The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It ha...The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).展开更多
Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compar...Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.展开更多
[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through...[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through field investigations and specimen identification,supplemented by a review of relevant literature.[Results]A total of 84 species of lycophytes and ferns were identified,encompassing 55 genera and 29 families.This included 14 species of lycophytes distributed across 8 genera and 3 families,as well as 70 species of ferns belonging to 47 genera and 26 families.Polypodiaceae and Selaginella were the dominant family and genus,respectively,while oligospecific families and monotypic genera were significant components of lycophytes and ferns in the region.The distribution types of these families were primarily cosmopolitan and tropical.The Germline differentiation degree(SD)was 3.34,and the proportion of rare or endangered species among lycophytes and ferns was 8.33%.[Conclusions]Yunzhongshan Nature Reserve possesses a diverse array of lycophyte and fern species.This study offers valuable scientific insights that can inform efforts related to the conservation of biodiversity,resource utilization and development,species introduction,and system evolution of lycophytes and ferns within the reserve.展开更多
The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part ...The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part of the protection zone of the Tatra National Park and since 1993 it has been part of the transition zone of the Tatra Biosphere Reserve.In recent years,tourism has taken a major role in the transition zone of this biosphere reserve.In the presented contribution,we therefore evaluate the impact of developing tourism in the cadastral area of the municipality ofŽdiar between 1950 and 2022.We rely primarily on available statistical data from various sources and on the analysis of the historical and contemporary landscape structure.During this period,almost 50%of the area has changed land cover.The activities that have significantly changed the landscape include afforestation,deforestation,agrointensification,deurbanisation(naturalisation),urbanisation(anthropisation):tourism development and construction of a water reservoir.Tourism has become the main driver of the economy here and opens up opportunities especially for local inhabitants.However,the lack of completed tourism infrastructure is a drawback.We recommend the establishment of the Coordinating Council of the Tatra Biosphere Reserve and permanent employees at the National Park Administration.展开更多
The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and f...The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.展开更多
Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve fun...Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve function,and establish a multi-parameter coupled mathematical prediction model,providing a theoretical basis for precision instrument design and operation optimization.Methods:A total of 45 reproductive-age patients undergoing single-port laparoscopic ovarian cystectomy were selected.Through orthogonal experimental design,the instrument diameter(3/5/8 mm)and bending angle(30°/60°/90°)were divided into 9 groups,with5 cases in each group.Changes in serum AMH(anti-müllerian hormone),FSH(follicle-stimulating hormone),INHB(inhibin B)and ultrasonic AFC(antral follicle count)indexes were measured before surgery and on the 2nd to 3rd day of the first menstrual period after surgery.Enhanced CT images and laparoscopic images of ovarian force distribution were obtained.Finite element analysis(FEA)of the single-port instrument-ovarian tissue model was performed using ABAQUS software to calculate stress distribution in the ovarian cortex.Oscillatory shear experiments were used to determine the characteristics of viscoelastic property changes in the linear viscoelastic range of ovarian tissue.Results:The rate of decrease in AMH was lower in the 3 mm diameter-30°angle group(P<0.05);the peak Von Mises stress in the D3-θ30 group was lower than that in the other groups(P<0.05);the optimal parameter combination was a diameter of 3.13 mm and an angle of 21.72°,with the model calculating an AMH attenuation of 20%.Ovarian tissue changed with the frequency of the oscillatory shear test.In the low-frequency region(<1 Hz):G'>G''(elasticity-dominated);in the high-frequency region(>5 Hz):G''>G'(viscosity-dominated);the crossover point was at 5 Hz,where G'=G''=5 kPa.Before ovarian dissection:G'was relatively high and G''was relatively low,with elasticity dominating.During dissection:G'decreased and G''increased,with instrument stress causing damage.After dissection:G'further decreased and G''continued to rise,resulting in irreversible damage to the ovarian stroma.Conclusion:The engineering parameters of minimally invasive instruments significantly affect the ovarian reserve function index AMH and the peak Von Mises stress of the ovary through mechanical stress transmission.Using an instrument with a diameter of 3.13 mm and a bending angle of 21.72°can more effectively reduce the impact of single-port laparoscopic surgery on AMH decline.展开更多
Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pre...Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pregnancy outcomes in DOR.Methods:We enrolled 377 DOR patients treated with acupuncture and with records of pregnancy outcomes(139 cases of pregnancy and 238 cases failed)exported from the International Patient Registry Platform of Acupuncture-moxibustion(IPRPAM).The predictive variables were determined using Spearman’s correlation analysis and feature engineering methods.The model was constructed by adopting logistic regression,naïve Bayes,random forest,support vector machine,extreme gradient boosting,the knearest neighbor algorithm,linear discriminant analysis,and neural network methods.The models were validated by the area under the curve(AUC),accuracy(ACC),and importance sequencing,and individual pregnancy prediction was conducted for the best-performing model.Results:The key factors determining pregnancy after acupuncture in patients with DOR were age,luteinizing hormone(LH)level after treatment,follicle-stimulating hormone(FSH)level after treatment,the ratio of FSH to LH(FSH/LH)after treatment,and history of acupuncture treatment.Random forest model ACC was 0.95,Fβwas 0.93,Logloss was 0.30,Logloss value was the lowest,the model variables exhibited the highest accuracy and precision.Conclusion:The random forest model for the effects of acupuncture on pregnancy outcomes in patients with DOR,constructed based on the IPRPAM,presents a favorable value for clinical application.展开更多
OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess...OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.METHODS:Twenty patients diagnosed with DOR(DOR group) and twenty healthy controls(HC group) who underwent rs-fMRI scans were included.The DOR group received acupuncture and underwent a subsequent rsfMRI scan.Amplitude of low-frequency fluctuations(ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups,and to evaluate the immediate effects of acupuncture on DOR patients' brain regions.Common brain regions were identified as seed points for functional connectivity(FC) analysis.RESULTS:In this study,a total of 20 HCs and 20 patients with DOR were initially enrolled.However,due to incomplete personal information,three participants were removed from the HC group.Additionally,two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan,leading to their exclusion due to excessive head movement parameters.Consequently,17 HCs and 16 DOR patients completed the entire study protocol.Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus(ITG) and middle temporal gyrus(MTG),while ALFF values in the bilateral superior frontal gyrus(SFG),middle frontal gyrus(MFG),and left inferior frontal gyrus(IFG) were decreased compared to HCs.Following acupuncture intervention,ALFF values in the left SFG,MFG,and supplementary motor area(SMA) of DOR patients increased.Furthermore,functional connectivity(FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.CONCLUSION:This study highlights abnormal neural activity in the SFG,MFG,IFG,and ACC in DOR patients compared to HCs.Acupuncture was found to regulate the activity of the SFG,bringing it closer to normal levels,and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.展开更多
Kataveni et al’s meta-analysis offers an important contemporary synthesis of randomized evidence comparing fractional flow reserve-guided percutaneous coronary intervention and coronary artery bypass grafting(CABG)in...Kataveni et al’s meta-analysis offers an important contemporary synthesis of randomized evidence comparing fractional flow reserve-guided percutaneous coronary intervention and coronary artery bypass grafting(CABG)in multivessel coronary artery disease(CAD).The pooled analysis found no significant difference in all-cause mortality or stroke,yet CABG was superior in reducing myocardial infarction,major adverse cardiac events,and repeat revascularization.These results confirm CABG’s durability even in the era of physiological lesion assessment and second-generation drug-eluting stents.From a traditional Chinese medicine(TCM)perspective,multivessel CAD corresponds to syndromes such as“heart vessel obstruction”and“Qi and blood stagnation”,in which local blockage is compounded by systemic imbalance.While revascularization addresses the structural impediment to blood flow,TCM approaches,including herbal medicine,acupuncture,and lifestyle therapy,aim to improve microcirculation,reduce inflammation,and support recovery,potentially mitigating recurrent ischemic events.This commentary argues that future research should integrate optimal revascularization strategies with rigorously evaluated TCM interventions to address both the anatomical and systemic dimensions of CAD and improve long-term patient outcomes.展开更多
Collaborative forest management (CFM) is a form of forest governance in which local communities are involved in the management and decision-making processes related to forest resources. It is believed that forests und...Collaborative forest management (CFM) is a form of forest governance in which local communities are involved in the management and decision-making processes related to forest resources. It is believed that forests under such management are better in tree diversity and conservation status and thus hold more carbon stocks. The study assessed the impact of CFM on carbon stocks, tree species diversity & tree species density in Mabira Central Forest Reserve. Data were collected from plots that were systematically laid in the different purposively selected forest areas. The study findings show that there is no difference in stem density and carbon stocks between CFM and non-CFM areas. CFM areas had lower species richness compared to non-CFM areas. CFM areas, however, exhibited more species diversity than non-CFM areas. Climax colonization may favor a few dominant species over others, hence lowering species diversity despite the number of species being many in the understory, hence at the same time increasing species richness. Likewise, disturbance in CFM area may affect natural colonization and favor the emergency of many species either naturally or through assisted regeneration by reforestation, hence increasing diversity, whereas artificial selection of preferred species through harvesting may lower species richness, as observed. Recommendations for improving collaborative forest management (CFM) areas include implementing targeted interventions to enhance carbon sequestration, such as promoting reforestation and afforestation with high-carbon-storing species and strengthening monitoring and evaluation frameworks to assess carbon stock changes over time. Additionally, efforts should focus on enhancing biodiversity conservation by implementing more stringent protection measures and reducing human disturbance while encouraging community participation in biodiversity monitoring and conservation education.展开更多
Recently,the outbreak and spread of larch caterpillar(Dendrolimus superans)pests have emerged as significant contributors to forest degradation in the Changbai Mountains,China.Understanding the spatiotemporal distribu...Recently,the outbreak and spread of larch caterpillar(Dendrolimus superans)pests have emerged as significant contributors to forest degradation in the Changbai Mountains,China.Understanding the spatiotemporal distribution patterns of these pests is crucial for effective management and protection of forest ecosystems.This study proposes a pest monitoring approach based on Sentinel imagery.Through time-series analysis,we extracted pest-sensitive features and developed a random forest classifier that integrated Sentinel-1,Sentinel-2,and field sampling data from 2019–2023 to monitor larch caterpillar pests in the Changbai Mountains National Nature Reserve(CMNNR),Northeast China.Our findings indicated that bands green(B3),near-infrared(B8),short wave infrared(B11 and B12)from Sentinel-2 remote sensing images exhibited notable discriminative capabilities for identifying larch caterpillar pests.Specifically,the Normalized Difference Vegetation Index(NDVI)at the end of the growing season emerged as the most valuable feature for pest extraction.Incorporating Synthetic Aperture Radar(SAR)features along with optical data marginally enhances model performance.Furthermore,our approach unveiled the outbreak of larch caterpillar pests,achieving classification map with overall accuracy exceeding 85%and Kappa coefficient surpassing 0.8 for five study years.The pest outbreak began in 2019 and progressively intensified over time.In September 2019,the affected area spanned 114.23 km^(2).The infested area exhibited a declining trend from 2020 to 2023.This study introduces a novel method for the high-precision identification of larch caterpillar pests,offering technical advancements and theoretical underpinnings to support forest management strategies.展开更多
Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their ...Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their complex interactions.However,existing studies often fail to fully consider vegetation response,constituting a gap in the comprehensive assessment of changes in ecosystem services.Therefore,a coupled model framework integrating climate change,land use change,and vegetation dynamics was developed to allow for the simulation of dynamic ecosystem service scenarios throughout the twenty-first century.The Jiulianshan National Nature Reserve in Jiangxi Province was considered as the study area.The results showed that ecosystem services and their synergistic effects will be optimized under scenarios that emphasize strict protection of ecological lands and incorporating the SSP1-2.6 scenario.However,sustaining optimized ecosystem services poses significant challenges in scenarios characterized by resource-intensive development and ongoing climate warming,as in the SSP5-8.5 scenario.Notably,discernible variations exist in balancing and synergizing the management of ecosystem services across diverse land uses and forest types.Our study underscores the importance of integrating vegetation response into the framework of ecosystem service forecasting,which is essential for assisting nature reserves in effectively addressing the multifaceted risks associated with climate change and rapid socio-economic development.展开更多
The precision of dynamic reserve calculations in gas reservoirs is crucial for the rational and efficient development of oil and gas fields and the formulation of gas well production plans.The Shaximiao gas reservoir ...The precision of dynamic reserve calculations in gas reservoirs is crucial for the rational and efficient development of oil and gas fields and the formulation of gas well production plans.The Shaximiao gas reservoir in the ZT block of northwestern Sichuan is densely packed and highly heterogeneous,featuring complex gas-water distribution,substantial variations in test production among gas wells,and a rapid decline rate.To precisely determine the dynamic reserves of these tight water-bearing gas wells,this study focuses on the water-tight gas reservoirs in the ZT block of northwestern Sichuan,conducting core X-ray diffraction,constant-rate mercury injection,and reservoir rock stress sensitivity experiments.Utilizing the experimental findings,the porosity and permeability of the rock samples under effective stress conditions are adjusted via binary linear regression.These adjusted parameters are then incorporated into the water-sealed gas material balance method,thereby establishing a novel approach for calculating dynamic reserves in water-tight gas reservoirs under stress sensitivity conditions.The results show that:(1)the rock porosity ranges from 6.08%to 10.22%,permeability ranges from 0.035 mD to 0.547 mD,clay mineral content ranges from 6.58%to 19.14%,pore radius distribution ranges from 90μm to 180μm,throat radius distribution ranges from 0.61μm to 3.41μm,with significant differences in throat distribution,indicating poor reservoir fluid flow capacity and strong tightness;(2)after aging experiments,rock samples exhibit plastic deformation,with porosity and permeability unable to fully recover after pressure relief.The stress sensitivity curve of rock samples shows a two-stage characteristic,with moderate to strong stress sensitivity;(3)porosity stress sensitivity is mainly influenced by pore radius and mineral composition-larger pore radius and higher clay content lead to stronger stress sensitivity,with porosity loss rates ranging from 8.26%to 23.69%.Permeability stress sensitivity is mainly influenced by throat radius and mineral composition-smaller throat radius and higher clay content result in stronger stress sensitivity,with permeability loss rates ranging from 47.91%to 62.03%;(4)a comparative analysis between the traditional dynamic reserve calculation method for gas wells and the new method considering stress sensitivity shows a relative error between 0.90%and 2.41%,with the new method demonstrating better accuracy.This study combines physical experimental results with an effective stress model of reservoir rocks to develop a new method for calculating dynamic reserves of water-bearing tight gas reservoirs under effective stress conditions,providing experimental data and example calculation results to support subsequent dynamic evaluation of gas reservoirs and the establishment of rational well allocation plans.展开更多
OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspe...OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspension administration,and moxibustion therapy was simultaneously given.The morphological ovarian changes were observed by hematoxylin and eosin staining.The miRNA expression profile was detected by RNA sequencing,and bioinformatics analysis was performed.Cytoscape software 3.6.1 was used to establish a regulatory network and differentially expressed miRNAs were verified by reverse transcription quantitative polymerase chain reaction(RT-qPCR).RESULTS:Decreased number of mature follicles,increased atresia follicles,and abnormal granulosa cell morphology were observed in the model group compared with the control group.The moxibustion group demonstrated increased mature follicles,decreased atretic follicles,and significantly decreased abnormal morphology of granulosa cells compared with the model group.Additionally,RNA sequencing results manifested significantly up-regulated miRNA expressions(miR-92b-3p,miR-26-5p_R+1_1ss10TC,miR-206-3p,miR-9993b-3p_1ss6GA,miR-7857-3p_R-1,miR-219a-2-3p_1ss10GC,miR-3968-p5_1ss10AT,and PC-5p-6478_1795)and down-regulated miR-664-2-5p_R+1 in the model group,compared with the control group,and the moxibustion group reversed abnormal disorder levels of these miRNAs.Moreover,these differentially expressed miRNAs were mainly involved in the phosphatidylinositol-3-kinase/protein kinase B signaling pathway and nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 signaling pathway.Finally,network and RT-qPCR verification revealed miR-9993b-3p_1ss6GA as the most critical miRNA.CONCLUSION:This experiment proved the effectiveness of moxibustion in improving the ovarian reserve of rats by regulating miRNA expression,especially miR-9993b-3p_1ss6GA.展开更多
BACKGROUND The neuroendoscopic approach has the advantages of a clear operative field,convenient tumor removal,and less damage,and is the development direction of modern neurosurgery.At present,transnasal surgery for ...BACKGROUND The neuroendoscopic approach has the advantages of a clear operative field,convenient tumor removal,and less damage,and is the development direction of modern neurosurgery.At present,transnasal surgery for sphenoidal pituitary tumor is widely used.But it has been found in clinical practice that some patients with this type of surgery may experience post-operative nausea and vomiting and other discomforts.AIM To explore the effect of reserved gastric tube application in the neuroendoscopic endonasal resection of pituitary tumors.METHODS A total of 60 patients who underwent pituitary adenoma resection via the endoscopic endonasal approach were selected and randomly divided into the experimental and control groups,with 30 in each group.Experimental group:After anesthesia,a gastric tube was placed through the mouth under direct vision using a visual laryngoscope,and the fluid accumulated in the oropharynx was suctioned intermittently with low negative pressure throughout the whole process after nasal disinfection,during the operation,and when the patient recovered from anesthesia.Control group:Given the routine intraoperative care,no gastric tube was left.The number of cases of nausea/vomiting/aspiration within 24 h post-operation was counted and compared between the two groups;the scores of pharyngalgia after waking up,6 h post-operation,and 24 h postoperation.The frequency of postoperative cerebrospinal fluid leakage and intracranial infection were compared.The hospitalization days of the two groups were statistically compared.RESULTS The times of postoperative nausea and vomiting in the experimental group were lower than that in the control group,and the difference in the incidence of nausea was statistically significant(P<0.05).After the patient woke up,the scores of sore throat 6 h after the operation and 24 h after operation were lower than those in the control group,and the difference was statistically significant(P<0.05).The number of cases of postoperative cerebrospinal fluid leakage and intracranial infection was higher than that of the control group,but there was no statistically significant difference from the control group(P>0.05).The hospitalization days of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).CONCLUSION Reserving a gastric tube in the endoscopic endonasal resection of pituitary tumors,combined with intraoperative and postoperative gastrointestinal decompression,can effectively reduce the incidence of nausea,reduce the number of vomiting and aspiration in patients,and reduce the complications of sore throat The incidence rate shortened the hospitalization days of the patients.展开更多
Tropical peat comprises decomposed dead plant material and acts like a sponge to absorb water,making it fully saturated.However,drought periods dry it readily and increases its vulnerability to fire.Peat fires emit gr...Tropical peat comprises decomposed dead plant material and acts like a sponge to absorb water,making it fully saturated.However,drought periods dry it readily and increases its vulnerability to fire.Peat fires emit greenhouse gases and particles contributing to haze,and prevention by constructing fire-break canals to reduce fire spread into forest reserves is crucial.This paper aims to determine peat physical and chemical properties near a fire-break canal at different fire frequency areas.Peat sampling was conducted at two forest reserves in Malaysia which represent low fire frequency and high fire frequency areas.The results show that peat properties were not affected by the construction of a fire-break canal,however lignin and cellulose content increased significantly from the distance of the canal in both areas.The study concluded that fire frequency did not significantly influence peat properties except for porosity.The higher fibre content in the high frequency area did not influence moisture content nor the ability to regain moisture.Thus,fire frequency might contribute differently to changes in physical and chemical properties,hence management efforts to construct fire-break canals and restoration efforts should protect peatlands from further degradation.These findings will benefit future management and planning for forest reserves.展开更多
Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,i...Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,is an important ecological barrier area in the temperate arid zone.The evaluation of its important ecosystem services is of great significance to improve the management level and ecological protection efficiency of the reserve.In the present study,we assessed the spatiotemporal variations of four ecosystem services(including net primary productivity(NPP),water yield,soil conservation,and habitat quality)in the TBPNR from 2000 to 2020 based on the environmental and social data using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.In addition,the coldspot and hotspot areas of ecosystem services were identified by hotspot analysis,and the trade-off and synergistic relationships between ecosystem services were analyzed using factor analysis in a geographic detector.During the study period,NPP and soil conservation values in the reserve increased by 48.20%and 25.56%,respectively;conversely,water yield decreased by 16.56%,and there was no significant change in habitat quality.Spatially,both NPP and habitat quality values were higher in the northern part and lower in the southern part,whereas water yield showed an opposite trend.Correlation analysis revealed that NPP showed a synergistic relationship with habitat quality and soil conservation,and exhibited a trade-off relationship with water yield.Water yield and habitat quality also had a trade-off relationship.NPP and habitat quality were affected by annual average temperature and Normalized Difference Vegetation Index(NDVI),respectively,while water yield and soil conservation were more affected by digital elevation model(DEM).Therefore,attention should be paid to the spatial distribution and dynamics of trade-off and synergistic relationships between ecosystem services in future ecological management.The findings of the present study provide a reference that could facilitate the sustainable utilization of ecosystem services in the typical fragile areas of Northwest China.展开更多
Numerous engineering cases have demonstrated that the expansive soil channel slope remains susceptible to damage with the implementation of a rigid or closed protective structure. It is common for the protective struc...Numerous engineering cases have demonstrated that the expansive soil channel slope remains susceptible to damage with the implementation of a rigid or closed protective structure. It is common for the protective structure to experience bulging failure due to excessive swelling pressure. To investigate the swelling pressure properties of expansive soil, the constant volume test was employed to study the influence of water content and reserved expansion deformation on the characteristics of swelling pressure in strong expansive soils, and also to explore the evolution mechanism of the swelling pressure. The findings demonstrate that the swelling pressure-time curve can be classified into swelling pressure-time softening and swelling pressure-time stability type. The swelling pressuretime curve of the specimen with low water content is the swelling pressure-time softening type, and the softening level will be weakened with increasing reserved expansion deformation. Besides, the maximum swelling pressure Psmax decreases with increasing water content and reserved expansion deformation, especially for expansion ratio η from 24% to 37%. The reserved deformation has little effect on reducing Psmax when it is beyond 7% of the expansion rate. The specimen with low water content has a more homogeneous structure due to the significant expansion-filling effect, and the fracture and reorganization of the aggregates in the specimens with low water content cause the swelling pressure-time softening behavior. In addition, the proposed swelling pressure-time curve prediction model has a good prediction on the test results. If necessary, a deformation space of about 7% expansion rate is recommended to be reserved in the engineering to reduce the swelling pressure except for keeping a stable water content.展开更多
Shish crystals are crucial to achieving high performance low-dimensional ultra-high molecular weight polyethylene(UHMWPE)products.Typically,high stretch and shear flow fields are necessary for the formation of shish c...Shish crystals are crucial to achieving high performance low-dimensional ultra-high molecular weight polyethylene(UHMWPE)products.Typically,high stretch and shear flow fields are necessary for the formation of shish crystals.In this study,UHMWPE gel films with reserved shish crystals were prepared by gel molding,the structural evolution and properties of UHMWPE films stretched at temperatu res of 100,110,120and 130℃were investigated by in situ small-angle X-ray scattering(SAXS)/ultra-small-angle X-ray scattering(USAXS)/wide-angle X-ray diffraction(WAXD)measu rements as well as scanning electron microscopy(SEM)and differential scanning calorimetry(DSC)measurements.Our findings showed that the reserved shish crystals can facilitate the formation and structural evolution of shish-kebab crystals during the hot stretching.Additionally,the reserved shish crystals promote the structu ral evolution of UHMWPE films to a greater extent when stretched at 120 and 130℃,compared to 100 and 110℃,resulting in higher crystallinity,orientation,thermal properties,breaking strength and Young's modulus.Com pared to UHMWPE high-entangled films with reserved shish crystals prepared by compression molding,UHMWPE low-entangled films with reserved shish crystals prepared by gel molding are more effective in inducing the formation and evolution of shish-kebab crystals during the hot stretching,resulting in increased breaking strength and Young's modulus.展开更多
Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian reserve.Methods:A compr...Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian reserve.Methods:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google Scholar.We included studies that assigned infertile women with low ovarian reserve in experimental studies.Ovarian reserve parameters were measured before and after PRP injection into ovaries.The data of each study was retrieved and subsequently compiled.Results:Of 301 articles collected and reviewed,six studies were finally included in the meta-analysis.Following PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not AMH.Although it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.展开更多
文摘The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).
文摘Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.
基金Supported by National Key Protected Plant Investigation Project in Anxi Yunzhongshan Nature Reserve Primarily Focusing on Alsophila spinulosa,Paris polyphylla,and Angiopteris fokiensis([350524]BWZ[CS]2024003).
文摘[Objectives]To analyze the composition of lycophytes and ferns in Yunzhongshan Nature Reserve,Fujian Province.[Methods]This study examined the composition of lycophytes and ferns in Yunzhongshan Nature Reserve through field investigations and specimen identification,supplemented by a review of relevant literature.[Results]A total of 84 species of lycophytes and ferns were identified,encompassing 55 genera and 29 families.This included 14 species of lycophytes distributed across 8 genera and 3 families,as well as 70 species of ferns belonging to 47 genera and 26 families.Polypodiaceae and Selaginella were the dominant family and genus,respectively,while oligospecific families and monotypic genera were significant components of lycophytes and ferns in the region.The distribution types of these families were primarily cosmopolitan and tropical.The Germline differentiation degree(SD)was 3.34,and the proportion of rare or endangered species among lycophytes and ferns was 8.33%.[Conclusions]Yunzhongshan Nature Reserve possesses a diverse array of lycophyte and fern species.This study offers valuable scientific insights that can inform efforts related to the conservation of biodiversity,resource utilization and development,species introduction,and system evolution of lycophytes and ferns within the reserve.
基金supported by the Scientific Grant Agency of the Ministry of Education,Science,Research and Sport of the Slovak Republic and the Slovak Academy of Sciences under grants APVV-20-0108Implementation of Agenda 2030 Through biosphere reserves,VEGA-2/0023/31+1 种基金Analysis and evaluations of the environmental history of selected types of Slovak landscape from the early prehistory to the present and VEGA-1/0504/25Classification of archetypes of the Slovak landscape in the context of socioeconomic changes and current climate developments.
文摘The Goral municipality of Ždiar(a Conservation Reserve of Folk Architecture since 1977)is one of the most attractive areas in Slovakia under the growing influence of the developing tourism.Since 1949 it has been part of the protection zone of the Tatra National Park and since 1993 it has been part of the transition zone of the Tatra Biosphere Reserve.In recent years,tourism has taken a major role in the transition zone of this biosphere reserve.In the presented contribution,we therefore evaluate the impact of developing tourism in the cadastral area of the municipality ofŽdiar between 1950 and 2022.We rely primarily on available statistical data from various sources and on the analysis of the historical and contemporary landscape structure.During this period,almost 50%of the area has changed land cover.The activities that have significantly changed the landscape include afforestation,deforestation,agrointensification,deurbanisation(naturalisation),urbanisation(anthropisation):tourism development and construction of a water reservoir.Tourism has become the main driver of the economy here and opens up opportunities especially for local inhabitants.However,the lack of completed tourism infrastructure is a drawback.We recommend the establishment of the Coordinating Council of the Tatra Biosphere Reserve and permanent employees at the National Park Administration.
基金supported by the Scientific Research Project of China Three Gorges Group Co.LTD(Contract Number:202103368).
文摘The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.
文摘Objective:To investigate the quantitative influence of engineering parameters(diameter,bending angle)of minimally invasive surgical instruments and single-port laparoscopic surgery on biomarkers of ovarian reserve function,and establish a multi-parameter coupled mathematical prediction model,providing a theoretical basis for precision instrument design and operation optimization.Methods:A total of 45 reproductive-age patients undergoing single-port laparoscopic ovarian cystectomy were selected.Through orthogonal experimental design,the instrument diameter(3/5/8 mm)and bending angle(30°/60°/90°)were divided into 9 groups,with5 cases in each group.Changes in serum AMH(anti-müllerian hormone),FSH(follicle-stimulating hormone),INHB(inhibin B)and ultrasonic AFC(antral follicle count)indexes were measured before surgery and on the 2nd to 3rd day of the first menstrual period after surgery.Enhanced CT images and laparoscopic images of ovarian force distribution were obtained.Finite element analysis(FEA)of the single-port instrument-ovarian tissue model was performed using ABAQUS software to calculate stress distribution in the ovarian cortex.Oscillatory shear experiments were used to determine the characteristics of viscoelastic property changes in the linear viscoelastic range of ovarian tissue.Results:The rate of decrease in AMH was lower in the 3 mm diameter-30°angle group(P<0.05);the peak Von Mises stress in the D3-θ30 group was lower than that in the other groups(P<0.05);the optimal parameter combination was a diameter of 3.13 mm and an angle of 21.72°,with the model calculating an AMH attenuation of 20%.Ovarian tissue changed with the frequency of the oscillatory shear test.In the low-frequency region(<1 Hz):G'>G''(elasticity-dominated);in the high-frequency region(>5 Hz):G''>G'(viscosity-dominated);the crossover point was at 5 Hz,where G'=G''=5 kPa.Before ovarian dissection:G'was relatively high and G''was relatively low,with elasticity dominating.During dissection:G'decreased and G''increased,with instrument stress causing damage.After dissection:G'further decreased and G''continued to rise,resulting in irreversible damage to the ovarian stroma.Conclusion:The engineering parameters of minimally invasive instruments significantly affect the ovarian reserve function index AMH and the peak Von Mises stress of the ovary through mechanical stress transmission.Using an instrument with a diameter of 3.13 mm and a bending angle of 21.72°can more effectively reduce the impact of single-port laparoscopic surgery on AMH decline.
基金Supported by the Qihuang Scholars Program in 202114th Five-Year National Key R&D Program Project:2022YFC3500504。
文摘Objective:To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve(DOR)based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pregnancy outcomes in DOR.Methods:We enrolled 377 DOR patients treated with acupuncture and with records of pregnancy outcomes(139 cases of pregnancy and 238 cases failed)exported from the International Patient Registry Platform of Acupuncture-moxibustion(IPRPAM).The predictive variables were determined using Spearman’s correlation analysis and feature engineering methods.The model was constructed by adopting logistic regression,naïve Bayes,random forest,support vector machine,extreme gradient boosting,the knearest neighbor algorithm,linear discriminant analysis,and neural network methods.The models were validated by the area under the curve(AUC),accuracy(ACC),and importance sequencing,and individual pregnancy prediction was conducted for the best-performing model.Results:The key factors determining pregnancy after acupuncture in patients with DOR were age,luteinizing hormone(LH)level after treatment,follicle-stimulating hormone(FSH)level after treatment,the ratio of FSH to LH(FSH/LH)after treatment,and history of acupuncture treatment.Random forest model ACC was 0.95,Fβwas 0.93,Logloss was 0.30,Logloss value was the lowest,the model variables exhibited the highest accuracy and precision.Conclusion:The random forest model for the effects of acupuncture on pregnancy outcomes in patients with DOR,constructed based on the IPRPAM,presents a favorable value for clinical application.
基金Innovation and Development Joint Fund of Natural Science Foundation of Shandong Province:based on the Nuclear Factor-erythroid 2 Related Factor 2/AU-rich Element Antioxidant Pathway,the Effect and Mechanism of Menstrual Stimulation Acupuncture on in vitro Fertilization and Embryo Transfer Pregnancy Outcomes in Poor Ovarian Response Patients were Studied (ZR2022LZY008)Shandong Provincial Traditional Chinese Medicine High-level Personnel Training Program Supported by Special Funds (No.6 [2021])+3 种基金Qilu Health and Health Leading Talents Training Project (No.3 [2020])Clinical Science and Technology Innovation Program of Jinan Science and Technology Bureau:Study on the Regulatory Mechanism of Menstrual Regulation and Pregnancy Promotion Acupuncture Method based on rs-functional Magnetic Resonance Imaging Technology on the Brain Function Network of Decreasing Ovarian Reserve Patients (202225059)Shandong Traditional Chinese Medicine Science and Technology Development Plan Project:a Multimodal Neuroimaging Study of Menstrual Stimulation Acupuncture in Patients with Polycystic Ovary Syndrome (No.Q-2022099)Shandong Traditional Chinese Medicine Science and Technology Development Plan Project:based on the Immunoregulation of Treg Cells,the Mechanism of Menstruation and Pregnancy Promotion Injection in the Treatment of Early-onset Ovarian Insufficiency was Explored (No.B-2022002)。
文摘OBJECTIVE:To examine the variations in brain regions among individuals with decreasing ovarian reserve(DOR) compared to healthy controls using resting-state functional magnetic resonance imaging(rs-fMRI),and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.METHODS:Twenty patients diagnosed with DOR(DOR group) and twenty healthy controls(HC group) who underwent rs-fMRI scans were included.The DOR group received acupuncture and underwent a subsequent rsfMRI scan.Amplitude of low-frequency fluctuations(ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups,and to evaluate the immediate effects of acupuncture on DOR patients' brain regions.Common brain regions were identified as seed points for functional connectivity(FC) analysis.RESULTS:In this study,a total of 20 HCs and 20 patients with DOR were initially enrolled.However,due to incomplete personal information,three participants were removed from the HC group.Additionally,two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan,leading to their exclusion due to excessive head movement parameters.Consequently,17 HCs and 16 DOR patients completed the entire study protocol.Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus(ITG) and middle temporal gyrus(MTG),while ALFF values in the bilateral superior frontal gyrus(SFG),middle frontal gyrus(MFG),and left inferior frontal gyrus(IFG) were decreased compared to HCs.Following acupuncture intervention,ALFF values in the left SFG,MFG,and supplementary motor area(SMA) of DOR patients increased.Furthermore,functional connectivity(FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.CONCLUSION:This study highlights abnormal neural activity in the SFG,MFG,IFG,and ACC in DOR patients compared to HCs.Acupuncture was found to regulate the activity of the SFG,bringing it closer to normal levels,and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.
文摘Kataveni et al’s meta-analysis offers an important contemporary synthesis of randomized evidence comparing fractional flow reserve-guided percutaneous coronary intervention and coronary artery bypass grafting(CABG)in multivessel coronary artery disease(CAD).The pooled analysis found no significant difference in all-cause mortality or stroke,yet CABG was superior in reducing myocardial infarction,major adverse cardiac events,and repeat revascularization.These results confirm CABG’s durability even in the era of physiological lesion assessment and second-generation drug-eluting stents.From a traditional Chinese medicine(TCM)perspective,multivessel CAD corresponds to syndromes such as“heart vessel obstruction”and“Qi and blood stagnation”,in which local blockage is compounded by systemic imbalance.While revascularization addresses the structural impediment to blood flow,TCM approaches,including herbal medicine,acupuncture,and lifestyle therapy,aim to improve microcirculation,reduce inflammation,and support recovery,potentially mitigating recurrent ischemic events.This commentary argues that future research should integrate optimal revascularization strategies with rigorously evaluated TCM interventions to address both the anatomical and systemic dimensions of CAD and improve long-term patient outcomes.
文摘Collaborative forest management (CFM) is a form of forest governance in which local communities are involved in the management and decision-making processes related to forest resources. It is believed that forests under such management are better in tree diversity and conservation status and thus hold more carbon stocks. The study assessed the impact of CFM on carbon stocks, tree species diversity & tree species density in Mabira Central Forest Reserve. Data were collected from plots that were systematically laid in the different purposively selected forest areas. The study findings show that there is no difference in stem density and carbon stocks between CFM and non-CFM areas. CFM areas had lower species richness compared to non-CFM areas. CFM areas, however, exhibited more species diversity than non-CFM areas. Climax colonization may favor a few dominant species over others, hence lowering species diversity despite the number of species being many in the understory, hence at the same time increasing species richness. Likewise, disturbance in CFM area may affect natural colonization and favor the emergency of many species either naturally or through assisted regeneration by reforestation, hence increasing diversity, whereas artificial selection of preferred species through harvesting may lower species richness, as observed. Recommendations for improving collaborative forest management (CFM) areas include implementing targeted interventions to enhance carbon sequestration, such as promoting reforestation and afforestation with high-carbon-storing species and strengthening monitoring and evaluation frameworks to assess carbon stock changes over time. Additionally, efforts should focus on enhancing biodiversity conservation by implementing more stringent protection measures and reducing human disturbance while encouraging community participation in biodiversity monitoring and conservation education.
基金Under the auspices of National Natural Science Foundation of China(No.42171407,42077242)Key Program of National Natural Science Foundation of China(No.42330607)。
文摘Recently,the outbreak and spread of larch caterpillar(Dendrolimus superans)pests have emerged as significant contributors to forest degradation in the Changbai Mountains,China.Understanding the spatiotemporal distribution patterns of these pests is crucial for effective management and protection of forest ecosystems.This study proposes a pest monitoring approach based on Sentinel imagery.Through time-series analysis,we extracted pest-sensitive features and developed a random forest classifier that integrated Sentinel-1,Sentinel-2,and field sampling data from 2019–2023 to monitor larch caterpillar pests in the Changbai Mountains National Nature Reserve(CMNNR),Northeast China.Our findings indicated that bands green(B3),near-infrared(B8),short wave infrared(B11 and B12)from Sentinel-2 remote sensing images exhibited notable discriminative capabilities for identifying larch caterpillar pests.Specifically,the Normalized Difference Vegetation Index(NDVI)at the end of the growing season emerged as the most valuable feature for pest extraction.Incorporating Synthetic Aperture Radar(SAR)features along with optical data marginally enhances model performance.Furthermore,our approach unveiled the outbreak of larch caterpillar pests,achieving classification map with overall accuracy exceeding 85%and Kappa coefficient surpassing 0.8 for five study years.The pest outbreak began in 2019 and progressively intensified over time.In September 2019,the affected area spanned 114.23 km^(2).The infested area exhibited a declining trend from 2020 to 2023.This study introduces a novel method for the high-precision identification of larch caterpillar pests,offering technical advancements and theoretical underpinnings to support forest management strategies.
基金supported by the National Natural Science Foundation of China (32160292, 32471681, and 32201575)Jiangxi “Double Thousand Plan”(jxsq2020101080)+1 种基金the Natural Science Foundation of Jiangxi Province (20224BAB205008, 20224BAB213033, and 20242BAB2538)Jiangxi Province Science and Technology+Water Resources” Joint Plan Project (2023KSG01001 and 2022KSG01010)
文摘Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their complex interactions.However,existing studies often fail to fully consider vegetation response,constituting a gap in the comprehensive assessment of changes in ecosystem services.Therefore,a coupled model framework integrating climate change,land use change,and vegetation dynamics was developed to allow for the simulation of dynamic ecosystem service scenarios throughout the twenty-first century.The Jiulianshan National Nature Reserve in Jiangxi Province was considered as the study area.The results showed that ecosystem services and their synergistic effects will be optimized under scenarios that emphasize strict protection of ecological lands and incorporating the SSP1-2.6 scenario.However,sustaining optimized ecosystem services poses significant challenges in scenarios characterized by resource-intensive development and ongoing climate warming,as in the SSP5-8.5 scenario.Notably,discernible variations exist in balancing and synergizing the management of ecosystem services across diverse land uses and forest types.Our study underscores the importance of integrating vegetation response into the framework of ecosystem service forecasting,which is essential for assisting nature reserves in effectively addressing the multifaceted risks associated with climate change and rapid socio-economic development.
基金supported by CNPC Southwest Oil and Gas Field Branch's 2023 Scientific Research Program Project(20230303-14).
文摘The precision of dynamic reserve calculations in gas reservoirs is crucial for the rational and efficient development of oil and gas fields and the formulation of gas well production plans.The Shaximiao gas reservoir in the ZT block of northwestern Sichuan is densely packed and highly heterogeneous,featuring complex gas-water distribution,substantial variations in test production among gas wells,and a rapid decline rate.To precisely determine the dynamic reserves of these tight water-bearing gas wells,this study focuses on the water-tight gas reservoirs in the ZT block of northwestern Sichuan,conducting core X-ray diffraction,constant-rate mercury injection,and reservoir rock stress sensitivity experiments.Utilizing the experimental findings,the porosity and permeability of the rock samples under effective stress conditions are adjusted via binary linear regression.These adjusted parameters are then incorporated into the water-sealed gas material balance method,thereby establishing a novel approach for calculating dynamic reserves in water-tight gas reservoirs under stress sensitivity conditions.The results show that:(1)the rock porosity ranges from 6.08%to 10.22%,permeability ranges from 0.035 mD to 0.547 mD,clay mineral content ranges from 6.58%to 19.14%,pore radius distribution ranges from 90μm to 180μm,throat radius distribution ranges from 0.61μm to 3.41μm,with significant differences in throat distribution,indicating poor reservoir fluid flow capacity and strong tightness;(2)after aging experiments,rock samples exhibit plastic deformation,with porosity and permeability unable to fully recover after pressure relief.The stress sensitivity curve of rock samples shows a two-stage characteristic,with moderate to strong stress sensitivity;(3)porosity stress sensitivity is mainly influenced by pore radius and mineral composition-larger pore radius and higher clay content lead to stronger stress sensitivity,with porosity loss rates ranging from 8.26%to 23.69%.Permeability stress sensitivity is mainly influenced by throat radius and mineral composition-smaller throat radius and higher clay content result in stronger stress sensitivity,with permeability loss rates ranging from 47.91%to 62.03%;(4)a comparative analysis between the traditional dynamic reserve calculation method for gas wells and the new method considering stress sensitivity shows a relative error between 0.90%and 2.41%,with the new method demonstrating better accuracy.This study combines physical experimental results with an effective stress model of reservoir rocks to develop a new method for calculating dynamic reserves of water-bearing tight gas reservoirs under effective stress conditions,providing experimental data and example calculation results to support subsequent dynamic evaluation of gas reservoirs and the establishment of rational well allocation plans.
基金the National Natural Science Foundation of China:Based on Phosphatidylinositol-3-kinase/Protein kinase B Signaling Pathway Study microRNAs Regulating Mechanism of Moxibustion Improve Ovarian Function(No.81804179)to Explore the miRNA Mechanism of Acupuncture and Moxibustion Against Oxygen Stress in Improving Ovarian Function based on Nuclear Factor Erythropoietin-2-related Factor 2/AU-rich Element Pathway(No.81774408)to Explore the Effect and Molecular Mechanism of Moxibustion on Granulosa Cells in Premature Ovarian Failure based on"Autophagy-apoptosis Cross-talk"(No.81973957)。
文摘OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspension administration,and moxibustion therapy was simultaneously given.The morphological ovarian changes were observed by hematoxylin and eosin staining.The miRNA expression profile was detected by RNA sequencing,and bioinformatics analysis was performed.Cytoscape software 3.6.1 was used to establish a regulatory network and differentially expressed miRNAs were verified by reverse transcription quantitative polymerase chain reaction(RT-qPCR).RESULTS:Decreased number of mature follicles,increased atresia follicles,and abnormal granulosa cell morphology were observed in the model group compared with the control group.The moxibustion group demonstrated increased mature follicles,decreased atretic follicles,and significantly decreased abnormal morphology of granulosa cells compared with the model group.Additionally,RNA sequencing results manifested significantly up-regulated miRNA expressions(miR-92b-3p,miR-26-5p_R+1_1ss10TC,miR-206-3p,miR-9993b-3p_1ss6GA,miR-7857-3p_R-1,miR-219a-2-3p_1ss10GC,miR-3968-p5_1ss10AT,and PC-5p-6478_1795)and down-regulated miR-664-2-5p_R+1 in the model group,compared with the control group,and the moxibustion group reversed abnormal disorder levels of these miRNAs.Moreover,these differentially expressed miRNAs were mainly involved in the phosphatidylinositol-3-kinase/protein kinase B signaling pathway and nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 signaling pathway.Finally,network and RT-qPCR verification revealed miR-9993b-3p_1ss6GA as the most critical miRNA.CONCLUSION:This experiment proved the effectiveness of moxibustion in improving the ovarian reserve of rats by regulating miRNA expression,especially miR-9993b-3p_1ss6GA.
基金Traditional Chinese Medicine Science and Technology Project in Jiangsu Province,No.YB2015113the Science and Technology Program of Nantong Health Committee,No.MA2019003,No.MA2021017,No.MB2021026,and No.MB2021027+1 种基金Science and Technology Program of Nantong City,No.Key003,No.MS12015016 and No.JCZ2022040Kangda College of Nanjing Medical University,No.KD2021JYYJYB025,No.KD2022KYJJZD019,No.KD2022KYJJZD022,and No.2023ZC127.
文摘BACKGROUND The neuroendoscopic approach has the advantages of a clear operative field,convenient tumor removal,and less damage,and is the development direction of modern neurosurgery.At present,transnasal surgery for sphenoidal pituitary tumor is widely used.But it has been found in clinical practice that some patients with this type of surgery may experience post-operative nausea and vomiting and other discomforts.AIM To explore the effect of reserved gastric tube application in the neuroendoscopic endonasal resection of pituitary tumors.METHODS A total of 60 patients who underwent pituitary adenoma resection via the endoscopic endonasal approach were selected and randomly divided into the experimental and control groups,with 30 in each group.Experimental group:After anesthesia,a gastric tube was placed through the mouth under direct vision using a visual laryngoscope,and the fluid accumulated in the oropharynx was suctioned intermittently with low negative pressure throughout the whole process after nasal disinfection,during the operation,and when the patient recovered from anesthesia.Control group:Given the routine intraoperative care,no gastric tube was left.The number of cases of nausea/vomiting/aspiration within 24 h post-operation was counted and compared between the two groups;the scores of pharyngalgia after waking up,6 h post-operation,and 24 h postoperation.The frequency of postoperative cerebrospinal fluid leakage and intracranial infection were compared.The hospitalization days of the two groups were statistically compared.RESULTS The times of postoperative nausea and vomiting in the experimental group were lower than that in the control group,and the difference in the incidence of nausea was statistically significant(P<0.05).After the patient woke up,the scores of sore throat 6 h after the operation and 24 h after operation were lower than those in the control group,and the difference was statistically significant(P<0.05).The number of cases of postoperative cerebrospinal fluid leakage and intracranial infection was higher than that of the control group,but there was no statistically significant difference from the control group(P>0.05).The hospitalization days of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).CONCLUSION Reserving a gastric tube in the endoscopic endonasal resection of pituitary tumors,combined with intraoperative and postoperative gastrointestinal decompression,can effectively reduce the incidence of nausea,reduce the number of vomiting and aspiration in patients,and reduce the complications of sore throat The incidence rate shortened the hospitalization days of the patients.
基金This research was funded by the Ministry of Higher Education Malaysia via the Fundamental Research Grant Scheme(FRGS/1/2020/WAB03/UPM/02/1)。
文摘Tropical peat comprises decomposed dead plant material and acts like a sponge to absorb water,making it fully saturated.However,drought periods dry it readily and increases its vulnerability to fire.Peat fires emit greenhouse gases and particles contributing to haze,and prevention by constructing fire-break canals to reduce fire spread into forest reserves is crucial.This paper aims to determine peat physical and chemical properties near a fire-break canal at different fire frequency areas.Peat sampling was conducted at two forest reserves in Malaysia which represent low fire frequency and high fire frequency areas.The results show that peat properties were not affected by the construction of a fire-break canal,however lignin and cellulose content increased significantly from the distance of the canal in both areas.The study concluded that fire frequency did not significantly influence peat properties except for porosity.The higher fibre content in the high frequency area did not influence moisture content nor the ability to regain moisture.Thus,fire frequency might contribute differently to changes in physical and chemical properties,hence management efforts to construct fire-break canals and restoration efforts should protect peatlands from further degradation.These findings will benefit future management and planning for forest reserves.
基金This research was funded by the Key Laboratory for Sustainable Development of Xinjiang's Historical and Cultural Tourism,Xinjiang University,China(LY2022-06)the Tianchi Talent Project.
文摘Nature reserves play a significant role in providing ecosystem services and are key sites for biodiversity conservation.The Tianchi Bogda Peak Natural Reserve(TBPNR),located in Xinjiang Uygur Autonomous Region,China,is an important ecological barrier area in the temperate arid zone.The evaluation of its important ecosystem services is of great significance to improve the management level and ecological protection efficiency of the reserve.In the present study,we assessed the spatiotemporal variations of four ecosystem services(including net primary productivity(NPP),water yield,soil conservation,and habitat quality)in the TBPNR from 2000 to 2020 based on the environmental and social data using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.In addition,the coldspot and hotspot areas of ecosystem services were identified by hotspot analysis,and the trade-off and synergistic relationships between ecosystem services were analyzed using factor analysis in a geographic detector.During the study period,NPP and soil conservation values in the reserve increased by 48.20%and 25.56%,respectively;conversely,water yield decreased by 16.56%,and there was no significant change in habitat quality.Spatially,both NPP and habitat quality values were higher in the northern part and lower in the southern part,whereas water yield showed an opposite trend.Correlation analysis revealed that NPP showed a synergistic relationship with habitat quality and soil conservation,and exhibited a trade-off relationship with water yield.Water yield and habitat quality also had a trade-off relationship.NPP and habitat quality were affected by annual average temperature and Normalized Difference Vegetation Index(NDVI),respectively,while water yield and soil conservation were more affected by digital elevation model(DEM).Therefore,attention should be paid to the spatial distribution and dynamics of trade-off and synergistic relationships between ecosystem services in future ecological management.The findings of the present study provide a reference that could facilitate the sustainable utilization of ecosystem services in the typical fragile areas of Northwest China.
基金financially supported by the National Key R&D Program of China (Grant No. 2019YFC1509901)。
文摘Numerous engineering cases have demonstrated that the expansive soil channel slope remains susceptible to damage with the implementation of a rigid or closed protective structure. It is common for the protective structure to experience bulging failure due to excessive swelling pressure. To investigate the swelling pressure properties of expansive soil, the constant volume test was employed to study the influence of water content and reserved expansion deformation on the characteristics of swelling pressure in strong expansive soils, and also to explore the evolution mechanism of the swelling pressure. The findings demonstrate that the swelling pressure-time curve can be classified into swelling pressure-time softening and swelling pressure-time stability type. The swelling pressuretime curve of the specimen with low water content is the swelling pressure-time softening type, and the softening level will be weakened with increasing reserved expansion deformation. Besides, the maximum swelling pressure Psmax decreases with increasing water content and reserved expansion deformation, especially for expansion ratio η from 24% to 37%. The reserved deformation has little effect on reducing Psmax when it is beyond 7% of the expansion rate. The specimen with low water content has a more homogeneous structure due to the significant expansion-filling effect, and the fracture and reorganization of the aggregates in the specimens with low water content cause the swelling pressure-time softening behavior. In addition, the proposed swelling pressure-time curve prediction model has a good prediction on the test results. If necessary, a deformation space of about 7% expansion rate is recommended to be reserved in the engineering to reduce the swelling pressure except for keeping a stable water content.
基金financially supported by the National Natural Science Foundation of China(Nos.52173021 and 52373038)Key Research and Development Programme of Zhejiang Province(No.2023C01209)S&T Innovation 2025 Major Special Programme of Ningbo(No.2023Z079)。
文摘Shish crystals are crucial to achieving high performance low-dimensional ultra-high molecular weight polyethylene(UHMWPE)products.Typically,high stretch and shear flow fields are necessary for the formation of shish crystals.In this study,UHMWPE gel films with reserved shish crystals were prepared by gel molding,the structural evolution and properties of UHMWPE films stretched at temperatu res of 100,110,120and 130℃were investigated by in situ small-angle X-ray scattering(SAXS)/ultra-small-angle X-ray scattering(USAXS)/wide-angle X-ray diffraction(WAXD)measu rements as well as scanning electron microscopy(SEM)and differential scanning calorimetry(DSC)measurements.Our findings showed that the reserved shish crystals can facilitate the formation and structural evolution of shish-kebab crystals during the hot stretching.Additionally,the reserved shish crystals promote the structu ral evolution of UHMWPE films to a greater extent when stretched at 120 and 130℃,compared to 100 and 110℃,resulting in higher crystallinity,orientation,thermal properties,breaking strength and Young's modulus.Com pared to UHMWPE high-entangled films with reserved shish crystals prepared by compression molding,UHMWPE low-entangled films with reserved shish crystals prepared by gel molding are more effective in inducing the formation and evolution of shish-kebab crystals during the hot stretching,resulting in increased breaking strength and Young's modulus.
文摘Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian reserve.Methods:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google Scholar.We included studies that assigned infertile women with low ovarian reserve in experimental studies.Ovarian reserve parameters were measured before and after PRP injection into ovaries.The data of each study was retrieved and subsequently compiled.Results:Of 301 articles collected and reviewed,six studies were finally included in the meta-analysis.Following PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not AMH.Although it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.
