IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the...IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the United States Trade Representative released a report on the investigation of China under Section 301 of the Trade Act of 1974, claiming China's acts, policies, and practices regarding technology transfer, intellectual property, and innovation are “unreasonable and discriminatory, and burden U.S. commerce.”展开更多
The Unconventional Oil and Gas industry has seen growth over the last ten years that has drastically transformed the domestic energy outlook while bringing up increased concerns over climate and environmental issues. ...The Unconventional Oil and Gas industry has seen growth over the last ten years that has drastically transformed the domestic energy outlook while bringing up increased concerns over climate and environmental issues. The rise of ESG and RSG can be seen as direct answers to these growing issues as communities and operators have both begun to demand better practices to limit the overall effects of UOG production. Few quantifiable metrics exist that holistically try to determine the overall effect UOG production has on local water resources. The FR2 metric/framework developed in this paper attempts to use commonly kept data such as water withdrawn and flowback volumes in conjunction with a new water stress index to quantify the effects operators are having on local water supplies. Testing this framework on a handful of operators from the Marcellus basin using open-source data revealed the value added by these methods as well as their use in a general RSG program.展开更多
The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role i...The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and proteostasis.In this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements.We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases.In summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.展开更多
BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acu...BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute pancreatitis.AIM To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute pan-creatitis.METHODS The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)groups.Relevant data was collected for each group.Western blot analysis assessed PLD2 protein expression in patient serum.Real-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil migration.Serum levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent assay.Transwell migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil migration.RESULTS Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumor necrosis factor-α,interleukin-1β,and interleukin-6 in the severe group were higher than those in the moderate and mild groups(P<0.05),and the levels in the moderate group were also higher than those in the mild group(P<0.05).The number of migrating neutrophils in the severe group was higher than that in the moderate and mild groups(P<0.05),and the moderate group was also higher than the mild group(P<0.05).In addition,the number of migrating neutrophils in the mild group combined with PLD2 inhibitor was higher than that in the mild group(P<0.05),and the number of migrating neutrophils in the moderate group combined with PLD2 inhibitor was higher than that in the moderate group(P<0.05).The number of migrating neutrophils in the severe group+PLD2 inhibitor group was significantly higher than that in the severe group(P<0.05),indicating that PLD2 inhibitors significantly stimulated neutrophil migration.CONCLUSION PLD2 exerted a crucial regulatory role in the pathological progression of acute pancreatitis.Its protein expression varied among patients based on the severity of the disease,and a negative correlation existed between PLD2 expression and disease severity.Additionally,PLD2 appeared to impede acute pancreatitis progression by limiting neutrophil migration.展开更多
This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging...This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability.The results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly charging.Additionally,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.展开更多
Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality worldwide.Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy.Long...Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality worldwide.Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy.Long non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies.Studies have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be characterized.Therefore,our study aimed to explore the role and underlying mechanism of SNHG4 in GC.Methods:We used qRT-PCR to analyze SNHG4 expression in GC tissues and cells.Kaplan-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC patients.Cellular function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and invasion.We also established xenograft mouse models to explore the effect of SNHG4 on GC tumor growth.Mechanically,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC patients.SNHG4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in vitro.The in vivo experiment indicated that SNHG4 facilitated GC tumor growth.Furthermore,SNHG4 was demonstrated to bind to miR-409-3p.Moreover,CREB1 was directly targeted by miR-409-3p.Rescue assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell malignancy.Additionally,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1.Conclusion:In conclusion,we verified that the SNHG4 promoted GC growth and metastasis by binding to miR-409-3p to upregulate CREB1,which may deepen the understanding of the underlying mechanism in GC development.展开更多
BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing...BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.展开更多
The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and di...The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and discrete element method(DEM)was employed to investigate the mechanical behavior of asphalt pavement containing a pre-existing TD crack.The mesoscopic parameters of the model were calibrated based on the mixture modulus and the static mechanical response on the MLS66 test road.Finally,an analysis was performed to assess how variations in TD crack depth and longitudinal length affect the distribution patterns of transverse tensile stress,vertical shear stress,and vertical compressive stress.The results indicate that the vertical propagation of TD crack significantly increases both the tensile stress value and range on the middle surface,while the longitudinal development of TD crack has minimal impact.This phenomenon may result in more severe fatigue failure on the middle surface.With the vertical and longitudinal development of TD crack,the vertical shear stress and compressive stress show obvious"two-stage"characteristics.When the crack's vertical length reaches 40 mm,there is a sharp increase in stress on the upper surface.As the crack continues to propagate vertically,the growth of stress on the upper surface becomes negligible,while the stress in the middle and lower layers increased significantly.Conversely,for longitudinal development of TD crack,any changes in stress are insignificant when their length is less than 180 mm;however,as they continue to develop longitudinally beyond this threshold,there is a sharp increase in stress levels.These findings hold great significance for understanding pavement structure deterioration and maintenance behavior associated with TD crack.展开更多
This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and stru...This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.展开更多
This study examines the effects of e-banking service quality on customer satisfaction in the Commercial Bank of Ethiopia(CBE)branches in Wolaita Sodo town.Using a causal research design,the study explored the cause-an...This study examines the effects of e-banking service quality on customer satisfaction in the Commercial Bank of Ethiopia(CBE)branches in Wolaita Sodo town.Using a causal research design,the study explored the cause-and-effect relationship between service quality dimensions and customer satisfaction.A sample of 385 customers was selected using convenience sampling,with 365 questionnaires returned.Data were collected through questionnaires and analyzed using SPSS V.21.The Cronbach’s alpha value of 0.72 from a pilot study confirmed reliability.Descriptive and inferential statistics,including multiple linear regression and one-way ANOVA,were employed.Results revealed that three service quality dimensions-responsiveness,reliability,and assurance-were statistically significant and positively influenced customer satisfaction,while two dimensions showed negative associations.The regression model’s coefficient of determination(R²)was 0.621,indicating a moderate explanatory power.Findings suggest that CBE managers and stakeholders should prioritize improving responsiveness,reliability,and assurance by providing prompt,dependable,and trustworthy services.Due to limitations in time and resources,this study was confined to CBE branches in Wolaita Sodo town;future research could expand to a national level or other service sectors.展开更多
BACKGROUND Steroids remain the primary treatment for severe alcohol-associated hepatitis(AAH),though there is little available tools to predict patient response to steroids.It was hypothesized that phosphatidylethanol...BACKGROUND Steroids remain the primary treatment for severe alcohol-associated hepatitis(AAH),though there is little available tools to predict patient response to steroids.It was hypothesized that phosphatidylethanol(PEth)value will inversely corre-late with response to steroid therapy based on Lille score in AAH.AIM To assess the relationship of patient factors,focusing on pre-steroid therapy PEth value,to steroid therapy response in AAH.METHODS A retrospective case control study was performed on patients who received≥4 days of steroid therapy for AAH at our hospital between July 1,2019 and June 30,2022.A total of 2087 patients were screened for AAH and those treated with steroids were included for statistical analysis utilizing independent sample t-test and for categorical variables using the χ^(2) test.RESULTS No correlation was found between PEth value,pre-steroids abstinence length,or number of drinks per week pre-steroids and response to steroids.Non-responder status significantly correlated with older age(P=0.024),lower albumin(P=0.003),and higher bilirubin(P=0.010)pre-steroids.Our study suggests that age,pre-steroid albumin,and pre-steroid bilirubin levels may predict nonresponse to steroid therapy.Non-responders have increased incidence of death and higher medical costs.CONCLUSION Identifying non-responders through these identified factors should prompt early referral for liver transplantation.Future prospective studies with larger population size are needed to assess the efficacy of combined pre-steroid age,albumin,bilirubin and other biochemical markers as predictors of steroid response.展开更多
Probiotic supplementation enhances the abundance of gutassociated Rhodobacteraceae species,critical symbionts contributing to the health and physiological fitness of Litopenaeus vannamei.Understanding the role of Rhod...Probiotic supplementation enhances the abundance of gutassociated Rhodobacteraceae species,critical symbionts contributing to the health and physiological fitness of Litopenaeus vannamei.Understanding the role of Rhodobacteraceae in shaping the shrimp gut microbiota is essential for optimizing probiotic application.This study investigated whether probiotics benefit shrimp health and fitness via the recruitment of Rhodobacteraceae commensals in the gut.Probiotic supplementation significantly enhanced feed conversion efficiency,digestive enzyme activity,and immune responses,thereby promoting shrimp growth.Additionally,probiotics induced pronounced shifts in gut microbial composition,enriched gut Rhodobacteraceae abundance,and reduced community variability,leading to a more stable gut microbiome.Network analysis revealed that the removal of Rhodobacteraceae nodes disrupted gut microbial connectivity more rapidly than the removal of nonRhodobacteraceae nodes,indicating a disproportionate role of Rhodobacteraceae in maintaining network stability.Probiotic supplementation facilitated the migration of Rhodobacteraceae taxa from the aquatic environment to the shrimp gut while reinforcing deterministic selection in gut microbiota assembly.Transcriptomic analysis revealed that up-regulation of amino acid metabolism and NF-κB signaling pathways was positively correlated with Rhodobacteraceae abundance.These findings demonstrate that probiotic supplementation enriches key Rhodobacteraceae taxa,stabilizes gut microbial networks,and enhances host digestive and immune functions,ultimately improving shrimp growth performance.This study provides novel perspectives on the ecological and molecular mechanisms underlying the beneficial effects of probiotics on shrimp fitness.展开更多
Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic pr...Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a common tumor with a poor prognosis.Early intervention is essential;thus,good prognostic markers to identify patients who benefit from first transarterial chemoembolization(...BACKGROUND Hepatocellular carcinoma(HCC)is a common tumor with a poor prognosis.Early intervention is essential;thus,good prognostic markers to identify patients who benefit from first transarterial chemoembolization(TACE)are needed.AIM To investigate the efficacy of computed tomography(CT)radiomics in predicting the success of the first TACE in patients with advanced HCC and to develop an early prediction model based on clinical radiomics features.METHODS Data from 122 patients with advanced HCC treated with TACE were analyzed.Intratumoral and peritumoral areas on arterial and venous CT images were selected to extract radiomic features,which were screened in the training cohort using the minimum redundancy maximum correlation.Then,support vector machines were used to construct the model.To construct a receiver operating characteristic curve,the predictive efficacy of each model was evaluated on the basis of the area under the curve(AUC).RESULTS Among the 122 patients,72 patients were effectively treated via TACE,and in 50 patients,this treatment was ineffective.In the radiomics model,the areas under the curve of the venous phase model were 0.867(95%CI:0.790-0.940)in the training cohort and 0.755(0.600-0.910)in the validation cohort,indicating good predictive efficacy.The multivariate logistic regression results indicated that preoperative alpha-fetoprotein levels(P=0.01)were a risk factor for TACE.The screened clinical features were combined with the radiomic features to construct a combined model.This combined model had an AUC of 0.92(0.87-0.95)in the training cohort and 0.815(0.67-0.95)in the validation cohort.CONCLUSION CT radiomics has good value in predicting the efficacy of the first TACE treatment in patients with HCC.The combined model was a better tool for predicting the first TACE efficacy in patients with advanced HCC and could provide an efficient predictive tool to help with the selection of patients for TACE.展开更多
The emergence of novel phytopathogens and the accelerated spread of plant diseases to new regions,driven by global climate change,constitute significant threats to agricultural resources.Rice,a major tropical staple c...The emergence of novel phytopathogens and the accelerated spread of plant diseases to new regions,driven by global climate change,constitute significant threats to agricultural resources.Rice,a major tropical staple crucial for global food security,possesses six transcription factor superfamilies-AP2/ERF,bHLH,bZIP,MYB,NAC,and WRKY-that function in innate immunity against pathogens.We review their biological functions and regulatory mechanisms in rice immunity.展开更多
The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with...The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this study.The indoor model test verified the accuracy of the numerical model.The influence laws of different hard combinations,train operating speeds and modes were studied and evaluated accordingly.The results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 Hz.The vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the source.Furthermore,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the superstructure.The vibration response under the reversible operation of the train is greater than that of the unidirectional operation.The operating speed of the train is proportional to its vibration response.The vibration amplification area appears between the middle and the top of the superstructure at a higher train speed.Its vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are required.Within the scope of application,this study provides some suggestions for constructing subway stations and superstructures.展开更多
BACKGROUND:The lack of a stable,easy-to-operate animal model for severe trauma has hindered the research progress.The aim of this study is to develop a mouse model that replicates the pathophysiological conditions of ...BACKGROUND:The lack of a stable,easy-to-operate animal model for severe trauma has hindered the research progress.The aim of this study is to develop a mouse model that replicates the pathophysiological conditions of severe trauma,providing a reliable research tool.METHODS:Male C57BL/6J mice(aged 8-10 weeks and weighting approximately 20 g)were used to establish the severe trauma model.Under anesthesia,a midshaft femoral fracture was created and packed with sterile cotton.A midline incision was made from the inguinal region to the sternum,exposing the abdominal organs for 30 min.The right femoral artery was cannulated to induce controlled blood loss at 30%,35%,40%,and 50%of the total blood volume.Survival rates were monitored for 24 h post-induction.In the mice that experienced 30%blood loss,the mean arterial pressure,body temperature,blood gas parameters,peripheral blood inflammatory markers,and major organ pathological changes were assessed.RESULTS:Mice with femoral fractures,soft tissue injuries,abdominal organ exposure,and 30%blood loss exhibited stable survival rates.Increased blood loss significantly reduced survival rates.Mean arterial pressure decreased initially,recovering within 0-15 min and returning to baseline by 50 min.Similarly,the body temperature decreased initially and gradually recovered to baseline within 50 min.Levels of peripheral blood inflammatory markers remained elevated for 12 h post-injury.Distant organs,including intestines,lungs,liver,spleen and kidneys,displayed varying degrees of injury.CONCLUSION:The established mouse model replicates the pathophysiological responses to severe trauma,indicating stability and reproducibility,which could be an useful tool for further trauma research.展开更多
The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increas...The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.展开更多
The microstructure design for thermal conduction pathways in polymeric electrical encapsulation materials is essential to meet the stringent requirements for efficient thermal management and thermal runaway safety in ...The microstructure design for thermal conduction pathways in polymeric electrical encapsulation materials is essential to meet the stringent requirements for efficient thermal management and thermal runaway safety in modern electronic devices.Hence,a composite with three-dimensional network(Ho/U-BNNS/WPU)is developed by simultaneously incorporating magnetically modified boron nitride nanosheets(M@BNNS)and non-magnetic organo-grafted BNNS(U-BNNS)into waterborne polyurethane(WPU)to synchronous molding under a horizontal magnetic field.The results indicate that the continuous in-plane pathways formed by M@BNNS aligned along the magnetic field direction,combined with the bridging structure established by U-BNNS,enable Ho/U-BNNS/WPU to exhibit exceptional in-plane(λ//)and through-plane thermal conductivities(λ_(⊥)).In particular,with the addition of 30 wt%M@BNNS and 5 wt%U-BNNS,theλ//andλ_(⊥)of composites reach 11.47 and 2.88 W m^(-1) K^(-1),respectively,which representing a 194.2%improvement inλ_(⊥)compared to the composites with a single orientation of M@BNNS.Meanwhile,Ho/U-BNNS/WPU exhibits distinguished thermal management capabilities as thermal interface materials for LED and chips.The composites also demonstrate excellent flame retardancy,with a peak heat release and total heat release reduced by 58.9%and 36.9%,respectively,compared to WPU.Thus,this work offers new insights into the thermally conductive structural design and efficient flame-retardant systems of polymer composites,presenting broad application potential in electronic packaging fields.展开更多
This work investigated the dynamic behavior of vertical pipes conveying gas-liquid two-phase flow when subjected to external excitations at both ends.Even with minimal excitation amplitude,resonance can occur when the...This work investigated the dynamic behavior of vertical pipes conveying gas-liquid two-phase flow when subjected to external excitations at both ends.Even with minimal excitation amplitude,resonance can occur when the excitation frequency aligns with the natural frequency of the pipe,significantly increasing the degree of operational risk.The governing equation of motion based on the Euler-Bernoulli beam is derived for the relative deflection with stationary simply supported ends,with the effects of the external excitations represented by source terms distributed along the pipe length.The fourth-order partial differential equation is solved via the generalized integral transform technique(GITT),with the solution successfully verified via comparison with results in the literature.A comprehensive analysis of the vibration phenomena and changes in the motion state of the pipe is conducted for three classes of external excitation conditions:same frequency and amplitude(SFSA),same frequency but different amplitudes(SFDA),and different frequencies and amplitudes(DFDA).The numerical results show that with increasing gas volume fraction,the position corresponding to the maximum vibration displacement shifts upward.Compared with conditions without external excitation,the vibration displacement of the pipe conveying two-phase flow under external excitation increases significantly.The frequency of external excitation has a significant effect on the dynamic behavior of a pipe conveying two-phase flow.展开更多
文摘IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the United States Trade Representative released a report on the investigation of China under Section 301 of the Trade Act of 1974, claiming China's acts, policies, and practices regarding technology transfer, intellectual property, and innovation are “unreasonable and discriminatory, and burden U.S. commerce.”
文摘The Unconventional Oil and Gas industry has seen growth over the last ten years that has drastically transformed the domestic energy outlook while bringing up increased concerns over climate and environmental issues. The rise of ESG and RSG can be seen as direct answers to these growing issues as communities and operators have both begun to demand better practices to limit the overall effects of UOG production. Few quantifiable metrics exist that holistically try to determine the overall effect UOG production has on local water resources. The FR2 metric/framework developed in this paper attempts to use commonly kept data such as water withdrawn and flowback volumes in conjunction with a new water stress index to quantify the effects operators are having on local water supplies. Testing this framework on a handful of operators from the Marcellus basin using open-source data revealed the value added by these methods as well as their use in a general RSG program.
基金supported by the National Natural Science Foundation of China,Nos.92049120 and 81870897STI2030-Major Projects,No.2021ZD0204001+6 种基金Guangdong Key Project for Development of New Tools for the Diagnosis and Treatment of Autism,No.2018B030335001the Natural Science Foundation of Jiangsu Province,No.BK20181436the National Major Scientific and Technological Special Project for Significant New Drug Development,No.2019ZX09301102the Discipline Construction Program of the Second Affiliated Hospital of Soochow University,No.XKTJ-TD202003Sino-German Cooperation Mobility Programme,No.M-0679the Science and Technology Project of Suzhou,No.SKY2022161Research Project of Neurological Diseases of the Second Affiliated Hospital of Soochow University Medical Center,No.ND2023A01(all to QHM)。
文摘The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and proteostasis.In this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements.We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases.In summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.
文摘BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute pancreatitis.AIM To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute pan-creatitis.METHODS The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)groups.Relevant data was collected for each group.Western blot analysis assessed PLD2 protein expression in patient serum.Real-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil migration.Serum levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent assay.Transwell migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil migration.RESULTS Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumor necrosis factor-α,interleukin-1β,and interleukin-6 in the severe group were higher than those in the moderate and mild groups(P<0.05),and the levels in the moderate group were also higher than those in the mild group(P<0.05).The number of migrating neutrophils in the severe group was higher than that in the moderate and mild groups(P<0.05),and the moderate group was also higher than the mild group(P<0.05).In addition,the number of migrating neutrophils in the mild group combined with PLD2 inhibitor was higher than that in the mild group(P<0.05),and the number of migrating neutrophils in the moderate group combined with PLD2 inhibitor was higher than that in the moderate group(P<0.05).The number of migrating neutrophils in the severe group+PLD2 inhibitor group was significantly higher than that in the severe group(P<0.05),indicating that PLD2 inhibitors significantly stimulated neutrophil migration.CONCLUSION PLD2 exerted a crucial regulatory role in the pathological progression of acute pancreatitis.Its protein expression varied among patients based on the severity of the disease,and a negative correlation existed between PLD2 expression and disease severity.Additionally,PLD2 appeared to impede acute pancreatitis progression by limiting neutrophil migration.
基金State Grid Henan Power Company Science and Technology Project‘Key Technology and Demonstration Application of Multi-Domain Electric Vehicle Aggregated Charging Load Dispatch’(5217L0240003).
文摘This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability.The results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly charging.Additionally,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.
文摘Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality worldwide.Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy.Long non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies.Studies have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be characterized.Therefore,our study aimed to explore the role and underlying mechanism of SNHG4 in GC.Methods:We used qRT-PCR to analyze SNHG4 expression in GC tissues and cells.Kaplan-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC patients.Cellular function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and invasion.We also established xenograft mouse models to explore the effect of SNHG4 on GC tumor growth.Mechanically,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC patients.SNHG4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in vitro.The in vivo experiment indicated that SNHG4 facilitated GC tumor growth.Furthermore,SNHG4 was demonstrated to bind to miR-409-3p.Moreover,CREB1 was directly targeted by miR-409-3p.Rescue assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell malignancy.Additionally,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1.Conclusion:In conclusion,we verified that the SNHG4 promoted GC growth and metastasis by binding to miR-409-3p to upregulate CREB1,which may deepen the understanding of the underlying mechanism in GC development.
文摘BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.
基金supported by National Key R&D Program of China(Grant No.2021YFB2601200)Open Fund of National Engineering Research Center of Highway Maintenance Technology(Changsha University of Science&Technology)(No.kfj230207).
文摘The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and discrete element method(DEM)was employed to investigate the mechanical behavior of asphalt pavement containing a pre-existing TD crack.The mesoscopic parameters of the model were calibrated based on the mixture modulus and the static mechanical response on the MLS66 test road.Finally,an analysis was performed to assess how variations in TD crack depth and longitudinal length affect the distribution patterns of transverse tensile stress,vertical shear stress,and vertical compressive stress.The results indicate that the vertical propagation of TD crack significantly increases both the tensile stress value and range on the middle surface,while the longitudinal development of TD crack has minimal impact.This phenomenon may result in more severe fatigue failure on the middle surface.With the vertical and longitudinal development of TD crack,the vertical shear stress and compressive stress show obvious"two-stage"characteristics.When the crack's vertical length reaches 40 mm,there is a sharp increase in stress on the upper surface.As the crack continues to propagate vertically,the growth of stress on the upper surface becomes negligible,while the stress in the middle and lower layers increased significantly.Conversely,for longitudinal development of TD crack,any changes in stress are insignificant when their length is less than 180 mm;however,as they continue to develop longitudinally beyond this threshold,there is a sharp increase in stress levels.These findings hold great significance for understanding pavement structure deterioration and maintenance behavior associated with TD crack.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3003805)Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2022356)Guangzhou Basic and Applied Basic Research Project(Grant No.2023A04J0955).
文摘This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.
文摘This study examines the effects of e-banking service quality on customer satisfaction in the Commercial Bank of Ethiopia(CBE)branches in Wolaita Sodo town.Using a causal research design,the study explored the cause-and-effect relationship between service quality dimensions and customer satisfaction.A sample of 385 customers was selected using convenience sampling,with 365 questionnaires returned.Data were collected through questionnaires and analyzed using SPSS V.21.The Cronbach’s alpha value of 0.72 from a pilot study confirmed reliability.Descriptive and inferential statistics,including multiple linear regression and one-way ANOVA,were employed.Results revealed that three service quality dimensions-responsiveness,reliability,and assurance-were statistically significant and positively influenced customer satisfaction,while two dimensions showed negative associations.The regression model’s coefficient of determination(R²)was 0.621,indicating a moderate explanatory power.Findings suggest that CBE managers and stakeholders should prioritize improving responsiveness,reliability,and assurance by providing prompt,dependable,and trustworthy services.Due to limitations in time and resources,this study was confined to CBE branches in Wolaita Sodo town;future research could expand to a national level or other service sectors.
文摘BACKGROUND Steroids remain the primary treatment for severe alcohol-associated hepatitis(AAH),though there is little available tools to predict patient response to steroids.It was hypothesized that phosphatidylethanol(PEth)value will inversely corre-late with response to steroid therapy based on Lille score in AAH.AIM To assess the relationship of patient factors,focusing on pre-steroid therapy PEth value,to steroid therapy response in AAH.METHODS A retrospective case control study was performed on patients who received≥4 days of steroid therapy for AAH at our hospital between July 1,2019 and June 30,2022.A total of 2087 patients were screened for AAH and those treated with steroids were included for statistical analysis utilizing independent sample t-test and for categorical variables using the χ^(2) test.RESULTS No correlation was found between PEth value,pre-steroids abstinence length,or number of drinks per week pre-steroids and response to steroids.Non-responder status significantly correlated with older age(P=0.024),lower albumin(P=0.003),and higher bilirubin(P=0.010)pre-steroids.Our study suggests that age,pre-steroid albumin,and pre-steroid bilirubin levels may predict nonresponse to steroid therapy.Non-responders have increased incidence of death and higher medical costs.CONCLUSION Identifying non-responders through these identified factors should prompt early referral for liver transplantation.Future prospective studies with larger population size are needed to assess the efficacy of combined pre-steroid age,albumin,bilirubin and other biochemical markers as predictors of steroid response.
基金supported by the National Natural Science Foundation of China(32371596)Key Natural Science Foundation of Zhejiang Province(Z25C030002)+2 种基金Science and Technology Innovation Yongjiang 2035 Key Research and Development Project of Ningbo(2024Z279)One Health Interdisciplinary Research Project(HZ202404)K.C.Wong Magna Fund in Ningbo University。
文摘Probiotic supplementation enhances the abundance of gutassociated Rhodobacteraceae species,critical symbionts contributing to the health and physiological fitness of Litopenaeus vannamei.Understanding the role of Rhodobacteraceae in shaping the shrimp gut microbiota is essential for optimizing probiotic application.This study investigated whether probiotics benefit shrimp health and fitness via the recruitment of Rhodobacteraceae commensals in the gut.Probiotic supplementation significantly enhanced feed conversion efficiency,digestive enzyme activity,and immune responses,thereby promoting shrimp growth.Additionally,probiotics induced pronounced shifts in gut microbial composition,enriched gut Rhodobacteraceae abundance,and reduced community variability,leading to a more stable gut microbiome.Network analysis revealed that the removal of Rhodobacteraceae nodes disrupted gut microbial connectivity more rapidly than the removal of nonRhodobacteraceae nodes,indicating a disproportionate role of Rhodobacteraceae in maintaining network stability.Probiotic supplementation facilitated the migration of Rhodobacteraceae taxa from the aquatic environment to the shrimp gut while reinforcing deterministic selection in gut microbiota assembly.Transcriptomic analysis revealed that up-regulation of amino acid metabolism and NF-κB signaling pathways was positively correlated with Rhodobacteraceae abundance.These findings demonstrate that probiotic supplementation enriches key Rhodobacteraceae taxa,stabilizes gut microbial networks,and enhances host digestive and immune functions,ultimately improving shrimp growth performance.This study provides novel perspectives on the ecological and molecular mechanisms underlying the beneficial effects of probiotics on shrimp fitness.
基金supported by the National Natural Science Foundation of China (Nos. 22375157 and W2433042)the Key Scientific and Technological Innovation Team of Shaanxi Province(No. 2020TD-001)+1 种基金the Fundamental Research Funds for Central Universities, State Key Laboratory of Electrical Insulation and Power Equipment (No. EIPE23409)the Instrument Analysis Center of Xi’an Jiaotong University for assistance。
文摘Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a common tumor with a poor prognosis.Early intervention is essential;thus,good prognostic markers to identify patients who benefit from first transarterial chemoembolization(TACE)are needed.AIM To investigate the efficacy of computed tomography(CT)radiomics in predicting the success of the first TACE in patients with advanced HCC and to develop an early prediction model based on clinical radiomics features.METHODS Data from 122 patients with advanced HCC treated with TACE were analyzed.Intratumoral and peritumoral areas on arterial and venous CT images were selected to extract radiomic features,which were screened in the training cohort using the minimum redundancy maximum correlation.Then,support vector machines were used to construct the model.To construct a receiver operating characteristic curve,the predictive efficacy of each model was evaluated on the basis of the area under the curve(AUC).RESULTS Among the 122 patients,72 patients were effectively treated via TACE,and in 50 patients,this treatment was ineffective.In the radiomics model,the areas under the curve of the venous phase model were 0.867(95%CI:0.790-0.940)in the training cohort and 0.755(0.600-0.910)in the validation cohort,indicating good predictive efficacy.The multivariate logistic regression results indicated that preoperative alpha-fetoprotein levels(P=0.01)were a risk factor for TACE.The screened clinical features were combined with the radiomic features to construct a combined model.This combined model had an AUC of 0.92(0.87-0.95)in the training cohort and 0.815(0.67-0.95)in the validation cohort.CONCLUSION CT radiomics has good value in predicting the efficacy of the first TACE treatment in patients with HCC.The combined model was a better tool for predicting the first TACE efficacy in patients with advanced HCC and could provide an efficient predictive tool to help with the selection of patients for TACE.
基金supported by Research Program for Agricultural Science and Technology Development,Republic of Korea(PJ01570601)the Fellowship Program(PJ01661001)of the National Institute of Agricultural Sciences,Republic of KoreaRural Development Administration,Republic of Korea.
文摘The emergence of novel phytopathogens and the accelerated spread of plant diseases to new regions,driven by global climate change,constitute significant threats to agricultural resources.Rice,a major tropical staple crucial for global food security,possesses six transcription factor superfamilies-AP2/ERF,bHLH,bZIP,MYB,NAC,and WRKY-that function in innate immunity against pathogens.We review their biological functions and regulatory mechanisms in rice immunity.
基金National Natural Science Foundation of China under Grant No.51578463。
文摘The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this study.The indoor model test verified the accuracy of the numerical model.The influence laws of different hard combinations,train operating speeds and modes were studied and evaluated accordingly.The results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 Hz.The vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the source.Furthermore,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the superstructure.The vibration response under the reversible operation of the train is greater than that of the unidirectional operation.The operating speed of the train is proportional to its vibration response.The vibration amplification area appears between the middle and the top of the superstructure at a higher train speed.Its vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are required.Within the scope of application,this study provides some suggestions for constructing subway stations and superstructures.
基金supported by the National Natural Science Foundation of China(82102315).
文摘BACKGROUND:The lack of a stable,easy-to-operate animal model for severe trauma has hindered the research progress.The aim of this study is to develop a mouse model that replicates the pathophysiological conditions of severe trauma,providing a reliable research tool.METHODS:Male C57BL/6J mice(aged 8-10 weeks and weighting approximately 20 g)were used to establish the severe trauma model.Under anesthesia,a midshaft femoral fracture was created and packed with sterile cotton.A midline incision was made from the inguinal region to the sternum,exposing the abdominal organs for 30 min.The right femoral artery was cannulated to induce controlled blood loss at 30%,35%,40%,and 50%of the total blood volume.Survival rates were monitored for 24 h post-induction.In the mice that experienced 30%blood loss,the mean arterial pressure,body temperature,blood gas parameters,peripheral blood inflammatory markers,and major organ pathological changes were assessed.RESULTS:Mice with femoral fractures,soft tissue injuries,abdominal organ exposure,and 30%blood loss exhibited stable survival rates.Increased blood loss significantly reduced survival rates.Mean arterial pressure decreased initially,recovering within 0-15 min and returning to baseline by 50 min.Similarly,the body temperature decreased initially and gradually recovered to baseline within 50 min.Levels of peripheral blood inflammatory markers remained elevated for 12 h post-injury.Distant organs,including intestines,lungs,liver,spleen and kidneys,displayed varying degrees of injury.CONCLUSION:The established mouse model replicates the pathophysiological responses to severe trauma,indicating stability and reproducibility,which could be an useful tool for further trauma research.
文摘The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.
基金support from the National Natural Science Foundation of China(22268025,52473083,and 22475176)Key Research and Development Program of Yunnan Province(202403AP140036)+2 种基金Natural Science Basic Research Program of Shaanxi(2024JC-TBZC-04)Applied Basic Research Program of Yunnan Province(202201AT070115 and 202201BE070001-031)supported by the Innovation Capability Support Program of Shaanxi(2024RS-CXTD-57).
文摘The microstructure design for thermal conduction pathways in polymeric electrical encapsulation materials is essential to meet the stringent requirements for efficient thermal management and thermal runaway safety in modern electronic devices.Hence,a composite with three-dimensional network(Ho/U-BNNS/WPU)is developed by simultaneously incorporating magnetically modified boron nitride nanosheets(M@BNNS)and non-magnetic organo-grafted BNNS(U-BNNS)into waterborne polyurethane(WPU)to synchronous molding under a horizontal magnetic field.The results indicate that the continuous in-plane pathways formed by M@BNNS aligned along the magnetic field direction,combined with the bridging structure established by U-BNNS,enable Ho/U-BNNS/WPU to exhibit exceptional in-plane(λ//)and through-plane thermal conductivities(λ_(⊥)).In particular,with the addition of 30 wt%M@BNNS and 5 wt%U-BNNS,theλ//andλ_(⊥)of composites reach 11.47 and 2.88 W m^(-1) K^(-1),respectively,which representing a 194.2%improvement inλ_(⊥)compared to the composites with a single orientation of M@BNNS.Meanwhile,Ho/U-BNNS/WPU exhibits distinguished thermal management capabilities as thermal interface materials for LED and chips.The composites also demonstrate excellent flame retardancy,with a peak heat release and total heat release reduced by 58.9%and 36.9%,respectively,compared to WPU.Thus,this work offers new insights into the thermally conductive structural design and efficient flame-retardant systems of polymer composites,presenting broad application potential in electronic packaging fields.
基金financially supported by the Key Research and Development Program of Shandong Province(Grant Nos.2022CXGC020405,2023CXGC010415 and 2025TSGCCZZB0238)the National Natural Science Foundation of China(Grant No.52171288)the financial support from CNPq,FAPERJ,ANP,Embrapii,and China National Petroleum Corporation(CNPC).
文摘This work investigated the dynamic behavior of vertical pipes conveying gas-liquid two-phase flow when subjected to external excitations at both ends.Even with minimal excitation amplitude,resonance can occur when the excitation frequency aligns with the natural frequency of the pipe,significantly increasing the degree of operational risk.The governing equation of motion based on the Euler-Bernoulli beam is derived for the relative deflection with stationary simply supported ends,with the effects of the external excitations represented by source terms distributed along the pipe length.The fourth-order partial differential equation is solved via the generalized integral transform technique(GITT),with the solution successfully verified via comparison with results in the literature.A comprehensive analysis of the vibration phenomena and changes in the motion state of the pipe is conducted for three classes of external excitation conditions:same frequency and amplitude(SFSA),same frequency but different amplitudes(SFDA),and different frequencies and amplitudes(DFDA).The numerical results show that with increasing gas volume fraction,the position corresponding to the maximum vibration displacement shifts upward.Compared with conditions without external excitation,the vibration displacement of the pipe conveying two-phase flow under external excitation increases significantly.The frequency of external excitation has a significant effect on the dynamic behavior of a pipe conveying two-phase flow.
