Background:Visual-spatial neglect(VSN)is a neuropsychological syndrome,and right-hemisphere stroke is the most common cause.The pathogenetic mechanism of VSN remains unclear.This study aimed to investigate the behavio...Background:Visual-spatial neglect(VSN)is a neuropsychological syndrome,and right-hemisphere stroke is the most common cause.The pathogenetic mechanism of VSN remains unclear.This study aimed to investigate the behavioral and event-related potential(ERP)changes in patients with or without VSN after right-hemisphere stroke.Methods:Eleven patients with VSN with right-hemisphere stroke(VSN group)and 11 patients with non-VSN with righthemisphere stroke(non-VSN group)were recruited along with one control group of 11 age-and gender-matched healthy participants.The visual-spatial function was evaluated using behavioral tests,and ERP examinations were performed.Results:The response times in the VSN and non-VSN groups were both prolonged compared with those of normal controls(P<0.001).In response to either valid or invalid cues in the left side,the accuracy in the VSN group was lower than that in the non-VSN group(P<0.001),and the accuracy in the non-VSN group was lower than that in controls(P<0.05).The P1 latency in the VSN group was significantly longer than that in the control group(F[2,30]=5.494,P=0.009),and the N1 amplitude in the VSN group was significantly lower than that in the control group(F[2,30]=4.343,P=0.022).When responding to right targets,the lefthemisphere P300 amplitude in the VSN group was significantly lower than that in the control group(F[2,30]=4.255,P=0.025).With either left or right stimuli,the bilateral-hemisphere P300 latencies in the VSN and non-VSN groups were both significantly prolonged(all P<0.05),while the P300 latency did not differ significantly between the VSN and non-VSN groups(all P>0.05).Conclusions:Visual-spatial attention function is impaired after right-hemisphere stroke,and clinicians should be aware of the subclinical VSN.Our findings provide neuroelectrophysiological evidence for the lateralization of VSN.展开更多
文摘Background:Visual-spatial neglect(VSN)is a neuropsychological syndrome,and right-hemisphere stroke is the most common cause.The pathogenetic mechanism of VSN remains unclear.This study aimed to investigate the behavioral and event-related potential(ERP)changes in patients with or without VSN after right-hemisphere stroke.Methods:Eleven patients with VSN with right-hemisphere stroke(VSN group)and 11 patients with non-VSN with righthemisphere stroke(non-VSN group)were recruited along with one control group of 11 age-and gender-matched healthy participants.The visual-spatial function was evaluated using behavioral tests,and ERP examinations were performed.Results:The response times in the VSN and non-VSN groups were both prolonged compared with those of normal controls(P<0.001).In response to either valid or invalid cues in the left side,the accuracy in the VSN group was lower than that in the non-VSN group(P<0.001),and the accuracy in the non-VSN group was lower than that in controls(P<0.05).The P1 latency in the VSN group was significantly longer than that in the control group(F[2,30]=5.494,P=0.009),and the N1 amplitude in the VSN group was significantly lower than that in the control group(F[2,30]=4.343,P=0.022).When responding to right targets,the lefthemisphere P300 amplitude in the VSN group was significantly lower than that in the control group(F[2,30]=4.255,P=0.025).With either left or right stimuli,the bilateral-hemisphere P300 latencies in the VSN and non-VSN groups were both significantly prolonged(all P<0.05),while the P300 latency did not differ significantly between the VSN and non-VSN groups(all P>0.05).Conclusions:Visual-spatial attention function is impaired after right-hemisphere stroke,and clinicians should be aware of the subclinical VSN.Our findings provide neuroelectrophysiological evidence for the lateralization of VSN.
