Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due...Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due to the frequency of other types of joint diseases and the existence of degenerative and dystrophic valve disease. In adults, the initial rheumatic attack is marked by the predominance of joint damage over cardiac damage. However, it is often at this age that rheumatic valve disease is discovered. The revised Jones criteria also find their place in the diagnosis of AAR in adults. Objective: To study the demographic, clinical, and biological characteristics of acute rheumatic fever (ARF) in the General Medicine Department of the Siguiri Prefectural Hospital. Materials and Methods: This descriptive observational study examined the demographic, clinical and biological characteristics of acute rheumatic fever (ARF) at the Siguiri Prefectural Hospital, Guinea, between April 1 and September 31, 2021 according to Jones criteria. The data were collected on a form containing sociodemographic variables (age, sex, profession), rheumatological, cardiac, pulmonary and neurological clinical signs, biological variables and treatment. Results: Figure 1 shows the flow of the hospital frequency of the RAA in the General Medicine Department of the Prefectural Hospital of Siguiri. During the study period, 420 patients were hospitalized, of whom 161 patients had AAR, a frequency of 38.33%. Table 1 shows the distribution of patients diagnosed with ARB, by sociodemographic characteristics. The average age was 44.7 ± 19.78 years and the extremes of 14 and 90 years, the female sex dominated with a ratio of 0.75. The informal sector was in the majority in 45.34% of cases and most were illiterate, i.e. 53.42%. In our study, the incidence was lower during the dry season than during the rainy season, a hot season with high rainfall and humidity, the rainy period was a provider with a peak in August and September. The lifestyle was characterized by overcrowding in 87.58% of patients. The main complaint was fever, i.e. 88.82%. Rheumatological manifestations such as arthritis were 98.14%, chest pain was 37.89% (61 cases). The diagnosis was confirmed by ASLO titration in 85.71% of patients and 98.55% (136 cases) had a titration greater than 400 U/ml. Conclusion: The results obtained from our study show a high prevalence of acute rheumatic fever, which makes it a worrying health problem in the Siguiri health district. Young female adult patients, married with an informal profession and not in school residing in Siguiri were the most encountered in our study. The main functional signs mentioned by the patients were fever, cough and abdominal pain;osteoarticular pain and chest pain dominated the clinical picture. Almost all of our patients had an ASLO titer greater than 400 U/ml and a positive C-reactive protein. Our results show a high risk of spread of acute rheumatic fever within the population of Siguiri. Due to the serious complications caused by acute rheumatic fever, particular attention must be paid to it by carrying out other, much larger studies in order to identify the problem of RAA.展开更多
Rheumatic fever is a disease according to the theory of traditional Chinese medicine(TCM),and its main clinical manifestations include coma and confusion of eyes and head,severe limb drowsiness,fever without conscious...Rheumatic fever is a disease according to the theory of traditional Chinese medicine(TCM),and its main clinical manifestations include coma and confusion of eyes and head,severe limb drowsiness,fever without consciousness,sticky and greasy stool,short and blood urine,red tongue with yellow and greasy coating,and slippery rapid pulse.Colorectal cancer is a common malignant tumor in the digestive tract.According to the theory of TCM,rheumatic fever is the main etiology and pathogenesis of colorectal cancer,which is the common syndrome of colorectal cancer.The method of antipyretic and removing dampness has been widely used in TCM treatment for colorectal cancer which is effective.From the perspective of rheumatic fever,the article summarizes the material basis of colorectal cancer from the perspectives of gene,protein,metabolism,and microorganism,discussing the potential mechanism of rheumatic fever in the occurrence and development of colorectal cancer combined with the theory of TCM,summarizing the defects of the research direction at this stage,in order to better guide the prevention and treatment of colorectal cancer.展开更多
Although an association between the group A beta hemolytic streptococcus and rheumatic fever has been recognized for more than half a century, many important issues about this relationship remain incompletely defined....Although an association between the group A beta hemolytic streptococcus and rheumatic fever has been recognized for more than half a century, many important issues about this relationship remain incompletely defined. The initiating pharyngeal throat infection and展开更多
Acute rheumatic fever (ARF) is an inflammatory disease that occurs following an infection with certain strains of group A beta-hemolytic streptococci. Despite dramatic falls in the incidence, Acute Rheumatic Fever rem...Acute rheumatic fever (ARF) is an inflammatory disease that occurs following an infection with certain strains of group A beta-hemolytic streptococci. Despite dramatic falls in the incidence, Acute Rheumatic Fever remains a major cause of morbidity and mortality associated with acquired heart disease in developing countries. Infective endocarditis (IE) is defined as a microbial infection of the endothelial surface of the heart. IE occurs most frequently in patients with chronic rheumatic heart disease. As far as we know, the simultaneous occurrence of both conditions has not been previously reported. References to our outpatient clinic with complaints of fever and joint pain, clinical and laboratory findings suggestive of infective endocarditis fits both with both the ARF and remitted entirely with appropriate treatment, as far as we know, we think that this is not a case of our similar event in the literature. Here we present a case of a fifteen-year-old girl with concurrent acute rheumatic fever and infective endocarditis.展开更多
Sydenham chorea(SC)is the neurological manifestation associated with acute rheu-matic fever(ARF).ARF and rheumatic heart disease(RHD)are autoimmune complica-tions triggered by a group A streptococcal(GAS)infection.In ...Sydenham chorea(SC)is the neurological manifestation associated with acute rheu-matic fever(ARF).ARF and rheumatic heart disease(RHD)are autoimmune complica-tions triggered by a group A streptococcal(GAS)infection.In ARF/RHD and SC,tissue cross-reactive antibodies and T-cells generated against GAS antigens have been impli-cated in the pathogenesis.In SC,antibodies against GAS antigens are known to cross-react with neuronal proteins causing neurological manifestations including choreiform movements and neuropsychiatric symptoms such as irritability,attention deficit,and obsessive-compulsive disorder.Previous studies in a rat autoimmune valvulitis(RAV)model of RHD,have shown that injection of streptococcal M protein could cause both cardiac and neurological symptoms.In this study it was shown that adoptive transfer of serum with anti-GAS M antibodies to naive rats caused carditis but failed to demon-strate neurobehavioral symptoms.However,when the blood-brain barrier(BBB)was disrupted using lipopolysaccharide,all animals that received anti-GAS M protein anti-bodies,developed neurobehavioral defects in addition to carditis.This highlights that impaired BBB integrity is essential for the development of neurobehavioral symptoms.The use of the RAV model and the disruption of BBB required for the development of neurobehavioral changes provides a platform to further investigate the mechanisms that lead to antibodies binding to basal ganglia structures that cause SC.展开更多
Rheumatic fever is a complication following an episode of group A streptococcal pharyngitis. It is an acute immunologically mediated, multisystem inflammatory disorder. Acute rheumatic heart disease during the active ...Rheumatic fever is a complication following an episode of group A streptococcal pharyngitis. It is an acute immunologically mediated, multisystem inflammatory disorder. Acute rheumatic heart disease during the active phase of rheumatic fever sometimes progresses to chronic rheumatic heart disease. Despite its declining importance in industrialised countries rheumatic fever remains the leading cause of death from heart disease in children and young adults in less developed regions. Fifteen to twenty million new cases emerge every year in developing countries.~1展开更多
Rheumatic fever (RF) is considered to be an autoimmune disease that is a delayed response to pharyngeal infection by Beta-hemolytic Group A streptococcus (GSA). One of the severe complications is carditis. A significa...Rheumatic fever (RF) is considered to be an autoimmune disease that is a delayed response to pharyngeal infection by Beta-hemolytic Group A streptococcus (GSA). One of the severe complications is carditis. A significant decline in the incidence of RF has been observed since the 1960s, so that in the early 80s some of the experts in developed countries declared that this disease was vanishing. Unfortunately, in the mid 1980s, resurgence展开更多
Rheumatic heart disease (RHD) is the most common cause of acquired heart disease in children and young adults worldwide and particularly developing countries continuing to experience a high incidence of this disease. ...Rheumatic heart disease (RHD) is the most common cause of acquired heart disease in children and young adults worldwide and particularly developing countries continuing to experience a high incidence of this disease. The unexpected increase in the incidence of the disease in certain areas may explain the clinical and epidemiological characteristics of this disease. The key manifestation of RHD is the cardiac valvular abnormalities characterized principally by deforming the layered and avascular leaflet architecture due to inflammation and subsequent diffuse fibrosis. Mitral valve is mostly involved and pulmonary valve is rarely affected. Background of these case reports highlighted the increased incidence of rheumatic pulmonary valve disease in Thoothukudi region of India in Tamil Nadu state.展开更多
Background:The neuropsychiatric disorders due to post-streptococcal autoimmune complications such as Sydenham's chorea(SC)are associated with acute rheumatic fever and rheumatic heart disease(ARF/RHD).An animal mo...Background:The neuropsychiatric disorders due to post-streptococcal autoimmune complications such as Sydenham's chorea(SC)are associated with acute rheumatic fever and rheumatic heart disease(ARF/RHD).An animal model that exhibits char-acteristics of both cardiac and neurobehavioral defects in ARF/RHD would be an important adjunct for future studies.Since age,gender,strain differences,and geno-types impact on the development of autoimmunity,we investigated the behavior of male and female Wistar and Lewis rat strains in two age cohorts(6 weeks and 12 weeks)under normal husbandry conditions and following exposure to group A streptococcus(GAS).Methods:Standard behavioral assessments were performed to determine the impair-ments in fine motor control(food manipulation test),gait and balance(beam walk-ing test),and obsessive-compulsive behavior(grooming and marble burying tests).Furthermore,electrocardiography,histology,and behavioral assessments were per-formed on male and female Lewis rats injected with GAS antigens.Results:For control Lewis rats there were no significant age and gender dependent differences in marble burying,food manipulation,beam walking and grooming be-haviors.In contrast significant age-dependent differences were observed in Wistar rats in all the behavioral tests except for food manipulation.Therefore,Lewis rats were selected for further experiments to determine the effect of GAS.After ex-posure to GAS,Lewis rats demonstrated neurobehavioral abnormalities and cardiac pathology akin to SC and ARF/RHD,respectively.Conclusion:We have characterised a new model that provides longitudinal stability of age-dependent behavior,to simultaneously investigate both neurobehavioral and cardiac abnormalities associated with post-streptococcal complications.展开更多
Selected mainly were acupoints in the adjacent areas and along the meridians,assisted by ashi points.Fengmen(BL 12),Geshu(BL 17)and Xuehai(SP 10)were selected for migratory arthralgia;Shenshu(BL 23)and Guanyuan(CV 4)f...Selected mainly were acupoints in the adjacent areas and along the meridians,assisted by ashi points.Fengmen(BL 12),Geshu(BL 17)and Xuehai(SP 10)were selected for migratory arthralgia;Shenshu(BL 23)and Guanyuan(CV 4)for cold-aggravated arthralgia;Pishu(BL 20),Zusanli(ST 36)and Yinlingquan(SP 9)for damp arthralgia;Dazhui(GV 14)and Quchi(LI 11)for heat-induced arthralgia.Acupuncture in combination with far infra-red radiation was performed.76 patients with rheumatoid arthritis were treated and 74 cases with herb therapy as control.The result showed that there was statistically significant difference in curative effect between the 2 groups,χ^(2)=10.18,P<0.01,indicating that the curative effect was significantly better in the treatment group than in the control group.Statistics showed that there was no significant difference in curative effect among the 4 syndromic types,namely migratory arthralgia,cold-aggravated arthralgia,damp-induced arthralgia and heat-induced arthralgia.But there was a statistically significant difference in curative effect between the above 4 syndromic types and deficiency-type arthralgia,indicating that the curative effect in deficiency-type arthralgia was worst.展开更多
文摘Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due to the frequency of other types of joint diseases and the existence of degenerative and dystrophic valve disease. In adults, the initial rheumatic attack is marked by the predominance of joint damage over cardiac damage. However, it is often at this age that rheumatic valve disease is discovered. The revised Jones criteria also find their place in the diagnosis of AAR in adults. Objective: To study the demographic, clinical, and biological characteristics of acute rheumatic fever (ARF) in the General Medicine Department of the Siguiri Prefectural Hospital. Materials and Methods: This descriptive observational study examined the demographic, clinical and biological characteristics of acute rheumatic fever (ARF) at the Siguiri Prefectural Hospital, Guinea, between April 1 and September 31, 2021 according to Jones criteria. The data were collected on a form containing sociodemographic variables (age, sex, profession), rheumatological, cardiac, pulmonary and neurological clinical signs, biological variables and treatment. Results: Figure 1 shows the flow of the hospital frequency of the RAA in the General Medicine Department of the Prefectural Hospital of Siguiri. During the study period, 420 patients were hospitalized, of whom 161 patients had AAR, a frequency of 38.33%. Table 1 shows the distribution of patients diagnosed with ARB, by sociodemographic characteristics. The average age was 44.7 ± 19.78 years and the extremes of 14 and 90 years, the female sex dominated with a ratio of 0.75. The informal sector was in the majority in 45.34% of cases and most were illiterate, i.e. 53.42%. In our study, the incidence was lower during the dry season than during the rainy season, a hot season with high rainfall and humidity, the rainy period was a provider with a peak in August and September. The lifestyle was characterized by overcrowding in 87.58% of patients. The main complaint was fever, i.e. 88.82%. Rheumatological manifestations such as arthritis were 98.14%, chest pain was 37.89% (61 cases). The diagnosis was confirmed by ASLO titration in 85.71% of patients and 98.55% (136 cases) had a titration greater than 400 U/ml. Conclusion: The results obtained from our study show a high prevalence of acute rheumatic fever, which makes it a worrying health problem in the Siguiri health district. Young female adult patients, married with an informal profession and not in school residing in Siguiri were the most encountered in our study. The main functional signs mentioned by the patients were fever, cough and abdominal pain;osteoarticular pain and chest pain dominated the clinical picture. Almost all of our patients had an ASLO titer greater than 400 U/ml and a positive C-reactive protein. Our results show a high risk of spread of acute rheumatic fever within the population of Siguiri. Due to the serious complications caused by acute rheumatic fever, particular attention must be paid to it by carrying out other, much larger studies in order to identify the problem of RAA.
文摘Rheumatic fever is a disease according to the theory of traditional Chinese medicine(TCM),and its main clinical manifestations include coma and confusion of eyes and head,severe limb drowsiness,fever without consciousness,sticky and greasy stool,short and blood urine,red tongue with yellow and greasy coating,and slippery rapid pulse.Colorectal cancer is a common malignant tumor in the digestive tract.According to the theory of TCM,rheumatic fever is the main etiology and pathogenesis of colorectal cancer,which is the common syndrome of colorectal cancer.The method of antipyretic and removing dampness has been widely used in TCM treatment for colorectal cancer which is effective.From the perspective of rheumatic fever,the article summarizes the material basis of colorectal cancer from the perspectives of gene,protein,metabolism,and microorganism,discussing the potential mechanism of rheumatic fever in the occurrence and development of colorectal cancer combined with the theory of TCM,summarizing the defects of the research direction at this stage,in order to better guide the prevention and treatment of colorectal cancer.
文摘Although an association between the group A beta hemolytic streptococcus and rheumatic fever has been recognized for more than half a century, many important issues about this relationship remain incompletely defined. The initiating pharyngeal throat infection and
文摘Acute rheumatic fever (ARF) is an inflammatory disease that occurs following an infection with certain strains of group A beta-hemolytic streptococci. Despite dramatic falls in the incidence, Acute Rheumatic Fever remains a major cause of morbidity and mortality associated with acquired heart disease in developing countries. Infective endocarditis (IE) is defined as a microbial infection of the endothelial surface of the heart. IE occurs most frequently in patients with chronic rheumatic heart disease. As far as we know, the simultaneous occurrence of both conditions has not been previously reported. References to our outpatient clinic with complaints of fever and joint pain, clinical and laboratory findings suggestive of infective endocarditis fits both with both the ARF and remitted entirely with appropriate treatment, as far as we know, we think that this is not a case of our similar event in the literature. Here we present a case of a fifteen-year-old girl with concurrent acute rheumatic fever and infective endocarditis.
基金supported by an Ideas Grant(APP2010336)from National Health and Medical Research Council(NHMRC)Australia.
文摘Sydenham chorea(SC)is the neurological manifestation associated with acute rheu-matic fever(ARF).ARF and rheumatic heart disease(RHD)are autoimmune complica-tions triggered by a group A streptococcal(GAS)infection.In ARF/RHD and SC,tissue cross-reactive antibodies and T-cells generated against GAS antigens have been impli-cated in the pathogenesis.In SC,antibodies against GAS antigens are known to cross-react with neuronal proteins causing neurological manifestations including choreiform movements and neuropsychiatric symptoms such as irritability,attention deficit,and obsessive-compulsive disorder.Previous studies in a rat autoimmune valvulitis(RAV)model of RHD,have shown that injection of streptococcal M protein could cause both cardiac and neurological symptoms.In this study it was shown that adoptive transfer of serum with anti-GAS M antibodies to naive rats caused carditis but failed to demon-strate neurobehavioral symptoms.However,when the blood-brain barrier(BBB)was disrupted using lipopolysaccharide,all animals that received anti-GAS M protein anti-bodies,developed neurobehavioral defects in addition to carditis.This highlights that impaired BBB integrity is essential for the development of neurobehavioral symptoms.The use of the RAV model and the disruption of BBB required for the development of neurobehavioral changes provides a platform to further investigate the mechanisms that lead to antibodies binding to basal ganglia structures that cause SC.
文摘Rheumatic fever is a complication following an episode of group A streptococcal pharyngitis. It is an acute immunologically mediated, multisystem inflammatory disorder. Acute rheumatic heart disease during the active phase of rheumatic fever sometimes progresses to chronic rheumatic heart disease. Despite its declining importance in industrialised countries rheumatic fever remains the leading cause of death from heart disease in children and young adults in less developed regions. Fifteen to twenty million new cases emerge every year in developing countries.~1
文摘Rheumatic fever (RF) is considered to be an autoimmune disease that is a delayed response to pharyngeal infection by Beta-hemolytic Group A streptococcus (GSA). One of the severe complications is carditis. A significant decline in the incidence of RF has been observed since the 1960s, so that in the early 80s some of the experts in developed countries declared that this disease was vanishing. Unfortunately, in the mid 1980s, resurgence
文摘We have treated 30 cases of rheumatic gonitis by using acupuncture and the pricking method, with satisfactory therapeutic results reported as follows.
文摘Rheumatic heart disease (RHD) is the most common cause of acquired heart disease in children and young adults worldwide and particularly developing countries continuing to experience a high incidence of this disease. The unexpected increase in the incidence of the disease in certain areas may explain the clinical and epidemiological characteristics of this disease. The key manifestation of RHD is the cardiac valvular abnormalities characterized principally by deforming the layered and avascular leaflet architecture due to inflammation and subsequent diffuse fibrosis. Mitral valve is mostly involved and pulmonary valve is rarely affected. Background of these case reports highlighted the increased incidence of rheumatic pulmonary valve disease in Thoothukudi region of India in Tamil Nadu state.
基金RAM Rafeek is recipient of International Postgraduate Research Award(IPRA)from University of New England.CM Lobbe and E.Wilkinson are recipients of student scholarship from the Royal College of Pathologists of Australasia(RCPA).
文摘Background:The neuropsychiatric disorders due to post-streptococcal autoimmune complications such as Sydenham's chorea(SC)are associated with acute rheumatic fever and rheumatic heart disease(ARF/RHD).An animal model that exhibits char-acteristics of both cardiac and neurobehavioral defects in ARF/RHD would be an important adjunct for future studies.Since age,gender,strain differences,and geno-types impact on the development of autoimmunity,we investigated the behavior of male and female Wistar and Lewis rat strains in two age cohorts(6 weeks and 12 weeks)under normal husbandry conditions and following exposure to group A streptococcus(GAS).Methods:Standard behavioral assessments were performed to determine the impair-ments in fine motor control(food manipulation test),gait and balance(beam walk-ing test),and obsessive-compulsive behavior(grooming and marble burying tests).Furthermore,electrocardiography,histology,and behavioral assessments were per-formed on male and female Lewis rats injected with GAS antigens.Results:For control Lewis rats there were no significant age and gender dependent differences in marble burying,food manipulation,beam walking and grooming be-haviors.In contrast significant age-dependent differences were observed in Wistar rats in all the behavioral tests except for food manipulation.Therefore,Lewis rats were selected for further experiments to determine the effect of GAS.After ex-posure to GAS,Lewis rats demonstrated neurobehavioral abnormalities and cardiac pathology akin to SC and ARF/RHD,respectively.Conclusion:We have characterised a new model that provides longitudinal stability of age-dependent behavior,to simultaneously investigate both neurobehavioral and cardiac abnormalities associated with post-streptococcal complications.
文摘Selected mainly were acupoints in the adjacent areas and along the meridians,assisted by ashi points.Fengmen(BL 12),Geshu(BL 17)and Xuehai(SP 10)were selected for migratory arthralgia;Shenshu(BL 23)and Guanyuan(CV 4)for cold-aggravated arthralgia;Pishu(BL 20),Zusanli(ST 36)and Yinlingquan(SP 9)for damp arthralgia;Dazhui(GV 14)and Quchi(LI 11)for heat-induced arthralgia.Acupuncture in combination with far infra-red radiation was performed.76 patients with rheumatoid arthritis were treated and 74 cases with herb therapy as control.The result showed that there was statistically significant difference in curative effect between the 2 groups,χ^(2)=10.18,P<0.01,indicating that the curative effect was significantly better in the treatment group than in the control group.Statistics showed that there was no significant difference in curative effect among the 4 syndromic types,namely migratory arthralgia,cold-aggravated arthralgia,damp-induced arthralgia and heat-induced arthralgia.But there was a statistically significant difference in curative effect between the above 4 syndromic types and deficiency-type arthralgia,indicating that the curative effect in deficiency-type arthralgia was worst.
