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Fatigue Performance of Fabrics of Stent-Grafts Supported with Z-Stents vs. Ringed Stents 被引量:1
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作者 林婧 宋戈 +4 位作者 管晓宁 王璐 杜佳 NUTLEY Mark GUIDOIN Robert 《Journal of Donghua University(English Edition)》 EI CAS 2013年第5期367-370,共4页
Stent-grafts were commercialized rapidly and gained a broad clinical acceptance over the past two decades. However,relatively more recent recognition of particular stent-graft design shortcomings have been identified ... Stent-grafts were commercialized rapidly and gained a broad clinical acceptance over the past two decades. However,relatively more recent recognition of particular stent-graft design shortcomings have been identified which need to be addressed. It appears that various stent-graft designs may be more or less resistant to metal fatigue and /or fabric abrasions which can lead to type III and type IV endoleaks over the long term. Therefore,it is necessary to investigate the fatigue performance of the most common stentgraft designs: Z-stents and ringed stents,in a long-term in vitro fatigue simulation environment. This paper aimed to analyze nondestructively( gross observations) and destructively( fabric characteristics,mechanical and chemical properties) in order to put forward suggestions to improve the fabric and stent characteristics that may prevent type III and IV endoleaks. The fabric supported with ringed stent-grafts remained nearly completely intact after 168h. However, the fabric supported with Z-stents demonstrated significant damage. Fabric characteristics and tensile strength of the fibers did not present a significant difference between the control and fatigue simulated specimens. The crystallinity declined for both specimens. The fatigue performance of fabrics supported with ringed stents appears to be superior to that supported with Z-stents. The potential for a dynamic and destructive interaction between the apices of Z-stents which can lead to fraying and /or tearing of the graft fabric must be addressed in future designs. 展开更多
关键词 STENT-GRAFT FATIGUE performance FABRICS Z-stents ringed STENTS
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ATOMIC FORCE MICROSCOPY STUDIES OF POLYCAPROLACTONE RINGED SPHERULITES
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作者 Jian-bin Zhang De-zhu Ma +1 位作者 Hua Zhong Xiao-lie Luo Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2000年第6期569-572,共4页
The surface morphology of free-surface PCL ringed spherulites was investigated by using atomic force microscopy. The spherulites were obtained by crystallization of PCL/PVC blends of different compositions. It was fou... The surface morphology of free-surface PCL ringed spherulites was investigated by using atomic force microscopy. The spherulites were obtained by crystallization of PCL/PVC blends of different compositions. It was found that the ringed spherulite exhibited regularly fluctuating rings on its surface. Compared with the bright-dark ring pattern of the spherulite under a polarizing microscope, it was proved that the optical characteristics of the ringed spherulite under polarizing microscope coincided with its surface characteristics. The bright rings in polarizing micrographs of the spherulite coincided with the convex rings on its surface, while the dark rings coincided with the concave rings. 展开更多
关键词 AFM surface morphology ringed spherulites PCL/PVC blends
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Affine Structures on a Ringed Space and Schemes
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作者 Fengwen AN 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2011年第1期139-160,共22页
The author first introduces the notion of affine structures on a ringed space and then obtains several related properties.Affine structures on a ringed space,arising from complex analytical spaces of algebraic schemes... The author first introduces the notion of affine structures on a ringed space and then obtains several related properties.Affine structures on a ringed space,arising from complex analytical spaces of algebraic schemes,behave like differential structures on a smooth manifold.As one does for differential manifolds,pseudogroups of affine transformations are used to define affine atlases on a ringed space.An atlas on a space is said to be an affine structure if it is maximal.An affine structure is said to be admissible if there is a sheaf on the underlying space such that they are coincide on all affine charts,which are in deed affine open sets of a scheme.In a rigour manner,a scheme is defined to be a ringed space with a specified affine structure if the affine structures make a contribution to the cases such as analytical spaces of algebraic schemes.Particularly,by the whole of affine structures on a space,two necessary and sufficient conditions,that two spaces are homeomorphic and that two schemes are isomorphic,coming from the main theorems of the paper,are obtained respectively.A conclusion is drawn that the whole of affine structures on a space and a scheme,as local data,encode and reflect the global properties of the space and the scheme,respectively. 展开更多
关键词 Affine structure Pseudogroup of affine transformations ringed space SCHEME
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Systematic Relationship of a Corystosperms(Fengweioxylon)and its Palaeoecological Significance
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作者 JIANG Zikun TIAN Ning +5 位作者 HAO Ruiying WANG Yongdong NING Zhenguo WU Hao SUN Deyu WANG Cai 《Acta Geologica Sinica(English Edition)》 2026年第1期13-19,共7页
The wood anatomy of corystosperms is fundamentally consistent with that of gymnosperms,yet their growth ring boundaries share anatomical features with extant angiosperms.This transitional morphology strongly supports ... The wood anatomy of corystosperms is fundamentally consistent with that of gymnosperms,yet their growth ring boundaries share anatomical features with extant angiosperms.This transitional morphology strongly supports the interpretation of corystosperms as an evolutionary intermediate between gymnosperms and angiosperms.The first application of X-Ray fluorescence(XRF)chemical analysis to fossil wood taxa of Fengweioxylon yielded the above conclusion.By using growth ring analysis and ecological reconstructions,we suggest that corystosperms were large evergreen trees with leaf retention periods of three to five years.They likely thrived in warm summer environments where prolonged foliage retention provided adaptive benefits. 展开更多
关键词 XRF corystosperms growth ring PALAEOCLIMATE PHYLOGENETICS
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A novel scaling method for the elastic ring supporting structure of an aero-engine rotor system: analytical and experimental investigations
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作者 Lei LI Tianyue MA +4 位作者 Zhong LUO Dongwu GAO Xiangdong GE Hui MA Shibin WANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期1-18,共18页
The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometr... The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometric distortions, leading to a diminution in the predictive accuracy of the distorted similitude. To address this challenge, this study formulates a novel set of scaling laws, tailored to account for the intricate geometric distortions associated with elastic rings. The proposed scaling laws are formulated based on the intrinsic deformation characteristics of elastic rings, rather than the traditional systemic governing equations. Numerical and experimental cases are conducted to assess the efficacy and precision of the proposed scaling laws, and the obtained results are compared with those achieved by traditional methods. The outcomes demonstrate that the scaling laws put forth by this study significantly enhance the predictive capabilities for deformations of elastic rings. 展开更多
关键词 rotor system AERO-ENGINE elastic ring scaling method supporting structure
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Design and Optimization of Bio-inspired Herringbone Textured Bearing for Turbocharger Using Artificial Intelligence Technique
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作者 Hara Prakash Mishra Suraj Kumar Behera 《Journal of Bionic Engineering》 2026年第1期354-379,共26页
Floating ring bearings are widely used in high-speed turbomachinery such as turbochargers and turbogenerators.Research-ers have recently explored various surface texturing strategies on the inner surface of floating r... Floating ring bearings are widely used in high-speed turbomachinery such as turbochargers and turbogenerators.Research-ers have recently explored various surface texturing strategies on the inner surface of floating rings to enhance bearing performance.In this study,the herring patterns are textured on the inner surface of the floating ring.This pattern is inspired by the secondary flight feathers of the Indian pigeon,which aid the bird in reducing viscous drag during flight.The result-ing Herringbone Textured Floating Ring Bearing(HTFRB)is investigated for its potential application in locomotive turbo-chargers.The HTFRB is numerically modeled using the Reynolds equation to evaluate the bearing's pressure distribution and static characteristics,including load-carrying capacity,power loss,and side leakage.Dynamic characteristics are determined by solving the zeroth-and first-order perturbed Reynolds equation.A Sobol sensitivity analysis is conducted to quantify the influence of groove parameters-helix angle,groove depth,groove width ratio,and number of grooves-on bearing performance metrics.An artificial intelligence-based optimization framework,integrating artificial neural networks and adaptive neuro-fuzzy inference systems,is developed to maximize load carrying capacity while minimiz-ing power loss,side leakage,and friction coefficient.The optimized texture parameters obtained from this framework are employed to validate the ANN model and evaluate the static and dynamic characteristics of the HTFRB.The dynamic coefficients of the HTFRB are further employed to evaluate the stability and robustness of the turbocharger rotor-HTFRB system.This study underscores the potential of combining bio-inspired texture design with numerical modeling and AI-based optimization to develop high-performance HTFRB. 展开更多
关键词 Floating ring bearing Surface texture Herringbone pattern Hydrodynamic lubrication Dynamic coefficient Stability analysis TURBOCHARGER Sobol sensitivity
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On the effect of axial separation in axis-offset collisions of vortex rings
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作者 Yuze WANG Xin CHEN +3 位作者 Bofu WANG Xiang QIU Yulu LIU Quan ZHOU 《Science China(Technological Sciences)》 2026年第2期114-126,共13页
This study examines the dynamics of axis-offset collisions between two vortex rings using particle image velocimetry(PIV)measurements.At a fixed Reynolds number,the influence of axial separation on the flow evolution ... This study examines the dynamics of axis-offset collisions between two vortex rings using particle image velocimetry(PIV)measurements.At a fixed Reynolds number,the influence of axial separation on the flow evolution is systematically investigated.Finite-time Lyapunov exponent(FTLE)fields and combined vorticity-velocity analyses reveal three distinct interaction regimes.(1)In the collision and radial outflow regime(H/R_(ring)0.893,where H is the axial separation distance and R_(ring)is the ring radius),vortex rings undergo axial compression and generate strong radial outflows,with negligible material exchange between oppositely signed vortices.(2)In the collision and rebound regime(H/R_(ring)=1.786),the rings—bearing the same sign—experience a near-elastic rebound,leading to disintegration without reconnection.(3)In the merging-splitting and recovery regime(H/R_(ring)=2.679),the rings exhibit transient merging followed by splitting and coherence recovery,accompanied by significant material exchange.For even larger offsets(H/R_(ring)=3.572),interactions are negligible.These findings categorize axis-offset vortex ring interactions into three regimes based on flow behavior and yield insights relevant to enhanced mixing and heat dissipation in engineering applications. 展开更多
关键词 vortex rings axis-offset collision vortex dynamics
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Effect of fluorination positions at diphenylamino flanking groups on the photovoltaic performance for nonfused ring electron acceptors
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作者 Yang Gao Huarui Zhang +7 位作者 Yan Xie Xinjun Xu Yahui Liu Hao Lu Wenkai Zhang Yuqiang Liu Cuihong Li Zhishan Bo 《Chinese Chemical Letters》 2026年第1期368-373,共6页
The fluorination strategy has been proven effective in significantly enhancing the photovoltaic performance of organic solar cells(OSCs) based on non-fused ring electron acceptors(NFREAs).However,research on the impac... The fluorination strategy has been proven effective in significantly enhancing the photovoltaic performance of organic solar cells(OSCs) based on non-fused ring electron acceptors(NFREAs).However,research on the impact of fluorination positions at side chains on NFREAs device performance remains scant.In this study,we introduce two isomeric NFREAs,designated as GA-2F-E and GA-2F,distinguished by their fluorination positions at the side chains.Both NFREAs share a thiophene[3,2-b]thiophene core,but their side chains differ:GA-2F-E features two(4-butylphenyl)-N-(4-fluorophenyl) amino groups,whereas GA-2F's side chains consist of bis(4-fluorophenyl)amino and bis(4-butylphenyl)amino groups attached to opposite sides of the core.To delve into the influence of fluorination positions on the optoelectronic properties,aggregation behavior,and overall efficiency of the acceptor molecules,a comprehensive investigation was conducted.The findings reveal that,despite similar photophysical properties and comparable absorption bandwidths,GA-2F-E,with fluorine atoms positioned on both sides of the molecular framework,demonstrates more compact π-π stacking,reduced bimolecular recombination,superior exciton transport,and a more balanced,higher mobility.As a result of these advantages,OSCs optimized with D18:GA-2F-E achieve a remarkable power conversion efficiency(PCE) of 16.45 %,surpassing the 15.83 %PCE of devices utilizing D18:GA-2F.This research underscores the potential of NFREAs in future applications and highlights the significance of fluorination positions in enhancing OSC performance,paving the way for the development of more efficient NFREAs. 展开更多
关键词 Organic solar cells Non-fused ring electron acceptors Fluorination position Diphenylamino groups Power conversion efficiencies
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Asymmetric Side‑Group Engineering of Nonfused Ring Electron Acceptors for High‑Efficiency Thick‑Film Organic Solar Cells
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作者 Dawei Li Nan Wei +11 位作者 Ya‑Nan Chen Xiaodong Wang Xu Han Ziqing Bian Xinyuan Zhang Zhe Zhang Wenkai Zhang Xinjun Xu Cuihong Li Yahui Liu Hao Lu Zhishan Bo 《Nano-Micro Letters》 2026年第3期227-239,共13页
A nonfused ring electron acceptor(NFREA),designated as TT-Ph-C6,has been synthesized with the aim of enhancing the power conversion efficiency(PCE)of organic solar cells(OSCs).By integrating asymmetric phenylalkylamin... A nonfused ring electron acceptor(NFREA),designated as TT-Ph-C6,has been synthesized with the aim of enhancing the power conversion efficiency(PCE)of organic solar cells(OSCs).By integrating asymmetric phenylalkylamino side groups,TT-Ph-C6 demonstrates excellent solubility and its crystal structure exhibits compact packing structures with a three-dimensional molecular stacking network.These structural attributes markedly promote exciton diffusion and charge carrier mobility,particularly advantageous for the fabrication of thick-film devices.TT-Ph-C6-based devices have attained a PCE of 18.01%at a film thickness of 100 nm,and even at a film thickness of 300 nm,the PCE remains at 14.64%,surpassing that of devices based on 2BTh-2F.These remarkable properties position TT-Ph-C6 as a highly promising NFREA material for boosting the efficiency of OSCs. 展开更多
关键词 Organic solar cells Nonfused ring electron acceptors ASYMMETRIC Power conversion efficiency
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RNF145 Promotes Hepatocellular Carcinoma Metastasis through Ubiquitination and Degradation of PCDH9
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作者 Huan Zhang Zhangwendi Xu +5 位作者 Yien Xu Mao Li Lingrui Liu Caiyun He Wenhuan Zhong Jiliang Qiu 《Oncology Research》 2026年第2期570-591,共22页
Objective:Ring finger protein 145(RNF145),an E3 ubiquitin ligase,is significantly upregulated in hepatocellular carcinoma(HCC).However,its role in HCC remains unknown.The study aimed to investigate the functions and u... Objective:Ring finger protein 145(RNF145),an E3 ubiquitin ligase,is significantly upregulated in hepatocellular carcinoma(HCC).However,its role in HCC remains unknown.The study aimed to investigate the functions and underlying mechanisms of RNF145 in HCC.Methods:The role of RNF145 in HCC was investigated using data from The Cancer Genome Atlas(TCGA)and in vitro experimental assays.Its oncogenic functions were assessed using the transwell migration assay and the wound-healing assay.The molecular mechanism was explored through protein immunoprecipitation and western blot analyses.Data from public databases were analyzed to correlate RNF145 expression with clinicopathological features.Univariate and multivariate Cox analyses established RNF145 as an independent prognostic factor.Subsequently,a prognostic nomogram was constructed.Results:RNF145 was upregulated in HCC.The expression level of RNF145 in HCC showed significant correlations with histological grade,pathological stage,and vascular invasion.Functionally,knockdown of RNF145 effectively abolished the migratory and invasive capacities of HCC cells.This pro-metastatic effect is mediated through the RNF145-driven ubiquitination and subsequent degradation of protocadherin 9(PCDH9).Conclusion:Our findings confirm the significant upregulation of RNF145 in HCC and promote metastasis by facilitating PCDH9 ubiquitination and degradation,highlighting its role as a prognostic biomarker and a potential therapeutic target. 展开更多
关键词 Ring finger protein 145(RNF145) protocadherin 9(PCDH9) hepatocellular carcinoma METASTASIS
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Cassiterite U-Pb dating of the Nasarawa lithium deposit,Central Nigeria
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作者 Gao-jie Liu Xiang-ping Chen +7 位作者 Peng-fei Wang Jian-qing Wang Yu-yu Tang Peng Hu Liang Cao Jun-sheng Jiang Binta Fatima Etsu Ji-kun Wang 《China Geology》 2026年第1期217-218,I0024,共3页
1.Objective Nigeria lies between the West African Craton and the Congo Craton,south of the Tuareg Shield(Ogunmola JK et al.,2015).The Nasarawa pegmatite field mainly comprises of the Precambrian Basement Complex(inclu... 1.Objective Nigeria lies between the West African Craton and the Congo Craton,south of the Tuareg Shield(Ogunmola JK et al.,2015).The Nasarawa pegmatite field mainly comprises of the Precambrian Basement Complex(including Archean-Proterozoic migmatite,gneiss,schists and Pan-African “Older Granites”),Mesozoic alkaline ring complexes(“Younger Granites”) and sedimentary basins(Yang QD et al.,2023;Fig.1a).“Older Granites” are part of the Pan-African mobile belt;“Younger Granites” has significant peralkaline characteristics.“Younger Granites” has a wide distribution in the north-central region of Nigeria,including areas such as Kano,Jos-Bauchi,Mada,and Nasarawa,and the emplacement age gradually decreases from north to south from 213 Ma(Dutse complex) to 141 Ma(Afu complex)(Amuda AK et al.,2021). 展开更多
关键词 peralkaline chara precambrian basement complex including west african craton congo cratonsouth alkaline ring complexes younger sedimentary basins yang nasarawa pegmatite field CASSITERITE
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Photoinduced skeletal editing of oxetanes:light-driven pathway connecting four-membered heterocycles and beyond
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作者 Ha Eun Kim Yoonsu Park 《Science Bulletin》 2026年第3期469-471,共3页
Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has... Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has depended on multi-step routes such as polar or radical cyclization,cycloadditions,and the manipulation of various functional groups to achieve ring formation or connection[1,2]. 展开更多
关键词 organic pharmaceutical synthesis cyclic moleculesthe design valuable heterocyclic compoundsfor OXETANES polar radical cyclizationcycloadditionsand ring formation connection stepwise transformation ofactivated functional groups photoinduced skeletal editing
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RNF213 Formed and Decorated Membrane-Based Structures in U-2 OS Cells
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作者 Toshiyuki Habu 《BIOCELL》 2026年第1期1-10,共10页
RING protein 213(RNF213),the susceptibility gene for Moyamoya disease(MMD),possesses two active AAA+ATPase(ATPases Associated with diverse cellular Activities)modules,a RING,and RNF213-ZNFX1 finger(RZ finger)domains.S... RING protein 213(RNF213),the susceptibility gene for Moyamoya disease(MMD),possesses two active AAA+ATPase(ATPases Associated with diverse cellular Activities)modules,a RING,and RNF213-ZNFX1 finger(RZ finger)domains.Several RNF213 variants have been reported in MMD patients,including the p.R4810K variant(rs112735431),which is a founder polymorphism associated with MMDin EastAsia.To elucidate the function of RNF213 and its variant,we investigated the localization of RNF213 and the R4810K variant in this study.RNF213 induced circular hole structures near the nucleus,similar to lipid droplets(LDs),in U-2 OS cells.The holes decorated with tagged RNF213 protein were colocalized with mCherry-RAB5A and mCherry-peroxisome,but not mCherry-RAB9A and other organelles.RNF213 decorated the holes,and the structures were growing and changing to cylindrical objects,but not the R4810K variant efficiently.Furthermore,both AAA+ATPase modules and the ubiquitin ligase domain of RNF213 were required for the formation of the hole structures and cylindrical objects.These findings suggest that RNF213 activity may be involved in the formation of organelle-like structures,and this structure formation by RNF213 may be responsible for vascular functions. 展开更多
关键词 RING protein 213(RNF213) cellular localization Moyamoya disease(MMD)disease-associated variation
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利用重磁资料研究Vøring盆地断裂构造与油气远景
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作者 殷睿 张春灌 +1 位作者 袁炳强 胡洪川 《海洋地质前沿》 北大核心 2025年第5期43-54,共12页
挪威中部近海的Vøring盆地油气地质条件良好,为了深入了解该区的断裂构造特征和油气勘探潜力,系统整理了现有的重磁数据。使用变纬度化极技术消除跨纬度变化对于磁力数据的影响,并运用位场边缘识别技术提取本区位场边缘识别信息。... 挪威中部近海的Vøring盆地油气地质条件良好,为了深入了解该区的断裂构造特征和油气勘探潜力,系统整理了现有的重磁数据。使用变纬度化极技术消除跨纬度变化对于磁力数据的影响,并运用位场边缘识别技术提取本区位场边缘识别信息。综合已有地质和地球物理认识,对研究区的重磁异常特征进行系统分析,确定了Vøring盆地的断裂构造特征,划分了油气勘探有利区。研究结果表明,Vøring盆地内次级断裂走向复杂,有NE、近SN向2组主要断裂,同时多被沿NW和近EW向发育的2组断裂切断。盆地还发育有4条大的边界断裂(F1—F4),这些断裂控制了本区次级构造的发育。在Vøring盆地内圈定了油气勘探有利区,在重力垂向二阶导数异常图上反映为异常幅值高、异常梯度变化大、有断裂控制的异常带及其侧翼。 展开更多
关键词 挪威 Vøring盆地 重磁异常 断裂构造 勘探有利区
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低氧抑制精子纤毛微管稳定性致精子发生障碍的分子机制研究
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作者 王潇 张梦洁 +2 位作者 邓芳 殷骏 倪兵 《陆军军医大学学报》 北大核心 2025年第10期1059-1068,共10页
目的旨在探讨低氧环境对精细胞分化及精子纤毛微管稳定性的影响及其分子机制,以明确低氧条件对雄性生殖功能的潜在危害。方法采用48只8周龄SPF级健康雄性SD大鼠(体质量300~399 g),由陆军军医大学实验动物研究所提供。大鼠实验设计如下:... 目的旨在探讨低氧环境对精细胞分化及精子纤毛微管稳定性的影响及其分子机制,以明确低氧条件对雄性生殖功能的潜在危害。方法采用48只8周龄SPF级健康雄性SD大鼠(体质量300~399 g),由陆军军医大学实验动物研究所提供。大鼠实验设计如下:①氧浓度梯度实验:设置21%常氧对照、13.5%、11.8%、10.4%氧浓度,分别模拟海拔3500、4500、5500 m低氧环境,持续暴露2个月,每组样本量为6只;②氧暴露时间梯度实验:在10.4%氧浓度下暴露0、0.5、1.0、2.0个月,每组样本量为6只。采用流式分选技术分离圆形精细胞,并采用以下方法测量相关指标:①转录组测序,分析低氧胁迫下精子分化障碍及纤毛结构异常的基因表达谱变化;②Western blot,检测关键蛋白CEP290、RING 1A、H2AK119ub的表达水平;②荧光漂白恢复技术(fluorescence recovery after photobleaching/FRAP),监测微管组装动力学,评估低氧对微管稳定性的即时影响。结果实验结果显示,在氧浓度梯度实验中,10.4%氧浓度暴露2个月后,大鼠睾丸生精小管中精原细胞、次级精母细胞及圆形精细胞的比例显著增加(P<0.05),分别为21%常氧组的(1.33±0.04)倍、(1.06±0.01)倍、(1.60±0.02)倍;而初级精母细胞和长形精细胞的比例显著降低(P<0.05),分别为21%常氧组的(0.89±0.01)倍、(0.88±0.0002)倍。这种变化呈现出明显的氧浓度依赖性。在时间梯度实验中,暴露于10.4%氧浓度0.5个月时,精原细胞、次级精母细胞及圆形精细胞的比例开始增加(P<0.05),分别为0个月对照组的(1.11±0.03)倍、(1.04±0.01)倍、(1.29±0.003)倍;而初级精母细胞和长形精细胞的比例在暴露1个月后开始显著降低(P<0.05),分别为0个月对照组的(0.94±0.03)倍、(0.95±0.008)倍。暴露于10.4%氧浓度2个月的大鼠,其附睾内精子尾部畸形率显著增加(P<0.0001),畸形率从21%常氧组的(12.1±1.7)%上升至(30.8±3.7)%。精母细胞系G2暴露于1%低氧环境中24 h后,FRAP显示微管组装速率降低,微管动态不稳定性增加,荧光恢复最大值从21%常氧组的(0.37±0.02)倍下降至(0.29±0.01)倍。转录组测序结果显示,低氧环境下纤毛基体关键分子CEP290的转录水平上调,上调倍数为21%常氧组的(1.81±0.11)倍;而PRC1复合体成员RING 1A、RING 1B、CBX2、PHC1及PCGF1的表达水平下调,分别为21%常氧组的(0.74±0.02)倍、(0.73±0.01)倍、(0.78±0.02)倍、(0.71±0.01)倍、(0.86±0.03)倍。Western blot验证结果显示,CEP290蛋白表达水平在低氧组上调,RING 1A蛋白表达水平下调。ChIPqPCR实验显示,RING 1A及其产物H2AK119ub在CEP290启动子区的结合显著减少(P<0.0001),结合强度分别为21%常氧组的(0.38±0.02)倍、(0.52±0.06)倍。而在siRING 1A组G2细胞中,H2AK119ub在CEP290启动子区的结合显著减少(P<0.0001),结合强度为对照组的(0.74±0.06)倍,同时CEP290 mRNA水平显著上升(P<0.0001),上调倍数为(3.35±0.37)倍。结论低氧环境通过RING 1AH2AK119ub-CEP290信号轴抑制精子纤毛微管稳定性,影响精细胞分化,导致精子发生障碍。 展开更多
关键词 低氧 精子生成 纤毛 微管稳定性 RING 1A
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面向智算中心光网络的Ring Allreduce业务算网协同部署算法研究 被引量:1
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作者 黄婷婷 袁志林 +1 位作者 翟德伟 李泳成 《电信科学》 北大核心 2025年第4期44-52,共9页
随着人工智能大模型训练与推理业务的快速发展,智算中心面临算网协同调度的新挑战。为优化分布式智算Ring Allreduce业务的部署问题,首先,通过扩展传统波平面,开发了算力波平面技术,实现了算力与网络资源的一体化虚拟管理。然后,基于算... 随着人工智能大模型训练与推理业务的快速发展,智算中心面临算网协同调度的新挑战。为优化分布式智算Ring Allreduce业务的部署问题,首先,通过扩展传统波平面,开发了算力波平面技术,实现了算力与网络资源的一体化虚拟管理。然后,基于算力波平面,提出了一种高效路由、波长、算力和时隙分配(routing,wavelength,computing power and time slot assignment,RWCTA)算法用于环规约(Ring Allreduce)业务部署。仿真结果表明,与传统基于波平面的部署算法相比,基于算力波平面的RWCTA算法能有效降低62.4%的总业务完成时间和54.5%的平均业务计算时间。 展开更多
关键词 智算中心光网络 算网协同 Ring Allreduce业务 路由、波长、算力和时隙分配 算力波平面
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Late spring-early summer drought and soil properties jointly modulate two pine species?decline and climatic sensitivity in temperate Northern China 被引量:1
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作者 Yuheng Li Zhaofei Fan +10 位作者 Lihong Xu Xiao Zhang Zhongjie Shi Xiaohui Yang Wei Xiong Ling Cong Semyun Kwon Leilei Pan f Hanzhi Li Shuo Wen Xiaoyan Shang 《Forest Ecosystems》 2025年第1期146-158,共13页
Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts o... Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree species.The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species.This study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris var.mongolica(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern China.Using a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry sites.We reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate relationships.Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships.However,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate relationship.Lower clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth.Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables.Considering the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at drier sites with lower clayed soil or higher nutrient regimes. 展开更多
关键词 Tree rings Climate sensitivity Growth decline Global warming DROUGHT Soil property
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Comprehensive evaluation of the vector magnetic field data from Macao Science Satellite-1A 被引量:1
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作者 XinYi Rang Chao Xiong +7 位作者 YuYang Huang ChunYu Xu FengJue Wang BoHao Qian Fan Yin SiShan Song Keke Zhang PengFei Liu 《Earth and Planetary Physics》 2025年第3期521-531,共11页
In this study,we present a comprehensive evaluation of the magnetic field measurements from the Vector Field Magnetometer(VFM)aboard the recently launched Macao Science Satellite-1(MSS-1).One-year data from November 2... In this study,we present a comprehensive evaluation of the magnetic field measurements from the Vector Field Magnetometer(VFM)aboard the recently launched Macao Science Satellite-1(MSS-1).One-year data from November 2,2023,to November 1,2024,are considered.The MSS-1 flies with a low inclination(41°)and is designed to provide high-resolution magnetic field measurements,especially for monitoring the evolution of the South Atlantic Anomaly.Earlier studies confirmed the possibility of using MSS-1A data to model the Earth’s main magnetic field(e.g.,Jiang Y et al.,2024).Therefore,in this study we focus on the magnetic signatures related to the external field,which are primarily associated with magnetospheric and ionospheric currents.The global distributions of the magnetic residuals from MSS-1A show a pattern consistent with that derived from the European Space Agency’s Swarm A satellite.A statistical survey of the conjugated observations(withΔt<5 min andΔR<150 km)between the two satellites showed that the difference between their magnetic residuals is within±3 nanoteslas.By separating the magnetic residuals at the noon and midnight hours,we see that the MSS-1A data can effectively capture features of the magnetospheric and ionospheric currents,such as the magnetospheric ring current and ionospheric equatorial electrojet.Moreover,the magnetic residuals from MSS-1A show a diamagnetic effect caused by post-sunset equatorial plasma bubbles,which also suggests that the MSS-1A data have the potential to reveal the ionospheric structures.The comprehensive evaluations performed within this study demonstrate that the MSS-1A provides high-quality magnetic field data reaching the level of the Swarm satellite,which enables a deeper understanding of the modeling of Earth’s magnetic field as well as monitoring of the magnetic environment. 展开更多
关键词 MSS satellite magnetic field residuals ring current equatorial electrojet diamagnetic effect
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Finite element analysis and experimental study on the sealing performance of low-phenyl silicone rubber sealing rings 被引量:1
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作者 Ming Gao Dongkai Li +6 位作者 Kun Liu Shuliang Xu Feng Zhao Ben Guo Anhui Pan Xiao Xie Huanre Han 《Railway Sciences》 2025年第1期123-137,共15页
Purpose–The brake pipe system was an essential braking component of the railway freight trains,but the existing E-type sealing rings had problems such as insufficient low-temperature resistance,poor heat stability an... Purpose–The brake pipe system was an essential braking component of the railway freight trains,but the existing E-type sealing rings had problems such as insufficient low-temperature resistance,poor heat stability and short service life.To address these issues,low-phenyl silicone rubber was prepared and tested,and the finite element analysis and experimental studies on the sealing performance of its sealing rings were carried out.Design/methodology/approach–The low-temperature resistance and thermal stability of the prepared lowphenyl silicone rubber were studied using low-temperature tensile testing,differential scanning calorimetry,dynamic thermomechanical analysis and thermogravimetric analysis.The sealing performance of the lowphenyl silicone rubber sealing ring was studied by using finite element analysis software abaqus and experiments.Findings–The prepared low-phenyl silicone rubber sealing ring possessed excellent low-temperature resistance and thermal stability.According to the finite element analysis results,the finish of the flange sealing surface and groove outer edge should be ensured,and extrusion damage should be avoided.The sealing rings were more susceptible to damage in high compression ratio and/or low-temperature environments.When the sealing effect was ensured,a small compression ratio should be selected,and rubbers with hardness and elasticity less affected by temperature should be selected.The prepared low-phenyl silicone rubber sealing ring had zero leakage at both room temperature(RT)and�508C.Originality/value–The innovation of this study is that it provides valuable data and experience for the future development of the sealing rings used in the brake pipe flange joints of the railway freight cars in China. 展开更多
关键词 Low-phenyl silicone rubber Sealing ring Sealing performance Finite element analysis LEAKAGE
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Towards a blank design method for manufacturing big-tapered profiled ring disk by spinning-rolling process 被引量:1
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作者 Xuechao LI Lianggang GUO +1 位作者 Xiaoqing CHEN Heng LI 《Chinese Journal of Aeronautics》 2025年第1期70-86,共17页
The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien... The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process. 展开更多
关键词 Blank design method Spinning-rolling process Big-tapered profiled ring disk Rolling ratio Intelligent FE simulation
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