urban risks.This paper adopts a complex systems perspective to examine the intricacies of coupled urban risks,emphasizing the critical role of human decisions and behavior in shaping these dynamics.We focus on two key dimensions:cascading hazards in urban environments and cascading failures across interdependent exposed systems in cities.Existing risk assessment models often fail to capture the complexity of these processes,particularly when factoring in human decision-making.To tackle these challenges,we advocate for a standardized taxonomy of cascading hazards,urban components,and their interactions.At its core is a people-centric perspective,emphasizing the bidirectional interactions between people and the systems that serve them.Building on this foundation,we argue the need for an integrated,people-centric risk assessment framework that evaluates event impacts in relation to the hierarchical needs of people and incorporates their preparedness and response capacities.By leveraging real-time data,advanced simulations,and innovative validation methods,this framework aims to enhance the accuracy of coupled urban risk modeling.To effectively manage coupled urban risks,cities can draw from proven strategies in real complex systems.However,given the escalating uncertainties and complexities associated with climate change,prioritizing people-centric strategies is crucial.This approach will empower cities to build resilience not only against known hazards but also against evolving and unforeseen challenges in an increasingly uncertain world.
基金support from the National Natural Science Foundation of China(U20A20112,42061160480,42377196,and 52479095)the NSFC/RGC Joint Research Scheme(42061160480 and N_HKUST620/20)+1 种基金the Research Grants Council of the Hong Kong SAR Government(16203720,T22-606/23-R,and JRFS25266S09)the Project of Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone(HZQB-KCZYB-2020083)。
文摘A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiagu.The objective is to address two key unresolved issues:the evolution of detached glacier materials into debris flows or debris floods and the amplification of the impact range and threats.A comprehensive framework is developed that considers the impacts of near-field and far-field hazards.Numerical modeling,remote sensing,and field investigations were integrated to understand the interactions,transformations,and amplifications of hazards in the glacier hazard chain.The results indicate that extensive,nearly saturated sediments on the glacier valley floor,when entrained,amplify the magnitude of the mass flow.The topography plays a crucial role.When the valley outlet is perpendicular to the river course,topographic obstacles cause immediate halting,resulting in the formation of high barrier dams.Conversely,when the glacier valley aligns nearly parallel to the river course,the mass flow can travel a much longer distance upon entering the river,causing an enlarged affected area.The barrier dams can breach rapidly,causing breaching floods that amplify the downstream impact from several kilometers to hundreds of kilometers.Our analysis reveals that the overall impacts remain spatially limited.Specifically,downstream areas along the Yarlung Zangbo-Brahmaputra River are unlikely to face greater threats from the upstream floods than local monsoon floods.Our findings provide the foundation for the management of glacier hazard chains.
基金supported by the Open Fund of the Laboratory for Earth Surface Processes,Ministry of Education,Peking University,Beijing,China,and the Cultivation Fund Program for Excellent Dissertation in Fujian Normal University,China(No.LWPYS202315)the Research Start-up Fund of Fujian Normal University,China(No.Y0720304X13).
文摘Fifty agricultural soil samples collected from Fuzhou,southeast China,were first investigated for the occurrence,distribution,and potential risks of twelve organophosphate esters(OPEs).The total concentration of OPEs(ΣOPEs)in soil ranged from 1.33 to 96.5 ng/g dry weight(dw),with an average value of 17.1 ng/g dw.Especially,halogenated-OPEs were the predominant group with amean level of 9.75 ng/g dw,and tris(1-chloro-2-propyl)phosphate(TCIPP)was the most abundant OPEs,accounting for 51.1%ofΣOPEs.The concentrations of TCIPP andΣOPEs were found to be significantly higher(P<0.05)in soils of urban areas than those in suburban areas.In addition,the use of agricultural plastic films and total organic carbon had a positive effect on the occurrence of OPE in this study.The positive matrix factorization model suggested complex sources of OPEs in agricultural soils from Fuzhou.The ecological risk assessment demonstrated that tricresyl phosphate presented a medium risk to land-based organisms(0.1≤risk quotient<1.0).Nevertheless,the carcinogenic and noncarcinogenic risks for human exposure to OPEs through soil ingestion and dermal absorption were negligible.These findings would facilitate further investigations into the pollution management and risk control of OPEs.
基金supported by the National Natural Science Foundation of China(No.42205178)China Postdoctoral Science Foundation(No.2022M720459).
文摘With the continuous control of anthropogenic emissions,China’s air quality has improved significantly in recent years.Given this background,research on how the short-term exposure risks caused by air pollution in China have changed is insufficient.This study utilized hourly concentration data from ground observation stations and the official air quality guidelines of the Ministry of Ecology and Environment of China and the World Health Organization as standards to systematically investigate the spatiotemporal characteristics and short-term exposure risks of air pollution in China from 2015 to 2022.The results indicate that various atmospheric pollutants except for ozone showed a decreasing trend yearly.Nationwide,both single pollutant air pollution days(SAPDs)and multiple pollutant air pollution days(MAPDs)showed varying degrees of reduction within 15 and 25 days,respectively.SAPD was dominated mainly by excessive PM_(2.5)and PM_(10)pollutants,while MAPD was dominated mainly by excessive pollutant combinations,including PM_(2.5)+PM_(10),CO+PM_(2.5)+PM_(10),and SO_(2)+PM_(2.5)+PM_(10).As the concentration of atmospheric pollutants decreased,the total excess risk(ER)decreased yearly from 2015 to 2022,but there were significant regional differences.Now,the ER is less than 0.25%in southern China,in the range of 0.25%-0.5%in the North China Plain and some cities in the northeast,and higher than 1%in the northwest.Particulate matter is currently the primary pollutant posing short-term exposure risk in China,especially due to the impact of sandstorm weather.This study indicates that China’s atmospheric cleaning action is significantly beneficial for reducing health risks.
基金supported by the National Natural Science Foundation of China(No.32171615)the National Key R&D Program of China(2019YFC1804102)。
文摘Agricultural soil is related to food security and human health,antibiotics and heavy metals(HMs),as two typical pollutants,possess a high coexistence rate in the environmental medium,which is extremely prone to inducing antibiotic-HMs combined pollution.Recently,frequent human activities have led to more prominent antibiotics-HMs combined contamination in agricultural soils,especially the production and spread of antibiotic resistance genes(ARGs),heavy metal resistance genes(MRGs),antibiotic resistant bacteria(ARB),and antibiotics-HMs complexes(AMCs),which seriously threaten soil ecology and human health.This review describes the main sources(Intrinsic and manmade sources),composite mechanisms(co-selective resistance,oxidative stress,and Joint toxicity mechanism),environmental fate and the potential risks(soil ecological and human health risks)of antibiotics and HMs in agricultural soils.Finally,the current effective source blocking,transmission control,and attenuation strategies are classified for discussion,such as the application of additives and barrier materials,as well as plant and animal remediation and bioremediation,etc.,pointing out that future research should focus on the whole chain process of“source-processterminal”,intending to provide a theoretical basis and decision-making reference for future research.
文摘Ideological and political education is crucial for implementing the fundamental task of fostering virtue through education.Colleges and universities,as the main front,shoulder the important responsibility of cultivating talent.At present,with the exchange and collision of Eastern and Western cultures,it is necessary to accelerate the effective integration of excellent traditional Chinese culture with ideological and political education in colleges and universities.Firstly,based on college classrooms,excavate the ideological and political elements of traditional culture and integrate them into courses;Secondly,carry out practical activities,such as traditional culture themed lectures and experience activities,to enhance students’cultural identity;Thirdly,build a“Internet+”new system,use new media platforms to spread traditional culture,and strengthen the leading role of ideological and political education,to help build a cultural power.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program (STEP,2019QZKK0402)Science and Technology Plan Project of Xizang Autonomous Region to Y.Q. (XZ202201ZY0030G)National Natural Science Foundation of China (32201424 to Z.Y.L.and 31872233 to Y.Q.)。
文摘Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors such as genetic diversity and the impacts of climate and land-use changes,hindering effective conservation planning.To address these limitations,we developed an enhanced extinction risk assessment framework using Diploderma lizards as a model.This framework incorporates long-term field surveys,environmental data,and land-use information to predict distributional changes for 10 recently described Diploderma species on the Qinghai-Xizang Plateau,which hold ecological significance but remain underassessed in conservation assessment.By integrating the distribution data and genetically inferred effective population sizes(Ne),we conducted scenario analyses and used a rank-sum approach to calculate Risk ranking scores(RRS)for each species.This approach revealed significant discrepancies with the IUCN Red List assessments.Notably,D.yangi and D.qilin were identified as facing the highest extinction risk.Furthermore,D.vela,D.batangense,D.flaviceps,D.dymondi,D.yulongense,and D.laeviventre,currently classified as“Least Concern”,were found to warrant reclassification as“Vulnerable”due to considerable threat from projected range contractions.Exploring the relationship between morphology and RRS revealed that traits such as snout-vent length and relative tail length could serve as potential predictors of extinction risk,offering preliminary metrics for assessing species vulnerability when comprehensive data are unavailable.This study enhances the precision of extinction risk assessment frameworks and demonstrates their capacity to refine and update risk assessments,especially for lesser-known taxa.
基金supported by the National Natural Science Foundation of China(U2243238)the Program of the National Key Research and Development Plan(2023YFC3209304).
文摘Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabits a large population on the floodplains.Many floodplain management modes have been presented,but implementation effects of these management modes have not been evaluated correctly.An integrated model was first proposed to evaluate the flood risks to people’s life and property,covering an improved module of two-dimensional(2D)morphodynamic processes and a module of flood risk evaluation for people,buildings and crops on the floodplains.Two simulation cases were then conducted to validate the model accuracy,including the hyperconcentrated flood event and dike-breach induced flood event occurring in the LYR.Finally,the integrated model was applied to key floodplains in the LYR,and the effects of different floodplain management modes were quantified on the risks to people’s life and property under an extreme flood event.Results indicate that:①Satisfactory accuracy was achieved in the simulation of these two flood events.The maximum sediment concentration was just underestimated by 9%,and the simulated inundation depth agreed well with the field record;②severe inundation was predicted to occur in most domains under the current topography(SchemeⅠ),which would be alleviated after implementing different floodplain management modes,with the area in slight inundation degree accounting for a large proportion under the mode of“construction of protection embankment”(SchemeⅡ)and the area in medium inundation degree occupying a high ratio under the mode of“floodplain partition harnessing”(SchemeⅢ);and③compared with SchemeⅠ,the high-risk area for people’s life and property would reduce by 21%–49%under SchemeⅡ,and by 35%–93%under SchemeⅢ.
基金supported by the Open Fund of the Granite Formation Research Center of China Geological Survey(grant numbers PMGR202009,PMGR202108,PMGR202115)the Geological Survey of China(grant number DD20190154).
文摘To assess the effect of mining activity on heavy metal pollution and associated health risks in tin mining regions,water and soil sampling was conducted near a tin mining site in Hunan Province.The content and distribution of heavy metals were determined.Pollution,ecological risks,and potential health hazards were evaluated using the ground accumulation index,potential ecological risk index,and health risk assessment models,respectively.The results indicated elevated levels of heavy metals in water and soil samples compared to acceptable background values.Ground accumulation index assessment revealed extreme pollution of soil with As and Cd and moderate pollution with Cu,Pb,and Zn.Cr and Hg were categorized as non-pollutants.Water samples exhibited extreme pollution levels of Hg,Cr,Cd,and As;moderate pollution levels of Pb;and moderate to high pollution levels of Cu and Zn.The tin mining area demonstrated a significantly high level of potential ecological risk,where As and Cd were the primary risk elements in soil,whereas Cr,Cd,and As contributed predominantly to water ecological risk.The human health risk assessment highlighted As,Cd,Cr,Hg,Pb,and Cu in water and As and Pb in soil as the principal non-carcinogenic factors.The primary carcinogenic factors were As,Cr,and Cd in water and As in soil,with As posing the greatest risk for non-carcinogenic and carcinogenic effects.Furthermore,oral intake was the primary exposure route,with children being particularly vulnerable to the adverse effects of heavy metal pollution.
基金funded by the European Union's Horizon 2020 Research and Innovation Programme under grant No.896932(TTV guide TX project)and grant No.824087(EOSC-Life)。
文摘Introduction Gender and sex are related to important quality and safety issues in scientific,health,and clinical research.Sex refers to biological characteristics,while gender encompasses the sociocultural norms,identities,and relationships that shape communities and organizations,as well as influence actions,behaviors,contexts,and knowledge.Both gender and sex intersect with other social categories.In this context,in addition to sex or gender,the intersectionality refers to overlapping or interdependent systems of discrimination by more than one factor,such as age,disability,ethnicity,geographic location,socioeconomic status,and sexuality,among others.
文摘Non-obstructive azoospermia is a common condition associated with significant health risks,including increased mortality,cancer,and chronic diseases such as metabolic and cardiovascular disorders.This review aims to highlight the potential health challenges faced by men with this condition compared to fertile counterparts.Through a comprehensive bibliographic search on PubMed,using the following algorithm:(“infertility,male”[MeSH Terms]OR“azoospermia”[MeSH Terms])AND(“mortality”[MeSH Terms]OR“neoplasms”[MeSH Terms]OR“chronic disease”[MeSH Terms]OR“diabetes mellitus”[MeSH Terms]OR“heart diseases”[MeSH Terms]),we analyzed existing literature to explore the associations between infertility,specifically azoospermia,and adverse health outcomes.Findings indicate that infertile men are at a higher risk of death,various cancers(particularly testicular cancer),metabolic syndrome,diabetes,hypogonadism,and cardiovascular disease.Although research specifically addressing azoospermia is limited,available studies support the notion that men with this condition may experience heightened health vulnerabilities.Given these risks,it is imperative for healthcare professionals,especially urologists,to conduct thorough health assessments for men diagnosed with azoospermia.Informing patients of these potential health issues and integrating comprehensive evaluations into their care can facilitate early detection and intervention for life-threatening conditions.Ultimately,men with azoospermia should receive ongoing monitoring to address their specific health concerns,thus improving their long-term health outcomes.
文摘Against the backdrop of the new era,artificial intelligence(AI),as a key driver for industrial transformation and upgrading,is accelerating innovation and development in the field of education.Obviously,it undoubtedly brings new challenges to university governance.Based on this,this paper mainly conducts relevant analysis and research on the risks and countermeasures of AI empowering university governance.The purpose is to further promote the digital development of universities,thereby providing students with better education and management services,and hoping to offer some references for peers.
文摘Co-branding,as an innovative consumer model,is increasingly favored by“Generation Z”consumers and has become a preferred strategy for many brands to expand their market reach and achieve widespread recognition.However,with the rapid growth of the co-branding economy,trademark infringement issues related to co-branded products have become more prevalent,posing significant obstacles to the successful execution of co-branding marketing activities.Based on the different legal statuses of trademarks,this study systematically analyzes the various infringement risks that may arise in the use of trademarks within co-branding practices and explores corresponding risk prevention measures.The objective is to provide strong support for the healthy and sustainable development of the co-branding economy.
基金supported by the National Natural Science Foundation of China(No.42030706).
文摘Excessive concentrations of toxic metals are a global threat to aquatic systems.Taking a typical tributary(Zijiang River,ZR)of the midstream of the Yangtze River as the research area,the concentration distribution and chemical fractions occurrence characteristics of five toxic metals(Cd,Cr,Cu,Pb,and Zn)were analyzed,their potential sources were explored,and their contamination and ecological risk was assessed.In the surface waters and sediments,there were high concentrations of Zn,a low concentration of Cd,and small spatial differences in concentration among the upstream,midstream,and downstream.In terms of speciation,Cd mainly existed in the acid-soluble fraction,Pb mainly existed in the reducible fraction,and Cr,Cu,and Zn mainly existed in the residue fraction.The potential sources in surface waters and sediments were determined to be industrial emissions and agricultural non-point sources through the absolute principal component scores–multiple linear regression model(APCS–MLR).Based on the assessment results of total concentration and speciation,Cd was the typical contamination element in ZR sediments.In addition,the secondary phase enrichment factor(SPEF)based on speciation underestimates the degree of Pb contamination,and the ecological risk of Zn assessed by the ratio of secondary phase and primary phase(RSP)and the risk assessment code(RAC)was higher than that of Cr,which was inconsistent with the results based on total concentrations.SOM and Al/Fe/Mn cycles in sediments influenced the geochemical behavior of toxic metals.
基金supported by the National Geographic Society through an early career grant to A.Rico (EC-59809C-19)Support Programme-PlanGenT (CIDEGENT/2020/043)of the Generalitat ValencianaR.Oliveira acknowledges"Fundacao de Amparo a Pesquisa do Estado de Sao Paulo"-FAPESP (Project 2018/03108-0).
文摘Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored.Here we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian Amazon.We studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian population.No significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain.The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption.This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological concern.Furthermore,carcinogenic risks may be expected due to the continued exposure to Cr and As.The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled.Moreover,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.
文摘Objective:To identify predictive factors for brucellosis by analyzing cases with and without focal involvement.Methods:This single-center retrospective study included adults(≥18 years)diagnosed with brucellosis at AğrıTraining and Research Hospital between January 1,2022 and December 31,2024.Patients were evaluated for organ involvement based on localized symptoms and classified accordingly.Logistic regression analysis was performed to identify demographic,clinical,and laboratory predictors of organ involvement.Results:A total of 210 cases were analyzed including 115 females(54.8%)and 95 males(45.2%).Among patients with focal involvement,the proportion of males was higher(54.4%),and comorbidities were also more common(34.4%).Days of complaints before hospital admission was significantly longer in patients with focal involvement(median 31 days)compared to those without focal involvement(median 20 days)(P=0.004).Lower back pain and testicular pain were more common in focal cases,with elevated levels of leukocytes,neutrophils,monocytes,C-reactive protein,and erythrocyte sedimentation rate(ESR).Osteoarticular involvement was found in 61/90 cases(67.7%).Logistic regression identified male sex(OR 2.56;95%CI 1.29-5.04),subacute(OR 3.74;95%CI 1.36-10.32)or chronic presentation(OR 29.01;95%CI 2.96-284.20),and elevated ESR(OR 1.03;95%CI 1.01-1.05)as independent risk factors for focal involvement.The model explained 33.9%of the variance,with 74.3%accuracy.Conclusions:Male sex,subacute or chronic brucellosis,and elevated ESR are key risk factors for focal brucellosis.
基金supported by the National Key Research and Development Program of China(Nos.2021YFC3200801 and 2021YFC3200804).
文摘Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied worldwide.However,their occurrence and potential risks in aquatic environments remain largely unknown.This work investigated 11 HMW SPAs and 3 LAC parabens in the river and treated industrial wastewater samples along the Yangtze River,the largest river and most important source water in China.For convenience of comparison,6 short alkyl chain(SAC)parabens were also included.In 15 industrial wastewater treatment plant effluents(effluent-IWTPs)and 34 surface water monitoring sections along the river,19 out of 20 target compounds were detected with total concentrations(TCs)from 152.5 to 1955.5 ng/L and 141.3 to 1364.9 ng/L in effluent-IWTPs and surface water,respectively.HMW SPAs 1,3,5-tris-[(3,5-di–tert–butyl–4-hydroxyphenyl)methyl]-1,3,5-triazinane-2,4,6-trione(AO3114)and octadecyl 3-(3,5-di–tert–butyl–4-hydroxyphenyl)propionate(AO1076)were the dominant ones.HMWSPAs bis(3–tert–butyl–4–hydroxy-5-methylphenyl)propionate(AO245)and 4,4'-sulfanediylbis(2–tert–butyl–5-methylphenol)(AO-TBM6)and SAC parabens propylparaben(PrP)and butylparaben(BuP)posed medium to high potential ecological risks in 27 surface water monitoring sections.Additionally,AO-TBM6 also exhibited potential health risks in 2 out of 11 drinking water sources.Though the ecotoxicity data are very limited,the ubiquitous presence of the LAC parabens including hexylparaben(HeP)and octylparaben(OcP)in surface water should be of concern since these compounds usually exhibit stronger estrogen potencies than the SAC ones.Finally,kernel density analysis revealed that regulation of industrial discharges is necessary to mitigate the HMW SPA and paraben contamination.
