A new triterpenoid saponin, namely unifloroside, together with five known compounds, was isolated from Rhaponticum uniflorum (L.) DC. The structure of the new triterpenoid saponin was elucidated as 3_O_ α_L_arabin...A new triterpenoid saponin, namely unifloroside, together with five known compounds, was isolated from Rhaponticum uniflorum (L.) DC. The structure of the new triterpenoid saponin was elucidated as 3_O_ α_L_arabinopyranosyl_urs_9(11),12_dien_28_oic acid β_D_glucopyranosyl ester mainly by using 1D, 2D_NMR techniques and chemical methods.展开更多
From the roots of Rhaponticum uniflorum a new triterpene was isolated together with ursolic acid(2), 3-oxo-19a-hydroxyurs-12-en-28-oic acid (3), pomolic acid (4), 2a,3a,19a-trihydroxyurs-12-en-28-oic acid (5), arctic ...From the roots of Rhaponticum uniflorum a new triterpene was isolated together with ursolic acid(2), 3-oxo-19a-hydroxyurs-12-en-28-oic acid (3), pomolic acid (4), 2a,3a,19a-trihydroxyurs-12-en-28-oic acid (5), arctic acid (6), catechin (7) and b-sitosterol (8). The structure of the new compound was elucidated as 2a,3a,19a,25-tetrahydroxyurs-12-en-23,28-dioic acid (1) on the basis of spectral and chemical methods.展开更多
An anlytical method for the separation and quantitative determination of three phytoecdysteroids in Rhaponticum uniflorum by high performance liquid chromatography has been developed.Three phytoecdysteroids,ecdysteron...An anlytical method for the separation and quantitative determination of three phytoecdysteroids in Rhaponticum uniflorum by high performance liquid chromatography has been developed.Three phytoecdysteroids,ecdysterone (Ⅰ),rha- pontisterone(Ⅱ) and turkesterone(Ⅲ) were separated and determined quantitatively by using the solvent system MeOH-H_2O(40∶60) at 242 nm with flow rate of 1.5ml/min,the operation can be completed in 10 minutes.Using the external standard method,the content of three phytoecdysteroids in the roots and aerial parts of Rhaponticum uniflorum obtained from dif- ferent localities was determined.It is proved that this method is sensitive and accurate,and with good reproducibility.展开更多
Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopy...Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopyranosyl]-urs-12, 19 （29）-dien-oic acid-28-O-[β-b-glucopyranosyl] ester 2 mainly by 1D, 2D NMR techniques and chemical methods.展开更多
Menopause is characterized by various physical,mental and emotional symptoms.ERr 731®is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal sympt...Menopause is characterized by various physical,mental and emotional symptoms.ERr 731®is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms.The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731®supplementation in alleviating the severity of menopausal symptoms.In this review,we searched across three online databases up to March 2023,evaluated the quality of the included studies by the Physiotherapy Evidence Database scale,and assessed the risk of bias by the Cochrane Risk of Bias tool.We then performed a metaanalysis using RevMan software to estimate the pooled mean difference(MD).The study protocol was registered in the Prospective Register of Systematic Reviews(CRD42023416808).After screening and evaluation,we included four high-quality studies(a total of 390 participants;the ERr 731®group:193 participants;the control group:197 participants)in the meta-analysis.The results showed that ERr 731®supplementation significantly reduced the Menopause Rating Scale score(MD:–15.12;P<0.001),compared with control therapy.Sensitivity analysis revealed no effect of individual studies on the overall pooled estimate or overall observed heterogeneity.The current review provides evidence that ERr 731®supplementation is effective in reducing menopause symptoms.Potential bias and high heterogeneity in the results warrant further clinical studies.展开更多
The large life cycle Rhaponticum integrifolium in natural populations (Qashqadaryo, Uzbekistan) was studied. Duration of before generative, generative and senile periods of Rhaponticum integrifolium is 2 - 5, 8 - 10 a...The large life cycle Rhaponticum integrifolium in natural populations (Qashqadaryo, Uzbekistan) was studied. Duration of before generative, generative and senile periods of Rhaponticum integrifolium is 2 - 5, 8 - 10 and 2 - 4 years respectively. The beginning of phenophases depends on the height of the terrain above sea level: raising the terrain from 400 to 1500 m leads to a delay in the onset of phenophases. Age states of Rhaponticum integrifolium in different ecological and phytogenetic conditions were revealed. Updated distribution of detected participation of vegetation and the raw Rhaponticum integrifolium in Uzbekistan, describes the dynamics of the contents ecdysteroids in the periods of vegetation. At the same time, a map of the species area in Central Asia was made and the term of its phytomass recovery under different operating modes of thickets was determined.展开更多
文摘A new triterpenoid saponin, namely unifloroside, together with five known compounds, was isolated from Rhaponticum uniflorum (L.) DC. The structure of the new triterpenoid saponin was elucidated as 3_O_ α_L_arabinopyranosyl_urs_9(11),12_dien_28_oic acid β_D_glucopyranosyl ester mainly by using 1D, 2D_NMR techniques and chemical methods.
文摘From the roots of Rhaponticum uniflorum a new triterpene was isolated together with ursolic acid(2), 3-oxo-19a-hydroxyurs-12-en-28-oic acid (3), pomolic acid (4), 2a,3a,19a-trihydroxyurs-12-en-28-oic acid (5), arctic acid (6), catechin (7) and b-sitosterol (8). The structure of the new compound was elucidated as 2a,3a,19a,25-tetrahydroxyurs-12-en-23,28-dioic acid (1) on the basis of spectral and chemical methods.
文摘An anlytical method for the separation and quantitative determination of three phytoecdysteroids in Rhaponticum uniflorum by high performance liquid chromatography has been developed.Three phytoecdysteroids,ecdysterone (Ⅰ),rha- pontisterone(Ⅱ) and turkesterone(Ⅲ) were separated and determined quantitatively by using the solvent system MeOH-H_2O(40∶60) at 242 nm with flow rate of 1.5ml/min,the operation can be completed in 10 minutes.Using the external standard method,the content of three phytoecdysteroids in the roots and aerial parts of Rhaponticum uniflorum obtained from dif- ferent localities was determined.It is proved that this method is sensitive and accurate,and with good reproducibility.
基金supported by the Education Bureau of Fujian Province(No.JS06025)National Natural Sciences Foundation of China(No.29772010)
文摘Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopyranosyl]-urs-12, 19 （29）-dien-oic acid-28-O-[β-b-glucopyranosyl] ester 2 mainly by 1D, 2D NMR techniques and chemical methods.
文摘A new phytoecdysteroid was isolated from the root of Rhaponticum uniflorum. Its structure has been shown to be 2, 3, 20, 22-diacetonide ajugasterone.
文摘Menopause is characterized by various physical,mental and emotional symptoms.ERr 731®is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms.The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731®supplementation in alleviating the severity of menopausal symptoms.In this review,we searched across three online databases up to March 2023,evaluated the quality of the included studies by the Physiotherapy Evidence Database scale,and assessed the risk of bias by the Cochrane Risk of Bias tool.We then performed a metaanalysis using RevMan software to estimate the pooled mean difference(MD).The study protocol was registered in the Prospective Register of Systematic Reviews(CRD42023416808).After screening and evaluation,we included four high-quality studies(a total of 390 participants;the ERr 731®group:193 participants;the control group:197 participants)in the meta-analysis.The results showed that ERr 731®supplementation significantly reduced the Menopause Rating Scale score(MD:–15.12;P<0.001),compared with control therapy.Sensitivity analysis revealed no effect of individual studies on the overall pooled estimate or overall observed heterogeneity.The current review provides evidence that ERr 731®supplementation is effective in reducing menopause symptoms.Potential bias and high heterogeneity in the results warrant further clinical studies.
文摘The large life cycle Rhaponticum integrifolium in natural populations (Qashqadaryo, Uzbekistan) was studied. Duration of before generative, generative and senile periods of Rhaponticum integrifolium is 2 - 5, 8 - 10 and 2 - 4 years respectively. The beginning of phenophases depends on the height of the terrain above sea level: raising the terrain from 400 to 1500 m leads to a delay in the onset of phenophases. Age states of Rhaponticum integrifolium in different ecological and phytogenetic conditions were revealed. Updated distribution of detected participation of vegetation and the raw Rhaponticum integrifolium in Uzbekistan, describes the dynamics of the contents ecdysteroids in the periods of vegetation. At the same time, a map of the species area in Central Asia was made and the term of its phytomass recovery under different operating modes of thickets was determined.
