OBJECTIVE:To explore the correlation between acupuncture treatment for allergic rhinitis(AR) and hypothalamic-pituitary-adrenal(HPA) axis regulation by investigating changes in serum immune factors,HPA axis-associated...OBJECTIVE:To explore the correlation between acupuncture treatment for allergic rhinitis(AR) and hypothalamic-pituitary-adrenal(HPA) axis regulation by investigating changes in serum immune factors,HPA axis-associated hormone levels,activation levels of paraventricular nucleus(PVN) neurons,and the severity of nasal mucosal lesions,in rats with AR before and after acupuncture treatment.METHODS:After establishing the AR rat model,ovalbumin was administered via nasal drip to all groups except the blank control.Each group received continuous treatment for 14 d:the acupuncture,acupuncture + RU-486(mifepristone),and RU-486 groups received acupuncture only,RU486 intraperitoneal injection and acupuncture,and RU-486 intraperitoneal injection only,respectively.Following the intervention period,behavioral scoring was performed on all AR rats,and peripheral blood,nasal mucosa samples,and brains tissue(containing PVN region) were obtained following euthanization.Interleukin(IL-4,IL-5,IL-13),interferon gamma(IFN-γ),corticosterone(CORT),and corticotrophin-releasing hormone(CRH) levels were evaluated in peripheral blood samples.Adrenocorticotropic hormone(ACTH) levels were determined using an enzyme-linked immunoassay assay,and hematoxylin and eosin staining was performed on the nasal mucosa samples.The expression levels of c-Fos in PVN neurons following acupuncture treatment were evaluated by immunofluorescent staining.RESULTS:Following the intervention period,the behavioral scores for the blank control group were lower than those of other groups(P < 0.05),while the acupuncture group scores were lower than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).The blank control group had lower serum IL-4,IL-5,and IL-13 levels than those in the other groups(P < 0.05).The acupuncture group had lower serum IL-4,IL-5,and IL-13 levels than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).The blank control group had the highest serum IFN-γ levels among all groups,followed by the acupuncture group.The serum CORT,CRH,and ACTH levels in the blank control group were lower than those in the remaining groups(P < 0.05).These biomarker levels were also lower in the acupuncture group than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).Compared with model,rats in the acupuncture group exhibited an increased c-Fos expression in PVN neurons.CONCLUSION:Acupuncture can alleviate AR symptoms and regulate serum inflammatory factor levels and HPA axis-related hormones in AR rats.Moreover,these effects are inhibited by glucocorticoid antagonists,suggesting that acupuncture may regulate AR symptoms through HPA axis regulation.展开更多
Background:Allergic rhinitis(AR)is a kind of immune disease mediated by Ig E.We are intrigued by the potential role of DEK proto-oncogene(DEK)in inflammation-related diseases.We investigated the effects and mechanisms...Background:Allergic rhinitis(AR)is a kind of immune disease mediated by Ig E.We are intrigued by the potential role of DEK proto-oncogene(DEK)in inflammation-related diseases.We investigated the effects and mechanisms of DEK in treating AR,aiming to identify potential new treatment targets for AR.Methods:The AR mouse model was induced by house dust mite(HDM)(1 mg/m L).HNEp Cs stimulated by HDM(1 mg/m L)were pretreated for 24 h with or without DEK lentivirus.The effect of DEK knockout or knockdown on AR was evaluated in vitro and in vivo using western blotting,ELISA,flow cytometry,real-time quantitative PCR,immunohistochemistry,HE staining,PAS staining,Diff staining,and immunofluorescence.Results:After DEK knockdown,the inflammatory response of AR mice was reduced.In addition,DEK deletion mitigated nasal tissue damage and mitochondrial division.Our further studies showed that DEK deletion or inhibition led to the down-regulation of Rho A activity and decreased phosphorylation of Ezrin and Drp1 proteins,and inhibited mitochondrial division.Overall,DEK deficiency mitigated AR by down-regulating Rho A/Ezrin/Drp1 pathway activity.Conclusion:DEK alleviates AR through Rho A/Ezrin/Drp1 signaling pathway,which provides a new perspective for developing improved therapies and understanding the pathogenesis of AR.展开更多
Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturat...Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.展开更多
Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy....Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy.This multicenter,non-inferiority,single-blinded randomized controlled trial aimed to compare the differences in efficacy between warm needling(WN)therapy and loratadine(LO)in improving AR symptoms and quality of life.Methods:A total of 98 patients with persistent AR(PAR)were randomly divided into two groups in a 1:1 ratio:treatment group receiving WN therapy at Dazhui(GV14)and normal acupuncture at other acupoints for 12 sessions in 4 weeks and control group receiving LO at a dosage of 10 mg/day for oral administration.The study duration was 28 weeks(4-week treatment period with a 24-week follow-up).The primary outcome was the mean change in the Total Nasal Symptom Score(TNSS)from baseline to week 28,and the secondary outcomes included the Total Non-Nasal Symptom Score(TNNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)score.Statistical analyses were conducted us-ing SPSS22.0.Both intention-to-treat and treatment compliance analyses were performed to analyze all outcomes.Results:After intervention,TNSS scores improved from baseline to week 28 by 5.18(95%confidence interval[CI]:3.91,6.45;P<0.001)in the WN group and 4.59(95%CI 3.28,5.89;P<0.001)in the LO group,but the changes did not differ between the groups(P=0.515).The margin by 95%CI(−1.20,2.38)was not reached,indicating non-inferiority.WN therapy resulted in clinical improvements in TNNSS,with a significant difference com pared with LO treatment(f=5.466,P=0.021).WN therapy also resulted in clinical improvements in RQLQ scores,with a significant difference compared with LO(f=9.222,P=0.003).Conclusions:WN therapy demonstrated comparable efficacy to oral LO in improving nasal symptoms of PAR.However,it showed superior effects in alleviating concomitant nasal symptoms and enhancing patients’quality of life.展开更多
OBJECTIVE:To evaluate the clinical efficacy and safety of Tuomin Zhiti decoction(脱敏止嚏汤,TZD)in the shortterm treatment of seasonal allergic rhinitis(SAR).METHODS:This study is a randomized,double-blind placebo-con...OBJECTIVE:To evaluate the clinical efficacy and safety of Tuomin Zhiti decoction(脱敏止嚏汤,TZD)in the shortterm treatment of seasonal allergic rhinitis(SAR).METHODS:This study is a randomized,double-blind placebo-controlled,and single-center clinical trial.In April 2021,during the spring pollen season in Beijing,94 SAR patients aged 19-60 years were randomized(1∶1 ratio)to receive two weeks of TZD or placebo.The primary outcomes were the change of Total Nasal Symptom Score(TNSS)and Total Ocular Symptom Score(TOSS)from baseline to the end of treatment.Secondary outcomes were the changed score of the mini Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),Rescue Medication Score(RMS),and Patient Global Impression of Change(PGIC).All adverse events were recorded and evaluated by two senior physicians.RESULTS:TZD significantly reduced both the total nasal symptom scores and total ocular symptom scores compared to scores at baseline,while the placebo group showed an increasing trajectory in both symptom scores.Compared to the placebo group,the TZD group also showed a greater improvement in the quality of life,scores of RMS,nasal and eye symptoms scores after TZD treatment(P<0.001).Most notably,at the end of treatment,the proportion of remission measured by PGIC was significantly higher in the TZD group(82.97%)compared with the placebo group(47.72%,P<0.001).CONCLUSION:This study suggested that two weeks of TZD is an effective and safe treatment for SAR patients and spring pollen allergy,TZD could significantly improve the nasal and eye symptoms and improve the quality of life of patients.展开更多
Allergic rhinitis（AR）,with an increasing uptrend of the prevalence in many developed and developing countries,is a global health problem that affects people of all ages and ethnic groups.However,data on the prevalen...Allergic rhinitis（AR）,with an increasing uptrend of the prevalence in many developed and developing countries,is a global health problem that affects people of all ages and ethnic groups.However,data on the prevalence of self-reported AR in western China are rare.This study investigated the epidemiological features of self-reported AR in western China.In the cross-sectional,population-based study,a validated questionnaire survey on self-reported AR was carried out in 4 major cities in western China by multistage,stratified and cluster sampling,from January to December 2008.The total prevalence rate was 34.3%,with 32.3%（Chongqing）,34.3%（Chengdu）,37.9%（Urumqi）,30.3%（Nanning）,respectively.The prevalence presented to increase with age before 30 years old while decrease with age after 30 years old,and the highest prevalence was in 19-30 years group in Chongqing,Chengdu and Nanning which significantly showed ＂persistent and moderate-severe＂ type（P0.0001）;In Urumqi,there wasn＇t a significant increasing or decreasing trend of prevalence rate with age but with an ＂intermittent and mild＂predominance（P0.0001）.There were no distinct sexual differences in prevalence rates in the 4 cities.The morbidity was positively related to monthly average temperature and sunshine（r=0.76645,P=0.0036;r=0.67303,P=0.0165）,but negatively associated with relative humidity（r=-0.64391,P=0.0238） in Urumqi.Interestingly,the monthly morbidity was negatively associate with average temperature,sunshine and precipitation in Nanning（r=-0.81997,P=0.0011;r=-0.60787,P=0.0360;r=-0.59443,P=0.0415）.Self-reported AR is becoming common in western China with a rapid development in recent years,affecting about three persons out of ten.The climatic factors may have an indirect impact on the prevalence rate through the effects on the local allergens.展开更多
Objective To discuss the clinical efficacy of treating pediatric allergic rhinitis by combiningTuina with Chinese herbal medicines. Methods Twentyeight cases of pediatric allergic rhinitis were treated by combining pe...Objective To discuss the clinical efficacy of treating pediatric allergic rhinitis by combiningTuina with Chinese herbal medicines. Methods Twentyeight cases of pediatric allergic rhinitis were treated by combining pediatric Tuine and oral administration of Yupingfeng powder （玉屏风散） combined with Guizhi decoction （桂枝汤）. The clinical efficacy was observed after 6 treatments. Results The treatment of pediatric allergic rhinitis by combining Tuina and Chinese herbal medicines had an overall effectivness rate of 85.71%. Conclusion Combined treatment using pediatric Tuina and an herbal mixture of Yupingfeng powder （玉屏风散） and Guizhi decoction （桂枝汤） has positive therapeutic efficacy for treatment of pediatric allergic rhinitis, and should be considered as a treatment for this condition.展开更多
In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 （LFK）, a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activi...In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 （LFK）, a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model. Eighteen BALB/c mice were divided into three groups; the ovalbumin （OVA）-sen- sitized/challenged group, which received saline orally for 6 weeks （OVA group）, the OVA-sensitized/challenged group, which received LFK orally for 6 weeks （LFK-fed group）, and the non-sensitized group, which received saline for 6 weeks （saline control group）. Nasal rubbing and sneezing were monitored during the study. After the final challenge, interleukin （IL）-4, interferon （IFN）-y, and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined, eosinophilic infiltrate into the upper airway was quantified, and splenic CD4~CD25＋ regulatory T cells （Tregs） were examined by flow cytometry. We found that nasal rubbing was sig- nificantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35, and sneezing was significantly inhibited by LFK administration for 35 d. LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group. There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4, IFN-y, and OVA-specific IgE. Interestingly, the LFK-fed mice had a significantly greater percentage of splenic CD4＋CD25＋ Tregs than OVA group. Our results indicate that oral administration of LFK may alleviate nasal symptoms, reduce nasal eosinophilia, and increase the percentage of CD4＋CD25＋ Tregs in experimental allergic rhinitis.展开更多
OBJECTIVE:To preliminary investigate the distribution of Traditional Chinese Medicine(TCM)constitution among patients with allergic rhinitis(AR)and reveal the related factors with anxiety and depression.METHODS:Betwee...OBJECTIVE:To preliminary investigate the distribution of Traditional Chinese Medicine(TCM)constitution among patients with allergic rhinitis(AR)and reveal the related factors with anxiety and depression.METHODS:Between July 2020 and June 2021,specialist doctor recruited AR patients in Beijing and Shanghai.A total of 630 patients admitted to participate in the survey,and 516(81.9%)(male 54.3%,female 45.7%)participants completed the questionnaires.Three scales including Constitution in Chinese Medicine Questionnaire(CCMQ),Generalized Anxiety Disorder Questionnaire(GAD-7)and The Patient Health Queationaire-9(PHQ-9)were applied.Theχ^(2)and the Fisher’s exact test were used to evaluate the classification data,multivariate logistic regression was used to explore the related factors of anxiety and depression.RESULTS:According to 516 AR patients,the most commonly first-constitution was Yang-deficiency(22.1%)and frequent of all constitutions was inherited-special(21.6%).One third of AR patients(33.5%)suffered from anxiety,nearly half of AR patients(46.5%)were found to be depressive.Inherited-special(27.7%)was the most common constitution in patients with anxiety whereas Yang-deficiency(26.7%)was most common constitution in patients with depression.Sex,duration of symptoms,balanced,Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with anxiety;Sex,income,duration of symptoms,balanced,Qi-deficiency,Yang-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with depression.CONCLUSIONS:According to our study,the commonly constitution types of AR were Yang-deficiency and inherited-special.We found that the prevalence value of anxiety and depression were high.People with Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were more likely to have mental problems than the others.Controlling these influential factors might be beneficial for clinical health management of AR patients,and the government should apply appropriate mental health treatment services to offer psychiatric support.展开更多
OBJECTIVES: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. METHODS: Cytokine levels were determined before and after tr...OBJECTIVES: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. METHODS: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). RESULTS: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P展开更多
Objective:Formulating critical clinical questions and outcomes is essential for developing clinical practice guidelines(CPGs).This study aims to formulate the key clinical questions and outcomes for the CPG on acupunc...Objective:Formulating critical clinical questions and outcomes is essential for developing clinical practice guidelines(CPGs).This study aims to formulate the key clinical questions and outcomes for the CPG on acupuncture and moxibustion for allergic rhinitis(AR).Methods:PICO(patient,intervention,comparator,and outcome)question survey,Delphi survey,and consensus conference of the guideline development group(GDG)were employed.PICO questionnaires were used to gather and analyze the target users’key demands and interests.The GDG then selected the critical clinical questions and outcomes via a mixed method of Delphi survey and consensus conference.Results:Fifteen potential clinical questions and ten types of outcomes were formulated based on the analysis of 123 responses from seventeen countries on five continents.After two rounds of the Delphi survey and complete discussions,a consensus was reached by the GDG that all potential questions were included.After three rounds of the Delphi survey and complete debate,the consensus was reached that nine outcomes were considered important.Conclusion:Fifteen key clinical questions and nine important outcomes were formulated for the CPG.These covered issues elicited the most attention from global users in acupuncture therapy and AR.The results will contribute to the CPGs development and future clinical studies.展开更多
Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophils CCR3 and the granule protein rnRNA in the bone marrow,peripheral blood and nasal lavage fluid.Mc...Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophils CCR3 and the granule protein rnRNA in the bone marrow,peripheral blood and nasal lavage fluid.Mctliods:Twenty-four BALB/c mice were randomly divided into the control group.PBS therapy group.siKNA therapy group and the CCR3 siRNA therapy group(n=6).Allergic rhinitis model were sensitized and stimulated by ovalbunfin,and CCR3 siKNA therapy group were administered with CCH3 transnasally before stimulated.The levels of the eosinophils CCR3.MBP.ECP and EPO in bone marrow,peripheral blood and nasal lavage fluid were detected by RT-PCR.Results:Compared to the control group and CCR3 siR.NA therapy group,the nasal mucosa of the PBS therapy group and siRNA therapy group developed epithalaxy.goblet cells hyperplasia,squamous epithelium metaplasia,epithelium necrosis,lamina propria and submucosa gland hyperplasia,vasodilatation,tissue edema,and the characterized eosinophil infiltration.RT-PCR indicated that the CCR3 rnRNA,MBP.ECP and EPC)expression in bone marrow,peripheral blood and nasal lavage fluid of the CCR3 siKNA therapy group was lower than the PBS therapy group and siR.NA therapy group(P<0.05).Conclusions:The RNA interference therapy to CCR3 by local administration pernasal can suppress the process of the development,migration and invasion of the allergic rhinitis eosinophil,thus can reduce the effect of eosinophils and then reduce the inflammation effect of the allergic rhinitis.It may be a new treatment for respiratory tract allergic inflammation.展开更多
Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis.Hence,regulating the balance of intestinal flora may be useful for preventing and treating allergic rhin...Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis.Hence,regulating the balance of intestinal flora may be useful for preventing and treating allergic rhinitis.However,the underlying mechanism is unclear.Dendrobium nobile(Shihu)exhibits anti-inflammatory and immune activities.Hence,in this study,we investigated the mechanism via which Shihu may improve allergic rhinitis.Mouse models of allergic rhinitis with intestinal flora dysbiosis(Model-D,antibiotics induce intestinal flora dysbiosis with ovalbumin-induced allergy)and normal intestinal flora with allergic rhinitis(Model-N,ovalbumin-induced allergy)were established.The effect of Shihu on intestinal flora and inflammation caused during allergic rhinitis were analyzed.Allergic symptoms,infiltration of hematoxylin and eosin in the lungs and nose,and the release of various factors[interleukin(IL)-2,IL-4,IFN-y,IL-6,IL-10,and IL-17]in the lungs were evaluated.The results indicate that intestinal flora dysbiosis exacerbated lung and nose inflammation in allergic rhinitis.However,treatment with the Shihu extract effectively reversed these symp-toms.Besides,the Shihu extract inhibited the PI3K/AXT/mTOR pathway and increased the level of Forkhead box protein in the lungs.Additionally,the Shihu extract reversed intestinal flora dysbiosis at the phylum and genus levels and improved regulator T cell differentiation.Furthermore,in the Model-D group,the Shihu extract inhibited the decrease in the diversity and abundance of the intestinal flora.Screening was performed to determine which intestinal flora was positively correlated with Treg differentiation using Spearman5 s correlation analysis.In conclusion,we showed that Shihu extract restored the balance in intestinal flora and ameliorated inflammation in the lungs of allergic rhinitis mice and predicted a therapeutic new approach using Traditional Chinese Medicine to improve allergic rhinitis.展开更多
OBJECTIVE： To compare the efficacy of an acu- puncture regimen for persistent allergic rhinitis （PER）, aimed at improving a patient＇s mind or Shen in Traditional Chinese Medicine, to that of a sec- ond-generation ...OBJECTIVE： To compare the efficacy of an acu- puncture regimen for persistent allergic rhinitis （PER）, aimed at improving a patient＇s mind or Shen in Traditional Chinese Medicine, to that of a sec- ond-generation H-receptor antagonist, cetirizine hydrochloride. METHODS： This multicenter, randomized, con- trolled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screen- ing period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharma- cotherapy （1： 1） for 4 weeks with a 4-week fol- low-up. The primary outcome will be changes in 7-day average total nasal symptom score. Second- ary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-na- sal symptom score. RESULTS： The presence and seriousness of psycho- logical and emotional impairments should be con- sidered in therapeutic programs for allergic rhinitis. No clinical trial for treating allergic rhinitis via acu- puncture regulation of psychological and emotion- al activities has been reported. CONCLUSION： The findings of the trial will allow us to determine the effects of the mind （Shen）-regula- tion treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydro- chloride.展开更多
Background:Filiform needle acupuncture(FNA),the most classical and widely applied acupuncture method based on traditional Chinese medicine theory,has shown a promising effect in the treatment of allergic rhinitis(AR)....Background:Filiform needle acupuncture(FNA),the most classical and widely applied acupuncture method based on traditional Chinese medicine theory,has shown a promising effect in the treatment of allergic rhinitis(AR).Objective:To evaluate the efficacy,safety,cost-effectiveness,and patient preference of FNA in the treatment of AR by comparing FNA with sham acupuncture,no treatment,and conventional medication.Search strategy:Eight electronic databases were systematically searched from inception to October 14,2021.Additional studies were acquired from clinical trial registration platforms and reference lists.Inclusion criteria:Randomized controlled trials were included if they compared FNA with either sham acupuncture,no treatment or conventional medication for AR.Data extraction and analysis:Two researchers extracted data independently of each other using a predesigned data acquisition form,and results were cross-checked after completion.The primary outcome was symptom score(Total Nasal Symptom Score or Visual Analogue Scale),and the secondary outcomes were the AR control questionnaire,quality of life(QoL)score(Different versions of Rhinoconjunctivitis Quality of Life Questionnaire),medication score(use of rescue medication),mental health score,total IgE,adverse event rate,clinical economic indicators,and patient satisfaction score.Standardized mean difference(SMD)or mean difference(MD)with 95% confidence interval was used to calculate the effect size for continuous data,while risk ratio with 95%CI was used for dichotomous data.Results:Thirty studies were included in this review.Compared with sham acupuncture,FNA significantly reduced the symptom score(SMD:-0.29[-0.43,-0.15]),AR’s impact on QoL(SMD:-0.23[-0.37,-0.08])and medication score(SMD:-0.3[-0.49,-0.11]).Compared with no treatment,FNA dramatically reduced the symptom score(SMD:-0.8[-1.2,-0.39])and AR’s impact on QoL(SMD:-0.82[-1.13,-0.52]).There were no increased rates of adverse events with FNA compared to sham acupuncture and no treatment.FNA increased patient satisfaction and may be cost-effective.Most pieces of evidence from the above two comparisons were of high confidence.Moreover,FNA significantly outperformed conventional medication in reducing the symptom score(SMD:-0.48[-0.85,-0.1])and displayed a lower rate of adverse events,but the quality of evidence was very low.Conclusion:FNA is an effective and safe intervention for AR and can help with symptom relief,QoL improvement,reducing medication usage,and increasing patient satisfaction.Further studies are needed to verify its cost-effectiveness and superiority over conventional medication and the best therapeutic strategies.展开更多
OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its ...OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective study.METHOD:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and doctor.The CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health condition.The outcomes(dependent variables) were incidence and intensity of AR and concomitant medications used.Data were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables positively.After controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment course.CONCLUSION:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR.展开更多
Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for AR.However,these CPGs mentioned acupuncture without m...Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for AR.However,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for AR.Hence,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat AR.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group(GDG)played an important role.The clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi method.The CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion interventions.These include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of evidence.The CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.展开更多
The survey aims to collect clinical questions for the clinical practice guideline on acupuncture and moxibustion in treating allergic rhinitis.The survey is consisted of multiple-choice questions,ranking questions,and...The survey aims to collect clinical questions for the clinical practice guideline on acupuncture and moxibustion in treating allergic rhinitis.The survey is consisted of multiple-choice questions,ranking questions,and open questions.Readers are recommended to complete the open questions using PICO(Patients,Intervention,Comparator and Outcome)framework,referring to the examples.The survey might take about 30 min,and the responses from readers will greatly contribute to the formation of this guideline.展开更多
Summary： The relationship of interleukin-4 （IL-4） C-33T and C-590T （C-589T） gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T a...Summary： The relationship of interleukin-4 （IL-4） C-33T and C-590T （C-589T） gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T （C-589T）] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical soitvcare was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 （-589） polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI （1.61 2.31）, P=0.00]. Meta-analysis of the TT＋TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI （1.13-9.25）, P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI-（1.80-3.23）, P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with aller- gic rhinitis.展开更多
OBJECTIVE:To examine the efficacy of early intervention(4 weeks before pollen dispersal)with sphenopalatine ganglion(Xinwu acupoint)stimulation in patients with allergies after the onset of seasonal allergic rhinitis(...OBJECTIVE:To examine the efficacy of early intervention(4 weeks before pollen dispersal)with sphenopalatine ganglion(Xinwu acupoint)stimulation in patients with allergies after the onset of seasonal allergic rhinitis(SAR).METHODS:This is a prospective,randomized and unblinded half-open study.Forty-one SAR volunteers were randomly assigned to either the sphenopalatine ganglion(SPG)acupuncture plus supplementary acupuncture(SPG group)or the sham-SPG acupuncture plus supplementary acupuncture(SA group)stimulation 4 weeks before the onset of allergy season.The changes of the total nasal symptom score(TNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were measured on the first week in the onset of allergy season.RESULTS:Four patients dropped out due to local hematoma and pain in the SPG and SA groups.The remaining 37 patients continued through to the end of the trial.After early intervention 4 weeks before the onset of allergy season,the sneezing,nasal congestion and itchiness scores in the first week of onset time were significantly lower in the SPG group than in the SA group patients(P<0.001).The RQLQ score obtained at the onset of symptoms indicated that symptoms were more significantly ameliorated in the SPG group than in the SA group(P<0.001).CONCLUSIONS:The results of this study confirmed that early intervention by sphenopalatine ganglion(Xinwu acupoint)stimulation can effectively improve the symptoms and the quality of SAR patients'daily lives.展开更多
基金the National Natural Science Foundation of China:to Explore the Mechanism of Acupuncture Treatment on Rats with Allergic Rhinitis from the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Serum Immune Factor Levels (No.82004455)。
文摘OBJECTIVE:To explore the correlation between acupuncture treatment for allergic rhinitis(AR) and hypothalamic-pituitary-adrenal(HPA) axis regulation by investigating changes in serum immune factors,HPA axis-associated hormone levels,activation levels of paraventricular nucleus(PVN) neurons,and the severity of nasal mucosal lesions,in rats with AR before and after acupuncture treatment.METHODS:After establishing the AR rat model,ovalbumin was administered via nasal drip to all groups except the blank control.Each group received continuous treatment for 14 d:the acupuncture,acupuncture + RU-486(mifepristone),and RU-486 groups received acupuncture only,RU486 intraperitoneal injection and acupuncture,and RU-486 intraperitoneal injection only,respectively.Following the intervention period,behavioral scoring was performed on all AR rats,and peripheral blood,nasal mucosa samples,and brains tissue(containing PVN region) were obtained following euthanization.Interleukin(IL-4,IL-5,IL-13),interferon gamma(IFN-γ),corticosterone(CORT),and corticotrophin-releasing hormone(CRH) levels were evaluated in peripheral blood samples.Adrenocorticotropic hormone(ACTH) levels were determined using an enzyme-linked immunoassay assay,and hematoxylin and eosin staining was performed on the nasal mucosa samples.The expression levels of c-Fos in PVN neurons following acupuncture treatment were evaluated by immunofluorescent staining.RESULTS:Following the intervention period,the behavioral scores for the blank control group were lower than those of other groups(P < 0.05),while the acupuncture group scores were lower than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).The blank control group had lower serum IL-4,IL-5,and IL-13 levels than those in the other groups(P < 0.05).The acupuncture group had lower serum IL-4,IL-5,and IL-13 levels than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).The blank control group had the highest serum IFN-γ levels among all groups,followed by the acupuncture group.The serum CORT,CRH,and ACTH levels in the blank control group were lower than those in the remaining groups(P < 0.05).These biomarker levels were also lower in the acupuncture group than those in the model control,acupuncture + RU486,and RU486 groups(P < 0.05).Compared with model,rats in the acupuncture group exhibited an increased c-Fos expression in PVN neurons.CONCLUSION:Acupuncture can alleviate AR symptoms and regulate serum inflammatory factor levels and HPA axis-related hormones in AR rats.Moreover,these effects are inhibited by glucocorticoid antagonists,suggesting that acupuncture may regulate AR symptoms through HPA axis regulation.
基金National Natural Science Foundation of China,Grant/Award Number:82260007 and 82260218The Department of Education of Jilin Province,(JJKH20240698KJ)+1 种基金Natural Science Research Foundation of Jilin Province for Sciences and Technology,Grant/Award Number:20210101215JC20240602100RC and 20240404025ZP。
文摘Background:Allergic rhinitis(AR)is a kind of immune disease mediated by Ig E.We are intrigued by the potential role of DEK proto-oncogene(DEK)in inflammation-related diseases.We investigated the effects and mechanisms of DEK in treating AR,aiming to identify potential new treatment targets for AR.Methods:The AR mouse model was induced by house dust mite(HDM)(1 mg/m L).HNEp Cs stimulated by HDM(1 mg/m L)were pretreated for 24 h with or without DEK lentivirus.The effect of DEK knockout or knockdown on AR was evaluated in vitro and in vivo using western blotting,ELISA,flow cytometry,real-time quantitative PCR,immunohistochemistry,HE staining,PAS staining,Diff staining,and immunofluorescence.Results:After DEK knockdown,the inflammatory response of AR mice was reduced.In addition,DEK deletion mitigated nasal tissue damage and mitochondrial division.Our further studies showed that DEK deletion or inhibition led to the down-regulation of Rho A activity and decreased phosphorylation of Ezrin and Drp1 proteins,and inhibited mitochondrial division.Overall,DEK deficiency mitigated AR by down-regulating Rho A/Ezrin/Drp1 pathway activity.Conclusion:DEK alleviates AR through Rho A/Ezrin/Drp1 signaling pathway,which provides a new perspective for developing improved therapies and understanding the pathogenesis of AR.
文摘Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.
基金Supported by Beijing Municipal Science&Technology Commission Program:Z151100004015117Shenzhen Science and Technology Plan Project:JCYJ20210324120804012Shenzhen Luohu District Soft Science Research Plan project:LX202202128。
文摘Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy.This multicenter,non-inferiority,single-blinded randomized controlled trial aimed to compare the differences in efficacy between warm needling(WN)therapy and loratadine(LO)in improving AR symptoms and quality of life.Methods:A total of 98 patients with persistent AR(PAR)were randomly divided into two groups in a 1:1 ratio:treatment group receiving WN therapy at Dazhui(GV14)and normal acupuncture at other acupoints for 12 sessions in 4 weeks and control group receiving LO at a dosage of 10 mg/day for oral administration.The study duration was 28 weeks(4-week treatment period with a 24-week follow-up).The primary outcome was the mean change in the Total Nasal Symptom Score(TNSS)from baseline to week 28,and the secondary outcomes included the Total Non-Nasal Symptom Score(TNNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)score.Statistical analyses were conducted us-ing SPSS22.0.Both intention-to-treat and treatment compliance analyses were performed to analyze all outcomes.Results:After intervention,TNSS scores improved from baseline to week 28 by 5.18(95%confidence interval[CI]:3.91,6.45;P<0.001)in the WN group and 4.59(95%CI 3.28,5.89;P<0.001)in the LO group,but the changes did not differ between the groups(P=0.515).The margin by 95%CI(−1.20,2.38)was not reached,indicating non-inferiority.WN therapy resulted in clinical improvements in TNNSS,with a significant difference com pared with LO treatment(f=5.466,P=0.021).WN therapy also resulted in clinical improvements in RQLQ scores,with a significant difference compared with LO(f=9.222,P=0.003).Conclusions:WN therapy demonstrated comparable efficacy to oral LO in improving nasal symptoms of PAR.However,it showed superior effects in alleviating concomitant nasal symptoms and enhancing patients’quality of life.
基金Supported by the Fundamental Research Funds for the Central Universities(No.2023-JYB-JBZD-009)High level Key Discipline of National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(No.zyyzdxk-2023251)+1 种基金General program of National Natural Science Foundation of China:Study on the Mechanism of"the Simultaneous Prevention of Different Diseases"of Allergic Constitution Regulating Formula based on DNA Trap Mediated Eosinophil-Derived Dendritic Cells Cell Crosstalk(No.82174243)General Project of Beijing Natural Science Foundation:Study on the Mechanism of Guominkang for Treating Allergic Rhinitis through Regulating Body Constitution based on Vacuolating Cytotoxin A-mediated Eosinophil-derived Dendritic Cell Cell immune microenvironment(No.7242227)。
文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Tuomin Zhiti decoction(脱敏止嚏汤,TZD)in the shortterm treatment of seasonal allergic rhinitis(SAR).METHODS:This study is a randomized,double-blind placebo-controlled,and single-center clinical trial.In April 2021,during the spring pollen season in Beijing,94 SAR patients aged 19-60 years were randomized(1∶1 ratio)to receive two weeks of TZD or placebo.The primary outcomes were the change of Total Nasal Symptom Score(TNSS)and Total Ocular Symptom Score(TOSS)from baseline to the end of treatment.Secondary outcomes were the changed score of the mini Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),Rescue Medication Score(RMS),and Patient Global Impression of Change(PGIC).All adverse events were recorded and evaluated by two senior physicians.RESULTS:TZD significantly reduced both the total nasal symptom scores and total ocular symptom scores compared to scores at baseline,while the placebo group showed an increasing trajectory in both symptom scores.Compared to the placebo group,the TZD group also showed a greater improvement in the quality of life,scores of RMS,nasal and eye symptoms scores after TZD treatment(P<0.001).Most notably,at the end of treatment,the proportion of remission measured by PGIC was significantly higher in the TZD group(82.97%)compared with the placebo group(47.72%,P<0.001).CONCLUSION:This study suggested that two weeks of TZD is an effective and safe treatment for SAR patients and spring pollen allergy,TZD could significantly improve the nasal and eye symptoms and improve the quality of life of patients.
基金supported by the Science Research grants for the 10th 5-year plan to SL.H. (2004BA720A19-02)
文摘Allergic rhinitis（AR）,with an increasing uptrend of the prevalence in many developed and developing countries,is a global health problem that affects people of all ages and ethnic groups.However,data on the prevalence of self-reported AR in western China are rare.This study investigated the epidemiological features of self-reported AR in western China.In the cross-sectional,population-based study,a validated questionnaire survey on self-reported AR was carried out in 4 major cities in western China by multistage,stratified and cluster sampling,from January to December 2008.The total prevalence rate was 34.3%,with 32.3%（Chongqing）,34.3%（Chengdu）,37.9%（Urumqi）,30.3%（Nanning）,respectively.The prevalence presented to increase with age before 30 years old while decrease with age after 30 years old,and the highest prevalence was in 19-30 years group in Chongqing,Chengdu and Nanning which significantly showed ＂persistent and moderate-severe＂ type（P0.0001）;In Urumqi,there wasn＇t a significant increasing or decreasing trend of prevalence rate with age but with an ＂intermittent and mild＂predominance（P0.0001）.There were no distinct sexual differences in prevalence rates in the 4 cities.The morbidity was positively related to monthly average temperature and sunshine（r=0.76645,P=0.0036;r=0.67303,P=0.0165）,but negatively associated with relative humidity（r=-0.64391,P=0.0238） in Urumqi.Interestingly,the monthly morbidity was negatively associate with average temperature,sunshine and precipitation in Nanning（r=-0.81997,P=0.0011;r=-0.60787,P=0.0360;r=-0.59443,P=0.0415）.Self-reported AR is becoming common in western China with a rapid development in recent years,affecting about three persons out of ten.The climatic factors may have an indirect impact on the prevalence rate through the effects on the local allergens.
文摘Objective To discuss the clinical efficacy of treating pediatric allergic rhinitis by combiningTuina with Chinese herbal medicines. Methods Twentyeight cases of pediatric allergic rhinitis were treated by combining pediatric Tuine and oral administration of Yupingfeng powder （玉屏风散） combined with Guizhi decoction （桂枝汤）. The clinical efficacy was observed after 6 treatments. Results The treatment of pediatric allergic rhinitis by combining Tuina and Chinese herbal medicines had an overall effectivness rate of 85.71%. Conclusion Combined treatment using pediatric Tuina and an herbal mixture of Yupingfeng powder （玉屏风散） and Guizhi decoction （桂枝汤） has positive therapeutic efficacy for treatment of pediatric allergic rhinitis, and should be considered as a treatment for this condition.
基金supported by the International Cooperation Program of Jiangsu Department of Science and Technology (BZ2011045)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD 2010-2013)the Health Promotion Project of Jiangsu Province (RC2007065 and RC2011071),China
文摘In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 （LFK）, a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model. Eighteen BALB/c mice were divided into three groups; the ovalbumin （OVA）-sen- sitized/challenged group, which received saline orally for 6 weeks （OVA group）, the OVA-sensitized/challenged group, which received LFK orally for 6 weeks （LFK-fed group）, and the non-sensitized group, which received saline for 6 weeks （saline control group）. Nasal rubbing and sneezing were monitored during the study. After the final challenge, interleukin （IL）-4, interferon （IFN）-y, and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined, eosinophilic infiltrate into the upper airway was quantified, and splenic CD4~CD25＋ regulatory T cells （Tregs） were examined by flow cytometry. We found that nasal rubbing was sig- nificantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35, and sneezing was significantly inhibited by LFK administration for 35 d. LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group. There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4, IFN-y, and OVA-specific IgE. Interestingly, the LFK-fed mice had a significantly greater percentage of splenic CD4＋CD25＋ Tregs than OVA group. Our results indicate that oral administration of LFK may alleviate nasal symptoms, reduce nasal eosinophilia, and increase the percentage of CD4＋CD25＋ Tregs in experimental allergic rhinitis.
基金the General Projects of National Natural Science Foundation of China:Research on the Mechanism of Regulating Body Formula Guominkang in Preventing and Treating Allergic Diseases by Regulating the "Bacterial Population PRPs DCs" Axis through Pulmonary Intestinal Co-regulation Based on the "Diagnosing and Treating Different Body Types"(No.81973715)Beijing Natural Science Foundation General Project:Study on the Mechanism of Traditional Chinese Medicine Formula "Guo Min Kang" in Preventing Allergic Rhinitis through the "Intestinal Microflora Dendritic Cells" Axis (No.7202110)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine:Traditional Chinese Medicine Constitution Treatment and Prevention Innovation Team (ZYYCXTD-C-202001)
文摘OBJECTIVE:To preliminary investigate the distribution of Traditional Chinese Medicine(TCM)constitution among patients with allergic rhinitis(AR)and reveal the related factors with anxiety and depression.METHODS:Between July 2020 and June 2021,specialist doctor recruited AR patients in Beijing and Shanghai.A total of 630 patients admitted to participate in the survey,and 516(81.9%)(male 54.3%,female 45.7%)participants completed the questionnaires.Three scales including Constitution in Chinese Medicine Questionnaire(CCMQ),Generalized Anxiety Disorder Questionnaire(GAD-7)and The Patient Health Queationaire-9(PHQ-9)were applied.Theχ^(2)and the Fisher’s exact test were used to evaluate the classification data,multivariate logistic regression was used to explore the related factors of anxiety and depression.RESULTS:According to 516 AR patients,the most commonly first-constitution was Yang-deficiency(22.1%)and frequent of all constitutions was inherited-special(21.6%).One third of AR patients(33.5%)suffered from anxiety,nearly half of AR patients(46.5%)were found to be depressive.Inherited-special(27.7%)was the most common constitution in patients with anxiety whereas Yang-deficiency(26.7%)was most common constitution in patients with depression.Sex,duration of symptoms,balanced,Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with anxiety;Sex,income,duration of symptoms,balanced,Qi-deficiency,Yang-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with depression.CONCLUSIONS:According to our study,the commonly constitution types of AR were Yang-deficiency and inherited-special.We found that the prevalence value of anxiety and depression were high.People with Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were more likely to have mental problems than the others.Controlling these influential factors might be beneficial for clinical health management of AR patients,and the government should apply appropriate mental health treatment services to offer psychiatric support.
文摘OBJECTIVES: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. METHODS: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). RESULTS: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P
基金Supported by the National Key R&D Program of China:2019YFC1712200。
文摘Objective:Formulating critical clinical questions and outcomes is essential for developing clinical practice guidelines(CPGs).This study aims to formulate the key clinical questions and outcomes for the CPG on acupuncture and moxibustion for allergic rhinitis(AR).Methods:PICO(patient,intervention,comparator,and outcome)question survey,Delphi survey,and consensus conference of the guideline development group(GDG)were employed.PICO questionnaires were used to gather and analyze the target users’key demands and interests.The GDG then selected the critical clinical questions and outcomes via a mixed method of Delphi survey and consensus conference.Results:Fifteen potential clinical questions and ten types of outcomes were formulated based on the analysis of 123 responses from seventeen countries on five continents.After two rounds of the Delphi survey and complete discussions,a consensus was reached by the GDG that all potential questions were included.After three rounds of the Delphi survey and complete debate,the consensus was reached that nine outcomes were considered important.Conclusion:Fifteen key clinical questions and nine important outcomes were formulated for the CPG.These covered issues elicited the most attention from global users in acupuncture therapy and AR.The results will contribute to the CPGs development and future clinical studies.
基金supported by the National Natural Science Fund Project in China(grant No.:81060084)Jiangxi Provincial Natural Science Fund Project in China(grant No.:2010gzy0251)+1 种基金Jiangxi Provincial Health Department Project in China(grant No.:20131059)Jiangxi Provincial Department of Science and Technology Project in China(grant No.:20133BBG70071)
文摘Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophils CCR3 and the granule protein rnRNA in the bone marrow,peripheral blood and nasal lavage fluid.Mctliods:Twenty-four BALB/c mice were randomly divided into the control group.PBS therapy group.siKNA therapy group and the CCR3 siRNA therapy group(n=6).Allergic rhinitis model were sensitized and stimulated by ovalbunfin,and CCR3 siKNA therapy group were administered with CCH3 transnasally before stimulated.The levels of the eosinophils CCR3.MBP.ECP and EPO in bone marrow,peripheral blood and nasal lavage fluid were detected by RT-PCR.Results:Compared to the control group and CCR3 siR.NA therapy group,the nasal mucosa of the PBS therapy group and siRNA therapy group developed epithalaxy.goblet cells hyperplasia,squamous epithelium metaplasia,epithelium necrosis,lamina propria and submucosa gland hyperplasia,vasodilatation,tissue edema,and the characterized eosinophil infiltration.RT-PCR indicated that the CCR3 rnRNA,MBP.ECP and EPC)expression in bone marrow,peripheral blood and nasal lavage fluid of the CCR3 siKNA therapy group was lower than the PBS therapy group and siR.NA therapy group(P<0.05).Conclusions:The RNA interference therapy to CCR3 by local administration pernasal can suppress the process of the development,migration and invasion of the allergic rhinitis eosinophil,thus can reduce the effect of eosinophils and then reduce the inflammation effect of the allergic rhinitis.It may be a new treatment for respiratory tract allergic inflammation.
基金This work was supported by the Shenzhen Key Discipline of Medicine(2020-2024)(SZXK039)Science and Technology Development Special Fund of Shenzhen Longgang District(LGKC YL WS2019000749 and LGKC YLWS2019000846)China Postdoctoral Science Foundation(2020M683137).
文摘Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis.Hence,regulating the balance of intestinal flora may be useful for preventing and treating allergic rhinitis.However,the underlying mechanism is unclear.Dendrobium nobile(Shihu)exhibits anti-inflammatory and immune activities.Hence,in this study,we investigated the mechanism via which Shihu may improve allergic rhinitis.Mouse models of allergic rhinitis with intestinal flora dysbiosis(Model-D,antibiotics induce intestinal flora dysbiosis with ovalbumin-induced allergy)and normal intestinal flora with allergic rhinitis(Model-N,ovalbumin-induced allergy)were established.The effect of Shihu on intestinal flora and inflammation caused during allergic rhinitis were analyzed.Allergic symptoms,infiltration of hematoxylin and eosin in the lungs and nose,and the release of various factors[interleukin(IL)-2,IL-4,IFN-y,IL-6,IL-10,and IL-17]in the lungs were evaluated.The results indicate that intestinal flora dysbiosis exacerbated lung and nose inflammation in allergic rhinitis.However,treatment with the Shihu extract effectively reversed these symp-toms.Besides,the Shihu extract inhibited the PI3K/AXT/mTOR pathway and increased the level of Forkhead box protein in the lungs.Additionally,the Shihu extract reversed intestinal flora dysbiosis at the phylum and genus levels and improved regulator T cell differentiation.Furthermore,in the Model-D group,the Shihu extract inhibited the decrease in the diversity and abundance of the intestinal flora.Screening was performed to determine which intestinal flora was positively correlated with Treg differentiation using Spearman5 s correlation analysis.In conclusion,we showed that Shihu extract restored the balance in intestinal flora and ameliorated inflammation in the lungs of allergic rhinitis mice and predicted a therapeutic new approach using Traditional Chinese Medicine to improve allergic rhinitis.
基金Supported by Capital Research on the Clinical Characteristic Application Projects,Beijing Municipal Science & Technology Commission(No.D101100050010022)
文摘OBJECTIVE： To compare the efficacy of an acu- puncture regimen for persistent allergic rhinitis （PER）, aimed at improving a patient＇s mind or Shen in Traditional Chinese Medicine, to that of a sec- ond-generation H-receptor antagonist, cetirizine hydrochloride. METHODS： This multicenter, randomized, con- trolled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screen- ing period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharma- cotherapy （1： 1） for 4 weeks with a 4-week fol- low-up. The primary outcome will be changes in 7-day average total nasal symptom score. Second- ary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-na- sal symptom score. RESULTS： The presence and seriousness of psycho- logical and emotional impairments should be con- sidered in therapeutic programs for allergic rhinitis. No clinical trial for treating allergic rhinitis via acu- puncture regulation of psychological and emotion- al activities has been reported. CONCLUSION： The findings of the trial will allow us to determine the effects of the mind （Shen）-regula- tion treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydro- chloride.
基金financially funded by the National Key R&D Program of China(No.2019YFC1712200).The funder is the Ministry of Science and Technology of the People’s Republic of China.This funding supported the collection and analysis of data。
文摘Background:Filiform needle acupuncture(FNA),the most classical and widely applied acupuncture method based on traditional Chinese medicine theory,has shown a promising effect in the treatment of allergic rhinitis(AR).Objective:To evaluate the efficacy,safety,cost-effectiveness,and patient preference of FNA in the treatment of AR by comparing FNA with sham acupuncture,no treatment,and conventional medication.Search strategy:Eight electronic databases were systematically searched from inception to October 14,2021.Additional studies were acquired from clinical trial registration platforms and reference lists.Inclusion criteria:Randomized controlled trials were included if they compared FNA with either sham acupuncture,no treatment or conventional medication for AR.Data extraction and analysis:Two researchers extracted data independently of each other using a predesigned data acquisition form,and results were cross-checked after completion.The primary outcome was symptom score(Total Nasal Symptom Score or Visual Analogue Scale),and the secondary outcomes were the AR control questionnaire,quality of life(QoL)score(Different versions of Rhinoconjunctivitis Quality of Life Questionnaire),medication score(use of rescue medication),mental health score,total IgE,adverse event rate,clinical economic indicators,and patient satisfaction score.Standardized mean difference(SMD)or mean difference(MD)with 95% confidence interval was used to calculate the effect size for continuous data,while risk ratio with 95%CI was used for dichotomous data.Results:Thirty studies were included in this review.Compared with sham acupuncture,FNA significantly reduced the symptom score(SMD:-0.29[-0.43,-0.15]),AR’s impact on QoL(SMD:-0.23[-0.37,-0.08])and medication score(SMD:-0.3[-0.49,-0.11]).Compared with no treatment,FNA dramatically reduced the symptom score(SMD:-0.8[-1.2,-0.39])and AR’s impact on QoL(SMD:-0.82[-1.13,-0.52]).There were no increased rates of adverse events with FNA compared to sham acupuncture and no treatment.FNA increased patient satisfaction and may be cost-effective.Most pieces of evidence from the above two comparisons were of high confidence.Moreover,FNA significantly outperformed conventional medication in reducing the symptom score(SMD:-0.48[-0.85,-0.1])and displayed a lower rate of adverse events,but the quality of evidence was very low.Conclusion:FNA is an effective and safe intervention for AR and can help with symptom relief,QoL improvement,reducing medication usage,and increasing patient satisfaction.Further studies are needed to verify its cost-effectiveness and superiority over conventional medication and the best therapeutic strategies.
基金Suppotred by the funds of Key Projects in the National S&T Pillar Program(No.2008BAI53B061)Major National S&T Program(No.2008ZX10005-013)
文摘OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective study.METHOD:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and doctor.The CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health condition.The outcomes(dependent variables) were incidence and intensity of AR and concomitant medications used.Data were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables positively.After controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment course.CONCLUSION:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR.
基金financially funded by the National Key Research and Development Program of China(No.2019YFC1712200 and2019YFC1712203)。
文摘Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for AR.However,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for AR.Hence,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat AR.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group(GDG)played an important role.The clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi method.The CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion interventions.These include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of evidence.The CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.
基金supported by the National key R&D Program of China:No.2019YFC1712200。
文摘The survey aims to collect clinical questions for the clinical practice guideline on acupuncture and moxibustion in treating allergic rhinitis.The survey is consisted of multiple-choice questions,ranking questions,and open questions.Readers are recommended to complete the open questions using PICO(Patients,Intervention,Comparator and Outcome)framework,referring to the examples.The survey might take about 30 min,and the responses from readers will greatly contribute to the formation of this guideline.
文摘Summary： The relationship of interleukin-4 （IL-4） C-33T and C-590T （C-589T） gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T （C-589T）] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical soitvcare was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 （-589） polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI （1.61 2.31）, P=0.00]. Meta-analysis of the TT＋TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI （1.13-9.25）, P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI-（1.80-3.23）, P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with aller- gic rhinitis.
基金National Natural Science Foundation of China:Study on the“Metabolic Memory”Effect of eNOS in Glomerular Endothelial Cells and the Role and Mechanism of AstragalosideⅣin the Early Stages of Diabetic Nephropathy(No.81774214)Fundamental Research Funds of Chinese Medicine in Capital Medical University:Exploration of the Efficacy and Mechanism of Early Acupuncture Intervention in Seasonal Recurrent Rhinitis:a Randomized Clinical Study(No.16ZY03)。
文摘OBJECTIVE:To examine the efficacy of early intervention(4 weeks before pollen dispersal)with sphenopalatine ganglion(Xinwu acupoint)stimulation in patients with allergies after the onset of seasonal allergic rhinitis(SAR).METHODS:This is a prospective,randomized and unblinded half-open study.Forty-one SAR volunteers were randomly assigned to either the sphenopalatine ganglion(SPG)acupuncture plus supplementary acupuncture(SPG group)or the sham-SPG acupuncture plus supplementary acupuncture(SA group)stimulation 4 weeks before the onset of allergy season.The changes of the total nasal symptom score(TNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were measured on the first week in the onset of allergy season.RESULTS:Four patients dropped out due to local hematoma and pain in the SPG and SA groups.The remaining 37 patients continued through to the end of the trial.After early intervention 4 weeks before the onset of allergy season,the sneezing,nasal congestion and itchiness scores in the first week of onset time were significantly lower in the SPG group than in the SA group patients(P<0.001).The RQLQ score obtained at the onset of symptoms indicated that symptoms were more significantly ameliorated in the SPG group than in the SA group(P<0.001).CONCLUSIONS:The results of this study confirmed that early intervention by sphenopalatine ganglion(Xinwu acupoint)stimulation can effectively improve the symptoms and the quality of SAR patients'daily lives.
