IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the...IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the United States Trade Representative released a report on the investigation of China under Section 301 of the Trade Act of 1974, claiming China's acts, policies, and practices regarding technology transfer, intellectual property, and innovation are “unreasonable and discriminatory, and burden U.S. commerce.”展开更多
Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has...Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has been quantitative,using deductive methods.The purpose of the current study was to systematically examine professional disaster response workers’emotions elicited spontaneously and in detail as they were experienced over time after a major disaster.This qualitative study will add to existing knowledge of psychopathology and the psychosocial effects of disasters on professional responders,which have not been explored by prior quantitative studies.Methods:A volunteer sample of 181 rescue and recovery workers for the 1995 bombing of the OKC Murrah Federal Building was interviewed approximately 3 years after the bombing.These responders were asked open-ended questions to elicit undirected responses in their own words.In these interviews,they were prompted to describe their feelings at 3 distinct time points:upon their arrival at the bombing scene(“immediately”),in the first 1 week following the bombing,and currently at the time of the interview(“now”).Results:Data items were coded into the 5 themes:Anticipation,Shock and awe,Negative reactions,Positive reactions,and Emotionally unengaged/unaffected.The emotional themes of the responders mapped into 2 conceptual domains.The first domain is related to common human responses to horrible events such as the bombing.The second domain is related to the professional identities of the disaster responders.Conclusions:Specific aspects of the professional responder roles asserted themselves,shaping their emotional responses distinctly from those of the bomb blast survivors.This study identified both negative and positive emotions,which may help identify risk for or resistance to posttraumatic stress disorder(PTSD).展开更多
1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Part...1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Partial hepatectomy is recommended for patients with early stage HCC.[2]A large proportion of patients with HCC inChina are diagnosed in the intermediate to advanced HCC stages,rendering them ineligible for hepatectomy due to aspects such as liver dysfunction,insufficient residual liver volume,or surgical technique.展开更多
Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility o...Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).展开更多
Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to respondin...Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to responding to public health emergencies,strengthens the foundation for human health and well-being,serving as an important cornerstone for promoting global scientific innovation.For this reason.展开更多
In accordance with the Opinions of the Central Committee of the Communist Party of China and the State Council on Promoting the Inheritance and Innovation of traditional Chinese Medicine(TCM),and to advance research o...In accordance with the Opinions of the Central Committee of the Communist Party of China and the State Council on Promoting the Inheritance and Innovation of traditional Chinese Medicine(TCM),and to advance research on clinically advantageous diseases in TCM and promote academic innovation,the China Association of Chinese Medicine(CACM)convened the 31st Clinical Advantage Disease Salon(Rhinosinusitis)in Beijing on 28 March 2024.During the meeting,experts in Chinese and Western medicine conducted extensive and in-depth discussions,formulating suggestions for the integrated diagnosis and treatment of rhinosinusitis using both TCM and Western medicine approaches.This review examines the challenges in rhinosinusitis diagnosis and treatment by analyzing its occurrence and development.Given the advantages of integrating TCM and Western medicine in the diagnosis and treatment of rhinosinusitis,key scientific research points are proposed in three areas:Prediction,diagnosis and treatment,and chronic disease management.These include(1)development of a rhinosinusitis prediction model,(2)optimal timing and treatment protocols for the combined use of TCM and Western medicine in rhinosinusitis,(3)research on the mechanism of TCM in preventing and treating rhinosinusitis,(4)construction of an integrated TCM and Western medicine recurrence prevention strategy for refractory rhinosinusitis,(5)prevention and self-management strategies for chronic rhinosinusitis.Based on the salon of TCM dominant diseases of rhinosinusitis,this article proposes a research paradigm for rhinosinusitis to promote the high-quality development of TCM and provide a reference for national research direction selection.展开更多
[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD ch...[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.展开更多
In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is p...In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.展开更多
It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as...It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as a touchy issue. In order to address this problem, this essay will review some of the major studies on teachers' response to students' writing in a historical way and, from these studies, some beneficial methods will be suggested, such as a process approach, collaborative ways of writing and motivational techniques.展开更多
Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% ...Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.展开更多
Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personali...Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.展开更多
This review aims to provide a concise overview of the trauma management evolution in the past decade. 1） Trauma care priorities have incorporated staff protection against infection and early decision making in additi...This review aims to provide a concise overview of the trauma management evolution in the past decade. 1） Trauma care priorities have incorporated staff protection against infection and early decision making in addition to the conventional ABCDE. 2） Five stratified levels for DAM have replaced the non-specific conventional Plans A ＆ B. 3） CT scanning can be the tunnel to death for the hemodynamically unstable patient. 4） DPL has virtually been replaced by the FAST USG. 5） Direct whole-body MDCT provides rapid imaging diagnosis ＆ expedites the definitive treatment but carries high radiation hazards. 6） The dynamic shock assessment by fluid resuscitation response provides more outcome-specific evaluation than the static blood volume loss model. 7） DCR comprising of permissive hypotension, hemostatic resuscitation ＆ DCS aims to overcome the lethal triad of trauma. Early transfusion of blood components of FFP ＆ platelet concentrates improves the outcome in massive blood transfusion. 8） DCS aims to rectify the deranged physiology and not to fully restore the damaged anatomy. 9） A pre-defined protocol for major pelvic fracture can be life-saving and the novel Pre-PPP （pre-peritoneal pelvic packing） may further reduce mortality coupled with the necessary TCAE. 10） Injury prevention is equally important if not more than the trauma resuscitation ＆ operation.展开更多
AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression(TRD) and to discuss them according to personal clinical experience.METHODS: Original studies, clinical trials, systemati...AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression(TRD) and to discuss them according to personal clinical experience.METHODS: Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries(Pub Med, Google Scholar e Quertle Searches) using terms: "treatment resistant depression", "treatment refractory depression", "partial response depression", "non responder depression", "optimization strategy", "switching strategy", "combination strategy", "augmentation strategy", selective serotonin reuptake inhibitors antidepressants(SSRI), tricyclic antidepressants(TCA), serotonin norepinephrine reuptake inhibitors antidepressants, mirtazapine, mianserine, bupropione, monoamine oxidase inhibitor antidepressant(MAOI), lithium, thyroid hormones, second generation antipsychotics(SGA), dopamine agonists, lamotrigine, psychostimulants, dextromethorphan, dextrorphan, ketamine, omega-3 fatty acids, S-adenosil-L-metionine, methylfolat, pindolol, sex steroids, glucocorticoid agents. Other citations of interest were further identified from references reported in the accessed articles. Selected publications were grouped by treatment strategy:(1) switching from an ineffective antidepressant(AD) to a new AD from a similar or different class;(2) combining the current AD regimen with a second AD from a different class; and(3) augmenting the current AD regimen with a second agent not thought to be an antidepressant itself.RESULTS: Switching from a TCA to another TCA provides only a modest advantage(response rate 9%-27%), while switching from a SSRI to another SSRI is more advantageous(response rate up to 75%). Evidence supports the usefulness of switching from SSRI to venlafaxine(5 positive trials out 6), TCA(2 positive trials out 3), and MAOI(2 positive trials out 2) but not from SSRI to bupropione, duloxetine and mirtazapine. Three reviews demonstrated that the benefits of intraand cross-class switch do not significantly differ. Data on combination strategy are controversial regarding TCA-SSRI combination(positive results in old studies, negative in more recent study) and bupropion-SSRI combination(three open series studies but not three controlled trails support the useful of this combination) and positive regard mirtazapine(or its analogue mianserine) combination with ADs of different classes. As regards the augmentation strategy, available evidences supported the efficacy of TCA augmentation with lithium salts and thyroid hormone(T3), but are conflicting regard the SSRI augmentation with these two drugs(1 positive trial out of 4 for lithium and 3 out of 5 for thyroid hormone). Double-blind controlled studies showed the efficacy of AD augmentation with aripiprazole(5 positive trials out 5), quetiapine(3 positive trials out 3) and, at less extent, of fluoxetine augmentation with olanzapine(3 positive trials out 6), so these drugs received the FDA indication for the acute treatment of TRD. Results on AD augmentation with risperidone are conflicting(2 short term positive trials, 1 short-term and 1 long-term negative trials). Case series and open-label trials showed that AD augmentation with pramipexole or ropinirole, two dopamine agonists, could be an effective treatment for TRD(response rate to pramipexole 48%-74%, to ropinirole 40%-44%) although one recent double-blind placebo-controlled study does not support the superiority of pramipexole over placebo. Evidences do not justify the use of psychostimulants, omega-3 fatty acids, S-adenosil-Lmetionine, methylfolate, pindolol, lamotrigine, and sex hormone as AD augmentation for TRD. Combining the available evidences with our experience we suggest treating non-responders to one SSRI bupropion or mirtazapine trial by switching to venlafaxine, and nonresponders to one venlafaxine trial by switching to a TCA or, if TCA are not tolerated, combining mirtazapine with SSRI or venlafaxine. In non-responders to two or more ADs(including at least one TCA if tolerated) current AD regimen could be augmented with lithium salts(mainly in patients with bipolar depression or suicidality), SGAs(mostly aripiprazole) or DA-agonists(mostly pramipexole). In patients with severe TRD, i.e., non-responders to combination and augmentation strategies as well as to electroconvulsive therapy if workable, we suggest to try a combination plus augmentation strategy.CONCLUSION: Our study identifies alternative effective treatment strategies for TRD. Further studies are needed to compare the efficacy of different strategies in more homogeneous subpopulations.展开更多
We studied gas-exchange, chlorophyll pigments, lipid peroxidation, antioxidant enzymes, and biomass partitioning responses in seedlings of four wolfberry species （Lycium chinense Mill. var. potaninii （Pojark.） A. M...We studied gas-exchange, chlorophyll pigments, lipid peroxidation, antioxidant enzymes, and biomass partitioning responses in seedlings of four wolfberry species （Lycium chinense Mill. var. potaninii （Pojark.） A. M. Lu, Lycium chinense Mill., Lycium barbarum L., and Lycium yunnanense Kuang ＆ A. M. Lu） under four water supply regimes. In all four species, drought affected seedlings in terms of chlorophyll content, net photosynthesis rate （Pn）＇ transpiration rate （E）, and lipid peroxidation. Drought also increased some antioxidant enzyme activities, such as peroxidase （POD）, catalase （CAT）, superoxide dismutase （SOD）, and ascorbate peroxidase （APX）. Significant changes in dry biomass partitioning also occurred in response to water stress. In particular, dry biomass of leaves and fruits decreased significantly. L. chinense Mill. and L. barbarum L. possessed greater drought tolerance and exhibited superior antioxidant processing ability and other related physiological traits compared to the other two species. L. chinense Mill. was the most tolerant to all levels of drought. In contrast,L, yunnanense Kuang ＆ A. M. Lu was more affected by water supply and had the lowest resistance to drought stress. These findings would provide some important information regarding genetic resources for future forest tree improvement in relation to drought tolerance.展开更多
The seismic behavior of frames with semi rigid connections and rotational dampers is examined.The ground acceleration due to earthquake is regarded as a stochastic process,and a pseudo excitation algorithm in frequen...The seismic behavior of frames with semi rigid connections and rotational dampers is examined.The ground acceleration due to earthquake is regarded as a stochastic process,and a pseudo excitation algorithm in frequency domain is implemented in a computer program to handle non orthogonal damping properties of the system.The computer program which incorporates detailed connection models and rotational damping models is used to investigate the effect of the connection of the semi rigid frame.It is shown from analytical studies that semi rigid frames with rotational dampers improve the seismic response of the building and may provide an effective and reliable earthquake resistant design solution.展开更多
文摘IN March 2018, the United States slapped tariffs of 25 percent on steel imports and 10 percent on aluminum in the name of national security under Section 232 of the Trade Expansion Act of 1962. Then, the Office of the United States Trade Representative released a report on the investigation of China under Section 301 of the Trade Act of 1974, claiming China's acts, policies, and practices regarding technology transfer, intellectual property, and innovation are “unreasonable and discriminatory, and burden U.S. commerce.”
文摘Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has been quantitative,using deductive methods.The purpose of the current study was to systematically examine professional disaster response workers’emotions elicited spontaneously and in detail as they were experienced over time after a major disaster.This qualitative study will add to existing knowledge of psychopathology and the psychosocial effects of disasters on professional responders,which have not been explored by prior quantitative studies.Methods:A volunteer sample of 181 rescue and recovery workers for the 1995 bombing of the OKC Murrah Federal Building was interviewed approximately 3 years after the bombing.These responders were asked open-ended questions to elicit undirected responses in their own words.In these interviews,they were prompted to describe their feelings at 3 distinct time points:upon their arrival at the bombing scene(“immediately”),in the first 1 week following the bombing,and currently at the time of the interview(“now”).Results:Data items were coded into the 5 themes:Anticipation,Shock and awe,Negative reactions,Positive reactions,and Emotionally unengaged/unaffected.The emotional themes of the responders mapped into 2 conceptual domains.The first domain is related to common human responses to horrible events such as the bombing.The second domain is related to the professional identities of the disaster responders.Conclusions:Specific aspects of the professional responder roles asserted themselves,shaping their emotional responses distinctly from those of the bomb blast survivors.This study identified both negative and positive emotions,which may help identify risk for or resistance to posttraumatic stress disorder(PTSD).
文摘1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Partial hepatectomy is recommended for patients with early stage HCC.[2]A large proportion of patients with HCC inChina are diagnosed in the intermediate to advanced HCC stages,rendering them ineligible for hepatectomy due to aspects such as liver dysfunction,insufficient residual liver volume,or surgical technique.
基金supported by National Key Research & Development Program of China (2022YFC3006201)。
文摘Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).
文摘Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to responding to public health emergencies,strengthens the foundation for human health and well-being,serving as an important cornerstone for promoting global scientific innovation.For this reason.
基金supported by the National Key Research&Development Program of China(2022YFC2504100)the Natural Science Foundation of China(No.82205202)+1 种基金the Beijing Municipal Health Commission High Level Public Health Technical Talent Construction Project(Discipline Backbone)(No.02-046)Scarce Resources and Representative Achievements of the "New 3+3" Project for the Inheritance of firewood of Traditional Chinese Medicine in Beijing(No.2023-XQZY-02).
文摘In accordance with the Opinions of the Central Committee of the Communist Party of China and the State Council on Promoting the Inheritance and Innovation of traditional Chinese Medicine(TCM),and to advance research on clinically advantageous diseases in TCM and promote academic innovation,the China Association of Chinese Medicine(CACM)convened the 31st Clinical Advantage Disease Salon(Rhinosinusitis)in Beijing on 28 March 2024.During the meeting,experts in Chinese and Western medicine conducted extensive and in-depth discussions,formulating suggestions for the integrated diagnosis and treatment of rhinosinusitis using both TCM and Western medicine approaches.This review examines the challenges in rhinosinusitis diagnosis and treatment by analyzing its occurrence and development.Given the advantages of integrating TCM and Western medicine in the diagnosis and treatment of rhinosinusitis,key scientific research points are proposed in three areas:Prediction,diagnosis and treatment,and chronic disease management.These include(1)development of a rhinosinusitis prediction model,(2)optimal timing and treatment protocols for the combined use of TCM and Western medicine in rhinosinusitis,(3)research on the mechanism of TCM in preventing and treating rhinosinusitis,(4)construction of an integrated TCM and Western medicine recurrence prevention strategy for refractory rhinosinusitis,(5)prevention and self-management strategies for chronic rhinosinusitis.Based on the salon of TCM dominant diseases of rhinosinusitis,this article proposes a research paradigm for rhinosinusitis to promote the high-quality development of TCM and provide a reference for national research direction selection.
基金Supported by Chongqing Major Research Project "Innovation in Hybrid Rice Breeding and New Materials" ( CSTC, 2007, AA1019 )Sichuan Province Breeding Research Project (06yzgg-01)~~
文摘[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.
基金The Special Project of the Ministry of Construction ofChina (No.20060909).
文摘In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.
文摘It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as a touchy issue. In order to address this problem, this essay will review some of the major studies on teachers' response to students' writing in a historical way and, from these studies, some beneficial methods will be suggested, such as a process approach, collaborative ways of writing and motivational techniques.
文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.
基金Supported by Grants from Beijing Academic Leaders Program,NO.2009-2-17Beijing Natural Science Foundation,No.7102029+5 种基金Capital Medical Developed Research Fund,No.2007-1023New Scholar Star Program of Ministry of EducationNational Basic Research Program of China,No.2011CB504300Specialized Research Fund for the Doctoral Program of Higher Education,No.20130001110108National Natural Science Foundation for Distinguished Young Scholars,No.81301748Science Fund for Creative Research Groups of the National Natural Science Foundation of China,No.IRT13003 and No.NIH/NCI U54 CA156735
文摘Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.
文摘This review aims to provide a concise overview of the trauma management evolution in the past decade. 1） Trauma care priorities have incorporated staff protection against infection and early decision making in addition to the conventional ABCDE. 2） Five stratified levels for DAM have replaced the non-specific conventional Plans A ＆ B. 3） CT scanning can be the tunnel to death for the hemodynamically unstable patient. 4） DPL has virtually been replaced by the FAST USG. 5） Direct whole-body MDCT provides rapid imaging diagnosis ＆ expedites the definitive treatment but carries high radiation hazards. 6） The dynamic shock assessment by fluid resuscitation response provides more outcome-specific evaluation than the static blood volume loss model. 7） DCR comprising of permissive hypotension, hemostatic resuscitation ＆ DCS aims to overcome the lethal triad of trauma. Early transfusion of blood components of FFP ＆ platelet concentrates improves the outcome in massive blood transfusion. 8） DCS aims to rectify the deranged physiology and not to fully restore the damaged anatomy. 9） A pre-defined protocol for major pelvic fracture can be life-saving and the novel Pre-PPP （pre-peritoneal pelvic packing） may further reduce mortality coupled with the necessary TCAE. 10） Injury prevention is equally important if not more than the trauma resuscitation ＆ operation.
文摘AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression(TRD) and to discuss them according to personal clinical experience.METHODS: Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries(Pub Med, Google Scholar e Quertle Searches) using terms: "treatment resistant depression", "treatment refractory depression", "partial response depression", "non responder depression", "optimization strategy", "switching strategy", "combination strategy", "augmentation strategy", selective serotonin reuptake inhibitors antidepressants(SSRI), tricyclic antidepressants(TCA), serotonin norepinephrine reuptake inhibitors antidepressants, mirtazapine, mianserine, bupropione, monoamine oxidase inhibitor antidepressant(MAOI), lithium, thyroid hormones, second generation antipsychotics(SGA), dopamine agonists, lamotrigine, psychostimulants, dextromethorphan, dextrorphan, ketamine, omega-3 fatty acids, S-adenosil-L-metionine, methylfolat, pindolol, sex steroids, glucocorticoid agents. Other citations of interest were further identified from references reported in the accessed articles. Selected publications were grouped by treatment strategy:(1) switching from an ineffective antidepressant(AD) to a new AD from a similar or different class;(2) combining the current AD regimen with a second AD from a different class; and(3) augmenting the current AD regimen with a second agent not thought to be an antidepressant itself.RESULTS: Switching from a TCA to another TCA provides only a modest advantage(response rate 9%-27%), while switching from a SSRI to another SSRI is more advantageous(response rate up to 75%). Evidence supports the usefulness of switching from SSRI to venlafaxine(5 positive trials out 6), TCA(2 positive trials out 3), and MAOI(2 positive trials out 2) but not from SSRI to bupropione, duloxetine and mirtazapine. Three reviews demonstrated that the benefits of intraand cross-class switch do not significantly differ. Data on combination strategy are controversial regarding TCA-SSRI combination(positive results in old studies, negative in more recent study) and bupropion-SSRI combination(three open series studies but not three controlled trails support the useful of this combination) and positive regard mirtazapine(or its analogue mianserine) combination with ADs of different classes. As regards the augmentation strategy, available evidences supported the efficacy of TCA augmentation with lithium salts and thyroid hormone(T3), but are conflicting regard the SSRI augmentation with these two drugs(1 positive trial out of 4 for lithium and 3 out of 5 for thyroid hormone). Double-blind controlled studies showed the efficacy of AD augmentation with aripiprazole(5 positive trials out 5), quetiapine(3 positive trials out 3) and, at less extent, of fluoxetine augmentation with olanzapine(3 positive trials out 6), so these drugs received the FDA indication for the acute treatment of TRD. Results on AD augmentation with risperidone are conflicting(2 short term positive trials, 1 short-term and 1 long-term negative trials). Case series and open-label trials showed that AD augmentation with pramipexole or ropinirole, two dopamine agonists, could be an effective treatment for TRD(response rate to pramipexole 48%-74%, to ropinirole 40%-44%) although one recent double-blind placebo-controlled study does not support the superiority of pramipexole over placebo. Evidences do not justify the use of psychostimulants, omega-3 fatty acids, S-adenosil-Lmetionine, methylfolate, pindolol, lamotrigine, and sex hormone as AD augmentation for TRD. Combining the available evidences with our experience we suggest treating non-responders to one SSRI bupropion or mirtazapine trial by switching to venlafaxine, and nonresponders to one venlafaxine trial by switching to a TCA or, if TCA are not tolerated, combining mirtazapine with SSRI or venlafaxine. In non-responders to two or more ADs(including at least one TCA if tolerated) current AD regimen could be augmented with lithium salts(mainly in patients with bipolar depression or suicidality), SGAs(mostly aripiprazole) or DA-agonists(mostly pramipexole). In patients with severe TRD, i.e., non-responders to combination and augmentation strategies as well as to electroconvulsive therapy if workable, we suggest to try a combination plus augmentation strategy.CONCLUSION: Our study identifies alternative effective treatment strategies for TRD. Further studies are needed to compare the efficacy of different strategies in more homogeneous subpopulations.
基金supported by the National Natural Science Foundation of China (31360191, 31660220)the Natural Science Foundation of Ningxia Hui Autonomous Region, China (NZ16121)the Self-option and Foundation of Ningxia Academy of Agriculture and Forestry Sciences, China (YES-16-0402, NKYZ-16-0402)
文摘We studied gas-exchange, chlorophyll pigments, lipid peroxidation, antioxidant enzymes, and biomass partitioning responses in seedlings of four wolfberry species （Lycium chinense Mill. var. potaninii （Pojark.） A. M. Lu, Lycium chinense Mill., Lycium barbarum L., and Lycium yunnanense Kuang ＆ A. M. Lu） under four water supply regimes. In all four species, drought affected seedlings in terms of chlorophyll content, net photosynthesis rate （Pn）＇ transpiration rate （E）, and lipid peroxidation. Drought also increased some antioxidant enzyme activities, such as peroxidase （POD）, catalase （CAT）, superoxide dismutase （SOD）, and ascorbate peroxidase （APX）. Significant changes in dry biomass partitioning also occurred in response to water stress. In particular, dry biomass of leaves and fruits decreased significantly. L. chinense Mill. and L. barbarum L. possessed greater drought tolerance and exhibited superior antioxidant processing ability and other related physiological traits compared to the other two species. L. chinense Mill. was the most tolerant to all levels of drought. In contrast,L, yunnanense Kuang ＆ A. M. Lu was more affected by water supply and had the lowest resistance to drought stress. These findings would provide some important information regarding genetic resources for future forest tree improvement in relation to drought tolerance.
基金The Project Advanced Buildings technology in a Dense Urban Environment of Hong Kong Polytechnic University the Application Lab of Digital Seismic Wave Data in Center for Analysis and Prediction+1 种基金 China Seismological Bureau and the Earthquake Prediction
文摘The seismic behavior of frames with semi rigid connections and rotational dampers is examined.The ground acceleration due to earthquake is regarded as a stochastic process,and a pseudo excitation algorithm in frequency domain is implemented in a computer program to handle non orthogonal damping properties of the system.The computer program which incorporates detailed connection models and rotational damping models is used to investigate the effect of the connection of the semi rigid frame.It is shown from analytical studies that semi rigid frames with rotational dampers improve the seismic response of the building and may provide an effective and reliable earthquake resistant design solution.
