Persistent and maladaptive drug-related memories represent a key component in drug addiction.Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconso...Persistent and maladaptive drug-related memories represent a key component in drug addiction.Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconsolidation updating procedure(MRUP),a non-pharmacological strategy intertwining two distinct memory processes:reconsolidation and extinction—alternatively termed“the memory retrieval-extinction procedure”.This procedure presents a promising approach to attenuate,if not erase,entrenched drug memories and prevent relapse.The present review delineates the applications,molecular underpinnings,and operational boundaries of MRUP in the context of various forms of substance dependence.Furthermore,we critically examine the methodological limitations of MRUP,postulating potential refinement to optimize its therapeutic efficacy.In addition,we also look at the potential integration of MRUP and neurostimulation treatments in the domain of substance addiction.Overall,existing studies underscore the significant potential of MRUP,suggesting that interventions predicated on it could herald a promising avenue to enhance clinical outcomes in substance addiction therapy.展开更多
Individuals will experience strong traumatic memories after traumatic events such as earthquakes,car accidents,or loss of loved ones,the most common of which is fear memory.In this experiment,a multisensory compound s...Individuals will experience strong traumatic memories after traumatic events such as earthquakes,car accidents,or loss of loved ones,the most common of which is fear memory.In this experiment,a multisensory compound stimulation model(electric stimulation+picture)was used as the conditional stimulus,and the skin electrical response was used as the index of fear response.The effect of retrievalextinction paradigm on the conditional fear extinction was tested.In addition,high-frequency rTMS was introduced as a treatment.To explore the therapeutic effect of TMS on conditional fear,with the aim of providing new measures for the treatment of PTSD.展开更多
基金supported by the National Natural Science Foundation of China(82071498,81871046,and 32161143022)STI2030-Major Projects(2022ZD0214500).
文摘Persistent and maladaptive drug-related memories represent a key component in drug addiction.Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconsolidation updating procedure(MRUP),a non-pharmacological strategy intertwining two distinct memory processes:reconsolidation and extinction—alternatively termed“the memory retrieval-extinction procedure”.This procedure presents a promising approach to attenuate,if not erase,entrenched drug memories and prevent relapse.The present review delineates the applications,molecular underpinnings,and operational boundaries of MRUP in the context of various forms of substance dependence.Furthermore,we critically examine the methodological limitations of MRUP,postulating potential refinement to optimize its therapeutic efficacy.In addition,we also look at the potential integration of MRUP and neurostimulation treatments in the domain of substance addiction.Overall,existing studies underscore the significant potential of MRUP,suggesting that interventions predicated on it could herald a promising avenue to enhance clinical outcomes in substance addiction therapy.
文摘Individuals will experience strong traumatic memories after traumatic events such as earthquakes,car accidents,or loss of loved ones,the most common of which is fear memory.In this experiment,a multisensory compound stimulation model(electric stimulation+picture)was used as the conditional stimulus,and the skin electrical response was used as the index of fear response.The effect of retrievalextinction paradigm on the conditional fear extinction was tested.In addition,high-frequency rTMS was introduced as a treatment.To explore the therapeutic effect of TMS on conditional fear,with the aim of providing new measures for the treatment of PTSD.
