The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It ha...The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).展开更多
Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it pr...Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it protects a vital temperate mountainous forest ecosystem on the Loess Plateau.The reserve is centred around the Liupan Mountain range,one of China’s youngest mountain chains,formed by Himalayan tectonic movements.展开更多
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
Ungulates serve as key components in maintaining ecosystem stability,and their ecological functions are closely linked to the integrity of giant panda habitats within Wanglang National Nature Reserve.Assessment of ung...Ungulates serve as key components in maintaining ecosystem stability,and their ecological functions are closely linked to the integrity of giant panda habitats within Wanglang National Nature Reserve.Assessment of ungulate habitat suitability in this reserve can provide critical insights into the distribution patterns of ungulate communities across protected areas while informing conservation strategy optimization.Therefore,six ungulate species were monitored,including Tufted deer(Elaphodus cephalophus),Chinese serow(Capricornis milneedwardsii),Chinese goral(Naemorhedus griseus),Sichuan takin(Budorcas taxicolor),Reeve's muntjac(Muntiacus reevesi),and Wild boar(Sus scrofa)in Wanglang National Nature Reserve.The infrared camera monitoring data(a total of 83 sites)and 23 environmental variables were collected from January 2011 to May 2019,the relative abundance index(RAI),independent samples t-test,and optimized MaxEnt model were employed to evaluate the habitat suitability of six ungulate species.Our findings were as follows:(1)there were significant differences in the annual RAI among the six ungulate species(P<0.01).(2)the suitable habitat area varied among species:Tufted deer occupied 9578 hm^(2)(31.08%of the total),Chinese serow 10,093 hm^(2)(32.75%);Chinese goral 9936 hm^(2)(32.24%);Sichuan takin 10,992 hm^(2)(35.67%);Reeve's muntjac 9542 hm^(2)(30.96%);and Wild boar 9642 hm^(2)(31.28%).(3)the spatial niche overlaps between each pair of the six ungulates were all relatively high(D=0.77-0.89).(4)the annual average temperature,precipitation during the coldest season,and vegetation were the key factors influencing habitat selection.These findings offer valuable references for the conservation of ungulates in natural reserve and are conducive to formulating more scientific and effective.展开更多
Dear Editor,Understanding patterns of species diversity is a primary research focus in macroecology,with its distribution patterns having been described and theoretically validated on a global scale(Peters et al.,2016...Dear Editor,Understanding patterns of species diversity is a primary research focus in macroecology,with its distribution patterns having been described and theoretically validated on a global scale(Peters et al.,2016;Sonne et al.,2025).Numerous studies have found that species richness of different taxa tends to decrease with increasing elevation and is modulated by latitudinal gradients(Peters et al.,2016;Dolson et al.,2024).This principle provides a crucial scientific basis for regional conservation planning.However,it still exhibits significant variations across different mountain ranges and taxa.展开更多
The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and ...The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and 19 bioclimatic variables were selected,and the environmental factors required for modeling were screened out by pearson correlation analysis and variance inflation factor(VIF)analysis.The potential suitable areas of Orchidaceae plants were predictat present and under different climate scenarios in 2090s by using geographic information system(GIS)and Maximum Entropy Model(MaxEnt).And then evaluated the prediction accuracy of the MaxEnt model using the AUC value,the TSS value and the Kappa value.The results showed that:1)The area under curve(AUC)values,true skill statistics(TSS)values and KAPPA values predicted by MaxEnt model were separately above 0.9,0.85 and 0.75.2)Under the climate scenario at present,the total suitable area of Orchidaceae plants was about 9.61×10^(6)km^(2),which was mainly distributed in Heilongjiang province.Among them,the high-suitable area of Cypripedium shanxiense S.C.Chen was the largest,the non-suitable area of Cypripedium guttatum Sw was the largest.3)Under different climate scenarios in 2090s,the total suitable area was slightly increasing(9.62×10^(6)km^(2)).Among them,Cypripedium shanxiense S.C.Chen and Gastrodiae Rhizoma both showed the trend of expansion to the southwest,China,and the suitable areas expanded significantly.Comprehensive factor analysis showed that temperature and precipitation were the main bioclimatic variables of suitable areas distribution,and the low emission scenario(SSP 2-4.5)will be more conducive to the survival of Orchidaceae plants.展开更多
In recent years,the combined effects of seismic disturbances and extreme rainfall events have intensified water turbidity and sedimentation in several lakes within the Jiuzhaigou Nature Reserve located within the Jiuz...In recent years,the combined effects of seismic disturbances and extreme rainfall events have intensified water turbidity and sedimentation in several lakes within the Jiuzhaigou Nature Reserve located within the Jiuzhaigou watershed in Southwest China.In July 2024,turbidity events were observed in multiple core lakes,with noticeable impacts on local ecological functions and landscape values.To quantitatively characterize lake physical changes and explore their driving mechanisms,this study developed an integrated“air-space-ground”lake morphological measurement framework that combines unmanned aerial vehicle(UAV),unmanned surface vehicles(USV),and satellite remote sensing to enable high-precision acquisition of lake bathymetry,relationships between water level and surface area,and storage capacity.Additionally,time-series analyses of fractional vegetation cover(FVC)and the Revised Universal Soil Loss Equation(RUSLE)model were applied to characterize the patterns of change in vegetation cover and soil erosion intensity before and after seismic and extreme rainfall events.The results show that:(1)The physical morphology of the lakes has changed significantly compared with the field measurements conducted in 2004.The surface areas of the Arrow Bamboo Lake and the Rhinoceros Lake decreased by 15.2%~17.0%,and lake storage capacity decreased by 20%~33%.In Long Lake,the difference between the minimum and maximum daily water levels reached 13.21 m,and since 2021,the annual mean water level has exhibited a continuous decline at a rate of 1.46 m·a^(-1).(2)Based on the results of the FVC time series analysis,the two earthquake events resulted in decreases in vegetation cover by 19.14%and 13.19%,and these decreases were accompanied by enhanced soil erosion under heavy rainfall conditions.This process facilitated the transport of large amounts of terrestrial material into the lakes,thereby contributing to water turbidity and sediment accumulation.RUSLE-based estimates further indicate that the two earthquakes increased the peak mean soil erosion modulus by 7.61 t·ha^(-1)·a^(-1)and 4.10 t·ha^(-1)·a^(-1),respectively,relative to pre-earthquake conditions.Based on these findings,it is recommended to implement slope vegetation restoration on the upstream areas of the core lakes,strengthen slope protection in accident-prone locations,and monitor water-sediment dynamics during heavy rainfall periods,to mitigate sedimentation risks and enhance the stability of the scenic area's ecosystem.展开更多
In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the Wo...In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the World Network of Biosphere Reserves(WNBR)as central actors in delivering biodiversity,climate and sustainable-development goals(SDGs).The plan—developed and opened for global consultation in the runup to the 5th World Congress of Biosphere Reserves—articulates strategic directions,measurable action targets and practical instruments to strengthen biosphere reserves as living laboratories for people and nature(Ma,2025).展开更多
Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distri...Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distributed tree genera worldwide,provide an ideal system for investigating large-scale spatial patterns of NSC within a single genus along extensive climatic gradients.Here,we compiled a global NSC database for pines across 74 sites,and assessed the spatial variation in total NSC,starch(St),and soluble sugars(SS)concentrations in stem sapwood,the primary reserve tissue,along site-specific mean annual temperature(MAT)and precipitation(MAP).Our results show that MAP exerted a stronger influence(R^(2)=20%–47%)on the spatial variation in total NSC and its components than did MAT(R^(2)=6%–16%).Tota concentrations declined nonlinearly with increasing MAP,with the rate of decline slowing beyond approximately 800 mm.While MAT had weaker effects on total NSC concentrations,both MAT and MAP jointly regulated NSC partitioning:Higher MAT and MAP were associated with reduced St concentrations but elevated SS concentrations and SS:St ratios.These findings suggest that pine species in cold and arid environments prioritize storing NSC as St,whereas in relatively warm and humid environments,NSC are preferentially mobilized into SS to support immediate metabolic and growth demands.展开更多
Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compar...Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.展开更多
The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the mos...The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the most crucial conservation approach involves the establishment and management of both in-situ and ex-situ nature reserves.Since the 1990s,seven nature reserves have been established in the middle and lower reaches of the Yangtze River,covering nearly one-third of its main stream.Additionally,two nature reserves,one in the Dongting Lake and another in the Poyang Lake,have been set up;and three ex-situ nature reserves have been established in three oxbows respectively in Hunan,Hubei,and Anhui provinces.Through measures such as improving the ecological environment quality within the reserves,regulating human activities,and conducting continuous monitoring,the finless porpoise population showed a slight increase in 2022 for the first time.The ex-situ population has continued to grow,with four individuals being released back into the main stream of the Yangtze River after undergoing reintroduction training in 2023.Based on the population development lasting for over three decades,and predictions of future ecological changes,orderly establishment and scientific management of nature reserves have played a key role in and will remain an important basis for the sustaining growth of the finless porpoise population.展开更多
[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through...[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through field investigations and specimen identification,supplemented by a review of relevant literature.[Results]A total of 84 species of lycophytes and ferns were identified,encompassing 55 genera and 29 families.This included 14 species of lycophytes distributed across 8 genera and 3 families,as well as 70 species of ferns belonging to 47 genera and 26 families.Polypodiaceae and Selaginella were the dominant family and genus,respectively,while oligospecific families and monotypic genera were significant components of lycophytes and ferns in the region.The distribution types of these families were primarily cosmopolitan and tropical.The Germline differentiation degree(SD)was 3.34,and the proportion of rare or endangered species among lycophytes and ferns was 8.33%.[Conclusions]Yunzhongshan Nature Reserve possesses a diverse array of lycophyte and fern species.This study offers valuable scientific insights that can inform efforts related to the conservation of biodiversity,resource utilization and development,species introduction,and system evolution of lycophytes and ferns within the reserve.展开更多
The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part ...The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part of the protection zone of the Tatra National Park and since 1993 it has been part of the transition zone of the Tatra Biosphere Reserve.In recent years,tourism has taken a major role in the transition zone of this biosphere reserve.In the presented contribution,we therefore evaluate the impact of developing tourism in the cadastral area of the municipality ofŽdiar between 1950 and 2022.We rely primarily on available statistical data from various sources and on the analysis of the historical and contemporary landscape structure.During this period,almost 50%of the area has changed land cover.The activities that have significantly changed the landscape include afforestation,deforestation,agrointensification,deurbanisation(naturalisation),urbanisation(anthropisation):tourism development and construction of a water reservoir.Tourism has become the main driver of the economy here and opens up opportunities especially for local inhabitants.However,the lack of completed tourism infrastructure is a drawback.We recommend the establishment of the Coordinating Council of the Tatra Biosphere Reserve and permanent employees at the National Park Administration.展开更多
The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and f...The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.展开更多
Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve fun...Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve function,and establish a multi-parameter coupled mathematical prediction model,providing a theoretical basis for precision instrument design and operation optimization.Methods:A total of 45 reproductive-age patients undergoing single-port laparoscopic ovarian cystectomy were selected.Through orthogonal experimental design,the instrument diameter(3/5/8 mm)and bending angle(30°/60°/90°)were divided into 9 groups,with5 cases in each group.Changes in serum AMH(anti-müllerian hormone),FSH(follicle-stimulating hormone),INHB(inhibin B)and ultrasonic AFC(antral follicle count)indexes were measured before surgery and on the 2nd to 3rd day of the first menstrual period after surgery.Enhanced CT images and laparoscopic images of ovarian force distribution were obtained.Finite element analysis(FEA)of the single-port instrument-ovarian tissue model was performed using ABAQUS software to calculate stress distribution in the ovarian cortex.Oscillatory shear experiments were used to determine the characteristics of viscoelastic property changes in the linear viscoelastic range of ovarian tissue.Results:The rate of decrease in AMH was lower in the 3 mm diameter-30°angle group(P<0.05);the peak Von Mises stress in the D3-θ30 group was lower than that in the other groups(P<0.05);the optimal parameter combination was a diameter of 3.13 mm and an angle of 21.72°,with the model calculating an AMH attenuation of 20%.Ovarian tissue changed with the frequency of the oscillatory shear test.In the low-frequency region(<1 Hz):G'>G''(elasticity-dominated);in the high-frequency region(>5 Hz):G''>G'(viscosity-dominated);the crossover point was at 5 Hz,where G'=G''=5 kPa.Before ovarian dissection:G'was relatively high and G''was relatively low,with elasticity dominating.During dissection:G'decreased and G''increased,with instrument stress causing damage.After dissection:G'further decreased and G''continued to rise,resulting in irreversible damage to the ovarian stroma.Conclusion:The engineering parameters of minimally invasive instruments significantly affect the ovarian reserve function index AMH and the peak Von Mises stress of the ovary through mechanical stress transmission.Using an instrument with a diameter of 3.13 mm and a bending angle of 21.72°can more effectively reduce the impact of single-port laparoscopic surgery on AMH decline.展开更多
Objective:To examine the research trends and hotspots of the application of cognitive reserve in stroke cognitive impairment using CiteSpace and provide a reference for developing effective measures to reduce the inci...Objective:To examine the research trends and hotspots of the application of cognitive reserve in stroke cognitive impairment using CiteSpace and provide a reference for developing effective measures to reduce the incidence of cognitive impairment in these patients.Methods:Using CiteSpace software,a visual analysis of 860 included articles related to cognitive reserve in stroke cognitive impairment patients was performed.Relevant literature regarding the application of cognitive reserve in poststroke cognitive impairment was retrieved from the Web of Science core collection database from January 2010 through January 2024.Citespace 6.3.R1(64-bit)was employed to visualize and analyze literature data,including general literature analysis,national publication distribution,literature co-citation,journal co-citation,keyword co-citation,keyword clustering,literature co-citation,and literature co-citation clustering.Results:A total of 860 articles were retrieved,indicating a rising trend in publications in this field,with the United States leading in publication count and FRONT NEUROL being the most frequently cited journal.The most frequently cited references usually focus on the prevention and influence factors of cognitive impairment and dementia.Conclusions:After eliminating keywords similar to the search terms,the top 3 keywords with the highest frequency and highest mediated centrality were dementia,cognitive influences,and risk factors,while education,influences,and cognitive assessment were emerging research focuses.展开更多
This article discusses the survival rate of fractional age and the net premium liability reserve for fractional age based on theα-power death hypothesis(specifically divided into cases of paying once a year and payin...This article discusses the survival rate of fractional age and the net premium liability reserve for fractional age based on theα-power death hypothesis(specifically divided into cases of paying once a year and paying m times a year),combined with the specific data of the life table with the help of R language and Actuarial software such as crystal ball compares the specific data fitted by theα-power hypothesis with the three traditional hypotheses,and finally concludes that the use of theα-power death hypothesis can improve the accuracy of fitting the fractional age survival rate and the life insurance net premium liability preparation The prediction accuracy of gold,this conclusion will provide a more accurate idea for all insurance companies and social institutions to calculate the fractional age net premium liability reserve.展开更多
Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pre...Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pregnancy outcomes in DOR.Methods:We enrolled 377 DOR patients treated with acupuncture and with records of pregnancy outcomes(139 cases of pregnancy and 238 cases failed)exported from the International Patient Registry Platform of Acupuncture-moxibustion(IPRPAM).The predictive variables were determined using Spearman’s correlation analysis and feature engineering methods.The model was constructed by adopting logistic regression,naïve Bayes,random forest,support vector machine,extreme gradient boosting,the knearest neighbor algorithm,linear discriminant analysis,and neural network methods.The models were validated by the area under the curve(AUC),accuracy(ACC),and importance sequencing,and individual pregnancy prediction was conducted for the best-performing model.Results:The key factors determining pregnancy after acupuncture in patients with DOR were age,luteinizing hormone(LH)level after treatment,follicle-stimulating hormone(FSH)level after treatment,the ratio of FSH to LH(FSH/LH)after treatment,and history of acupuncture treatment.Random forest model ACC was 0.95,Fβwas 0.93,Logloss was 0.30,Logloss value was the lowest,the model variables exhibited the highest accuracy and precision.Conclusion:The random forest model for the effects of acupuncture on pregnancy outcomes in patients with DOR,constructed based on the IPRPAM,presents a favorable value for clinical application.展开更多
BACKGROUND Coronary artery bypass grafting(CABG)and percutaneous coronary intervention(PCI)are well-established treatments for multivessel coronary artery disease(CAD),a condition where multiple heart arteries are nar...BACKGROUND Coronary artery bypass grafting(CABG)and percutaneous coronary intervention(PCI)are well-established treatments for multivessel coronary artery disease(CAD),a condition where multiple heart arteries are narrowed.A newer approach,fractional flow reserve(FFR)-guided PCI,uses a specialized measurement to select which artery blockages to treat,aiming to enhance patient outcomes.Despite its adoption,the comparative effectiveness of FFR-guided PCI vs CABG remains unclear,particularly regarding key health outcomes such as survival,heart-related complications,and the need for further procedures.AIM To evaluate the safety and effectiveness of FFR-guided PCI compared to CABG in patients with multivessel CAD.METHODS This meta-analysis followed standard reporting guidelines and included randomized controlled trials(RCTs)comparing FFR-guided PCI with CABG in patients with multivessel CAD.We searched medical databases,including PubMed,EMBASE,ScienceDirect,and ClinicalTrials.gov,from their start to May 2025.We calculated combined risk ratios(RRs)with 95%confidence intervals(95%CIs)to analyze the data.RESULTS Three RCTs were analyzed.There was no notable difference in all-cause mortality between FFR-guided PCI and CABG(RR=1.01,95%CI:0.78-1.31,P=0.93).However,FFR-guided PCI showed higher rates of major adverse cardiac events(MACEs;RR=1.30,95%CI:1.11-1.52,P=0.001),myocardial infarction(RR=1.49,95%CI:1.11-2.01,P=0.009),and repeat revascularization(RR=2.25,95%CI:1.78-2.85,P<0.00001).Stroke rates were comparable between the two treatments(RR=0.80,95%CI:0.54-1.20,P=0.28).CONCLUSION FFR-guided PCI and CABG have similar rates of all-cause mortality and stroke in patients with multivessel CAD.However,CABG results in fewer MACEs,myocardial infarctions,and repeat procedures.展开更多
OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess...OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.METHODS:Twenty patients diagnosed with DOR(DOR group) and twenty healthy controls(HC group) who underwent rs-fMRI scans were included.The DOR group received acupuncture and underwent a subsequent rsfMRI scan.Amplitude of low-frequency fluctuations(ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups,and to evaluate the immediate effects of acupuncture on DOR patients' brain regions.Common brain regions were identified as seed points for functional connectivity(FC) analysis.RESULTS:In this study,a total of 20 HCs and 20 patients with DOR were initially enrolled.However,due to incomplete personal information,three participants were removed from the HC group.Additionally,two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan,leading to their exclusion due to excessive head movement parameters.Consequently,17 HCs and 16 DOR patients completed the entire study protocol.Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus(ITG) and middle temporal gyrus(MTG),while ALFF values in the bilateral superior frontal gyrus(SFG),middle frontal gyrus(MFG),and left inferior frontal gyrus(IFG) were decreased compared to HCs.Following acupuncture intervention,ALFF values in the left SFG,MFG,and supplementary motor area(SMA) of DOR patients increased.Furthermore,functional connectivity(FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.CONCLUSION:This study highlights abnormal neural activity in the SFG,MFG,IFG,and ACC in DOR patients compared to HCs.Acupuncture was found to regulate the activity of the SFG,bringing it closer to normal levels,and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.展开更多
文摘The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).
文摘Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it protects a vital temperate mountainous forest ecosystem on the Loess Plateau.The reserve is centred around the Liupan Mountain range,one of China’s youngest mountain chains,formed by Himalayan tectonic movements.
文摘Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
基金project titled“Research on the Distribution Trend of Suitable Habitats for Terrestrial Wild Animals”(Number:SXBYKY2021029).
文摘Ungulates serve as key components in maintaining ecosystem stability,and their ecological functions are closely linked to the integrity of giant panda habitats within Wanglang National Nature Reserve.Assessment of ungulate habitat suitability in this reserve can provide critical insights into the distribution patterns of ungulate communities across protected areas while informing conservation strategy optimization.Therefore,six ungulate species were monitored,including Tufted deer(Elaphodus cephalophus),Chinese serow(Capricornis milneedwardsii),Chinese goral(Naemorhedus griseus),Sichuan takin(Budorcas taxicolor),Reeve's muntjac(Muntiacus reevesi),and Wild boar(Sus scrofa)in Wanglang National Nature Reserve.The infrared camera monitoring data(a total of 83 sites)and 23 environmental variables were collected from January 2011 to May 2019,the relative abundance index(RAI),independent samples t-test,and optimized MaxEnt model were employed to evaluate the habitat suitability of six ungulate species.Our findings were as follows:(1)there were significant differences in the annual RAI among the six ungulate species(P<0.01).(2)the suitable habitat area varied among species:Tufted deer occupied 9578 hm^(2)(31.08%of the total),Chinese serow 10,093 hm^(2)(32.75%);Chinese goral 9936 hm^(2)(32.24%);Sichuan takin 10,992 hm^(2)(35.67%);Reeve's muntjac 9542 hm^(2)(30.96%);and Wild boar 9642 hm^(2)(31.28%).(3)the spatial niche overlaps between each pair of the six ungulates were all relatively high(D=0.77-0.89).(4)the annual average temperature,precipitation during the coldest season,and vegetation were the key factors influencing habitat selection.These findings offer valuable references for the conservation of ungulates in natural reserve and are conducive to formulating more scientific and effective.
基金supported by the Guizhou Provincial Science and Technology Projects(Grant Nos.ZK[2022]540 and[2023]099)the Survey of Amphibian and Reptile Resources in Leigongshan Nature Reserve and Literature Publishing Services(P5226002023000019).
文摘Dear Editor,Understanding patterns of species diversity is a primary research focus in macroecology,with its distribution patterns having been described and theoretically validated on a global scale(Peters et al.,2016;Sonne et al.,2025).Numerous studies have found that species richness of different taxa tends to decrease with increasing elevation and is modulated by latitudinal gradients(Peters et al.,2016;Dolson et al.,2024).This principle provides a crucial scientific basis for regional conservation planning.However,it still exhibits significant variations across different mountain ranges and taxa.
基金funded by Project of Scientific Research Business Expenses of Provincial Scientific Research Institutes in Heilongjiang Province(No.CZKYF2023-1-B024)Heilongjiang Academy of Sciences Dean Fund Project(No.YZ2022ZR02)+1 种基金the Science and Technology Basic Resources Investigation Program of China(No.2019FY100500)the Fundamental Research Funds for the Central Universities(No.2572023CT11).
文摘The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and 19 bioclimatic variables were selected,and the environmental factors required for modeling were screened out by pearson correlation analysis and variance inflation factor(VIF)analysis.The potential suitable areas of Orchidaceae plants were predictat present and under different climate scenarios in 2090s by using geographic information system(GIS)and Maximum Entropy Model(MaxEnt).And then evaluated the prediction accuracy of the MaxEnt model using the AUC value,the TSS value and the Kappa value.The results showed that:1)The area under curve(AUC)values,true skill statistics(TSS)values and KAPPA values predicted by MaxEnt model were separately above 0.9,0.85 and 0.75.2)Under the climate scenario at present,the total suitable area of Orchidaceae plants was about 9.61×10^(6)km^(2),which was mainly distributed in Heilongjiang province.Among them,the high-suitable area of Cypripedium shanxiense S.C.Chen was the largest,the non-suitable area of Cypripedium guttatum Sw was the largest.3)Under different climate scenarios in 2090s,the total suitable area was slightly increasing(9.62×10^(6)km^(2)).Among them,Cypripedium shanxiense S.C.Chen and Gastrodiae Rhizoma both showed the trend of expansion to the southwest,China,and the suitable areas expanded significantly.Comprehensive factor analysis showed that temperature and precipitation were the main bioclimatic variables of suitable areas distribution,and the low emission scenario(SSP 2-4.5)will be more conducive to the survival of Orchidaceae plants.
基金financially supported by the National Social Science Fund Key Projects of China(Grant No.23AZD086)。
文摘In recent years,the combined effects of seismic disturbances and extreme rainfall events have intensified water turbidity and sedimentation in several lakes within the Jiuzhaigou Nature Reserve located within the Jiuzhaigou watershed in Southwest China.In July 2024,turbidity events were observed in multiple core lakes,with noticeable impacts on local ecological functions and landscape values.To quantitatively characterize lake physical changes and explore their driving mechanisms,this study developed an integrated“air-space-ground”lake morphological measurement framework that combines unmanned aerial vehicle(UAV),unmanned surface vehicles(USV),and satellite remote sensing to enable high-precision acquisition of lake bathymetry,relationships between water level and surface area,and storage capacity.Additionally,time-series analyses of fractional vegetation cover(FVC)and the Revised Universal Soil Loss Equation(RUSLE)model were applied to characterize the patterns of change in vegetation cover and soil erosion intensity before and after seismic and extreme rainfall events.The results show that:(1)The physical morphology of the lakes has changed significantly compared with the field measurements conducted in 2004.The surface areas of the Arrow Bamboo Lake and the Rhinoceros Lake decreased by 15.2%~17.0%,and lake storage capacity decreased by 20%~33%.In Long Lake,the difference between the minimum and maximum daily water levels reached 13.21 m,and since 2021,the annual mean water level has exhibited a continuous decline at a rate of 1.46 m·a^(-1).(2)Based on the results of the FVC time series analysis,the two earthquake events resulted in decreases in vegetation cover by 19.14%and 13.19%,and these decreases were accompanied by enhanced soil erosion under heavy rainfall conditions.This process facilitated the transport of large amounts of terrestrial material into the lakes,thereby contributing to water turbidity and sediment accumulation.RUSLE-based estimates further indicate that the two earthquakes increased the peak mean soil erosion modulus by 7.61 t·ha^(-1)·a^(-1)and 4.10 t·ha^(-1)·a^(-1),respectively,relative to pre-earthquake conditions.Based on these findings,it is recommended to implement slope vegetation restoration on the upstream areas of the core lakes,strengthen slope protection in accident-prone locations,and monitor water-sediment dynamics during heavy rainfall periods,to mitigate sedimentation risks and enhance the stability of the scenic area's ecosystem.
基金supported by the National Key Research and Development Program of China,China(2022YFE0209400).
文摘In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the World Network of Biosphere Reserves(WNBR)as central actors in delivering biodiversity,climate and sustainable-development goals(SDGs).The plan—developed and opened for global consultation in the runup to the 5th World Congress of Biosphere Reserves—articulates strategic directions,measurable action targets and practical instruments to strengthen biosphere reserves as living laboratories for people and nature(Ma,2025).
基金supported by the National Natural Science Foundation of China(Nos.42430503 and 42271048)the Hebei Natural Science Foundation(No.D2025205003)the Science Foundation of Hebei Normal University(No.L2025B31)。
文摘Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distributed tree genera worldwide,provide an ideal system for investigating large-scale spatial patterns of NSC within a single genus along extensive climatic gradients.Here,we compiled a global NSC database for pines across 74 sites,and assessed the spatial variation in total NSC,starch(St),and soluble sugars(SS)concentrations in stem sapwood,the primary reserve tissue,along site-specific mean annual temperature(MAT)and precipitation(MAP).Our results show that MAP exerted a stronger influence(R^(2)=20%–47%)on the spatial variation in total NSC and its components than did MAT(R^(2)=6%–16%).Tota concentrations declined nonlinearly with increasing MAP,with the rate of decline slowing beyond approximately 800 mm.While MAT had weaker effects on total NSC concentrations,both MAT and MAP jointly regulated NSC partitioning:Higher MAT and MAP were associated with reduced St concentrations but elevated SS concentrations and SS:St ratios.These findings suggest that pine species in cold and arid environments prioritize storing NSC as St,whereas in relatively warm and humid environments,NSC are preferentially mobilized into SS to support immediate metabolic and growth demands.
文摘Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.
基金supported by the National Natural Science Foundation of China(42225604,31500456,31430080)the 2023 Strategic Consultation Project of the Chinese National Committee for Man and the Biosphere,the National Key Programme of Research and Development of Ministry of Science and Technology of China(2022YFF1301603)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA23040403).
文摘The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the most crucial conservation approach involves the establishment and management of both in-situ and ex-situ nature reserves.Since the 1990s,seven nature reserves have been established in the middle and lower reaches of the Yangtze River,covering nearly one-third of its main stream.Additionally,two nature reserves,one in the Dongting Lake and another in the Poyang Lake,have been set up;and three ex-situ nature reserves have been established in three oxbows respectively in Hunan,Hubei,and Anhui provinces.Through measures such as improving the ecological environment quality within the reserves,regulating human activities,and conducting continuous monitoring,the finless porpoise population showed a slight increase in 2022 for the first time.The ex-situ population has continued to grow,with four individuals being released back into the main stream of the Yangtze River after undergoing reintroduction training in 2023.Based on the population development lasting for over three decades,and predictions of future ecological changes,orderly establishment and scientific management of nature reserves have played a key role in and will remain an important basis for the sustaining growth of the finless porpoise population.
基金Supported by National Key Protected Plant Investigation Project in Anxi Yunzhongshan Nature Reserve Primarily Focusing on Alsophila spinulosa,Paris polyphylla,and Angiopteris fokiensis([350524]BWZ[CS]2024003).
文摘[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through field investigations and specimen identification,supplemented by a review of relevant literature.[Results]A total of 84 species of lycophytes and ferns were identified,encompassing 55 genera and 29 families.This included 14 species of lycophytes distributed across 8 genera and 3 families,as well as 70 species of ferns belonging to 47 genera and 26 families.Polypodiaceae and Selaginella were the dominant family and genus,respectively,while oligospecific families and monotypic genera were significant components of lycophytes and ferns in the region.The distribution types of these families were primarily cosmopolitan and tropical.The Germline differentiation degree(SD)was 3.34,and the proportion of rare or endangered species among lycophytes and ferns was 8.33%.[Conclusions]Yunzhongshan Nature Reserve possesses a diverse array of lycophyte and fern species.This study offers valuable scientific insights that can inform efforts related to the conservation of biodiversity,resource utilization and development,species introduction,and system evolution of lycophytes and ferns within the reserve.
基金supported by the Scientific Grant Agency of the Ministry of Education,Science,Research and Sport of the Slovak Republic and the Slovak Academy of Sciences under grants APVV-20-0108Implementation of Agenda 2030 Through biosphere reserves,VEGA-2/0023/31+1 种基金Analysis and evaluations of the environmental history of selected types of Slovak landscape from the early prehistory to the present and VEGA-1/0504/25Classification of archetypes of the Slovak landscape in the context of socioeconomic changes and current climate developments.
文摘The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part of the protection zone of the Tatra National Park and since 1993 it has been part of the transition zone of the Tatra Biosphere Reserve.In recent years,tourism has taken a major role in the transition zone of this biosphere reserve.In the presented contribution,we therefore evaluate the impact of developing tourism in the cadastral area of the municipality ofŽdiar between 1950 and 2022.We rely primarily on available statistical data from various sources and on the analysis of the historical and contemporary landscape structure.During this period,almost 50%of the area has changed land cover.The activities that have significantly changed the landscape include afforestation,deforestation,agrointensification,deurbanisation(naturalisation),urbanisation(anthropisation):tourism development and construction of a water reservoir.Tourism has become the main driver of the economy here and opens up opportunities especially for local inhabitants.However,the lack of completed tourism infrastructure is a drawback.We recommend the establishment of the Coordinating Council of the Tatra Biosphere Reserve and permanent employees at the National Park Administration.
基金supported by the Scientific Research Project of China Three Gorges Group Co.LTD(Contract Number:202103368).
文摘The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.
文摘Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve function,and establish a multi-parameter coupled mathematical prediction model,providing a theoretical basis for precision instrument design and operation optimization.Methods:A total of 45 reproductive-age patients undergoing single-port laparoscopic ovarian cystectomy were selected.Through orthogonal experimental design,the instrument diameter(3/5/8 mm)and bending angle(30°/60°/90°)were divided into 9 groups,with5 cases in each group.Changes in serum AMH(anti-müllerian hormone),FSH(follicle-stimulating hormone),INHB(inhibin B)and ultrasonic AFC(antral follicle count)indexes were measured before surgery and on the 2nd to 3rd day of the first menstrual period after surgery.Enhanced CT images and laparoscopic images of ovarian force distribution were obtained.Finite element analysis(FEA)of the single-port instrument-ovarian tissue model was performed using ABAQUS software to calculate stress distribution in the ovarian cortex.Oscillatory shear experiments were used to determine the characteristics of viscoelastic property changes in the linear viscoelastic range of ovarian tissue.Results:The rate of decrease in AMH was lower in the 3 mm diameter-30°angle group(P<0.05);the peak Von Mises stress in the D3-θ30 group was lower than that in the other groups(P<0.05);the optimal parameter combination was a diameter of 3.13 mm and an angle of 21.72°,with the model calculating an AMH attenuation of 20%.Ovarian tissue changed with the frequency of the oscillatory shear test.In the low-frequency region(<1 Hz):G'>G''(elasticity-dominated);in the high-frequency region(>5 Hz):G''>G'(viscosity-dominated);the crossover point was at 5 Hz,where G'=G''=5 kPa.Before ovarian dissection:G'was relatively high and G''was relatively low,with elasticity dominating.During dissection:G'decreased and G''increased,with instrument stress causing damage.After dissection:G'further decreased and G''continued to rise,resulting in irreversible damage to the ovarian stroma.Conclusion:The engineering parameters of minimally invasive instruments significantly affect the ovarian reserve function index AMH and the peak Von Mises stress of the ovary through mechanical stress transmission.Using an instrument with a diameter of 3.13 mm and a bending angle of 21.72°can more effectively reduce the impact of single-port laparoscopic surgery on AMH decline.
基金supported by the Scientific Research Foundation of Hunan Provincial Education Department(No.23B0517)the National Natural Science Foundation of China(No.82360665).
文摘Objective:To examine the research trends and hotspots of the application of cognitive reserve in stroke cognitive impairment using CiteSpace and provide a reference for developing effective measures to reduce the incidence of cognitive impairment in these patients.Methods:Using CiteSpace software,a visual analysis of 860 included articles related to cognitive reserve in stroke cognitive impairment patients was performed.Relevant literature regarding the application of cognitive reserve in poststroke cognitive impairment was retrieved from the Web of Science core collection database from January 2010 through January 2024.Citespace 6.3.R1(64-bit)was employed to visualize and analyze literature data,including general literature analysis,national publication distribution,literature co-citation,journal co-citation,keyword co-citation,keyword clustering,literature co-citation,and literature co-citation clustering.Results:A total of 860 articles were retrieved,indicating a rising trend in publications in this field,with the United States leading in publication count and FRONT NEUROL being the most frequently cited journal.The most frequently cited references usually focus on the prevention and influence factors of cognitive impairment and dementia.Conclusions:After eliminating keywords similar to the search terms,the top 3 keywords with the highest frequency and highest mediated centrality were dementia,cognitive influences,and risk factors,while education,influences,and cognitive assessment were emerging research focuses.
文摘This article discusses the survival rate of fractional age and the net premium liability reserve for fractional age based on theα-power death hypothesis(specifically divided into cases of paying once a year and paying m times a year),combined with the specific data of the life table with the help of R language and Actuarial software such as crystal ball compares the specific data fitted by theα-power hypothesis with the three traditional hypotheses,and finally concludes that the use of theα-power death hypothesis can improve the accuracy of fitting the fractional age survival rate and the life insurance net premium liability preparation The prediction accuracy of gold,this conclusion will provide a more accurate idea for all insurance companies and social institutions to calculate the fractional age net premium liability reserve.
基金Supported by the Qihuang Scholars Program in 202114th Five-Year National Key R&D Program Project:2022YFC3500504。
文摘Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pregnancy outcomes in DOR.Methods:We enrolled 377 DOR patients treated with acupuncture and with records of pregnancy outcomes(139 cases of pregnancy and 238 cases failed)exported from the International Patient Registry Platform of Acupuncture-moxibustion(IPRPAM).The predictive variables were determined using Spearman’s correlation analysis and feature engineering methods.The model was constructed by adopting logistic regression,naïve Bayes,random forest,support vector machine,extreme gradient boosting,the knearest neighbor algorithm,linear discriminant analysis,and neural network methods.The models were validated by the area under the curve(AUC),accuracy(ACC),and importance sequencing,and individual pregnancy prediction was conducted for the best-performing model.Results:The key factors determining pregnancy after acupuncture in patients with DOR were age,luteinizing hormone(LH)level after treatment,follicle-stimulating hormone(FSH)level after treatment,the ratio of FSH to LH(FSH/LH)after treatment,and history of acupuncture treatment.Random forest model ACC was 0.95,Fβwas 0.93,Logloss was 0.30,Logloss value was the lowest,the model variables exhibited the highest accuracy and precision.Conclusion:The random forest model for the effects of acupuncture on pregnancy outcomes in patients with DOR,constructed based on the IPRPAM,presents a favorable value for clinical application.
文摘BACKGROUND Coronary artery bypass grafting(CABG)and percutaneous coronary intervention(PCI)are well-established treatments for multivessel coronary artery disease(CAD),a condition where multiple heart arteries are narrowed.A newer approach,fractional flow reserve(FFR)-guided PCI,uses a specialized measurement to select which artery blockages to treat,aiming to enhance patient outcomes.Despite its adoption,the comparative effectiveness of FFR-guided PCI vs CABG remains unclear,particularly regarding key health outcomes such as survival,heart-related complications,and the need for further procedures.AIM To evaluate the safety and effectiveness of FFR-guided PCI compared to CABG in patients with multivessel CAD.METHODS This meta-analysis followed standard reporting guidelines and included randomized controlled trials(RCTs)comparing FFR-guided PCI with CABG in patients with multivessel CAD.We searched medical databases,including PubMed,EMBASE,ScienceDirect,and ClinicalTrials.gov,from their start to May 2025.We calculated combined risk ratios(RRs)with 95%confidence intervals(95%CIs)to analyze the data.RESULTS Three RCTs were analyzed.There was no notable difference in all-cause mortality between FFR-guided PCI and CABG(RR=1.01,95%CI:0.78-1.31,P=0.93).However,FFR-guided PCI showed higher rates of major adverse cardiac events(MACEs;RR=1.30,95%CI:1.11-1.52,P=0.001),myocardial infarction(RR=1.49,95%CI:1.11-2.01,P=0.009),and repeat revascularization(RR=2.25,95%CI:1.78-2.85,P<0.00001).Stroke rates were comparable between the two treatments(RR=0.80,95%CI:0.54-1.20,P=0.28).CONCLUSION FFR-guided PCI and CABG have similar rates of all-cause mortality and stroke in patients with multivessel CAD.However,CABG results in fewer MACEs,myocardial infarctions,and repeat procedures.
基金Innovation and Development Joint Fund of Natural Science Foundation of Shandong Province:based on the Nuclear Factor-erythroid 2 Related Factor 2/AU-rich Element Antioxidant Pathway,the Effect and Mechanism of Menstrual Stimulation Acupuncture on in vitro Fertilization and Embryo Transfer Pregnancy Outcomes in Poor Ovarian Response Patients were Studied (ZR2022LZY008)Shandong Provincial Traditional Chinese Medicine High-level Personnel Training Program Supported by Special Funds (No.6 [2021])+3 种基金Qilu Health and Health Leading Talents Training Project (No.3 [2020])Clinical Science and Technology Innovation Program of Jinan Science and Technology Bureau:Study on the Regulatory Mechanism of Menstrual Regulation and Pregnancy Promotion Acupuncture Method based on rs-functional Magnetic Resonance Imaging Technology on the Brain Function Network of Decreasing Ovarian Reserve Patients (202225059)Shandong Traditional Chinese Medicine Science and Technology Development Plan Project:a Multimodal Neuroimaging Study of Menstrual Stimulation Acupuncture in Patients with Polycystic Ovary Syndrome (No.Q-2022099)Shandong Traditional Chinese Medicine Science and Technology Development Plan Project:based on the Immunoregulation of Treg Cells,the Mechanism of Menstruation and Pregnancy Promotion Injection in the Treatment of Early-onset Ovarian Insufficiency was Explored (No.B-2022002)。
文摘OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.METHODS:Twenty patients diagnosed with DOR(DOR group) and twenty healthy controls(HC group) who underwent rs-fMRI scans were included.The DOR group received acupuncture and underwent a subsequent rsfMRI scan.Amplitude of low-frequency fluctuations(ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups,and to evaluate the immediate effects of acupuncture on DOR patients' brain regions.Common brain regions were identified as seed points for functional connectivity(FC) analysis.RESULTS:In this study,a total of 20 HCs and 20 patients with DOR were initially enrolled.However,due to incomplete personal information,three participants were removed from the HC group.Additionally,two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan,leading to their exclusion due to excessive head movement parameters.Consequently,17 HCs and 16 DOR patients completed the entire study protocol.Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus(ITG) and middle temporal gyrus(MTG),while ALFF values in the bilateral superior frontal gyrus(SFG),middle frontal gyrus(MFG),and left inferior frontal gyrus(IFG) were decreased compared to HCs.Following acupuncture intervention,ALFF values in the left SFG,MFG,and supplementary motor area(SMA) of DOR patients increased.Furthermore,functional connectivity(FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.CONCLUSION:This study highlights abnormal neural activity in the SFG,MFG,IFG,and ACC in DOR patients compared to HCs.Acupuncture was found to regulate the activity of the SFG,bringing it closer to normal levels,and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.
