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FOXO4 D-Retro-Inverso影响细胞外基质的产生并缓解肺纤维化
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作者 刘颖 后钦珲 +4 位作者 王睿 刘媛 吴开松 杨亦斌 程真顺 《武汉大学学报(医学版)》 CAS 2024年第4期379-384,共6页
目的:观察FOXO4 D-Retro-Inverso(FOXO4-DRI)对肺纤维化小鼠模型及肺成纤维细胞活化和细胞外基质(ECM)生成的影响。方法:C57BL/6J雄鼠气管内滴注博来霉素构建肺纤维化模型,予以FOXO4-DRI治疗,第21天观察肺结构改变及纤维化标志物的表达... 目的:观察FOXO4 D-Retro-Inverso(FOXO4-DRI)对肺纤维化小鼠模型及肺成纤维细胞活化和细胞外基质(ECM)生成的影响。方法:C57BL/6J雄鼠气管内滴注博来霉素构建肺纤维化模型,予以FOXO4-DRI治疗,第21天观察肺结构改变及纤维化标志物的表达水平。人肺成纤维细胞MRC5予以TGF-β1刺激后给予FOXO4-DRI干预,检测成纤维细胞活化标志物及ECM表达水平。结果:气管内滴注博来霉素后成功诱导小鼠肺部结构破坏,纤维化评分升高(P<0.01),肺纤维化标志物表达量升高(P<0.01)。FOXO4-DRI治疗后小鼠肺部结构损坏减轻,纤维化评分降低(P<0.01),肺纤维化标志物表达降低(P<0.01)。TGF-β1诱导成纤维细胞活化标志物及ECM表达升高(P<0.01),给予FOXO4-DRI干预后上述分子表达下降(P<0.01)。结论:FOXO4-DRI抑制肺成纤维细胞活化及ECM产生而改善小鼠肺纤维化。 展开更多
关键词 肺纤维化 细胞外基质 FOXO4 D-retro-Inverso 成纤维细胞 博莱霉素
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Re-entry rocket basic flow characteristics and thermal environment of different retro-propulsion modes 被引量:2
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作者 Yifei SU Peijie SUN +1 位作者 Yangwen CUI Guigao LE 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第7期190-203,共14页
During the supersonic re-entry of multi-nozzle heavy rockets into the atmosphere,the basic flow state becomes increasingly complex due to the coupling effect between the retropropulsion plumes and the freestream.A num... During the supersonic re-entry of multi-nozzle heavy rockets into the atmosphere,the basic flow state becomes increasingly complex due to the coupling effect between the retropropulsion plumes and the freestream.A numerical method using the hybrid Reynolds-Averaged Navier-Stokes and Large Eddy Simulation(RES)method and discrete coordinate method is developed to accurately estimate the thermal environment.In addition,finite rate chemical kinetics is used to calculate the afterburning reactions.The numerical results agree well with wind tunnel data,which confirms the validity and accuracy of the numerical method.Computations are conducted for the heavy carrier rocket re-entry from 53.1 km to 39.5 km altitude with 180°angle of attack by using three different Supersonic Retro-Propulsion(SRP)modes.The numerical results reveal that these three SRP flow fields are all Short Penetration Models(SPM).As the re-entry altitudes decrease,both the plume-plume interaction and the plume-freestream interaction become weaker.The highest temperatures in the plume shear layers of the three SRP modes increase by 8.36%,7.33%and 6.92%respectively after considering afterburning reactions,and all occur at a reentry altitude of 39.5 km.As the rocket re-enters the atmosphere,the maximum heat flux on the rocket base plate of three SRP modes stabilizes at 290,170 and 200 kW/m^(2) respectively,but the maximum heat flux on the side wall increases significantly.When the altitude declines to 39.5 km,the extreme heat flux of the three modes increase by 84.16%,49.45%and 62.97%respectively compared to that at 53.1 km. 展开更多
关键词 Re-entry rocket MULTI-NOZZLE Supersonic retro propulsion Thermal environment Afterburning effect
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Endoscopic fibrin sealant closure of duodenal perforation after endoscopic retrograde cholangiopancreatography 被引量:6
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作者 Hsin-Yeh Yang Jui-Hao Chen 《World Journal of Gastroenterology》 SCIE CAS 2015年第45期12976-12980,共5页
Traditionally, perivaterian duodenal perforation can be managed conservatively or surgically. If a large volume of leakage results in fluid collection in the retroperitoneum, surgery may be necessary. Our case met the... Traditionally, perivaterian duodenal perforation can be managed conservatively or surgically. If a large volume of leakage results in fluid collection in the retroperitoneum, surgery may be necessary. Our case met the surgical indication for perivaterian duodenal perforation after endoscopic retrograde cholangiopancreatography(ERCP) with sphincterotomy and endoscopic papillary balloon dilatation. The patient developed a retroperitoneal abscess after the procedures, and a perivaterian perforation was suggested on computed tomography(CT). CT-guided abscess drainage was performed immediately. We unsuccessfully attempted to close the perforation with hemoclips initially. Subsequently, we used fibrin sealant(Tisseel) injection to occlude the perforation. Fibrin sealant injections have been previously used during endoscopy for wound closure and fistula repair. Based on our report, fibrin sealant injection can be considered as an alternative method for the treatment of ERCPrelated type Ⅱ perforations. 展开更多
关键词 Perivaterian DUODENAL PERFORATION ENDOSCOPIC retro
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Epidemiology and Prognosis of Retroplacental Hematoma in a Maternity Ward at a Regional Hospital Center in Southern Senegal 被引量:1
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作者 Babacar Biaye Omar Gassama +5 位作者 Mame Diarra Ndiaye Gueye Moussa Diallo Aminata Niass Mor Cisse Alassane Diouf Jean Charles Moreau 《Open Journal of Obstetrics and Gynecology》 2019年第2期149-157,共9页
Objectives: To study the epidemiological profile and the prognosis of the retro-placental hematoma (HRP) at the maternity ward at Kolda Regional Hospital Center. Materials and methods: This was a retrospective descrip... Objectives: To study the epidemiological profile and the prognosis of the retro-placental hematoma (HRP) at the maternity ward at Kolda Regional Hospital Center. Materials and methods: This was a retrospective descriptive cross-sectional study conducted over a period of 11 years: from January 1st, 2006 to December 31st, 2016, at Kolda Regional Hospital Center. It included all patients admitted for HRP during this period. The studied parameters concerned sociodemographic characteristics, gynecological obstetrical history;clinical, therapeutic and prognostic data (non-inclusion or exclusion criteria). The data were collected from medical records, the delivery room and the surgery room registers using a collection sheet developed for this purpose. The statistical analysis of the variables studied was done with the software Epi-info 3.5. For the qualitative variables, we calculated the frequencies and for the quantitative variables, we studied the distributions. Results: During the study period, 15,343 were recorded deliveries and we carried out the diagnosis of HRP in 301 patients (1.97%). The average age of the patients was 24 years with an average parity of 4.8 deliveries. Almost all the patients (87.5%) were evacuated and half had delivered by caesarean section. Maternal and fetal deaths were 7% and 72.1%, respectively. Uterine atony accounted for 21.2% of complications. One third of the cases of uterine atony had resulted in a hysterectomy. The average duration of hospitalization was 6 days. Conclusion: The retro-placental hematoma is a serious medico-obstetric emergency. It is burdened with high maternal and fetal morbidity and mortality in developing countries. 展开更多
关键词 retro-Placental HEMATOMA MORTALITY Kolda
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Seismic performance of damaged frame retrofitted with self-centering and energy-dissipating rocking wall 被引量:1
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作者 Genqi Xiao Haishen Wang Peng Pan 《Resilient Cities and Structures》 2023年第1期143-151,共9页
This paper proposes the novel concept of retrofitting damaged reinforced concrete frame with self-centering and energy-dissipating rocking wall.Parametric studies were carried out base on pushover and time-history anal... This paper proposes the novel concept of retrofitting damaged reinforced concrete frame with self-centering and energy-dissipating rocking wall.Parametric studies were carried out base on pushover and time-history analysis.In both pushover and time-history analysis,the soft-story mechanism was effectively mitigated through the rocking wall retrofit of the damaged structures.The results demonstrated that the stiffness and bearing capacity of the retrofitted system were improved compare to its intact state.Additionally,the seismic response of the damaged frame retrofitted using rocking wall in combination with post-tension and shear-type damper fell within the relevant design limits.Pushover analysis of the rocking wall indicated that there is a linear relationship between the wall thickness and the initial stiffness of the retrofitted system.The addition of post-tension tendon to the rocking wall system enables the wall to self-center and increases lateral stiffness and bearing capacity of the retrofitted system.When the shear-type damper was installed,the energy dissipation of the system was increased,and the stiffness and bearing capacity of the retrofitted system were also improved.In the time-history analysis,it was found that the thickness of the rocking wall is directly related to the maximum inter-story drift and the distribution patterns of inter-story drift of the frame.As the post-tension was added to the system,the maximum inter-story drift under rare earthquake excitation improved significantly.With the addition of shear-type dampers,the overall drift magnitude of the retrofitted system was fundamentally decreased. 展开更多
关键词 Rocking wall Damaged frame retrofit POST-TENSIONING Shear-type damper
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Retro-reflective Beamforming Technique with Applications in Wireless Power Transmission
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作者 WANG Xin LU Mingyu 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2019年第4期545-565,共21页
Retro reflective beamforming technique has the potential of enabling efficient wireless power transmission over long distance(on the order of meters and even kilometers).In retro reflective beamforming,wireless power ... Retro reflective beamforming technique has the potential of enabling efficient wireless power transmission over long distance(on the order of meters and even kilometers).In retro reflective beamforming,wireless power transmission is guided by pilot signal:Based upon pilot signal broadcasted by a wireless power receiver,a wireless power transmitter delivers focused microwave power beam(s)onto the location of wireless power receiver.When the wireless power receiver’s location is not fixed or when the wireless power receiver’s location is unknown to the wireless power transmitter,the microwave power beam would follow the wireless power receiver’s location dynamically as long as the wireless power receiver broadcasts pilot signal periodically.This paper reviews our research endeavors in recent years on retro reflective beamforming technique targeting three applications:(1)wireless charging for low power mobile/portable electronic devices,(2)space solar power satellites(SSPS)application,and(3)wireless charging in fully enclosed space.The feasibility and potential of retro reflective beamforming technique with applications in wireless power transmission are demonstrated by some preliminary experimental results. 展开更多
关键词 wireless power transmission retro⁃reflective beamforming MICROWAVE antenna array pilot signal
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无溶剂无催化剂条件下Retro-Diels-Alder反应绿色高效合成β-烯胺酯衍生物
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作者 李伟强 尹艳清 +3 位作者 万娟 王灼钰 张宗琴 黄超 《云南民族大学学报(自然科学版)》 CAS 2022年第1期41-46,共6页
以氧杂冰片烯二乙酯和各类伯胺、仲胺化合物为原料,在无溶剂、无催化剂,经0.5~72 h逆D-A反应合成10个β-烯胺酯化合物,产率最高可达77%.该反应首先通过Aza-Michael加成反应过程,形成氧杂冰片烯β-氨基酯中间体,然后再经Retro-Diels-Alde... 以氧杂冰片烯二乙酯和各类伯胺、仲胺化合物为原料,在无溶剂、无催化剂,经0.5~72 h逆D-A反应合成10个β-烯胺酯化合物,产率最高可达77%.该反应首先通过Aza-Michael加成反应过程,形成氧杂冰片烯β-氨基酯中间体,然后再经Retro-Diels-Alder反应,转化为β-烯胺酯目标化合物.实现了在绿色简单的无溶剂、无催化剂反应体系中,仅通过调控温度,高效构筑β-烯胺酯化合物.该方法操作简单,反应简便,对环境友好且收率良好,为合成β-烯胺酯化合物提供新的方法策略. 展开更多
关键词 retro-Diels-Alder反应 绿色合成 无溶剂 无催化剂 β-烯胺酯
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The Origin and Application of Retro-futurism
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作者 LIU Jihong 《Journal of Landscape Research》 2019年第5期104-108,共5页
Via case analysis and literature retrospect,a kind of active design style at present is initially explored: retro-futurism,and the design method of realizing this style and its artistic value are discussed.By reviewin... Via case analysis and literature retrospect,a kind of active design style at present is initially explored: retro-futurism,and the design method of realizing this style and its artistic value are discussed.By reviewing and analyzing the modeling element and spatial form of futurism in the space age,designers can refine the special formal language of this period,adjust these formal languages according to the need,and then place these formal languages in the context of the new era,thereby obtaining style of retrofuture.Retro-futurism design can create a strong visual style,arouse people’s nostalgia and trigger double associations about history and the future.By shaping model and space,people’s attention is directed to the perception of time,thereby stimulating people to reflect on technology and modern life.Its intrinsic complexity brings strong visual impact,makes it have wide application prospects in architecture,plane,clothing,products and other different design areas,and brings people richer visual experience. 展开更多
关键词 DESIGN AESTHETICS Visual CULTURE Space age retro-futurism Nostalgic DESIGN
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A Retrospective Analysis for Different Routes of Administration in Mice-Percutaneous Retro-Orbital, Jugular Catheter, Tail Vein and Femoral Cut Down Injections
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作者 Priyanka Prathipati Cristian Rodriguez-Aguayo +4 位作者 Brian L Walton Anil K. Sood Jamieson Greaver Christopher F. Janssen Gabriel Lopez-Berestein 《Journal of Biosciences and Medicines》 2020年第9期131-141,共11页
Liposomes effectively transport fatty proteins to targeted tissues. Laboratory experiments use multiple methods to administer liposomes, but comparison of these methods is not available. In this retrospective study, w... Liposomes effectively transport fatty proteins to targeted tissues. Laboratory experiments use multiple methods to administer liposomes, but comparison of these methods is not available. In this retrospective study, we characterized and compared four intravenous administration routes (tail vein, jugular catheter, femoral vein and percutaneous retro-orbital injections) in murine models. ApoE<sup>-/-</sup> mice were used to compare administration routes. Results indicate that the jugular catheter route delivered the highest amount of liposomes to tissues due to longer period of injections compared to other routes;however, this route failed to remain patent for 8/10 animals. Delivery via tail vein, femoral vein and percutaneous retro-orbital injections resulted in similar accumulation in the organs. When including technical difficulty and expense, percutaneous retro-orbital injections of liposomes are the most convenient and efficacious approach. 展开更多
关键词 Femoral Vein Jugular Catheter Liposomes retro-Orbital Tail Vein
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Percutaneous Mesh Expansion and Fixation at the Retro-Rectus Plane without Stabs by Using Redirecting Suture Hook in Midline Hernias Repair
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作者 Ahmed E Lasheen Alaa N. El Sadek +2 位作者 Adel M Tolba Emad Salah Ayman F Mehanna 《Surgical Science》 2011年第4期177-182,共6页
Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do t... Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance. 展开更多
关键词 PERCUTANEOUS FIXATION retro-Rectus Mesh Redirecting SUTURE HOOK
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Materno-Fetal Prognosis of Retro-Placental Hematoma at the Centre Hospitalier Universitaire Communautaire
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作者 N. R. Ngbale G. R. D. L. Kogboma-Wongo +6 位作者 A. Koirokpi C. E. Gaunefet G. D. Kossa Ko Ouakoua S. Ouapou D. M. Callot S. Matoulou-M’bala A. Sepou 《Open Journal of Obstetrics and Gynecology》 2020年第10期1351-1357,共7页
<strong>Introduction:</strong><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The majority... <strong>Introduction:</strong><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The majority of pregnancies and births go off without incident even though they all present risks. Retro-placental hematoma (RPH) is an extreme obstetric emergency. The aim of our study was to assess the maternal-fetal prognosis of this pathology in our patients. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b></span><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">This is a retrospective descriptive and analytical study over 5 years ranging from the period from January 1st, 2015 to December 31st, 2019. The study</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s population consisted of pregnant women, in the 3rd trimester, who </span><span style="font-family:Verdana;">were </span><span style="font-family:Verdana;">presented with the retro-placental</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">hematoma during the pregnancy or childbirth and taken care of in the maternity ward of the Centre Hospitalier Universitaire Communautaire. </span><b><span style="font-family:Verdana;">Results:</span></b></span><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">During our study period, we recorded 87 cases of retro-placental hematoma</span><span style="font-family:Verdana;">, </span><span style="font-family:Verdana;">and 40</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">763 deliveries. The frequency of retro-placental hematoma was</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.21% at delivery. The average maternal age was 26.4 years with extremes of 16 and 40 years. The parity</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s average was 3.8 with extremes of 1 and 13. The mean gestational age at the time of the onset of the accident was 35.9 amenorrhea</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">weeks (AW) with extremes of 28 and 40 AW. We performed 4 cases of hysterectomy (4.5%). We recorded 8 maternal deaths (9.2%) and 60 newborn deaths (69%). The causes of maternal death were dominated by afibrinogenemia 62.5%, followed by renal failure in 25%. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Retro-placental hematoma is a serious pathology during the pregnancy.</span></span> 展开更多
关键词 PROGNOSIS retro-Placental Hematoma (RPH) Bangui
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Acute Presentation of Massive Retrosternal Thyrotoxic Goitres
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作者 Joshil V. Lodhia Thomas D. Christensen +1 位作者 Ehab S. Bishay Maninder S. Kalkat 《Open Journal of Thoracic Surgery》 2013年第3期84-86,共3页
Approximately 5% of goitres extend below the thoracic inlet and can potentially become life threatening due to compression of the airway and major vessels. Approximately 7% of these goitres which require surgical rese... Approximately 5% of goitres extend below the thoracic inlet and can potentially become life threatening due to compression of the airway and major vessels. Approximately 7% of these goitres which require surgical resection will need an additional sternotomy to deliver the intra-thoracic component. Massive retrosternal toxic goitres presenting acutely are rare and are described infrequently in literature. We hereby present two cases of massive retrosternal thyrotoxic goitres presenting with acute respiratory failure, requiring non-invasive ventilation, as well as significant head and neck venous compression. Surgery on the thyrotoxic patient with a goitre, even if not significantly enlarged, is associated with a high peri-operative mortality due to cardiac instability and hemorrhage. We discuss the challenges of surgical intervention in these patients with particular emphasis on the timing of surgery to relieve compressive symptoms and the time needed to achieve a euthyroid state. We also emphasize the need for meticulous hemostasis, use of a cell-saver, transfusion protocols, adjuncts to hemostasis, as well as careful monitoring and continuous adjustments to the coagulation profile. 展开更多
关键词 PERIOPERATIVE Issues and Risk Analysis retro-Sternal Goitres SURGICAL Management STERNOTOMY
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Degradation of Retro-Reflectivity of Thermoplastic Pavement Markings: A Review
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作者 Victor Owusu Yaw A. Tuffour +1 位作者 Daniel A. Obeng Mohammed Salifu 《Open Journal of Civil Engineering》 2018年第3期301-311,共11页
For an effective thermoplastic pavement marking replacement strategy, the rate at which the marking’s retro-reflectivity deteriorates in service must be well established in order to avoid re-stripping that is too soo... For an effective thermoplastic pavement marking replacement strategy, the rate at which the marking’s retro-reflectivity deteriorates in service must be well established in order to avoid re-stripping that is too soon or too late. Against this background, this paper undertook a review of models that deal with degradation of thermoplastic pavement markings under different traffic and environmental conditions in order to establish service life and the terminal retro-reflectivity levels that have informed re-striping. Service life in the context of this paper is the time taken for a newly-installed marking to degrade to some minimum retro-reflectivity level below which motorists would find it difficult to navigate on the carriageway under night-time and poor visibility conditions. It was established that the minimum retro-reflectivity requiring re-stripping intervention reported varied, although commonly-adopted values tended to range from 50 mcd/m2/lx to 150 mcd/m2/lx. A number of empirical models, based on site specific conditions, have been developed by researchers using field data, to estimate marking retro-reflectivity at any time since placement. Whereas some of the models used time as the only independent variable, others used a combination of time, traffic level and a few other parameters to estimate retro-reflectivity. Even though degradation of marking retro-reflectivity is a reflection, among other things of material degeneration impacted by environmental and service conditions, almost all the models reviewed failed to consider environmental factors. Additionally, for some of the models, non-inclusion of the initial retro-reflectivity level and their generally low coefficient of determination statistic erode the confidence in their reliability. 展开更多
关键词 DEGRADATION Re-Striping retro-Reflectivity Service Life THERMOPLASTIC PAVEMENT MARKING
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Planar Retro-Reflector for Grazing Incident Beam of High-Energy X-Ray Photons
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作者 Hakob Jacob Bezirganyan Robert Bezirganyan Siranush Bezirganyan 《Journal of Applied Mathematics and Physics》 2016年第9期1731-1755,共25页
The grazing-incidence hard X-ray retro-reflector (GIRR) is a novel optical element, which completely suppresses the conventional mirror beam in the retro-reflection mode, and, at the same time, totally reflects the pr... The grazing-incidence hard X-ray retro-reflector (GIRR) is a novel optical element, which completely suppresses the conventional mirror beam in the retro-reflection mode, and, at the same time, totally reflects the primary grazing incident X-radiation backwards to its source in strictly anti-parallel direction with minimal scattering. The GIRR is a good alternative to hard X-ray normal-incidence Bragg mirror, and has a high potential for applications in various X-ray optical devices and techniques, such as, hard X-ray optical noise (or background) filters, high-quality hard X-ray waveguides, low-gain hard X-ray free electron laser resonators (XFELRs), X-ray holography, coherent X-ray diffraction imaging, phase-contrast imaging, as well as in hard X-ray optical data storage devices and deep space hard X-ray communications. The proposed optical element consists of single-crystal wafer covered by a thin, non-diffracting layer of low-absorbing material. 展开更多
关键词 X-Ray Diffraction Theory SINGLE-CRYSTAL Total retro-Reflection Mathieu Functions
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Tandem intramolecular Diels–Alder/retro-Diels–Alder cycloaddition of 2H-chromen-2-one as dienes with the expulsion of CO_2
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作者 Jian Zhang Jin-Long Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第9期1537-1540,共4页
To study the intramolecular Diels-Alder cycloadditon of 2H-chromen-2-one as a diene, a series of chiral N-allyl-N-benzylamides that contain a 2H-chrornen-2-one moiety were designed for the synthesis of benzo[f]isoindo... To study the intramolecular Diels-Alder cycloadditon of 2H-chromen-2-one as a diene, a series of chiral N-allyl-N-benzylamides that contain a 2H-chrornen-2-one moiety were designed for the synthesis of benzo[f]isoindol-1-ones via an intrarnolecular Diels-Alder and a subsequent retro-Diels-Alder cycloaddition with the expulsion of CO2. Both the yield (80%-89%) and absolute stereocontrol of the tandem reaction were high when an electron-withdrawing group was attached to the dienophile. The double bond in the styrene substructure remained in the products could be further derivatized by dihydroxylation. 展开更多
关键词 2H-Chromen-2-one Intramolecular Diels-Alder retro-Diels-Alder Benzo[J]isoindol-1 -one Dihydroxylation
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Biased retro-proportional navigation law for interception of high-speed targets with angular constraint 被引量:8
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作者 Liang YAN Ji-guang ZHAO +1 位作者 Huai-rong SHEN Yuan LI 《Defence Technology(防务技术)》 SCIE EI CAS 2014年第1期60-65,共6页
A new guidance law, called biased retro proportional navigation(BRPN), is proposed. The guidance law is designed to intercept high-speed targets with angular constraint, which can be used for ballistic target intercep... A new guidance law, called biased retro proportional navigation(BRPN), is proposed. The guidance law is designed to intercept high-speed targets with angular constraint, which can be used for ballistic target interception. BRPN guidance law is defined, and the exact time-varying bias for a required impact angle is derived. Furthermore, the simulation results(trajectory, variation of navigation ratio, capture region, etc) are compared with those of biased proportional navigation(BPN), proportional navigation and retro-proportional navigation. The results show that,at the cost of a higher intercept time, BRPN demands lower terminal lateral acceleration and has larger capture region compared to BPN. 展开更多
关键词 比例导引法 角度约束 拦截 横向加速度 制导律 仿真结果 时间成本 冲击角
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PRELIMINARY STUDY ON RETRO-REFLECTIVE COATED PAPER BASED ON MICROGLASS BEADS
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作者 YulongWang ChuanshanZhao TaoZhang 《天津科技大学学报》 CAS 2004年第A01期309-311,共3页
High-reflectivity micro-glass bead, as a kind of retro-reflective material, is widely used in reflective fabric or film and other reflective coatings. But it is rarely used in coated paper. The retro-reflective theory... High-reflectivity micro-glass bead, as a kind of retro-reflective material, is widely used in reflective fabric or film and other reflective coatings. But it is rarely used in coated paper. The retro-reflective theory of micro-bead is described. Also the effect of size of micro-bead, dosage of binder and different color layers on reflective properties of coated paper are discussed in this article. The results show that its retro-reflective efficiency is good, equally to reflective fabric or film when the micro-glass bead is used in coated paper. 展开更多
关键词 造纸工业 高反射率微珠 逆反射 涂层纸 硅酸盐材料
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铜催化不对称Kinugasa/Aldol反应构建手性螺环β-内酰胺
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作者 张杰豪 徐明金 +2 位作者 古满珍 马浩文 蔡倩 《化学学报》 北大核心 2025年第7期667-673,共7页
β-内酰胺和螺β-内酰胺是多种天然产物和生物活性化合物中的关键骨架结构,因其重要的生物学意义而备受关注.Kinugasa反应,即铜催化末端炔烃与硝酮的环加成反应,是构建β-内酰胺最直接高效的方法之一.通过将Kinugasa反应与其他反应结合... β-内酰胺和螺β-内酰胺是多种天然产物和生物活性化合物中的关键骨架结构,因其重要的生物学意义而备受关注.Kinugasa反应,即铜催化末端炔烃与硝酮的环加成反应,是构建β-内酰胺最直接高效的方法之一.通过将Kinugasa反应与其他反应结合,已发展出多种串联或一锅法策略,用于合成多取代的手性β-内酰胺或螺β-内酰胺.在前期工作中,发展了铜催化N-(2-酰基芳基)丙炔酰胺与硝酮的不对称Kinugasa/Aldol串联反应,成功构建了手性螺环β-内酰胺-二氢喹啉酮.该反应中,碱促进的retro-aldol/aldol差向异构化过程发挥了关键作用,这一过程将次要非对映异构体转化为主要产物,实现了非对映体富集,显著提升了产物的非对映选择性.在本研究中,为进一步拓展反应适用范围,探索了线性烷基酮连接的丙炔酰胺与硝酮的反应.该类反应在PhCF_(3)中进行,但由于反应条件下烷基醇产物的retro-aldol/aldol过程难以进行,导致级联反应的非对映选择性较低.为提高非对映选择性,在反应完成后引入极性溶剂N,N-二甲基甲酰胺(DMF),成功促进了retro-aldol/aldol差向异构化过程,从而以中等收率合成了一系列具有高非对映选择性的手性螺环β-内酰胺产物. 展开更多
关键词 不对称反应 铜催化 Kinugasa反应 ALDOL反应 retro-aldol/aldol过程
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《续文选》:畅扬复古的《文选》续作
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作者 赵俊玲 《聊城大学学报(社会科学版)》 2025年第1期123-130,共8页
汤绍祖《续文选》刊刻于万历三十年,编纂宗旨在于畅扬复古派主张。它隔代选录作品,所选起自《文选》后,越宋元而迄于明,受到了李攀龙《古今诗删》的直接影响;它录文详近略远,选录明代作品最多,于明代又选录后七子派作品最多,于后七子派... 汤绍祖《续文选》刊刻于万历三十年,编纂宗旨在于畅扬复古派主张。它隔代选录作品,所选起自《文选》后,越宋元而迄于明,受到了李攀龙《古今诗删》的直接影响;它录文详近略远,选录明代作品最多,于明代又选录后七子派作品最多,于后七子派又重视选录距编者时间最近的作家作品。同时,作为一部《文选》广续类总集,《续文选》又步趋《文选》,表现于体类划分与《文选》高度一致,选诗只重五言古诗,收录了诸多与《文选》有关联的作品。同时,受《文选》影响,《续文选》亦重视选录南朝作品,选明人作品重六朝派及濡染六朝之风的吴中文人,表现出重六朝的倾向。《续文选》是一部畅扬复古的《文选》广续类总集。 展开更多
关键词 《续文选》 《文选》 复古派 《文选》广续类总集
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Ultrasound-guided percutaneous transhepatic one-step biliary fistulation for biliary stricture after living donor liver transplantation
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作者 Zhuang Deng Xia-Jin Qi Tian-An Jiang 《Hepatobiliary & Pancreatic Diseases International》 2025年第4期468-470,共3页
To the Editor:Living donor liver transplantation continues to be a widely ac-cepted treatment for end-stage liver diseases[1].However,biliary complications remain a significant challenge,attributable to both surgical ... To the Editor:Living donor liver transplantation continues to be a widely ac-cepted treatment for end-stage liver diseases[1].However,biliary complications remain a significant challenge,attributable to both surgical and nonsurgical factors.These complications include bile leakage,biliary stricture,and choledocholithiasis,with a reported incidence of biliary stricture in pediatric living donor liver recip-ients ranging from 10%to 35%[2].Commonly employed thera-peutic approaches for biliary complications are endoscopic retro-grade cholangiopancreatography(ERCP),percutaneous transhepatic cholangioscopic lithotomy(PTCSL),and surgery,with ERCP often being the preferred initial treatment. 展开更多
关键词 ultrasound guided percutaneous transhepatic one step biliary fistulation donor liver transplantation endoscopic retro grade cholangiopancreatography bile leakagebiliary strictureand biliary stricture therapeutic approaches biliary complications living donor liver transplantation
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