BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chin...BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.展开更多
Food allergies are abnormal immune responses triggered by specific foods,affecting the quality of life of millions of people worldwide.In recent years,the prevalence of food allergies has increased significantly,espec...Food allergies are abnormal immune responses triggered by specific foods,affecting the quality of life of millions of people worldwide.In recent years,the prevalence of food allergies has increased significantly,especially in Westernized countries,prompting the scientific community to explore the complex mechanisms behind them.Dietary patterns and specific dietary components are important factors related to the occurrence,development,and prevention of food allergies.Studies have shown that the Mediterranean diet,which is high in fiber,rich in antioxidants,and healthy fats,shows potential protective effects by promoting the balance of intestinal flora,maintaining the intestinal barrier,and regulating immunity.In contrast,a high-fat,high-sugar,low-fiber Western diet is associated with an increased risk of allergies.Key dietary components such as omega-3 fatty acids,dietary fiber,vitamins A,D,and E,and bioactive substances such as quercetin and curcumin can regulate immune tolerance through multiple pathways,including epigenetic regulation and affecting mitochondrial function.However,advanced glycation end products(AGEs),emulsifiers,artificial sweeteners produced by food processing,and pesticide residues(such as glyphosate)may damage the intestinal barrier,disrupt the flora,and increase the risk of allergies.This review explored the risk and protective factors for food allergies from a dietary perspective,thus benefiting the progress of intervention and therapy of food allergy.展开更多
Objective To observe the effect of Danhong injection(DI)in patients with acute ST-segment elevation myocardial infarction(STEMI)at a high risk of no-reflow(NR)during primary percutaneous coronary intervention(PCI).Met...Objective To observe the effect of Danhong injection(DI)in patients with acute ST-segment elevation myocardial infarction(STEMI)at a high risk of no-reflow(NR)during primary percutaneous coronary intervention(PCI).Methods Patients were placed in a DI group and control group.The DI group was given DI and the control group was given physiologic saline.The administration lasted 4 to 6 days in both groups after PCI.Cardiac magnetic resonance(CMR)was carried out during the perioperative period(7±2 days).The primary endpoint of the study was myocardial infarct size(IS)imaged on delayed-enhancement CMR.The secondary endpoint was major adverse cardiac events observed 6 months after PCI.Results In total,160 high-risk NR patients were enrolled,and 110 patients completed the CMR examination.According to postoperative CMR,the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group(0.57±0.13 vs.0.48±0.17,P<0.01;49.3%±6.9%vs.46.2%±7.7%,P=0.03,respectively),whereas the IS was lower(19.7%±5.6%vs.22.2%±6.5%,P=0.04),compared with that in the control group.These differences were observed to be significant.After 6 months,the prevalence of major adverse cardiac events in the DI group decreased compared with that in the control group,but the differences were not observed to be significant(P>0.05).Conclusion The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI.展开更多
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Curre...Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion injury.However,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional exploration.In this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and autophagy.The therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box O.This review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins expression.This review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk factors.While Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug therapies.Overall,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.展开更多
Social disconnectedness in combination with depression, somatic disease, stigma, social exclusion and functional impairment has been described as a major risk factor for suicide in old age. However, protective factors...Social disconnectedness in combination with depression, somatic disease, stigma, social exclusion and functional impairment has been described as a major risk factor for suicide in old age. However, protective factors have not been focused on in the same way. The aim was to identify psychosocial risk and protective factors in suicidal older persons. A systematic review was performed in Academic Search Premier (34), Ovid Medline (0), PsycInfo (0), PubMed (66), CINAHL (3) and ProQuest (1078) for the period May - September, 2014. Results: Twelve studies were included in the final analysis. Psychosocial risk factors were categorized under four themes: Being a burden to others increases depression and hopelessness, the struggle due to poor social integration, the strain of physical illness and old age and Negative aspects of religious activity. A total of four protective factors emerged: a sense of belonging, maintaining social dignity, satisfaction with relationships and feeling useful and positive aspects of religious activity. In conclusion, the context of a suicidal older person in a home healthcare service may create a “vulnerable psychosocial state” in which she/he is confronted by stressful psychosocial life events including physical illness and social network changes. The fact that protective factors are solely related to social factors needs to be taken into account in future prevention studies.展开更多
Decisions are often needed about the need and/or extent of protective measures against explosive blast loads on built infrastructure. A decision support analysis considers fatality risks and cost-effectiveness of prot...Decisions are often needed about the need and/or extent of protective measures against explosive blast loads on built infrastructure. A decision support analysis considers fatality risks and cost-effectiveness of protective measures expressed in terms of expected cost spent on risk reduction per life saved for terrorist threats to infrastructure. The analysis is applicable to any item of infrastructure, but in this paper is applied to casualties arising from building facade glazing damage. Risks may be compared with risk acceptance criteria in the form of quantitative safety goals. The risk acceptability and cost-effectiveness of protective measures includes cost of the protective measures, attack probability,reduction in risk due to protective measures,probability of fatality conditional on successful terrorist attack and number of exposed individuals.展开更多
As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center direc...As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center directly impacts medical safety and infection control effectiveness.Professional protective training for personnel is crucial to ensure operational quality in this department.Systematic training enhances staff awareness of occupational exposure risks,standardizes protective measures in procedures,reduces cross-infection risks caused by improper operations,and ultimately lowers infection transmission risks.This paper analyzes the core content,implementation approaches,and practical role of professional protective training for disinfection supply center personnel in infection control.It aims to clarify the significant value of such training,providing references for medical institutions to optimize disinfection center management and strengthen infection control systems,thereby contributing to improved overall medical safety standards.展开更多
Sugars are widely recognized for their ability to stabilize cell membranes during dehydration.However,the precise mechanisms by which sugars interact with lipid bilayers remain unclear.This mini-review synthesizes fou...Sugars are widely recognized for their ability to stabilize cell membranes during dehydration.However,the precise mechanisms by which sugars interact with lipid bilayers remain unclear.This mini-review synthesizes four key hypotheses explaining sugar-mediated protection of dehydrated bilayers:the Water Replacement Hypothesis(WRH),Hydration Force Hypothesis(HFH),Headgroup Bridging Hypothesis(HBH),and Vitrification Hypothesis(VH).We argue that these mechanisms are not mutually exclusive but instead operate synergistically under different cellular contexts.We propose that these hypotheses are not mutually exclusive but likely operate under different cellular contexts.Future studies should prioritize the development of biologically realistic membrane models-incorporating diverse lipids,proteins,and asymmetric leaflets-to elucidate the exact roles and mechanisms of sugars in membrane stabilization.Such advancements will enhance our understanding of anhydrobiosis and inform cryopreservation strategies for mammalian cells.展开更多
Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven ...Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven deposition during cycling would result in significant capacity decay,low Coulombic efficiency,and electrolyte consumption,thus the undesirable cyclability severely hampers the practical applications.Herein,a phosphorus-doped carbon protective layer was coated onto the surface of Zn anode via using the plasma-enhanced chemical vapor deposition(PECVD)approach.Enhanced conductivity and lower nucleation overpotential induced by the P-doped carbon protective layer can effectively facilitate the ion diffusion kinetics and suppress side reactions.The as-fabricated P-C/Zn anode demonstrated excellent cycling stability during the zinc plating/stripping process,maintaining a low voltage hysteresis(34.8 m V)for over 1000 h under a current density of 2 m A/cm^(2)and a capacity of 2 m Ah/cm^(2).Moreover,the P-C/Zn||MnO_(2)full cell exhibited high specific capacity of about 252.5 m Ah/g at 2 A/g upon 700 long cycles.This study is helpful to design more efficient zinc-ion batteries towards the future applications.展开更多
A major problem facing the magnesium melting process is to address the oxidative combustion of magnesium.At present,there are still some problems in the method used to protect magnesium smelting.For example,the reacti...A major problem facing the magnesium melting process is to address the oxidative combustion of magnesium.At present,there are still some problems in the method used to protect magnesium smelting.For example,the reaction of covering flux with magnesium melt is likely to produce a large number of toxic and harmful gasses(Cl_(2) and HCl),the cost of such reaction is high,and there is a lack of clarity on the protection mechanism of CO_(2) acting as the protective gas of magnesium melt.Therefore,a new process is proposed in this paper to isolate the air on the surface of magnesium melt using MgO-C-Mg film.Based on the thermodynamic theory of MgO-C-Mg film formation during crude magnesium smelting,an investigation is conducted into the effect of different experimental conditions on the protective effect of magnesium.Not only is the protective mechanism of MgO-C-Mg film revealed,it is also verified that the MgO-C-Mg film can produce a more pronounced protective effect at suitable temperature.According to thermodynamic analysis,magnesium melt reacts with CO_(2) to form magnesium oxide and C.CO_(2) consumes C when the experimental temperature exceeds 700℃.This is contrary to the purpose of the experiment as it should be maintained at about 700℃.The experimental results show that an obvious protective effect can be produced on the magnesium melt by the MgO-C-Mg film generated under the following conditions of 90%CO_(2)-10%Ar,smelting temperature of 700℃,holding time of 60 min,and stirring time of 20 min.展开更多
BACKGROUND Myocardial infarction(MI)occupies a very high mortality and morbidity rate,and the search for effective pharmacological treatments has far-reaching implications for clinical research.AIM To explore the prot...BACKGROUND Myocardial infarction(MI)occupies a very high mortality and morbidity rate,and the search for effective pharmacological treatments has far-reaching implications for clinical research.AIM To explore the protective effects of Mongolian medicine Agari-5 on rats with MI.METHODS Sprague-Dawley rats were used,and both the Agari-5 and model groups had their coronary arteries clamped to induce MI.Proteomics was used to research the potential mechanism of action while ELISA,hematoxylin and eosin,and Masson’s staining were used to preliminarily investigate the protective impact of Agari-5 on rats with MI.RESULTS The current study has shown that Agari-5 might enhance cardiac function indicators,including echocardiography results of rats and creatine kinase,creatine kinase isoenzyme,and lactate dehydrogenase,in rats that had MI.According to the results of pathological staining,Agari-5 may lessen inflammatory cell infiltration and cardiomyocyte fibrosis,among other things.The proteome analysis revealed that there were 60 distinct proteins in total,four of which were associated with the heart.The expression of PSAT1,PDK1,SMAD4,and SDF2 proteins may be linked to the mechanism of their protective effects.CONCLUSION Potential therapeutic effects of Agari-5 for MI and its mechanism of action may be related to PSAT1,PDK1,SMAD4,and SDF2.展开更多
Rechargeable aqueous zinc(Zn)-metal batteries hold great promise for next-generation energy storage systems.However,their practical application is hindered by several challenges,including dendrite formation,corrosion,...Rechargeable aqueous zinc(Zn)-metal batteries hold great promise for next-generation energy storage systems.However,their practical application is hindered by several challenges,including dendrite formation,corrosion,and the competing hydrogen evolution reaction.To address these issues,we designed and fabricated a composite protective layer for Zn anodes by integrating carbon nanotubes(CNTs)with chitosan through a simple and scalable scraping process.The CNTs ensure uniform electric field distribution due to their high electrical conductivity,while protonated chitosan regulates ion transport and suppresses dendrite formation at the anode interface.The chitosan/CNTs composite layer also facilitates smooth Zn^(2+)deposition,enhancing the stability and reversibility of the Zn anode.As a result,the chitosan/CNTs@Zn anode demonstrates exceptional cycling stability,achieving over 3000 h of plating/stripping with minimal degradation.When paired with a V_(2)O_(5)cathode,the composite-protected anode significantly improves the cycle stability and energy density of the full cell.Techno-economic analysis confirms that batteries incorporating the chitosan/CNTs protective layer outperform those with bare Zn anodes in terms of energy density and overall performance under optimized conditions.This work provides a scalable and sustainable strategy to overcome the critical challenges of aqueous Zn-metal batteries,paving the way for their practical application in next-generation energy storage systems.展开更多
Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologie...Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function.Research focusing on protecting inner ear hair cells(HCs)from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence,suggesting potential strategies for preventing and treating SNHL.By synthesizing relevant studies on the inner ear,this review summarizes the emerging roles of histone modifications,DNA methylation,and noncoding RNAs in HC damage,with a focus on their therapeutic potential through epigenetic modulation.Moreover,this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL,emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.展开更多
The manufacture and obsolescence of smartphones produce numerous waste plastic accessories(e.g.,waste smartphone protective film(WSPF)),possessing immense potential for recycling.However,available recycling technologi...The manufacture and obsolescence of smartphones produce numerous waste plastic accessories(e.g.,waste smartphone protective film(WSPF)),possessing immense potential for recycling.However,available recycling technologies have limitations such as substrate damage and secondary pollutant generation.The present study aimed to develop a green disposal method that not only recycled polyethylene terephthalate(PET)from WSPF,but also reused the stripped polyacrylate(PAA)adhesive as an adsorbent to reduce solid waste generation.When the WSPF was treated in 1 mol/L NaOH solution at 90°C,the PAA hydrolyzed to two main by-products of 1-butanol and 2-ethylhexanol,weakening the binding strength between PAA and PET and then efficient separation of them.Further bench-scale test revealed that over 97.2%of detachment efficiency toward PAA was achieved during continuous treatment of 17 batches of WSPF(200 g for each)without supplement of NaOH and generation of wastewater.Meanwhile,the economic evaluation indicated that the recycling method would generate a net profit margin of 647%for the second year without considering the incurrence of new cost and input.Additionally,the pyrolysis of waste PAA enabled its conversion into potential adsorbent,which showed 2 to 4 times enhanced adsorption capacity toward styrene and ethyl acetate after modification with NaOH solution.This study provides a green method for recycling waste plastics and inspires a referable solution for solid waste treatment in the smartphone industry.展开更多
[Objectives]To investigate the protective effects of Siwu Xuanhu decoction on the liver of mice with acute liver injury induced by CCl 4.[Methods]A total of 48 ICR mice were randomly assigned to six groups:a blank con...[Objectives]To investigate the protective effects of Siwu Xuanhu decoction on the liver of mice with acute liver injury induced by CCl 4.[Methods]A total of 48 ICR mice were randomly assigned to six groups:a blank control group,a model group,a low dose group of Siwu Xuanhu decoction(100 mg/kg),a medium dose group of Siwu Xuanhu decoction(200 mg/kg),a high dose group of Siwu Xuanhu decoction(300 mg/kg),and a positive control group(silymarin 2 mg/kg).Each group comprised 8 mice.Each dosing group received the designated dose of the drug(10 mL/kg)via continuous gavage,while the blank group and the model group were administered an equivalent volume of normal saline for four weeks,three times per week.An acute liver injury model was established through the intraperitoneal administration of a 20%CCl 4 olive oil solution at a dosage of 2 mL/kg in all experimental groups,with the exception of the control group,which received an equivalent volume of the olive oil solution.After 24 h fasting with water intake,blood samples were collected from the ocular region.The blood samples were allowed to stand and subsequently subjected to centrifugation to isolate the upper layer of serum,and a diagnostic kit was employed to measure the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT)and interleukin-6(IL-6),and the activity of superoxide dismutase(SOD)in the serum.[Results]In comparison to the control group,serum levels of AST and ALT were significantly elevated in the model group.Furthermore,when compared to the model group,treatment with Siwu Xuanhu decoction resulted in a reduction of serum levels of ALT,AST,and IL-6,while simultaneously increasing SOD activities.[Conclusions]Siwu Xuanhu decoction exhibits a protective effect against acute liver injury induced by CCl 4 in mice.展开更多
[Objectives]To investigate the protective effects of xanthoxylin on acute lung injury induced by D-Galactosamine(D-GalN)and Lipopolysaccharide(LPS)in rats.[Methods]Sixty male SD rats were randomly divided into a norma...[Objectives]To investigate the protective effects of xanthoxylin on acute lung injury induced by D-Galactosamine(D-GalN)and Lipopolysaccharide(LPS)in rats.[Methods]Sixty male SD rats were randomly divided into a normal group,a model group,a silybin group(50 mg/kg),and three xanthoxylin groups(low-dose,medium-dose,high-dose as 60,120,and 240 mg/kg),10 rats per group.The rats were administered for 17 consecutive days,on day 14,all the rats except for the normal group were intraperitoneally injected with a D-GalN(400 mg/kg)/LPS(30μg/kg)mixture once to establish acute lung injury models.At 72 h after modeling,their serum MCP-1 levels,IL-1β,IL-6,PCT,CRP,TNF-αlevels in bronchoalveolar lavage fluid,and IL-1β,IL-6,TNF-αlevels in lung tissue were measured,and lung tissue histological examination were checked by HE staining.[Results]Compared with the model group,the serum MCP-1 levels,IL-1β,IL-6,PCT,CRP,TNF-αlevels in bronchoalveolar lavage fluid,and IL-1β,IL-6,TNF-αlevels in lung tissue in xanthoxylin groups were significantly decreased(P<0.05 or P<0.01),and lung tissue injury were alleviated.[Conclusions]Xanthoxylin has protective effects on acute lung injury in rats,and it may be related to the increase of anti-inflammatory capacity and the promotion of lung tissue self-healing.展开更多
Interest in the use of cellulose nanomaterial’s continues to grow,both in research and industry,not only due to the abundance of raw materials,low toxicity and sustainability,but also due to the attractive physical a...Interest in the use of cellulose nanomaterial’s continues to grow,both in research and industry,not only due to the abundance of raw materials,low toxicity and sustainability,but also due to the attractive physical and chemical properties that make nanocelluloses useful for a wide range of end-use applications.Among the large number of potential uses,and nanocelluloses modification and processing strategies,the chosen topic of this review focuses exclusively on plant-derived cellulose microfibers/nanofibers(CNF)and cellulose nanocrystals(CNC)processed into 2D structures—nanopapers and nanofilms—fabricated as self-standing films or applied as coatings.The end uses considered are:combinationwith standard papers and cardboards for packaging,mendingmaterial for the conservation and protection of cellulosic heritage artifacts,and component-parts of complex designs of functional devices for energy harvesting and storage.In these contexts,nanocelluloses provide high mechanical and ecofriendly properties,transparency and tunable haze,as well as flexibility/bendability in the resulting films.All these characteristics make them extremely attractive to a market seeking for sustainable,light weight and low cost raw materials for the production of goods.General perspectives on the current advantages and disadvantages of using CNF and CNC in the selected areas are also reviewed.展开更多
The global supply chain turbulence has increased the difficulty of protecting foreign well-known trademarks.Although there are many studies on cross-border trademark rights protection in academia,there is relatively l...The global supply chain turbulence has increased the difficulty of protecting foreign well-known trademarks.Although there are many studies on cross-border trademark rights protection in academia,there is relatively little research on its risk mitigation effectiveness in the context of supply chain fluctuations.Based on case studies of commercial law and data statistics,the study explores the relationship between protection efficiency and market response through legal applicability.Due to the long litigation cycle and uneven law enforcement,there are differences in market regulation,weakening the protection of well-known trademarks and exacerbating supply chain uncertainty.Strengthening international legal framework cooperation and promoting law enforcement linkage can enhance protection effectiveness.In theory,enriching the theory of cross-border trademark protection and expanding research on brand rights protection in the context of global supply chains.In practice,it helps enterprises adjust their trademark layout,avoid legal risks,and improve market competitiveness.Due to the complexity of the legal environment and limitations in data acquisition,future research will strengthen data analysis,promote international cooperation in intelligent supervision,and build a more efficient cross-border well-known trademark protection mechanism.展开更多
Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de...Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de-alloying lead to poor cyclic and bad high-rate performance,which has severely hindered its practical large-scale application.Herein,a novel stamen-structured Si-based anode material with a protective SiO_(x)layer and dual carbon layers(Si@SiO_(x)/C@C)is designed for high-performance LIBs.The protective SiO_(x)layer reduces side reactions and dual carbon layers enhance charge transport to improve reaction kinetics,while the unique structure provides buffering space for volume expansion.Such Si@SiO_(x)/C@C anode demonstrates impressive Li storage properties for a half-battery,including a discharge capacity of 2935 mA h g^(-1)at a current density 0.1 A g^(-1),cyclic performance(814 mA h g^(-1)at 2 A g^(-1)over 500 cycles and 988 mA h g^(-1)over 200 cycles at 1 A g^(-1))and a rate performance(609 mA h g^(-1)at 5 A g^(-1)).It also maintains a high reversible capacity of 131 mA h g^(-1)at 0.25 C after100 cycles for a full battery.This work provides insights into the novel design of multiple protective layers on Si-based anode materials for fast-charging and highly stable LIBs.展开更多
The aim and objective of this review is to figure out potential occupational risk factors among nursing staff in outpatient injection room and to provide corresponding measures.There are several main factors summarize...The aim and objective of this review is to figure out potential occupational risk factors among nursing staff in outpatient injection room and to provide corresponding measures.There are several main factors summarized,including needle injury,cytotoxic drug,radiological hazard,disinfection,social and psychological factors and management systems. Findings suggest that stable management system and awareness of self- protections are two key points in prevention and control of occupational hazard in outpatient injection room of cancer hospital.展开更多
基金Supported by the Special Project for Supporting the Development of Biomedicine and Health Industry in Hangzhou City,No.2022WJC123Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2022ZA143.
文摘BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.
基金the financial support received from the Open Project of National Center of Technology Innovation for Dairy(No.2024-KFKT-009)the Key R&D Program of Zhejiang Provincial Administration for Market Regulation(No.ZD2024001).
文摘Food allergies are abnormal immune responses triggered by specific foods,affecting the quality of life of millions of people worldwide.In recent years,the prevalence of food allergies has increased significantly,especially in Westernized countries,prompting the scientific community to explore the complex mechanisms behind them.Dietary patterns and specific dietary components are important factors related to the occurrence,development,and prevention of food allergies.Studies have shown that the Mediterranean diet,which is high in fiber,rich in antioxidants,and healthy fats,shows potential protective effects by promoting the balance of intestinal flora,maintaining the intestinal barrier,and regulating immunity.In contrast,a high-fat,high-sugar,low-fiber Western diet is associated with an increased risk of allergies.Key dietary components such as omega-3 fatty acids,dietary fiber,vitamins A,D,and E,and bioactive substances such as quercetin and curcumin can regulate immune tolerance through multiple pathways,including epigenetic regulation and affecting mitochondrial function.However,advanced glycation end products(AGEs),emulsifiers,artificial sweeteners produced by food processing,and pesticide residues(such as glyphosate)may damage the intestinal barrier,disrupt the flora,and increase the risk of allergies.This review explored the risk and protective factors for food allergies from a dietary perspective,thus benefiting the progress of intervention and therapy of food allergy.
基金supported by grant from the Capital health research and development of special project (2016-15011)
文摘Objective To observe the effect of Danhong injection(DI)in patients with acute ST-segment elevation myocardial infarction(STEMI)at a high risk of no-reflow(NR)during primary percutaneous coronary intervention(PCI).Methods Patients were placed in a DI group and control group.The DI group was given DI and the control group was given physiologic saline.The administration lasted 4 to 6 days in both groups after PCI.Cardiac magnetic resonance(CMR)was carried out during the perioperative period(7±2 days).The primary endpoint of the study was myocardial infarct size(IS)imaged on delayed-enhancement CMR.The secondary endpoint was major adverse cardiac events observed 6 months after PCI.Results In total,160 high-risk NR patients were enrolled,and 110 patients completed the CMR examination.According to postoperative CMR,the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group(0.57±0.13 vs.0.48±0.17,P<0.01;49.3%±6.9%vs.46.2%±7.7%,P=0.03,respectively),whereas the IS was lower(19.7%±5.6%vs.22.2%±6.5%,P=0.04),compared with that in the control group.These differences were observed to be significant.After 6 months,the prevalence of major adverse cardiac events in the DI group decreased compared with that in the control group,but the differences were not observed to be significant(P>0.05).Conclusion The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI.
文摘Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion injury.However,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional exploration.In this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and autophagy.The therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box O.This review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins expression.This review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk factors.While Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug therapies.Overall,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.
文摘Social disconnectedness in combination with depression, somatic disease, stigma, social exclusion and functional impairment has been described as a major risk factor for suicide in old age. However, protective factors have not been focused on in the same way. The aim was to identify psychosocial risk and protective factors in suicidal older persons. A systematic review was performed in Academic Search Premier (34), Ovid Medline (0), PsycInfo (0), PubMed (66), CINAHL (3) and ProQuest (1078) for the period May - September, 2014. Results: Twelve studies were included in the final analysis. Psychosocial risk factors were categorized under four themes: Being a burden to others increases depression and hopelessness, the struggle due to poor social integration, the strain of physical illness and old age and Negative aspects of religious activity. A total of four protective factors emerged: a sense of belonging, maintaining social dignity, satisfaction with relationships and feeling useful and positive aspects of religious activity. In conclusion, the context of a suicidal older person in a home healthcare service may create a “vulnerable psychosocial state” in which she/he is confronted by stressful psychosocial life events including physical illness and social network changes. The fact that protective factors are solely related to social factors needs to be taken into account in future prevention studies.
文摘Decisions are often needed about the need and/or extent of protective measures against explosive blast loads on built infrastructure. A decision support analysis considers fatality risks and cost-effectiveness of protective measures expressed in terms of expected cost spent on risk reduction per life saved for terrorist threats to infrastructure. The analysis is applicable to any item of infrastructure, but in this paper is applied to casualties arising from building facade glazing damage. Risks may be compared with risk acceptance criteria in the form of quantitative safety goals. The risk acceptability and cost-effectiveness of protective measures includes cost of the protective measures, attack probability,reduction in risk due to protective measures,probability of fatality conditional on successful terrorist attack and number of exposed individuals.
文摘As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center directly impacts medical safety and infection control effectiveness.Professional protective training for personnel is crucial to ensure operational quality in this department.Systematic training enhances staff awareness of occupational exposure risks,standardizes protective measures in procedures,reduces cross-infection risks caused by improper operations,and ultimately lowers infection transmission risks.This paper analyzes the core content,implementation approaches,and practical role of professional protective training for disinfection supply center personnel in infection control.It aims to clarify the significant value of such training,providing references for medical institutions to optimize disinfection center management and strengthen infection control systems,thereby contributing to improved overall medical safety standards.
基金supported by the National Natural Science Foundation of China,China(Grant No.52376052)the Anhui Provincial Natural Science Foundation,China(Grant No.2308085ME174).
文摘Sugars are widely recognized for their ability to stabilize cell membranes during dehydration.However,the precise mechanisms by which sugars interact with lipid bilayers remain unclear.This mini-review synthesizes four key hypotheses explaining sugar-mediated protection of dehydrated bilayers:the Water Replacement Hypothesis(WRH),Hydration Force Hypothesis(HFH),Headgroup Bridging Hypothesis(HBH),and Vitrification Hypothesis(VH).We argue that these mechanisms are not mutually exclusive but instead operate synergistically under different cellular contexts.We propose that these hypotheses are not mutually exclusive but likely operate under different cellular contexts.Future studies should prioritize the development of biologically realistic membrane models-incorporating diverse lipids,proteins,and asymmetric leaflets-to elucidate the exact roles and mechanisms of sugars in membrane stabilization.Such advancements will enhance our understanding of anhydrobiosis and inform cryopreservation strategies for mammalian cells.
基金financially supported by the National Natural Science Foundation of China(Nos.61904090 and 62464010)Project(No.202306)of State Key Laboratory of Physical Chemistry of Solid Surfaces(Xiamen University)。
文摘Zinc-ion battery(ZIB)has been regarded as one of the most promising sustainable energy storage systems due to its low cost,safety,and attractive electrochemical performance.However,the metallic zinc anode with uneven deposition during cycling would result in significant capacity decay,low Coulombic efficiency,and electrolyte consumption,thus the undesirable cyclability severely hampers the practical applications.Herein,a phosphorus-doped carbon protective layer was coated onto the surface of Zn anode via using the plasma-enhanced chemical vapor deposition(PECVD)approach.Enhanced conductivity and lower nucleation overpotential induced by the P-doped carbon protective layer can effectively facilitate the ion diffusion kinetics and suppress side reactions.The as-fabricated P-C/Zn anode demonstrated excellent cycling stability during the zinc plating/stripping process,maintaining a low voltage hysteresis(34.8 m V)for over 1000 h under a current density of 2 m A/cm^(2)and a capacity of 2 m Ah/cm^(2).Moreover,the P-C/Zn||MnO_(2)full cell exhibited high specific capacity of about 252.5 m Ah/g at 2 A/g upon 700 long cycles.This study is helpful to design more efficient zinc-ion batteries towards the future applications.
基金supported by the Yunnan Province Nonferrous Metal Vacuum Metallurgy Top Team[grant number 202305AS350012].
文摘A major problem facing the magnesium melting process is to address the oxidative combustion of magnesium.At present,there are still some problems in the method used to protect magnesium smelting.For example,the reaction of covering flux with magnesium melt is likely to produce a large number of toxic and harmful gasses(Cl_(2) and HCl),the cost of such reaction is high,and there is a lack of clarity on the protection mechanism of CO_(2) acting as the protective gas of magnesium melt.Therefore,a new process is proposed in this paper to isolate the air on the surface of magnesium melt using MgO-C-Mg film.Based on the thermodynamic theory of MgO-C-Mg film formation during crude magnesium smelting,an investigation is conducted into the effect of different experimental conditions on the protective effect of magnesium.Not only is the protective mechanism of MgO-C-Mg film revealed,it is also verified that the MgO-C-Mg film can produce a more pronounced protective effect at suitable temperature.According to thermodynamic analysis,magnesium melt reacts with CO_(2) to form magnesium oxide and C.CO_(2) consumes C when the experimental temperature exceeds 700℃.This is contrary to the purpose of the experiment as it should be maintained at about 700℃.The experimental results show that an obvious protective effect can be produced on the magnesium melt by the MgO-C-Mg film generated under the following conditions of 90%CO_(2)-10%Ar,smelting temperature of 700℃,holding time of 60 min,and stirring time of 20 min.
基金Supported by XinganLeague Science and Technology Programme Project,No.MBJH2023022.
文摘BACKGROUND Myocardial infarction(MI)occupies a very high mortality and morbidity rate,and the search for effective pharmacological treatments has far-reaching implications for clinical research.AIM To explore the protective effects of Mongolian medicine Agari-5 on rats with MI.METHODS Sprague-Dawley rats were used,and both the Agari-5 and model groups had their coronary arteries clamped to induce MI.Proteomics was used to research the potential mechanism of action while ELISA,hematoxylin and eosin,and Masson’s staining were used to preliminarily investigate the protective impact of Agari-5 on rats with MI.RESULTS The current study has shown that Agari-5 might enhance cardiac function indicators,including echocardiography results of rats and creatine kinase,creatine kinase isoenzyme,and lactate dehydrogenase,in rats that had MI.According to the results of pathological staining,Agari-5 may lessen inflammatory cell infiltration and cardiomyocyte fibrosis,among other things.The proteome analysis revealed that there were 60 distinct proteins in total,four of which were associated with the heart.The expression of PSAT1,PDK1,SMAD4,and SDF2 proteins may be linked to the mechanism of their protective effects.CONCLUSION Potential therapeutic effects of Agari-5 for MI and its mechanism of action may be related to PSAT1,PDK1,SMAD4,and SDF2.
基金supported by the National Natural Science Foundation of China(22279139,62227815,22465026,22469015)the National Key R&D Program of China(2022YFA1504500)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(2024JQ06,2022MS2010,2024MS05005)Inner Mongolia University Postgraduate Scientific Research Innovation Project(11200-5223737)。
文摘Rechargeable aqueous zinc(Zn)-metal batteries hold great promise for next-generation energy storage systems.However,their practical application is hindered by several challenges,including dendrite formation,corrosion,and the competing hydrogen evolution reaction.To address these issues,we designed and fabricated a composite protective layer for Zn anodes by integrating carbon nanotubes(CNTs)with chitosan through a simple and scalable scraping process.The CNTs ensure uniform electric field distribution due to their high electrical conductivity,while protonated chitosan regulates ion transport and suppresses dendrite formation at the anode interface.The chitosan/CNTs composite layer also facilitates smooth Zn^(2+)deposition,enhancing the stability and reversibility of the Zn anode.As a result,the chitosan/CNTs@Zn anode demonstrates exceptional cycling stability,achieving over 3000 h of plating/stripping with minimal degradation.When paired with a V_(2)O_(5)cathode,the composite-protected anode significantly improves the cycle stability and energy density of the full cell.Techno-economic analysis confirms that batteries incorporating the chitosan/CNTs protective layer outperform those with bare Zn anodes in terms of energy density and overall performance under optimized conditions.This work provides a scalable and sustainable strategy to overcome the critical challenges of aqueous Zn-metal batteries,paving the way for their practical application in next-generation energy storage systems.
基金supported by the National Natural Science Foundation of China(Nos.82271158,82301312,82071045,82101219,82071048).
文摘Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function.Research focusing on protecting inner ear hair cells(HCs)from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence,suggesting potential strategies for preventing and treating SNHL.By synthesizing relevant studies on the inner ear,this review summarizes the emerging roles of histone modifications,DNA methylation,and noncoding RNAs in HC damage,with a focus on their therapeutic potential through epigenetic modulation.Moreover,this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL,emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.
基金supported by the National Natural Science Foundation of China(No.42177354)Guangzhou Basic and Applied Basic Research Scheme(No.2024A04J6358)the National Key R&D Program of China(No.2019YFC0214402).
文摘The manufacture and obsolescence of smartphones produce numerous waste plastic accessories(e.g.,waste smartphone protective film(WSPF)),possessing immense potential for recycling.However,available recycling technologies have limitations such as substrate damage and secondary pollutant generation.The present study aimed to develop a green disposal method that not only recycled polyethylene terephthalate(PET)from WSPF,but also reused the stripped polyacrylate(PAA)adhesive as an adsorbent to reduce solid waste generation.When the WSPF was treated in 1 mol/L NaOH solution at 90°C,the PAA hydrolyzed to two main by-products of 1-butanol and 2-ethylhexanol,weakening the binding strength between PAA and PET and then efficient separation of them.Further bench-scale test revealed that over 97.2%of detachment efficiency toward PAA was achieved during continuous treatment of 17 batches of WSPF(200 g for each)without supplement of NaOH and generation of wastewater.Meanwhile,the economic evaluation indicated that the recycling method would generate a net profit margin of 647%for the second year without considering the incurrence of new cost and input.Additionally,the pyrolysis of waste PAA enabled its conversion into potential adsorbent,which showed 2 to 4 times enhanced adsorption capacity toward styrene and ethyl acetate after modification with NaOH solution.This study provides a green method for recycling waste plastics and inspires a referable solution for solid waste treatment in the smartphone industry.
基金Supported by Undergraduate Innovation and Entrepreneurship Training Program of Guangxi Zhuang Autonomous Region(S202310599089)Open Fund Project of Key Laboratory of Guangxi Universities on National Medicine in Youjiang River Basin(yykf2024-04).
文摘[Objectives]To investigate the protective effects of Siwu Xuanhu decoction on the liver of mice with acute liver injury induced by CCl 4.[Methods]A total of 48 ICR mice were randomly assigned to six groups:a blank control group,a model group,a low dose group of Siwu Xuanhu decoction(100 mg/kg),a medium dose group of Siwu Xuanhu decoction(200 mg/kg),a high dose group of Siwu Xuanhu decoction(300 mg/kg),and a positive control group(silymarin 2 mg/kg).Each group comprised 8 mice.Each dosing group received the designated dose of the drug(10 mL/kg)via continuous gavage,while the blank group and the model group were administered an equivalent volume of normal saline for four weeks,three times per week.An acute liver injury model was established through the intraperitoneal administration of a 20%CCl 4 olive oil solution at a dosage of 2 mL/kg in all experimental groups,with the exception of the control group,which received an equivalent volume of the olive oil solution.After 24 h fasting with water intake,blood samples were collected from the ocular region.The blood samples were allowed to stand and subsequently subjected to centrifugation to isolate the upper layer of serum,and a diagnostic kit was employed to measure the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT)and interleukin-6(IL-6),and the activity of superoxide dismutase(SOD)in the serum.[Results]In comparison to the control group,serum levels of AST and ALT were significantly elevated in the model group.Furthermore,when compared to the model group,treatment with Siwu Xuanhu decoction resulted in a reduction of serum levels of ALT,AST,and IL-6,while simultaneously increasing SOD activities.[Conclusions]Siwu Xuanhu decoction exhibits a protective effect against acute liver injury induced by CCl 4 in mice.
基金Supported by Scientific Research Start-up Fund for Introduced PhD.Talents of Guangxi University of Chinese Medicine,2023(2023BS024)Basic Research Ability Enhancement Project for Young and Middle-aged Teachers in Guangxi Universities(2022KY0286)+2 种基金Guangxi Key Research and Development Program(Guike AB21196016)Guangxi Science and Technology Base and Talent Special Project(Guike AD21238031)Guangxi Key Discipline of Zhuang Medicine in Chinese Medicine(GZXK-Z-20-64).
文摘[Objectives]To investigate the protective effects of xanthoxylin on acute lung injury induced by D-Galactosamine(D-GalN)and Lipopolysaccharide(LPS)in rats.[Methods]Sixty male SD rats were randomly divided into a normal group,a model group,a silybin group(50 mg/kg),and three xanthoxylin groups(low-dose,medium-dose,high-dose as 60,120,and 240 mg/kg),10 rats per group.The rats were administered for 17 consecutive days,on day 14,all the rats except for the normal group were intraperitoneally injected with a D-GalN(400 mg/kg)/LPS(30μg/kg)mixture once to establish acute lung injury models.At 72 h after modeling,their serum MCP-1 levels,IL-1β,IL-6,PCT,CRP,TNF-αlevels in bronchoalveolar lavage fluid,and IL-1β,IL-6,TNF-αlevels in lung tissue were measured,and lung tissue histological examination were checked by HE staining.[Results]Compared with the model group,the serum MCP-1 levels,IL-1β,IL-6,PCT,CRP,TNF-αlevels in bronchoalveolar lavage fluid,and IL-1β,IL-6,TNF-αlevels in lung tissue in xanthoxylin groups were significantly decreased(P<0.05 or P<0.01),and lung tissue injury were alleviated.[Conclusions]Xanthoxylin has protective effects on acute lung injury in rats,and it may be related to the increase of anti-inflammatory capacity and the promotion of lung tissue self-healing.
基金funded by Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET,Argentina),grant number PIP 0991by Universidad Nacional de Mar del Plata(UNMdP,Argentina),grant number 15/G686-ING690/23.
文摘Interest in the use of cellulose nanomaterial’s continues to grow,both in research and industry,not only due to the abundance of raw materials,low toxicity and sustainability,but also due to the attractive physical and chemical properties that make nanocelluloses useful for a wide range of end-use applications.Among the large number of potential uses,and nanocelluloses modification and processing strategies,the chosen topic of this review focuses exclusively on plant-derived cellulose microfibers/nanofibers(CNF)and cellulose nanocrystals(CNC)processed into 2D structures—nanopapers and nanofilms—fabricated as self-standing films or applied as coatings.The end uses considered are:combinationwith standard papers and cardboards for packaging,mendingmaterial for the conservation and protection of cellulosic heritage artifacts,and component-parts of complex designs of functional devices for energy harvesting and storage.In these contexts,nanocelluloses provide high mechanical and ecofriendly properties,transparency and tunable haze,as well as flexibility/bendability in the resulting films.All these characteristics make them extremely attractive to a market seeking for sustainable,light weight and low cost raw materials for the production of goods.General perspectives on the current advantages and disadvantages of using CNF and CNC in the selected areas are also reviewed.
文摘The global supply chain turbulence has increased the difficulty of protecting foreign well-known trademarks.Although there are many studies on cross-border trademark rights protection in academia,there is relatively little research on its risk mitigation effectiveness in the context of supply chain fluctuations.Based on case studies of commercial law and data statistics,the study explores the relationship between protection efficiency and market response through legal applicability.Due to the long litigation cycle and uneven law enforcement,there are differences in market regulation,weakening the protection of well-known trademarks and exacerbating supply chain uncertainty.Strengthening international legal framework cooperation and promoting law enforcement linkage can enhance protection effectiveness.In theory,enriching the theory of cross-border trademark protection and expanding research on brand rights protection in the context of global supply chains.In practice,it helps enterprises adjust their trademark layout,avoid legal risks,and improve market competitiveness.Due to the complexity of the legal environment and limitations in data acquisition,future research will strengthen data analysis,promote international cooperation in intelligent supervision,and build a more efficient cross-border well-known trademark protection mechanism.
基金supported by the National Key R&D Program of China(2021YFE0115800)the National Natural Science Foundation of China(22275142,22293022,U22B6011,52103285)+1 种基金the 111 National Project(Grant No.B20002)the Fundamental Research Funds for the Central Universities(2020-YB-005)。
文摘Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de-alloying lead to poor cyclic and bad high-rate performance,which has severely hindered its practical large-scale application.Herein,a novel stamen-structured Si-based anode material with a protective SiO_(x)layer and dual carbon layers(Si@SiO_(x)/C@C)is designed for high-performance LIBs.The protective SiO_(x)layer reduces side reactions and dual carbon layers enhance charge transport to improve reaction kinetics,while the unique structure provides buffering space for volume expansion.Such Si@SiO_(x)/C@C anode demonstrates impressive Li storage properties for a half-battery,including a discharge capacity of 2935 mA h g^(-1)at a current density 0.1 A g^(-1),cyclic performance(814 mA h g^(-1)at 2 A g^(-1)over 500 cycles and 988 mA h g^(-1)over 200 cycles at 1 A g^(-1))and a rate performance(609 mA h g^(-1)at 5 A g^(-1)).It also maintains a high reversible capacity of 131 mA h g^(-1)at 0.25 C after100 cycles for a full battery.This work provides insights into the novel design of multiple protective layers on Si-based anode materials for fast-charging and highly stable LIBs.
文摘The aim and objective of this review is to figure out potential occupational risk factors among nursing staff in outpatient injection room and to provide corresponding measures.There are several main factors summarized,including needle injury,cytotoxic drug,radiological hazard,disinfection,social and psychological factors and management systems. Findings suggest that stable management system and awareness of self- protections are two key points in prevention and control of occupational hazard in outpatient injection room of cancer hospital.
