Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen...Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.展开更多
In this paper,we focus on the channel estimation for multi-user MIMO-OFDM systems in rich scattering environments.We find that channel sparsity in the delay-angle domain is severely compromised in rich scattering envi...In this paper,we focus on the channel estimation for multi-user MIMO-OFDM systems in rich scattering environments.We find that channel sparsity in the delay-angle domain is severely compromised in rich scattering environments,so that most existing compressed sensing(CS)based techniques can harvest a very limited gain(if any)in reducing the channel estimation overhead.To address the problem,we propose the learning-based turbo message passing(LTMP)algorithm.Instead of exploiting the channel sparsity,LTMP is able to efficiently extract the channel feature via deep learning as well as to exploit the channel continuity in the frequency domain via block-wise linear modelling.More specifically,as a component of LTMP,we develop a multi-scale parallel dilated convolutional neural network(MPDCNN),which leverages frequency-space channel correlation in different scales for channel denoising.We evaluate the LTMP’s performance in MIMO-OFDM channels using the 3rd generation partnership project(3GPP)clustered delay line(CDL)channel models.Simulation results show that the proposed channel estimation method has more than 5 dB power gain than the existing algorithms when the normalized mean-square error of the channel estimation is-20 dB.The proposed algorithm also exhibits strong robustness in various environments.展开更多
Determining the pattern and mechanisms of species richness distribution at large spatial scales has been one of the core objectives in the field of ecology and biogeography.Although climate and soil effects on terrest...Determining the pattern and mechanisms of species richness distribution at large spatial scales has been one of the core objectives in the field of ecology and biogeography.Although climate and soil effects on terrestrial ecosystems are well-documented,largescale patterns in wetlands are poorly understood due to their unique hydrological processes and vegetation types.Here,we explored the pattern of plant species richness of Carex-dominated wetlands and its influencing mechanism in China based on a national field vegetation survey at 120 sites.Results showed that the community type and plant species richness of Carex-dominated wetlands differed significantly among different climate zones in China.The hierarchical partitioning analysis showed that community type and environmental context(spatial location,water regime,climate and soil conditions)together explained 41%of the variations in plant species richness,and community type had the greatest influence on species richness.Partial Least Squares Path Modeling result showed that plant species richness was directly affected by community type,climate factors,soil properties and water regime.Soil properties and water regime also indirectly affected plant species richness by directly affecting community type.These findings help us understand the pattern of plant diversity distribution in wetlands at large spatial scales and design effective conservation strategies for these valuable sedge meadow wetlands in a changing environment.展开更多
Mullite-silica rich glass(MSRG)composites are a more efficient material than chamotte for industrial utilization of clay in refractory applications.The properties of the MSRG composites depend on the amount and compos...Mullite-silica rich glass(MSRG)composites are a more efficient material than chamotte for industrial utilization of clay in refractory applications.The properties of the MSRG composites depend on the amount and composition of the mulite and glass phases,which are related to the chemical composition of the MSRG composites based on clay.In the present work,the relationship between the phase and the chemical composition of the MSRG composites,and the effects of the chemical composition of the glass phase on the viscosity and coefficient of thermal expansion(CTE)of the glass phase were discussed on the basis of the measurements on 17 MSRG composite samples produced from clay.It is found that the Al_(2)O_(3)/SiO_(2) ratio(AS ratio)in clay strongly affects the amount of the mullite and glass phases in the MSRG composites,and the distributions of SiO_(2),TiO_(2)and Al_(2)O_(3) contents in the mullite and glass phases.With the increase of the A/S ratio of clay,the mullite content increases but the the glass phase content decreases in the MSRG composites.The viscosity and CTE of the glass phase depend on its A/S ratio and the amount of impurity oxides.When the A/S ratio in the glass phase is less than 0.15,the viscosity of the liquid formed by the melting of the glass phase at elevated temperatures rapidly increases with the decrease in the A/S ratio.The CTE of the glass phase depends on the contents of Si0_(2)and(K_(2)O+Na_(2)O).展开更多
The publisher regrets to inform that in the article of Advanced Powder Materials 4(2025)100261,the published Figs.3 and 5 belong to the initially submitted version,which should be replaced by the final version.The dif...The publisher regrets to inform that in the article of Advanced Powder Materials 4(2025)100261,the published Figs.3 and 5 belong to the initially submitted version,which should be replaced by the final version.The differences between the initial and final versions of these figures are described below.展开更多
BACKGROUND Pancreatic cancer tissues mainly consist of fibrotic and dense stroma,which limits their therapeutic efficacy.The stromal fibroblasts of pancreatic tumors frequently express the secreted protein acidic and ...BACKGROUND Pancreatic cancer tissues mainly consist of fibrotic and dense stroma,which limits their therapeutic efficacy.The stromal fibroblasts of pancreatic tumors frequently express the secreted protein acidic and rich in cysteine(SPARC).AIM To assess the impact of SPARC and its oncological relevance in patients undergoing pancreatic cancer resection.METHODS Ninety-one pancreatic ductal adenocarcinoma specimens were obtained from patients with curative resection between January 2009 and December 2015 as a retrospective study.SPARC expression patterns were analyzed using immunohistochemistry.Oncological outcomes were analyzed based on SPARC expression patterns.Oncological outcomes,based on SPARC expression,were analyzed in The Cancer Genome Atlas-Pancreatic Adenocarcinoma cohort(retrieved from a public database).RESULTS Patients with stromal SPARC expression(sSPARC+)had poorer overall survival than that in those without it(sSPARC-)(P=0.035).However,among patients who received adjuvant treatment,no difference was observed in survival between the sSPARC+and the sSPARC-groups(P=0.14).In The Cancer Genome Atlas-Pancreatic Adenocarcinoma samples,the high SPARC expression group exhibited noticeably lower overall survival than that in the low expression group(cutoff:14.1295,P=0.0222).Furthermore,SPARC expression was strongly correlated with the percentage the CD10+stromal component(R2=0.804,P<0.001).CONCLUSION Adjuvant chemotherapy improves survivals in sSPARC+pancreatic cancer patients,indicating suggesting sSPARC expression as a prognostic biomarker and potential indicator for neoadjuvant treatment planning.展开更多
Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis ...Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.展开更多
Vanadium redox flow battery(VRFB)exhibits a great potential for application in large-scale and long-term energy storage systems due to its high safety,longevity,and environmental friendliness.However,the poor electroc...Vanadium redox flow battery(VRFB)exhibits a great potential for application in large-scale and long-term energy storage systems due to its high safety,longevity,and environmental friendliness.However,the poor electrocatalytic activity of the pristine graphite felt electrode seriously hinders the energy density and efficiency of VRFB.To address the issue,in this work,the rich active site-NiMoO_(4)nanorods were used to in situ modify graphite felt for high-performance VRFB.The rod-to-diameter ratio and deposition of NiMoO_(4)were controlled by adjusting the ratio of water/ethanol and concentration of the precursor solution to obtain the optimal length of NiMoO_(4)nanorods uniformly deposited on the graphite felt surface.This abundant micropores,dual active sites of Mo-O-Ni,and additional oxygen vacancies effectively increase the specific surface area,the number of active sites,and the hydrophilicity for graphite felt,which boosts the charge transfer and mass transfer for VO^(2+)/VO_(2)^(+)and V^(3+)/V^(2+)redox reactions.The modified battery exhibits an energy efficiency of 71.1%at 150 mA·cm^(-2),which is 19.8%higher than the blank battery.Furthermore,the modified battery shows excellent stability during 100 cycles.This work will promote the development and application of binary metal oxides with rich active sites in VRFB.展开更多
BACKGROUND Lower limb atherosclerotic occlusive disease(LAOD)is a common complication in diabetic patients,leading to significant symptoms and reduced quality of life.AIM To investigate the efficacy of autologous plat...BACKGROUND Lower limb atherosclerotic occlusive disease(LAOD)is a common complication in diabetic patients,leading to significant symptoms and reduced quality of life.AIM To investigate the efficacy of autologous platelet-rich gel(APRG)as an innovative treatment for LAOD,focusing on clinical outcomes such as symptom relief,flow values,ankle-brachial index(ABI),walking distance,and claudication severity.METHODS This retrospective study involved an analysis of electronic medical records(EMR)from 150 patients diagnosed with LAOD.Participants were assigned to either a treatment group(n=80)or a control group(n=70).Both groups received standard care and underwent dressing changes.In addition,the treatment group was given APRG.Primary outcomes included changes in pain levels,wound healing rates,flow values assessed by plethysmography,ABI measurements,walking distance,and claudication severity.Statistical analyses were conducted to determine the significance of the results.RESULTS The APRG group showed significant improvements after 12 weeks,including a 70%reduction in pain,a 65%increase in wound healing rates,and an average walking distance increase of 150 meters.Flow values improved by 20%,with significant enhancements in ABI measurements(P<0.01).Additionally,patient satisfaction was higher,and 60%of patients reported improved claudication severity,confirming the efficacy of APRG in enhancing clinical outcomes for lower LAOD.CONCLUSION The APRG demonstrates significant efficacy in managing LAOD in diabetic patients,improving key clinical parameters including flow values,ABI,walking distance,and claudication.These findings support the need for further prospective studies to validate long-term efficacy and optimize treatment strategies.展开更多
BACKGROUND Incisional hernias are a common complication of previous surgeries and remain a persistent issue in clinical practice,posing a significant burden on healthcare systems despite advances in education and tech...BACKGROUND Incisional hernias are a common complication of previous surgeries and remain a persistent issue in clinical practice,posing a significant burden on healthcare systems despite advances in education and technology.Surgical techniques,primarily involving the use of mesh to cover the abdominal wall gap,are widely used as a standard intervention strategy.AIM To examine the regeneration of the aponeurosis defect in the anterior abdominal wall in rats using regenerative mimetic factors of the extracellular matrix[ReGeneraTing Agent(RGTA)],adipose tissue micrografts(ATM),and platelet rich plasma(PRP)as regenerative agents.METHODS Regenerative agents such as RGTA,ATM,and PRP are gaining popularity.ATM involves autologous adipose tissue cells with mesenchymal stem cell markers and a high percentage of stromal vascular fraction cells.RGTAs are heparan sulfate(HS)mimetics that replace degraded HSs in damaged tissue,enhancing the quality and speed of repair.PRP is a concentrated plasma preparation containing seven fundamental proteins responsible for tissue production.An acellular dermal matrix is a biological implant free of cellular or antigenic components,making it an excellent material for reconstructive surgery.Polyglactin is a synthetic,absorbable mesh that loses 50%of its strength after fourteen days,providing initial support for new tissue regeneration before being completely absorbed.RESULTS Rats will undergo a laparotomy with a precise 2 cm by 2 cm excision of the anterior abdominal wall fascia below the umbilicus.They will be divided into sixteen groups,each receiving different combinations of regenerative factor injections into the denervated area in both non-contaminated and contaminated environments.A collagenelastin matrix will be used to join the aponeurosis edges,with an absorbable polyglactin mesh anchored over it.Samples will be taken for macroscopic,histological,and immunohistochemical evaluation of tissue regeneration.CONCLUSION Our study aims to demonstrate how these factors promote cell proliferation and healing of the denervated anterior abdominal wall,potentially reducing the frequency and complications of incisional hernias.This approach could offer a more economical and efficient treatment option compared to current costly methods.展开更多
基金supported by the National Key Research and Development Program of China(2023YFF0805602)National Natural Science Foundation of China(32225032,32001192,32271597)+1 种基金the Innovation Base Project of Gansu Province(2021YFF0703904)the Science and Technology Program of Gansu Province(24JRRA515,22JR5RA525,23JRRA1157).
文摘Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.
基金supported in part by the National Key Research and Development Program of China under Grant 2020YFB1804800.
文摘In this paper,we focus on the channel estimation for multi-user MIMO-OFDM systems in rich scattering environments.We find that channel sparsity in the delay-angle domain is severely compromised in rich scattering environments,so that most existing compressed sensing(CS)based techniques can harvest a very limited gain(if any)in reducing the channel estimation overhead.To address the problem,we propose the learning-based turbo message passing(LTMP)algorithm.Instead of exploiting the channel sparsity,LTMP is able to efficiently extract the channel feature via deep learning as well as to exploit the channel continuity in the frequency domain via block-wise linear modelling.More specifically,as a component of LTMP,we develop a multi-scale parallel dilated convolutional neural network(MPDCNN),which leverages frequency-space channel correlation in different scales for channel denoising.We evaluate the LTMP’s performance in MIMO-OFDM channels using the 3rd generation partnership project(3GPP)clustered delay line(CDL)channel models.Simulation results show that the proposed channel estimation method has more than 5 dB power gain than the existing algorithms when the normalized mean-square error of the channel estimation is-20 dB.The proposed algorithm also exhibits strong robustness in various environments.
基金Under the auspices of National Key Research and Development Program of China(No.2023YFF1305800)National Natural Science Foundation of China(No.42494820,U23A2004,42077070)Youth Innovation Promotion Association Chinese Academy of Sciences(No.2019234,2020237)。
文摘Determining the pattern and mechanisms of species richness distribution at large spatial scales has been one of the core objectives in the field of ecology and biogeography.Although climate and soil effects on terrestrial ecosystems are well-documented,largescale patterns in wetlands are poorly understood due to their unique hydrological processes and vegetation types.Here,we explored the pattern of plant species richness of Carex-dominated wetlands and its influencing mechanism in China based on a national field vegetation survey at 120 sites.Results showed that the community type and plant species richness of Carex-dominated wetlands differed significantly among different climate zones in China.The hierarchical partitioning analysis showed that community type and environmental context(spatial location,water regime,climate and soil conditions)together explained 41%of the variations in plant species richness,and community type had the greatest influence on species richness.Partial Least Squares Path Modeling result showed that plant species richness was directly affected by community type,climate factors,soil properties and water regime.Soil properties and water regime also indirectly affected plant species richness by directly affecting community type.These findings help us understand the pattern of plant diversity distribution in wetlands at large spatial scales and design effective conservation strategies for these valuable sedge meadow wetlands in a changing environment.
基金Research Project of Hubei Provincial Department of Science and Technology(Grant no.2024CSA075)Key Project of the National Natural Science Foundation of China(Grant No.U21A2058)for fnancially supporting this work.
文摘Mullite-silica rich glass(MSRG)composites are a more efficient material than chamotte for industrial utilization of clay in refractory applications.The properties of the MSRG composites depend on the amount and composition of the mulite and glass phases,which are related to the chemical composition of the MSRG composites based on clay.In the present work,the relationship between the phase and the chemical composition of the MSRG composites,and the effects of the chemical composition of the glass phase on the viscosity and coefficient of thermal expansion(CTE)of the glass phase were discussed on the basis of the measurements on 17 MSRG composite samples produced from clay.It is found that the Al_(2)O_(3)/SiO_(2) ratio(AS ratio)in clay strongly affects the amount of the mullite and glass phases in the MSRG composites,and the distributions of SiO_(2),TiO_(2)and Al_(2)O_(3) contents in the mullite and glass phases.With the increase of the A/S ratio of clay,the mullite content increases but the the glass phase content decreases in the MSRG composites.The viscosity and CTE of the glass phase depend on its A/S ratio and the amount of impurity oxides.When the A/S ratio in the glass phase is less than 0.15,the viscosity of the liquid formed by the melting of the glass phase at elevated temperatures rapidly increases with the decrease in the A/S ratio.The CTE of the glass phase depends on the contents of Si0_(2)and(K_(2)O+Na_(2)O).
文摘The publisher regrets to inform that in the article of Advanced Powder Materials 4(2025)100261,the published Figs.3 and 5 belong to the initially submitted version,which should be replaced by the final version.The differences between the initial and final versions of these figures are described below.
基金Supported by Faculty Research Grant from Yonsei University College of Medicine,No.6-2017-0155.
文摘BACKGROUND Pancreatic cancer tissues mainly consist of fibrotic and dense stroma,which limits their therapeutic efficacy.The stromal fibroblasts of pancreatic tumors frequently express the secreted protein acidic and rich in cysteine(SPARC).AIM To assess the impact of SPARC and its oncological relevance in patients undergoing pancreatic cancer resection.METHODS Ninety-one pancreatic ductal adenocarcinoma specimens were obtained from patients with curative resection between January 2009 and December 2015 as a retrospective study.SPARC expression patterns were analyzed using immunohistochemistry.Oncological outcomes were analyzed based on SPARC expression patterns.Oncological outcomes,based on SPARC expression,were analyzed in The Cancer Genome Atlas-Pancreatic Adenocarcinoma cohort(retrieved from a public database).RESULTS Patients with stromal SPARC expression(sSPARC+)had poorer overall survival than that in those without it(sSPARC-)(P=0.035).However,among patients who received adjuvant treatment,no difference was observed in survival between the sSPARC+and the sSPARC-groups(P=0.14).In The Cancer Genome Atlas-Pancreatic Adenocarcinoma samples,the high SPARC expression group exhibited noticeably lower overall survival than that in the low expression group(cutoff:14.1295,P=0.0222).Furthermore,SPARC expression was strongly correlated with the percentage the CD10+stromal component(R2=0.804,P<0.001).CONCLUSION Adjuvant chemotherapy improves survivals in sSPARC+pancreatic cancer patients,indicating suggesting sSPARC expression as a prognostic biomarker and potential indicator for neoadjuvant treatment planning.
文摘Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.
基金financially supported by National Natural Science Foundation of China(Nos.51872090 and 51772097)Hebei Natural Science Fund for Distinguished Young Scholar(No.E2019209433)+4 种基金Youth Talent Program of Hebei Provincial Education Department(No.BJ2018020)Natural Science Foundation of Hebei Province(Nos.E2020209151 and E2024209029)National Key R&D Plan Project(No.2022YFB4200305)Research Projects of CNPC(Nos.2024ZG50 and 2023DQ03-04)Innovation Capacity Enhancement Projects of Hebei Province(No.22567608H)
文摘Vanadium redox flow battery(VRFB)exhibits a great potential for application in large-scale and long-term energy storage systems due to its high safety,longevity,and environmental friendliness.However,the poor electrocatalytic activity of the pristine graphite felt electrode seriously hinders the energy density and efficiency of VRFB.To address the issue,in this work,the rich active site-NiMoO_(4)nanorods were used to in situ modify graphite felt for high-performance VRFB.The rod-to-diameter ratio and deposition of NiMoO_(4)were controlled by adjusting the ratio of water/ethanol and concentration of the precursor solution to obtain the optimal length of NiMoO_(4)nanorods uniformly deposited on the graphite felt surface.This abundant micropores,dual active sites of Mo-O-Ni,and additional oxygen vacancies effectively increase the specific surface area,the number of active sites,and the hydrophilicity for graphite felt,which boosts the charge transfer and mass transfer for VO^(2+)/VO_(2)^(+)and V^(3+)/V^(2+)redox reactions.The modified battery exhibits an energy efficiency of 71.1%at 150 mA·cm^(-2),which is 19.8%higher than the blank battery.Furthermore,the modified battery shows excellent stability during 100 cycles.This work will promote the development and application of binary metal oxides with rich active sites in VRFB.
文摘BACKGROUND Lower limb atherosclerotic occlusive disease(LAOD)is a common complication in diabetic patients,leading to significant symptoms and reduced quality of life.AIM To investigate the efficacy of autologous platelet-rich gel(APRG)as an innovative treatment for LAOD,focusing on clinical outcomes such as symptom relief,flow values,ankle-brachial index(ABI),walking distance,and claudication severity.METHODS This retrospective study involved an analysis of electronic medical records(EMR)from 150 patients diagnosed with LAOD.Participants were assigned to either a treatment group(n=80)or a control group(n=70).Both groups received standard care and underwent dressing changes.In addition,the treatment group was given APRG.Primary outcomes included changes in pain levels,wound healing rates,flow values assessed by plethysmography,ABI measurements,walking distance,and claudication severity.Statistical analyses were conducted to determine the significance of the results.RESULTS The APRG group showed significant improvements after 12 weeks,including a 70%reduction in pain,a 65%increase in wound healing rates,and an average walking distance increase of 150 meters.Flow values improved by 20%,with significant enhancements in ABI measurements(P<0.01).Additionally,patient satisfaction was higher,and 60%of patients reported improved claudication severity,confirming the efficacy of APRG in enhancing clinical outcomes for lower LAOD.CONCLUSION The APRG demonstrates significant efficacy in managing LAOD in diabetic patients,improving key clinical parameters including flow values,ABI,walking distance,and claudication.These findings support the need for further prospective studies to validate long-term efficacy and optimize treatment strategies.
文摘BACKGROUND Incisional hernias are a common complication of previous surgeries and remain a persistent issue in clinical practice,posing a significant burden on healthcare systems despite advances in education and technology.Surgical techniques,primarily involving the use of mesh to cover the abdominal wall gap,are widely used as a standard intervention strategy.AIM To examine the regeneration of the aponeurosis defect in the anterior abdominal wall in rats using regenerative mimetic factors of the extracellular matrix[ReGeneraTing Agent(RGTA)],adipose tissue micrografts(ATM),and platelet rich plasma(PRP)as regenerative agents.METHODS Regenerative agents such as RGTA,ATM,and PRP are gaining popularity.ATM involves autologous adipose tissue cells with mesenchymal stem cell markers and a high percentage of stromal vascular fraction cells.RGTAs are heparan sulfate(HS)mimetics that replace degraded HSs in damaged tissue,enhancing the quality and speed of repair.PRP is a concentrated plasma preparation containing seven fundamental proteins responsible for tissue production.An acellular dermal matrix is a biological implant free of cellular or antigenic components,making it an excellent material for reconstructive surgery.Polyglactin is a synthetic,absorbable mesh that loses 50%of its strength after fourteen days,providing initial support for new tissue regeneration before being completely absorbed.RESULTS Rats will undergo a laparotomy with a precise 2 cm by 2 cm excision of the anterior abdominal wall fascia below the umbilicus.They will be divided into sixteen groups,each receiving different combinations of regenerative factor injections into the denervated area in both non-contaminated and contaminated environments.A collagenelastin matrix will be used to join the aponeurosis edges,with an absorbable polyglactin mesh anchored over it.Samples will be taken for macroscopic,histological,and immunohistochemical evaluation of tissue regeneration.CONCLUSION Our study aims to demonstrate how these factors promote cell proliferation and healing of the denervated anterior abdominal wall,potentially reducing the frequency and complications of incisional hernias.This approach could offer a more economical and efficient treatment option compared to current costly methods.
