Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid ...Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.展开更多
With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a va...With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a variety of dermoscopic lesion images.This paper aims to develop and ne-tune a deep learning architecture to diagnose different skin cancer grades based on dermatoscopic images.Fine-tuning is a powerful method to obtain enhanced classication results by the customized pre-trained network.Regularization,batch normalization,and hyperparameter optimization are performed for ne-tuning the proposed deep network.The proposed ne-tuned ResNet50 model successfully classied 7-respective classes of dermoscopic lesions using the publicly available HAM10000 dataset.The developed deep model was compared against two powerful models,i.e.,InceptionV3 and VGG16,using the Dice similarity coefcient(DSC)and the area under the curve(AUC).The evaluation results show that the proposed model achieved higher results than some recent and robust models.展开更多
A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused ...A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate labeling.To mitigate these issues,an improved training framework has been proposed.In this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model performance.Notably,this enhancement is primarily attributed to the coupling effect of the soft labels and correction mechanism.This improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a disruption.It presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.展开更多
In today’s world of massive data and interconnected networks,it’s crucial to burgeon a secure and efficient digital watermarking method to protect the copyrights of digital content.Existing research primarily focuse...In today’s world of massive data and interconnected networks,it’s crucial to burgeon a secure and efficient digital watermarking method to protect the copyrights of digital content.Existing research primarily focuses on deep learning-based approaches to improve the quality of watermarked images,but they have some flaws.To overcome this,the deep learning digital image watermarking model with highly secure algorithms is proposed to secure the digital image.Recently,quantum logistic maps,which combine the concept of quantum computing with traditional techniques,have been considered a niche and promising area of research that has attracted researchers’attention to further research in digital watermarking.This research uses the chaotic behaviour of the quantum logistic map with Rivest–Shamir–Adleman(RSA)and Secure Hash(SHA-3)algorithms for a robust watermark embedding process,where a watermark is embedded into the host image.This way,the quantum chaos method not only helps limit the chance of tampering with the image content through reverse engineering but also assists in maintaining a high level of imperceptibility and strong robustness with efficient extraction or detection of watermark images.Lifting Wavelet Transformation(LWT)is a potential and computationally efficient version of traditional Discrete Wavelet Transform(DWT)where the host image is divided into four sub-bands to offer a multi-resolution view of an image with greater flexibility in watermarking methodologies.Furthermore,considering the robustness against attacks,a pre-trained Residual Neural Network(ResNet-50),a convolutional neural network with 50 layers deep,is used to better learn the complex features and efficiently extract the watermark from the image.By integrating RSA and SHA-3 algorithms,the proposed model demonstrates improved imperceptibility,robustness,and accuracy in watermark extraction compared to traditional methods.It achieves a Peak Signal-to-Noise Ratio(PSNR)of 49.83%,a Structural Similarity Index Measure(SSIM)of 0.98,and a Number of Pixels Change Rate(NPCR)of 99.79%,respectively.These results reflect the model’s effectiveness in delivering superior quality and security.Consequently,our proposed approach offers accurate results,exceptional invisibility,and enhanced robustness compared to the existing digital image watermarking techniques.展开更多
基金funded by the National Key Research and Development Program of China(No.2022YFC2804101)the Guangdong Provincial Key R&D Program(No.2023B1111050011)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010432)the Guangzhou Basic and Applied Basic Research Foundation(No.202201010305)the High-Level Talents Special Program of Zhejiang(No.2022R52036)。
文摘Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.
文摘With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin cancer.For this purpose,this work investigates the capability of deep networks in diagnosing a variety of dermoscopic lesion images.This paper aims to develop and ne-tune a deep learning architecture to diagnose different skin cancer grades based on dermatoscopic images.Fine-tuning is a powerful method to obtain enhanced classication results by the customized pre-trained network.Regularization,batch normalization,and hyperparameter optimization are performed for ne-tuning the proposed deep network.The proposed ne-tuned ResNet50 model successfully classied 7-respective classes of dermoscopic lesions using the publicly available HAM10000 dataset.The developed deep model was compared against two powerful models,i.e.,InceptionV3 and VGG16,using the Dice similarity coefcient(DSC)and the area under the curve(AUC).The evaluation results show that the proposed model achieved higher results than some recent and robust models.
基金supported by National Natural Science Foundation of China(Nos.12175277 and 11975271)the National Key R&D Program of China(No.2022YFE 03050003)。
文摘A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending disruption.However,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate labeling.To mitigate these issues,an improved training framework has been proposed.In this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model performance.Notably,this enhancement is primarily attributed to the coupling effect of the soft labels and correction mechanism.This improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a disruption.It presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.
文摘In today’s world of massive data and interconnected networks,it’s crucial to burgeon a secure and efficient digital watermarking method to protect the copyrights of digital content.Existing research primarily focuses on deep learning-based approaches to improve the quality of watermarked images,but they have some flaws.To overcome this,the deep learning digital image watermarking model with highly secure algorithms is proposed to secure the digital image.Recently,quantum logistic maps,which combine the concept of quantum computing with traditional techniques,have been considered a niche and promising area of research that has attracted researchers’attention to further research in digital watermarking.This research uses the chaotic behaviour of the quantum logistic map with Rivest–Shamir–Adleman(RSA)and Secure Hash(SHA-3)algorithms for a robust watermark embedding process,where a watermark is embedded into the host image.This way,the quantum chaos method not only helps limit the chance of tampering with the image content through reverse engineering but also assists in maintaining a high level of imperceptibility and strong robustness with efficient extraction or detection of watermark images.Lifting Wavelet Transformation(LWT)is a potential and computationally efficient version of traditional Discrete Wavelet Transform(DWT)where the host image is divided into four sub-bands to offer a multi-resolution view of an image with greater flexibility in watermarking methodologies.Furthermore,considering the robustness against attacks,a pre-trained Residual Neural Network(ResNet-50),a convolutional neural network with 50 layers deep,is used to better learn the complex features and efficiently extract the watermark from the image.By integrating RSA and SHA-3 algorithms,the proposed model demonstrates improved imperceptibility,robustness,and accuracy in watermark extraction compared to traditional methods.It achieves a Peak Signal-to-Noise Ratio(PSNR)of 49.83%,a Structural Similarity Index Measure(SSIM)of 0.98,and a Number of Pixels Change Rate(NPCR)of 99.79%,respectively.These results reflect the model’s effectiveness in delivering superior quality and security.Consequently,our proposed approach offers accurate results,exceptional invisibility,and enhanced robustness compared to the existing digital image watermarking techniques.
