Objective To analyze the 2022 multiple-country monkeypox outbreak and assess its importation risk into China.Methods Data was from United States Centers for Disease Control and Prevention.We described the global epide...Objective To analyze the 2022 multiple-country monkeypox outbreak and assess its importation risk into China.Methods Data was from United States Centers for Disease Control and Prevention.We described the global epidemic and calculated concentration index to measure economic-related inequality.Importation risk into China was evaluated and ranked by using risk matrix method and Borda count method,respectively.Results As of July 29,2022,of 79 countries or territories,39(49.37%,39/79),17(21.52%,17/79),6(7.59%,6/79),12(15.19%,12/79),and 5(6.33%,5/79)country or territories identified cases<10,10-,51-,101-,and>1,000.There were economic-related health disparities exist in the distribution of cases(the concentration index=0.42,P=0.027),and the inequality disadvantageous to the rich(pro-poor).There were 12(15.38%,12/78),15(19.23%,15/78),6(7.69%,6/78),and 45(57.69%,45/78)countries or territories with extremely high,high,moderate,and low importation risk.United States and France ranked first with the highest Borda points of 156,and counts of zero.Conclusion Of 78 countries or territories,the key attention need be paid to the United States and France,relatively.As the epidemic progresses,preparing prevention and control measures to further reduce importation risk was crucial.展开更多
For the current situation that the application of risk matrix method may result in too many risk ties which will block risk management and decision making, and based on the brief introduction of risk matrix method,thi...For the current situation that the application of risk matrix method may result in too many risk ties which will block risk management and decision making, and based on the brief introduction of risk matrix method,this paper subdivides the risk levels, gives an improved risk matrix method, conducts risk assessment of contractor support using the improved risk matrix method, and determines the risk rates and the acceptable level.展开更多
Objective To analyze the global epidemic status of the Ebola virus disease(EVD) and assess the importation risk into China.Methods Data from World Health Organization reports were used. We described the global epidemi...Objective To analyze the global epidemic status of the Ebola virus disease(EVD) and assess the importation risk into China.Methods Data from World Health Organization reports were used. We described the global epidemic status of EVD from 1976–2021, and assessed and ranked the importation risk of EVD from the diseaseoutbreaking countries into China using the risk matrix and Borda count methods, respectively.Results From 1976–2021, EVD mainly occurred in western and central Africa, with the highest cumulative number of cases(14,124 cases) in Sierra Leone, and the highest cumulative fatality rate(85%) in the Congo. Outbreaks of EVD have occurred in the Democratic Republic of the Congo and Guinea since 2018. The importation risk into China varies across countries with outbreaks of disease.The Democratic Republic of the Congo had an extremely high risk(23 Borda points), followed by Guinea and Liberia. Countries with a moderate importation risk were Nigeria, Uganda, Congo, Sierra Leone,Mali, and Gabon, while countries with a low importation risk included Sudan, Senegal, and Co te d’Ivoire.Conclusion China is under the risk of EVD importation with the globalization and severe epidemic status of EVD. Key attention need to be paid to the Democratic Republic of the Congo, Guinea, and Liberia. Therefore, it is necessary to prevent and prepare in advance for importation risk in China.展开更多
The study is a cross-sectional design assessment of the likelihood, frequency and severity of hazards associated with underwater operations in the Niger Delta. Five oil and gas companies were used for this study selec...The study is a cross-sectional design assessment of the likelihood, frequency and severity of hazards associated with underwater operations in the Niger Delta. Five oil and gas companies were used for this study selected by a purposive method given that they had the highest number of workers involved in underwater operations. A sample size of 418 was computed to which the questionnaires were administered with response rate of 95.93%. Data analyses were carried out to cover descriptive statistics, analysis of variance and Pearsonal correlation coefficients. The 4 by 4 risk assessment matrix for the likelihood and consequences showed that 8 out of 20 underwater hazards were categorized as having very high risk according to their risk ratings. The eight hazards categorized based on their risk IDs were H01, H03, H04, H08, H10, H11, H12, and H15. The 4 by 4 risk matrix for frequency and consequences revealed that two hazards (Piracy & bandit attack/kidnapping (H01) and Other main vessels/heavy object dropping or falling load/collision (H08)) were identified to be of very high risk.展开更多
This paper first analyzes the main potential risks in brand cultivation and formation of logistics enterprise. After that, based on field interview and questionnaire survey conducted in logistics enterprises of Guangx...This paper first analyzes the main potential risks in brand cultivation and formation of logistics enterprise. After that, based on field interview and questionnaire survey conducted in logistics enterprises of Guangxi and Hunan provinces, the author applies the risk matrix and Borda order method to appraise the risks in brand cultivation and formation of logistics industry and how to prevent these risks.展开更多
Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information techn...Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information technology industry, the paper reveals the industrial relevance in Chinese information technology industry. The paper also selects the relevant industries which are highly associated with the development of Chinese information technology industry based on industrial relevance degree to analyze the influences of these industries on the financial situation risk fluctuation in information technology industry and to design the matrix of financial situation risk in information technology industry. Then, the paper offers countermeasures and suggestions for the development of our information technology industry.展开更多
The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to...The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to open a new structural subdivision. We have researched types of risks, their identification, classification, and assessment possibilities in activities of small and medium-sized enterprises. We have used our own algorithm of identification, classification, and assessment of enterprises＇ risks. The goal of this research is to study the economic and financial risks＇ impact on small and medium-sized enterprises＇ development in Latvia. For study purpose, we have carried out the questionnaire of representative small and medium-sized enterprises about the economic and financial risks＇ impact on enterprises＇ development in Latvia. We have created classification of Latvian services sectors＇ economic and financial risks in the period from 2011 to 2012. Those risks have been included in the questionnaire. The risks matrix is a quantitative assessment tool of risks. We have created Latvian service sector economic and financial risks matrix. We have arranged risks by their sizes of possible losses for enterprises. For each risk has been assessed its probability of realization. We have created Latvian accommodations （hotel） and food services technological process risks map. Several parts of the risk map （segments） make it possible to assess each type of the risk separately in its segment. Risks matrix can be used to choose enterprises＇ strategy of risk management. Enterprise＇s strategy of risk management is developed by analysing zones of risk level.展开更多
Kernel-based methods work by embedding the data into a feature space and then searching linear hypothesis among the embedding data points. The performance is mostly affected by which kernel is used. A promising way is...Kernel-based methods work by embedding the data into a feature space and then searching linear hypothesis among the embedding data points. The performance is mostly affected by which kernel is used. A promising way is to learn the kernel from the data automatically. A general regularized risk functional （RRF） criterion for kernel matrix learning is proposed. Compared with the RRF criterion, general RRF criterion takes into account the geometric distributions of the embedding data points. It is proven that the distance between different geometric distdbutions can be estimated by their centroid distance in the reproducing kernel Hilbert space. Using this criterion for kernel matrix learning leads to a convex quadratically constrained quadratic programming （QCQP） problem. For several commonly used loss functions, their mathematical formulations are given. Experiment results on a collection of benchmark data sets demonstrate the effectiveness of the proposed method.展开更多
The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an ...The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an influx of migrants drawn by burgeoning industries, leading to unplanned urban growth and the emergence of vulnerable communities like Vila Socó. This article examines the interconnected factors—such as demographic shifts, inadequate planning, and regulatory oversight—that culminated in the devastating fire of 1984, claiming numerous lives and highlighting systemic failures. Utilizing the Haddon Matrix, this study dissects the Vila Socó incident, emphasizing the roles of human error, infrastructure integrity, and socio-economic disparities in disaster causation. By contextualizing the tragedy within Cubatão’s industrial trajectory, it underscores the urgent need for comprehensive risk assessment and proactive mitigation strategies in rapidly developing regions globally. Beyond its immediate focus, this work offers broader insights into the dynamics of industrial disasters and their socio-economic implications. As pipelines continue to play a vital role in global energy infrastructure, the lessons drawn from Vila Socó’s tragedy resonate deeply, emphasizing the imperative of robust safety protocols and accountable governance to prevent similar catastrophes in the future.展开更多
Background: Coronary heart disease(CHD) is characterized by arterial wall inflammation and matrix degradation. Matrix metalloproteinase(MMP)-22 and-29 and pro-inflammatory cytokine interleukin-18(IL18) are present in ...Background: Coronary heart disease(CHD) is characterized by arterial wall inflammation and matrix degradation. Matrix metalloproteinase(MMP)-22 and-29 and pro-inflammatory cytokine interleukin-18(IL18) are present in human hearts. IL18 may regulate MMP-22 and-29 expression, which may correlate with CHD progression. Methods and results: Immunoblot analysis showed that IL18 induced MMP-22 expression in human aortic smooth muscle cells. The Mann Whitney test from a prospective study of 194 CHD patients and 68 non-CHD controls demonstrated higher plasma levels of IL18, MMP-22 and-29 in CHD patients than in the controls. A logistic regression test suggested that plasma IL18(odds ratio(OR)=1.131, P=0.007), MMP-22(OR=1.213, P=0.040), and MMP-29(OR=1.198, P=0.033) were independent risk factors of CHD. Pearson's correlation test showed that IL18(coefficient(r)=0.214, P=0.045; r=0.246, P=0.031) and MMP-22(r=0.273, P=0.006; r=0.286, P=0.012) were associated with the Gensini score before and after adjusting for potential confounding factors. The multivariate Pearson's correlation test showed that plasma MMP-22 levels correlated positively with high-sensitive-C-reactive protein(hs-CRP)(r=0.167, P=0.023), and MMP-29 levels correlated negatively with triglyceride(r=-0.169, P=0.018). Spearman's correlation test indicated that plasma IL18 levels associated positively with plasma MMP-22(r=0.845, P<0.001) and MMP-29(r=0.548, P<0.001). Conclusions: Our observations suggest that IL18, MMP-22 and-29 serve as biomarkers and independent risk factors of CHD. Increased systemic IL18 in CHD patients may contribute to elevated plasma MMP-22 and-29 levels in these patients.展开更多
This paper tries to demonstrate that the principle of the risk allocation based on the balance is the most effective way to resolve the risk allocation problems of public-private partnership （PPP） contracts and pres...This paper tries to demonstrate that the principle of the risk allocation based on the balance is the most effective way to resolve the risk allocation problems of public-private partnership （PPP） contracts and presents suggestions how to carry out this principle. For PPP projects, it is necessary to set up a workable and commercially viable risk sharing mechanism to satisfy the different interests and the objectives of both the public sector and the private sector. An effective risk allocation mechanism is not only an important part in preparing project documents, but also an essential part in the success of PPP contracts. Risk allocation can be represented in a risk matrix. The more balanced the risk allocation is, the lower the risk degree of PPP contracts is. Therefore, the most effective risk allocation of PPP contracts is that the public sector and the private sector take part in risk management together in all the stages of the project and allocate the balanced risks. The outcomes of this paper can be used by both the public sector and the private sector to make a good choice of the PPP contract form.展开更多
Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitig...Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitigate these adverse impacts and address mine-closure issues.An integral framework for mine-closure risk management that includes risk assessment and risk treatment was proposed.Given the fuzziness and randomness of the transformation between qualitative and quantitative knowledge in the risk assessment process,a novel risk assessment method based on the cloud model was presented,which fully considers the uncertainty in risks themselves and in the reasoning process.Closed mine reutilization is an effective risk treatment option in response to the identified high risks,but it requires selecting optimal reutilization strategies for the successful implementation of the reuse plan.To this end,a hybrid semi-quantitative decision method is proposed to optimize decision-making.The results of a case study showed that this risk management methodology can help budget planning for risk treatment and provide an instructional framework to effectively reduce the negative effects of closed mines.展开更多
The paper discusses the framework for a risk-informed root cause analysis process.Such process enables scaling of the analysis performed based on the risk associated with the undesired event or condition,thereby creat...The paper discusses the framework for a risk-informed root cause analysis process.Such process enables scaling of the analysis performed based on the risk associated with the undesired event or condition,thereby creating tiers of analysis where the greater the risk,the more sophisticated the analysis.In a risk-informed root cause analysis process,a situation is normally not analyzed at a level less than what actually occurred.However,a situation may be investigated as though the consequence were greater than actually happened,especially if only slight differences in circumstances could result in a significantly higher consequence.While operational events or safety issues are normally expected to result only with negligible or marginal actual consequences,many of those would actually have certain potential to develop or propagate into catastrophic events.This potential can be expressed qualitatively or quantitatively.Risk-informing of root cause analysis relies on mapping the event or safety issue into a risk matrix which,traditionally,is a two-dimensional probability-consequence matrix.A new concept employed in the risk matrix for root cause analysis is that,while the probability reflects the observed or expected range of values(retaining,thus,its“traditional”meaning),the consequence reflects not only the observed or materialized impact(such as failure of equipment)but,also,its potential to propagate or develop into highly undesirable final state.The paper presents main elements of risk-informed root cause analysis process and discusses qualitative and quantitative aspects and approaches to determination of risk significance of operational events or safety issues.展开更多
Accidents and injuries related to work are major occupational health problems in most of the industrialized countries.Traditional approaches to manage workplace safety in mines have mainly focused on job redesign and ...Accidents and injuries related to work are major occupational health problems in most of the industrialized countries.Traditional approaches to manage workplace safety in mines have mainly focused on job redesign and technical aspects of engineering systems.It is being realized that compliance to rules and regulations of mines is a prerequisite;however,it is not sufficient to achieve further reduction in accident and injury rates in mines.Proactive approaches are necessary to further improve the safety standards in mines.Unsafe conditions and practices in mines lead to a number of accidents,which in turn may cause loss and injury to human lives,damages to property,and loss of production.Hazard identification and risk assessment is an important task for the mining industry which needs to consider all the risk factors at workplaces.Applications of risk management approaches in mines are necessary to identify and quantify potential hazards and to suggest effective solutions.In this paper,the following risk estimation techniques were discussed:(i)DGMS(Directorate General of Mines Safety,India)risk rating criterion,and(ii)a matrix based approach.The proposed tools were demonstrated through an application in an opencast coal mine in India.It was inferred that the risk assessment approach can be used as an effective tool to indentify and control hazards in mines.展开更多
The tool system of the organizational risk analyzer (ORA) to study the network of East Turkistan terrorists is selected. The model of the relationships among its personnel, knowledge, resources and task entities is re...The tool system of the organizational risk analyzer (ORA) to study the network of East Turkistan terrorists is selected. The model of the relationships among its personnel, knowledge, resources and task entities is represented by the meta-matrix in ORA, with which to analyze the risks and vulnerabilities of organizational structure quantitatively, and obtain the last vulnerabilities and risks of the organization. Case study in this system shows that it should be a shortcut to destroy effectively the network of terrorists by recognizing the caucus persons of the terrorism organization for the first and eliminating them when strikes the terror organization. It is vital to ensure effective use of the resources and control the risks of terrorist attacks.展开更多
基金partly supported by the National Natural Science Foundation of China[grant numbers 72122001,71934002]the National Key Research and Development Project of China[grant number 2021ZD0114101,2021ZD0114104,2021ZD0114105]+2 种基金National Statistical Science Research Project[grant numbers 2021LY038]the Fundamental Research Funds for the Central Universities supported by Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group,of Peking University[grant number 202204]National Science and Technology Project on Development Assistance for Technology,Developing China-ASEAN Public Health Research and Development Collaborating Center[grant number KY202101004]
文摘Objective To analyze the 2022 multiple-country monkeypox outbreak and assess its importation risk into China.Methods Data was from United States Centers for Disease Control and Prevention.We described the global epidemic and calculated concentration index to measure economic-related inequality.Importation risk into China was evaluated and ranked by using risk matrix method and Borda count method,respectively.Results As of July 29,2022,of 79 countries or territories,39(49.37%,39/79),17(21.52%,17/79),6(7.59%,6/79),12(15.19%,12/79),and 5(6.33%,5/79)country or territories identified cases<10,10-,51-,101-,and>1,000.There were economic-related health disparities exist in the distribution of cases(the concentration index=0.42,P=0.027),and the inequality disadvantageous to the rich(pro-poor).There were 12(15.38%,12/78),15(19.23%,15/78),6(7.69%,6/78),and 45(57.69%,45/78)countries or territories with extremely high,high,moderate,and low importation risk.United States and France ranked first with the highest Borda points of 156,and counts of zero.Conclusion Of 78 countries or territories,the key attention need be paid to the United States and France,relatively.As the epidemic progresses,preparing prevention and control measures to further reduce importation risk was crucial.
文摘For the current situation that the application of risk matrix method may result in too many risk ties which will block risk management and decision making, and based on the brief introduction of risk matrix method,this paper subdivides the risk levels, gives an improved risk matrix method, conducts risk assessment of contractor support using the improved risk matrix method, and determines the risk rates and the acceptable level.
基金funded by the National Natural Science Foundation of China[Grant No.71934002,Grant No.72122001]。
文摘Objective To analyze the global epidemic status of the Ebola virus disease(EVD) and assess the importation risk into China.Methods Data from World Health Organization reports were used. We described the global epidemic status of EVD from 1976–2021, and assessed and ranked the importation risk of EVD from the diseaseoutbreaking countries into China using the risk matrix and Borda count methods, respectively.Results From 1976–2021, EVD mainly occurred in western and central Africa, with the highest cumulative number of cases(14,124 cases) in Sierra Leone, and the highest cumulative fatality rate(85%) in the Congo. Outbreaks of EVD have occurred in the Democratic Republic of the Congo and Guinea since 2018. The importation risk into China varies across countries with outbreaks of disease.The Democratic Republic of the Congo had an extremely high risk(23 Borda points), followed by Guinea and Liberia. Countries with a moderate importation risk were Nigeria, Uganda, Congo, Sierra Leone,Mali, and Gabon, while countries with a low importation risk included Sudan, Senegal, and Co te d’Ivoire.Conclusion China is under the risk of EVD importation with the globalization and severe epidemic status of EVD. Key attention need to be paid to the Democratic Republic of the Congo, Guinea, and Liberia. Therefore, it is necessary to prevent and prepare in advance for importation risk in China.
文摘The study is a cross-sectional design assessment of the likelihood, frequency and severity of hazards associated with underwater operations in the Niger Delta. Five oil and gas companies were used for this study selected by a purposive method given that they had the highest number of workers involved in underwater operations. A sample size of 418 was computed to which the questionnaires were administered with response rate of 95.93%. Data analyses were carried out to cover descriptive statistics, analysis of variance and Pearsonal correlation coefficients. The 4 by 4 risk assessment matrix for the likelihood and consequences showed that 8 out of 20 underwater hazards were categorized as having very high risk according to their risk ratings. The eight hazards categorized based on their risk IDs were H01, H03, H04, H08, H10, H11, H12, and H15. The 4 by 4 risk matrix for frequency and consequences revealed that two hazards (Piracy & bandit attack/kidnapping (H01) and Other main vessels/heavy object dropping or falling load/collision (H08)) were identified to be of very high risk.
文摘This paper first analyzes the main potential risks in brand cultivation and formation of logistics enterprise. After that, based on field interview and questionnaire survey conducted in logistics enterprises of Guangxi and Hunan provinces, the author applies the risk matrix and Borda order method to appraise the risks in brand cultivation and formation of logistics industry and how to prevent these risks.
基金Key project of National Social Scientific Fund--"Study on Financing Early-warning and Fixation of Listed Corporations in Information Technology Industry based on the Dynamic Monitoring of Industrial Risk"(Project approval Number:15AGL008)
文摘Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information technology industry, the paper reveals the industrial relevance in Chinese information technology industry. The paper also selects the relevant industries which are highly associated with the development of Chinese information technology industry based on industrial relevance degree to analyze the influences of these industries on the financial situation risk fluctuation in information technology industry and to design the matrix of financial situation risk in information technology industry. Then, the paper offers countermeasures and suggestions for the development of our information technology industry.
文摘The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to open a new structural subdivision. We have researched types of risks, their identification, classification, and assessment possibilities in activities of small and medium-sized enterprises. We have used our own algorithm of identification, classification, and assessment of enterprises＇ risks. The goal of this research is to study the economic and financial risks＇ impact on small and medium-sized enterprises＇ development in Latvia. For study purpose, we have carried out the questionnaire of representative small and medium-sized enterprises about the economic and financial risks＇ impact on enterprises＇ development in Latvia. We have created classification of Latvian services sectors＇ economic and financial risks in the period from 2011 to 2012. Those risks have been included in the questionnaire. The risks matrix is a quantitative assessment tool of risks. We have created Latvian service sector economic and financial risks matrix. We have arranged risks by their sizes of possible losses for enterprises. For each risk has been assessed its probability of realization. We have created Latvian accommodations （hotel） and food services technological process risks map. Several parts of the risk map （segments） make it possible to assess each type of the risk separately in its segment. Risks matrix can be used to choose enterprises＇ strategy of risk management. Enterprise＇s strategy of risk management is developed by analysing zones of risk level.
基金supported by the National Natural Science Fundation of China (60736021)the Joint Funds of NSFC-Guangdong Province(U0735003)
文摘Kernel-based methods work by embedding the data into a feature space and then searching linear hypothesis among the embedding data points. The performance is mostly affected by which kernel is used. A promising way is to learn the kernel from the data automatically. A general regularized risk functional （RRF） criterion for kernel matrix learning is proposed. Compared with the RRF criterion, general RRF criterion takes into account the geometric distributions of the embedding data points. It is proven that the distance between different geometric distdbutions can be estimated by their centroid distance in the reproducing kernel Hilbert space. Using this criterion for kernel matrix learning leads to a convex quadratically constrained quadratic programming （QCQP） problem. For several commonly used loss functions, their mathematical formulations are given. Experiment results on a collection of benchmark data sets demonstrate the effectiveness of the proposed method.
文摘The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an influx of migrants drawn by burgeoning industries, leading to unplanned urban growth and the emergence of vulnerable communities like Vila Socó. This article examines the interconnected factors—such as demographic shifts, inadequate planning, and regulatory oversight—that culminated in the devastating fire of 1984, claiming numerous lives and highlighting systemic failures. Utilizing the Haddon Matrix, this study dissects the Vila Socó incident, emphasizing the roles of human error, infrastructure integrity, and socio-economic disparities in disaster causation. By contextualizing the tragedy within Cubatão’s industrial trajectory, it underscores the urgent need for comprehensive risk assessment and proactive mitigation strategies in rapidly developing regions globally. Beyond its immediate focus, this work offers broader insights into the dynamics of industrial disasters and their socio-economic implications. As pipelines continue to play a vital role in global energy infrastructure, the lessons drawn from Vila Socó’s tragedy resonate deeply, emphasizing the imperative of robust safety protocols and accountable governance to prevent similar catastrophes in the future.
基金supported by the University of Science and Technology Innovation Team of Henan(No.14IRTSTHN018)the Science and Technology Talents Team Construction Program of Zhengzhou City Science and Technology Talents(No.131PLJRC670),Chinathe National Institutes of Health(Nos.HL60942 and HL123568),USA
文摘Background: Coronary heart disease(CHD) is characterized by arterial wall inflammation and matrix degradation. Matrix metalloproteinase(MMP)-22 and-29 and pro-inflammatory cytokine interleukin-18(IL18) are present in human hearts. IL18 may regulate MMP-22 and-29 expression, which may correlate with CHD progression. Methods and results: Immunoblot analysis showed that IL18 induced MMP-22 expression in human aortic smooth muscle cells. The Mann Whitney test from a prospective study of 194 CHD patients and 68 non-CHD controls demonstrated higher plasma levels of IL18, MMP-22 and-29 in CHD patients than in the controls. A logistic regression test suggested that plasma IL18(odds ratio(OR)=1.131, P=0.007), MMP-22(OR=1.213, P=0.040), and MMP-29(OR=1.198, P=0.033) were independent risk factors of CHD. Pearson's correlation test showed that IL18(coefficient(r)=0.214, P=0.045; r=0.246, P=0.031) and MMP-22(r=0.273, P=0.006; r=0.286, P=0.012) were associated with the Gensini score before and after adjusting for potential confounding factors. The multivariate Pearson's correlation test showed that plasma MMP-22 levels correlated positively with high-sensitive-C-reactive protein(hs-CRP)(r=0.167, P=0.023), and MMP-29 levels correlated negatively with triglyceride(r=-0.169, P=0.018). Spearman's correlation test indicated that plasma IL18 levels associated positively with plasma MMP-22(r=0.845, P<0.001) and MMP-29(r=0.548, P<0.001). Conclusions: Our observations suggest that IL18, MMP-22 and-29 serve as biomarkers and independent risk factors of CHD. Increased systemic IL18 in CHD patients may contribute to elevated plasma MMP-22 and-29 levels in these patients.
文摘This paper tries to demonstrate that the principle of the risk allocation based on the balance is the most effective way to resolve the risk allocation problems of public-private partnership （PPP） contracts and presents suggestions how to carry out this principle. For PPP projects, it is necessary to set up a workable and commercially viable risk sharing mechanism to satisfy the different interests and the objectives of both the public sector and the private sector. An effective risk allocation mechanism is not only an important part in preparing project documents, but also an essential part in the success of PPP contracts. Risk allocation can be represented in a risk matrix. The more balanced the risk allocation is, the lower the risk degree of PPP contracts is. Therefore, the most effective risk allocation of PPP contracts is that the public sector and the private sector take part in risk management together in all the stages of the project and allocate the balanced risks. The outcomes of this paper can be used by both the public sector and the private sector to make a good choice of the PPP contract form.
基金financially supported by the National Key R&D Program of China(No.2018YFC0831800)the National Natural Science Foundation of China(No.71704178)+3 种基金the Beijing Excellent Talent Program(No.2017000020124G133)the Major Consulting Project of Chinese Academy of Engineering(No.2017-ZD-03)the National Statistical Science Research Project by National Bureau of Statistics of China(No.2017LY10)the Fundamental Research Funds for the Central Universities(No.2020YQNY08)。
文摘Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitigate these adverse impacts and address mine-closure issues.An integral framework for mine-closure risk management that includes risk assessment and risk treatment was proposed.Given the fuzziness and randomness of the transformation between qualitative and quantitative knowledge in the risk assessment process,a novel risk assessment method based on the cloud model was presented,which fully considers the uncertainty in risks themselves and in the reasoning process.Closed mine reutilization is an effective risk treatment option in response to the identified high risks,but it requires selecting optimal reutilization strategies for the successful implementation of the reuse plan.To this end,a hybrid semi-quantitative decision method is proposed to optimize decision-making.The results of a case study showed that this risk management methodology can help budget planning for risk treatment and provide an instructional framework to effectively reduce the negative effects of closed mines.
文摘The paper discusses the framework for a risk-informed root cause analysis process.Such process enables scaling of the analysis performed based on the risk associated with the undesired event or condition,thereby creating tiers of analysis where the greater the risk,the more sophisticated the analysis.In a risk-informed root cause analysis process,a situation is normally not analyzed at a level less than what actually occurred.However,a situation may be investigated as though the consequence were greater than actually happened,especially if only slight differences in circumstances could result in a significantly higher consequence.While operational events or safety issues are normally expected to result only with negligible or marginal actual consequences,many of those would actually have certain potential to develop or propagate into catastrophic events.This potential can be expressed qualitatively or quantitatively.Risk-informing of root cause analysis relies on mapping the event or safety issue into a risk matrix which,traditionally,is a two-dimensional probability-consequence matrix.A new concept employed in the risk matrix for root cause analysis is that,while the probability reflects the observed or expected range of values(retaining,thus,its“traditional”meaning),the consequence reflects not only the observed or materialized impact(such as failure of equipment)but,also,its potential to propagate or develop into highly undesirable final state.The paper presents main elements of risk-informed root cause analysis process and discusses qualitative and quantitative aspects and approaches to determination of risk significance of operational events or safety issues.
文摘Accidents and injuries related to work are major occupational health problems in most of the industrialized countries.Traditional approaches to manage workplace safety in mines have mainly focused on job redesign and technical aspects of engineering systems.It is being realized that compliance to rules and regulations of mines is a prerequisite;however,it is not sufficient to achieve further reduction in accident and injury rates in mines.Proactive approaches are necessary to further improve the safety standards in mines.Unsafe conditions and practices in mines lead to a number of accidents,which in turn may cause loss and injury to human lives,damages to property,and loss of production.Hazard identification and risk assessment is an important task for the mining industry which needs to consider all the risk factors at workplaces.Applications of risk management approaches in mines are necessary to identify and quantify potential hazards and to suggest effective solutions.In this paper,the following risk estimation techniques were discussed:(i)DGMS(Directorate General of Mines Safety,India)risk rating criterion,and(ii)a matrix based approach.The proposed tools were demonstrated through an application in an opencast coal mine in India.It was inferred that the risk assessment approach can be used as an effective tool to indentify and control hazards in mines.
文摘The tool system of the organizational risk analyzer (ORA) to study the network of East Turkistan terrorists is selected. The model of the relationships among its personnel, knowledge, resources and task entities is represented by the meta-matrix in ORA, with which to analyze the risks and vulnerabilities of organizational structure quantitatively, and obtain the last vulnerabilities and risks of the organization. Case study in this system shows that it should be a shortcut to destroy effectively the network of terrorists by recognizing the caucus persons of the terrorism organization for the first and eliminating them when strikes the terror organization. It is vital to ensure effective use of the resources and control the risks of terrorist attacks.
