This study aims to enhance the maneuvering advantages of the waterjet unit through parametric design,performance evaluation,and optimization of the one-piece waterjet propulsion steering and reversing gear(SRG).The SR...This study aims to enhance the maneuvering advantages of the waterjet unit through parametric design,performance evaluation,and optimization of the one-piece waterjet propulsion steering and reversing gear(SRG).The SRG’s performance evaluation stems mainly from the effect of the free surface,the varying sailing speeds of the ship,and its performance while functioning at the stern of the waterjet-propelled vessel.Parameters such as the length,width,and height of the steering gear,as well as the inclination,width,and curvature of the reversing gear,significantly influence the SRG.Although the free surface has a great impact on the force of the SRG,its performance trend remains unaffected.When the SRG operates at the stern of the ship,the optimized scheme’s lateral force improves by an average of 8.08%for sailing with a rudder angle condition and an average of 45.69%for reversing sailing with a rudder angle condition.The longitudinal force of the optimized scheme improves by more than 23%when sailing without a rudder angle condition and by an average of 31.75%when sailing with a reversed rudder angle condition.Additionally,the speed of the rotor has a minimal effect on the lateral force and a significant effect on the longitudinal force.展开更多
The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The ...The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$展开更多
The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The ...The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$展开更多
Turbine blade is one of the critical components of aircraft engine.The performance of the engine depends on the shape and dimensions of components,but superalloy blade material cannot be easily machined.Although inves...Turbine blade is one of the critical components of aircraft engine.The performance of the engine depends on the shape and dimensions of components,but superalloy blade material cannot be easily machined.Although investment casting is an ideal process for such net-shape components,it requires an accurate determination of the casting-die profile.In this paper,a reversing design methodology for investment casting die using ProCAST is proposed.By combining the methods of simplifying grid files and quick sorting,the efficiency of sorting and matching can be largely improved.Further,the mould/die cavity anti-deformation system can be easily built.With ProCAST,the optimized die profile for investment casting can be established.展开更多
According to the hydraulic calculation principles of the orifice outflow, the discharge capacity of the columnar reversing gate under the partial opening condition was calculated and checked. Using ANSYS, a large fini...According to the hydraulic calculation principles of the orifice outflow, the discharge capacity of the columnar reversing gate under the partial opening condition was calculated and checked. Using ANSYS, a large finite element analysis software, the discharge process was simulated. The distribution rule of the velocities in the gate chamber and downstream channel was obtained. An FEM model of the columnar reversing gate was built, and the natural vibration properties of the gate were analyzed. Based on the Westergaard added mass method, the added mass caused by the fluid-structure coupling motion was taken into account, and the effects of the coupling interaction were discussed. The results show that the size of the small gates meets the demand for discharge capacity, the current in the gate chamber is quite turbulent, the trunnion and arms are obviously impacted by flow, and the effects of water on vibration characteristics are remarkable. The study provides a reference for the design and calculation of gates of the same type.展开更多
To get a deeper understanding on the formation mechanisms and distribution laws of remaining oil during water flooding, and enhanced oil recovery(EOR) mechanisms by reversing water injection after water flooding, 3D v...To get a deeper understanding on the formation mechanisms and distribution laws of remaining oil during water flooding, and enhanced oil recovery(EOR) mechanisms by reversing water injection after water flooding, 3D visualization models of fractured-vuggy reservoir were constructed based on the elements and configuration of fractures and vugs, and typical fracture-vug structures by using advanced CT scanning and 3D printing technologies. Then, water flooding and reversing water injection experiments were conducted. The formation mechanisms of remaining oil during water flooding include inadequate injection-production well control, gravity difference between oil and water, interference between different flow channels, isolation by low connectivity channel, weak hydrodynamic force at the far end. Under the above effects, 7 kinds of remaining oil may come about, imperfect well-control oil, blind side oil, attic oil at the reservoir top, by-pass residual oil under gravity, by-pass residual oil in secondary channel, isolated oil in low connectivity channel, and remaining oil at far and weakly connected end. Some remaining oil can be recovered by reversing water injection after water flooding, but its EOR is related to the remaining oil type, fracture-cavity structure and reversing injection-production structure. Five of the above seven kinds of remaining oil can be produced by six EOR mechanisms of reversing water injection: gravity displacement, opening new flow channel, rising the outflow point, hydrodynamic force enhancement, vertically equilibrium displacement, and synergistic effect of hydrodynamic force and gravity.展开更多
Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety r...Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety range,broad-spectrum and multi-targets,etc.Therefore,traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer.Studies about applying traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below.展开更多
Regenerative medicine by cell transplantation is a novel therapy for treating end-stage organ failure and tissue damage. Cell-based therapy based on the transplantation of neural stem/progenitor cells （NSPCs） repres...Regenerative medicine by cell transplantation is a novel therapy for treating end-stage organ failure and tissue damage. Cell-based therapy based on the transplantation of neural stem/progenitor cells （NSPCs） represents an attractive strategy for the treatment of neurodegenerative diseases, but obtaining large numbers of these cells is difficult and their differentiation potential is strictly restricted in a spatiotemporally-regulated manner during central nervous system （CNS） development. Therefore, embryonic stem cells and induced pluripotent stem cells represent an attractive alternative for cell-transplantation therapy in regenerative medicine.展开更多
The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic sim...The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic simulation research of the new type reversing valve is conducted. The effects of the system parameters on the working performance are researched systematically and deeply. The regular understanding on the motion of the reversing valve is obtained, which provides theoretical basis for the innovation and manufacturing of a new generation of hydraulic breaker reversing valve.展开更多
The paper study the software and hardware principles of ultrasonic ranging reversing radar, design the vehicle reversing radar based on intelligent node of CAN bus, realize data communication and resource sharing with...The paper study the software and hardware principles of ultrasonic ranging reversing radar, design the vehicle reversing radar based on intelligent node of CAN bus, realize data communication and resource sharing with other intelligent nodes of the reversing radar. The experimental results show that, the design can achieve the expected technical indicators design, measurement precision and the reliability is high, which has certain guiding significance in the design of the car reversing radar, has wide application prospect and practical significance in the function of the extended CAN bus communication messages design and automotive CAN network.展开更多
This paper sets up a mathematical model of switching network and switching function by utilizing graph theory to describe the logical function of different paths.The function varies with open and closed states of air ...This paper sets up a mathematical model of switching network and switching function by utilizing graph theory to describe the logical function of different paths.The function varies with open and closed states of air doors in a complex mine air sub network, and the computer program for solving the switching function of complex networks are offered. It gives the method for discriminating a reversible branch in a complex network by means of the switching function, and the method of counter inverted logical control of airflow inversion by means of open and short circuit conversion of key branches. The research has solved the problem of the stablization of air flow for normal ventination and reversing ventination in a diagonal network.展开更多
There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that e...There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An atiempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to infl uence ageing: Neurogenesis;Epigenetic reprogramming;Removing dying cells;Mitochondria resuscitation;Calorie restriction;Plant-based diet;Regular physical activity;Chi Kung (Qigong);Overcoming anxiety, depression and stress;Positive mind-set;Some worrying;Vitamins and minerals;L-Theanine;Omega-3 and healthy fats;Coenzyme Q-10;Pyrroloquinoline quinone;Nitric oxide;Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily prac-tices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look atier them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.展开更多
Deserts usually impress people with the image of vast desolated sand area with no water or plants. But in China, it is no longer the case, as some parts of its vast deserts have become grassland, forest and even wetla...Deserts usually impress people with the image of vast desolated sand area with no water or plants. But in China, it is no longer the case, as some parts of its vast deserts have become grassland, forest and even wetland. In the Kubuqi Desert in north China's Inner Mongolia Autonomous Region, and the Babusha Desert and Mu Us Desert in northwest China's Gansu and Shaanxi provinces, just to name a few, efforts in different forms have been made to stop the deserts from expanding, and reclaim the land from the deserts, involving people from all walks of life, such as individuals, businesses and social organizations.展开更多
■With great ceremony and amidst a torrential downpour on the 1st July, 1997,Hong Kong ceased to be a British colony and was handed back to China. Since the 1842 British occupation of Hong
Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel ...Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.展开更多
Recently,Yu and co-workers deeply explore the potential impact of free electron transfer between co-catalysts and photocatalyst carriers on H_(2)evolution efficiency of active sites over MoS_(2+x).They pro-pose an ele...Recently,Yu and co-workers deeply explore the potential impact of free electron transfer between co-catalysts and photocatalyst carriers on H_(2)evolution efficiency of active sites over MoS_(2+x).They pro-pose an electron-reversal tactics to evade the unexpected electron transfer and synchronously regulate the above transfer in a beneficial orientation for weakening hydrogen adsorption on S sites.Herein,this highlight not only discusses and summarizes the essences of electron reversal and the optimized H ad-sorption/desorption mechanism,but also emphasizes the significance of femtosecond transient absorp-tion spectroscopy(fs-TAS)and in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS)for revealing charge transfer dynamics and processes.We anticipate that this highlight can disseminate a new per-spective on the roles of photocatalyst carriers in improving cocatalytic H_(2)-production kinetics.展开更多
Objective:To investigate the reversing effects of interferon a (IFN-a) on drug resistance of bone marrow cells in leukemia and its possible mechanism. Methods: Before and after the bone marrow cells extracted from50 c...Objective:To investigate the reversing effects of interferon a (IFN-a) on drug resistance of bone marrow cells in leukemia and its possible mechanism. Methods: Before and after the bone marrow cells extracted from50 cases of acute leukemia and 2 of chronic leukemia (BP) were incubated in the media with the addition of IFN-α,MDR1 mRNA expression and concentration of daunorubicin (DNR) in the cells were determined respectively withSAG-ISH and respectrofluorimetry. Results: Twenty-four (64. 2% ) our of all the 52 cases presented MDR1 mRNA expression. There was significant difference in the concentration of DNR between MDR1-positive and MDR1-negative cases before and after incubation. In all the 52 cases, no significant difference was found between the concentration of DNR before the incubation and that after the incubation. Conclusion: IFN-a can increase the concentration of DNR in the bone marrow cells in leukemia. No occurrence of MDR reversal is on the level of MDRl buton other levels.展开更多
Internet communication protocols define the behavior rules of network components when they communicate with each other.With the continuous development of network technologies,many private or unknown network protocols ...Internet communication protocols define the behavior rules of network components when they communicate with each other.With the continuous development of network technologies,many private or unknown network protocols are emerging in endlessly various network environments.Herein,relevant protocol specifications become difficult or unavailable to translate in many situations such as network security management and intrusion detection.Although protocol reverse engineering is being investigated in recent years to perform reverse analysis on the specifications of unknown protocols,most existing methods have proven to be time-consuming with limited efficiency,especially when applied on unknown protocol state machines.This paper proposes a state merging algorithm based on EDSM(Evidence-Driven State Merging)to infer the transition rules of unknown protocols in form of state machines with high efficiency.Compared with another classical state machine inferring method based on Exbar algorithm,the experiment results demonstrate that our proposed method could run faster,especially when dealing with massive training data sets.In addition,this method can also make the state machines have higher similarities with the reference state machines constructed from public specifications.展开更多
Ureaplasma Urealyticum(UU) can not only cause a wide range of nongonococcalinfectionsto urogenital tract,but also lead to infertility,sterility,intrauterinefetal infection,abortion or other bad consequences.For males,...Ureaplasma Urealyticum(UU) can not only cause a wide range of nongonococcalinfectionsto urogenital tract,but also lead to infertility,sterility,intrauterinefetal infection,abortion or other bad consequences.For males,UU may cause prostatitis,epididymitis and other diseases.With great harm to the human health,UU infection has been taken as one of the most important STDs in China for prevention and cure.However,the drug resistance of UU is increasingly stronger with the widespread use of antibiotics.Many nongonococcal patients with mycoplasma infection often fail to be cured after a long time of treatment,and drug sensitive tests find that,multidrug resistance brings physical and mental pains to patients all the time.Luckily,integrated Chinese traditional and western medicine greatly improves the cure rate,though the mechanism is not clear.There have been many studies on the reversion action and mechanism of TCM on the antibiotic resistance of bacteria,but studies on the reversion to UU drug resistance are deficient.Here we chose some voluntary patients with multidrug resistance as the research objects,who received treatment in my hospital in recent 3 years.They were given the oral administration of self-prescribed Cangbai Shiduqing Granule.Then,Cangbai Shiduqing Granule's reversion effect on UU drug resistance,namely,the sensitivity transformation situation of drug-resistant antibiotics,was observed.And the observation results are presented in the paper.展开更多
Objective:To evaluate inhibitory activity of methylglyoxal(MGO)mediated protein glycation and ability to potentiate its reversing activity and range of antioxidant properties of Sri Lankan low grown orthodox orange pe...Objective:To evaluate inhibitory activity of methylglyoxal(MGO)mediated protein glycation and ability to potentiate its reversing activity and range of antioxidant properties of Sri Lankan low grown orthodox orange pekoe grade black tea.Methods:Freeze dried black tea brew(BTB)was used as the sample in this study.Antiglycation and glycation reversing activity was studied in bovine serum albumin(BSA)-MGO model.Antioxidant properties were studied using total polyphenolic content,total flavonoid content,2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid,1,1-diphenyl-2-picrylhydrazine and ferric reducing antioxidant power in vitro antioxidant assays.Results:The results demonstrated significant(P<0.05)and dose dependant inhibition of BSA-MGO glycation[IC_(50):(164.30±4.85)μg/mL],potentiating of its reversing activity[EC_(50):(235.39±5.37)μg/mL]and marked antioxidant properties[total polyphenolic content:(119.55±9.97)mg gallic acid equivalents/g BTB;total flavonoid content:(6.04±1.26)mg quercetin equivalents/g BTB;2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid,1,1-diphenyl-2-picrylhydrazine and ferric reducing antioxidant power:(3.29±0.06),(1.95±0.15)and(1.31±0.19)mmol Trolox equivalents/g BTB,respectively].No correlations were observed between antioxidant activity and BSA-MGO glycation.Conclusions:The novel properties observed for Sri Lankan orange pekoe grade black tea indicate its usefulness as a supplementary beverage in managing MGO and advanced glycation end products related diseases and ailments.展开更多
基金supported by the Sanya Science and Education Innovation Park of Wuhan University of Technology(Grant No.2022KF0017)Hainan Provincial Natural Science Foundation of China(Grant No.522QN342)+1 种基金the National Natural Science Foundation of China(Grant No.52201376)Natural Science Foundation of Hubei Province,China(Grant No.2023AFB683).
文摘This study aims to enhance the maneuvering advantages of the waterjet unit through parametric design,performance evaluation,and optimization of the one-piece waterjet propulsion steering and reversing gear(SRG).The SRG’s performance evaluation stems mainly from the effect of the free surface,the varying sailing speeds of the ship,and its performance while functioning at the stern of the waterjet-propelled vessel.Parameters such as the length,width,and height of the steering gear,as well as the inclination,width,and curvature of the reversing gear,significantly influence the SRG.Although the free surface has a great impact on the force of the SRG,its performance trend remains unaffected.When the SRG operates at the stern of the ship,the optimized scheme’s lateral force improves by an average of 8.08%for sailing with a rudder angle condition and an average of 45.69%for reversing sailing with a rudder angle condition.The longitudinal force of the optimized scheme improves by more than 23%when sailing without a rudder angle condition and by an average of 31.75%when sailing with a reversed rudder angle condition.Additionally,the speed of the rotor has a minimal effect on the lateral force and a significant effect on the longitudinal force.
基金support of National Natural Science Foundation of China(39970892)
文摘The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$
文摘The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$
基金supported by National Key Technologies R&D Program under Grant No. 2006BAF04B02
文摘Turbine blade is one of the critical components of aircraft engine.The performance of the engine depends on the shape and dimensions of components,but superalloy blade material cannot be easily machined.Although investment casting is an ideal process for such net-shape components,it requires an accurate determination of the casting-die profile.In this paper,a reversing design methodology for investment casting die using ProCAST is proposed.By combining the methods of simplifying grid files and quick sorting,the efficiency of sorting and matching can be largely improved.Further,the mould/die cavity anti-deformation system can be easily built.With ProCAST,the optimized die profile for investment casting can be established.
文摘According to the hydraulic calculation principles of the orifice outflow, the discharge capacity of the columnar reversing gate under the partial opening condition was calculated and checked. Using ANSYS, a large finite element analysis software, the discharge process was simulated. The distribution rule of the velocities in the gate chamber and downstream channel was obtained. An FEM model of the columnar reversing gate was built, and the natural vibration properties of the gate were analyzed. Based on the Westergaard added mass method, the added mass caused by the fluid-structure coupling motion was taken into account, and the effects of the coupling interaction were discussed. The results show that the size of the small gates meets the demand for discharge capacity, the current in the gate chamber is quite turbulent, the trunnion and arms are obviously impacted by flow, and the effects of water on vibration characteristics are remarkable. The study provides a reference for the design and calculation of gates of the same type.
基金National Natural Science Foundation of China Enterprise Innovation and Development Joint Fund(U19B6003-02-06)。
文摘To get a deeper understanding on the formation mechanisms and distribution laws of remaining oil during water flooding, and enhanced oil recovery(EOR) mechanisms by reversing water injection after water flooding, 3D visualization models of fractured-vuggy reservoir were constructed based on the elements and configuration of fractures and vugs, and typical fracture-vug structures by using advanced CT scanning and 3D printing technologies. Then, water flooding and reversing water injection experiments were conducted. The formation mechanisms of remaining oil during water flooding include inadequate injection-production well control, gravity difference between oil and water, interference between different flow channels, isolation by low connectivity channel, weak hydrodynamic force at the far end. Under the above effects, 7 kinds of remaining oil may come about, imperfect well-control oil, blind side oil, attic oil at the reservoir top, by-pass residual oil under gravity, by-pass residual oil in secondary channel, isolated oil in low connectivity channel, and remaining oil at far and weakly connected end. Some remaining oil can be recovered by reversing water injection after water flooding, but its EOR is related to the remaining oil type, fracture-cavity structure and reversing injection-production structure. Five of the above seven kinds of remaining oil can be produced by six EOR mechanisms of reversing water injection: gravity displacement, opening new flow channel, rising the outflow point, hydrodynamic force enhancement, vertically equilibrium displacement, and synergistic effect of hydrodynamic force and gravity.
文摘Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety range,broad-spectrum and multi-targets,etc.Therefore,traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer.Studies about applying traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below.
文摘Regenerative medicine by cell transplantation is a novel therapy for treating end-stage organ failure and tissue damage. Cell-based therapy based on the transplantation of neural stem/progenitor cells （NSPCs） represents an attractive strategy for the treatment of neurodegenerative diseases, but obtaining large numbers of these cells is difficult and their differentiation potential is strictly restricted in a spatiotemporally-regulated manner during central nervous system （CNS） development. Therefore, embryonic stem cells and induced pluripotent stem cells represent an attractive alternative for cell-transplantation therapy in regenerative medicine.
文摘The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic simulation research of the new type reversing valve is conducted. The effects of the system parameters on the working performance are researched systematically and deeply. The regular understanding on the motion of the reversing valve is obtained, which provides theoretical basis for the innovation and manufacturing of a new generation of hydraulic breaker reversing valve.
文摘The paper study the software and hardware principles of ultrasonic ranging reversing radar, design the vehicle reversing radar based on intelligent node of CAN bus, realize data communication and resource sharing with other intelligent nodes of the reversing radar. The experimental results show that, the design can achieve the expected technical indicators design, measurement precision and the reliability is high, which has certain guiding significance in the design of the car reversing radar, has wide application prospect and practical significance in the function of the extended CAN bus communication messages design and automotive CAN network.
文摘This paper sets up a mathematical model of switching network and switching function by utilizing graph theory to describe the logical function of different paths.The function varies with open and closed states of air doors in a complex mine air sub network, and the computer program for solving the switching function of complex networks are offered. It gives the method for discriminating a reversible branch in a complex network by means of the switching function, and the method of counter inverted logical control of airflow inversion by means of open and short circuit conversion of key branches. The research has solved the problem of the stablization of air flow for normal ventination and reversing ventination in a diagonal network.
文摘There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An atiempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to infl uence ageing: Neurogenesis;Epigenetic reprogramming;Removing dying cells;Mitochondria resuscitation;Calorie restriction;Plant-based diet;Regular physical activity;Chi Kung (Qigong);Overcoming anxiety, depression and stress;Positive mind-set;Some worrying;Vitamins and minerals;L-Theanine;Omega-3 and healthy fats;Coenzyme Q-10;Pyrroloquinoline quinone;Nitric oxide;Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily prac-tices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look atier them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.
文摘Deserts usually impress people with the image of vast desolated sand area with no water or plants. But in China, it is no longer the case, as some parts of its vast deserts have become grassland, forest and even wetland. In the Kubuqi Desert in north China's Inner Mongolia Autonomous Region, and the Babusha Desert and Mu Us Desert in northwest China's Gansu and Shaanxi provinces, just to name a few, efforts in different forms have been made to stop the deserts from expanding, and reclaim the land from the deserts, involving people from all walks of life, such as individuals, businesses and social organizations.
文摘■With great ceremony and amidst a torrential downpour on the 1st July, 1997,Hong Kong ceased to be a British colony and was handed back to China. Since the 1842 British occupation of Hong
基金supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673)National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703)+2 种基金National Key Basic Research Program 973 of P.R.China(No.2010CB732404)Key Medical Projects of Jiangsu Province(No.BL2014078)Key Discipline of Jiangsu Province(2011-2015)
文摘Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
基金supported by the Natural Science Foundation of Hebei of China(Nos.B2020205013,B2022205008)the Science and Technology Project of Hebei Normal University of China(No.L2021K01).
文摘Recently,Yu and co-workers deeply explore the potential impact of free electron transfer between co-catalysts and photocatalyst carriers on H_(2)evolution efficiency of active sites over MoS_(2+x).They pro-pose an electron-reversal tactics to evade the unexpected electron transfer and synchronously regulate the above transfer in a beneficial orientation for weakening hydrogen adsorption on S sites.Herein,this highlight not only discusses and summarizes the essences of electron reversal and the optimized H ad-sorption/desorption mechanism,but also emphasizes the significance of femtosecond transient absorp-tion spectroscopy(fs-TAS)and in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS)for revealing charge transfer dynamics and processes.We anticipate that this highlight can disseminate a new per-spective on the roles of photocatalyst carriers in improving cocatalytic H_(2)-production kinetics.
文摘Objective:To investigate the reversing effects of interferon a (IFN-a) on drug resistance of bone marrow cells in leukemia and its possible mechanism. Methods: Before and after the bone marrow cells extracted from50 cases of acute leukemia and 2 of chronic leukemia (BP) were incubated in the media with the addition of IFN-α,MDR1 mRNA expression and concentration of daunorubicin (DNR) in the cells were determined respectively withSAG-ISH and respectrofluorimetry. Results: Twenty-four (64. 2% ) our of all the 52 cases presented MDR1 mRNA expression. There was significant difference in the concentration of DNR between MDR1-positive and MDR1-negative cases before and after incubation. In all the 52 cases, no significant difference was found between the concentration of DNR before the incubation and that after the incubation. Conclusion: IFN-a can increase the concentration of DNR in the bone marrow cells in leukemia. No occurrence of MDR reversal is on the level of MDRl buton other levels.
基金This work is supported by the National Natural Science Foundation of China(Grant Number:61471141,61361166006,61301099)Basic Research Project of Shenzhen,China(Grant Number:JCYJ20150513151706561)National Defense Basic Scientific Research Program of China(Grant Number:JCKY2018603B006).
文摘Internet communication protocols define the behavior rules of network components when they communicate with each other.With the continuous development of network technologies,many private or unknown network protocols are emerging in endlessly various network environments.Herein,relevant protocol specifications become difficult or unavailable to translate in many situations such as network security management and intrusion detection.Although protocol reverse engineering is being investigated in recent years to perform reverse analysis on the specifications of unknown protocols,most existing methods have proven to be time-consuming with limited efficiency,especially when applied on unknown protocol state machines.This paper proposes a state merging algorithm based on EDSM(Evidence-Driven State Merging)to infer the transition rules of unknown protocols in form of state machines with high efficiency.Compared with another classical state machine inferring method based on Exbar algorithm,the experiment results demonstrate that our proposed method could run faster,especially when dealing with massive training data sets.In addition,this method can also make the state machines have higher similarities with the reference state machines constructed from public specifications.
基金National Natural Science Fund(No:81072811)Beijing Administration of Traditional Chinese Medicine Development Plan in 13th Five-Year of Key Specialty of DermatologyProject from Human Resources Dept of Dongfang Hospital "Dongfang Famous Doctors"
文摘Ureaplasma Urealyticum(UU) can not only cause a wide range of nongonococcalinfectionsto urogenital tract,but also lead to infertility,sterility,intrauterinefetal infection,abortion or other bad consequences.For males,UU may cause prostatitis,epididymitis and other diseases.With great harm to the human health,UU infection has been taken as one of the most important STDs in China for prevention and cure.However,the drug resistance of UU is increasingly stronger with the widespread use of antibiotics.Many nongonococcal patients with mycoplasma infection often fail to be cured after a long time of treatment,and drug sensitive tests find that,multidrug resistance brings physical and mental pains to patients all the time.Luckily,integrated Chinese traditional and western medicine greatly improves the cure rate,though the mechanism is not clear.There have been many studies on the reversion action and mechanism of TCM on the antibiotic resistance of bacteria,but studies on the reversion to UU drug resistance are deficient.Here we chose some voluntary patients with multidrug resistance as the research objects,who received treatment in my hospital in recent 3 years.They were given the oral administration of self-prescribed Cangbai Shiduqing Granule.Then,Cangbai Shiduqing Granule's reversion effect on UU drug resistance,namely,the sensitivity transformation situation of drug-resistant antibiotics,was observed.And the observation results are presented in the paper.
文摘Objective:To evaluate inhibitory activity of methylglyoxal(MGO)mediated protein glycation and ability to potentiate its reversing activity and range of antioxidant properties of Sri Lankan low grown orthodox orange pekoe grade black tea.Methods:Freeze dried black tea brew(BTB)was used as the sample in this study.Antiglycation and glycation reversing activity was studied in bovine serum albumin(BSA)-MGO model.Antioxidant properties were studied using total polyphenolic content,total flavonoid content,2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid,1,1-diphenyl-2-picrylhydrazine and ferric reducing antioxidant power in vitro antioxidant assays.Results:The results demonstrated significant(P<0.05)and dose dependant inhibition of BSA-MGO glycation[IC_(50):(164.30±4.85)μg/mL],potentiating of its reversing activity[EC_(50):(235.39±5.37)μg/mL]and marked antioxidant properties[total polyphenolic content:(119.55±9.97)mg gallic acid equivalents/g BTB;total flavonoid content:(6.04±1.26)mg quercetin equivalents/g BTB;2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid,1,1-diphenyl-2-picrylhydrazine and ferric reducing antioxidant power:(3.29±0.06),(1.95±0.15)and(1.31±0.19)mmol Trolox equivalents/g BTB,respectively].No correlations were observed between antioxidant activity and BSA-MGO glycation.Conclusions:The novel properties observed for Sri Lankan orange pekoe grade black tea indicate its usefulness as a supplementary beverage in managing MGO and advanced glycation end products related diseases and ailments.
