Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The g...Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)were followed to conduct this systematic review.Studies published until August 2024 in PubMed,Web of Science,and Scopus databases were searched,identified,screened,and selected for a detailed review.The keywords included metformin,diabetes,reproduction,glutathione,and rodent models.Results:A total of 166 studies were identified,of which 11 met the inclusion criteria and were included in the qualitative synthesis.One additional study was identified through snowballing and citation tracking,bringing the total to 12 studies.The findings indicate that metformin and glutathione,administered alone or in combination with other compounds,improved sperm count,motility,and morphology;restored reproductive hormone levels;reduced oxidative stress markers;and improved testicular histopathology in diabetic male rodents.Conclusions:Coformulation of metformin and glutathione with other compounds was found to be more effective in improving fertility and reproductive parameters in diabetic male rodents compared to mono-administration.However,further studies on the coformulation of metformin and glutathione are needed to confirm their efficacy and elucidate the underlying mechanisms.Study registration:The study protocol was registered in the International Prospective Register of Systematic Reviews(PROSPERO)with registration number CRD42024561820.展开更多
Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely asso...Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely associated with female reproductive health.Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2(Nrf2)and Sirtuin 1(SIRT1),and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptorα(PPARα).This review focuses on the effects of Citrus on oxidative stress and lipid metabolism,aiming to provide new insights for promoting female reproductive health;however,further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.展开更多
Aim： To promote the provision of reproductive health services to young people by exploring the attitudes and perceptions of university students in Shanghai, China, toward reproductive health. Methods： From July 2004...Aim： To promote the provision of reproductive health services to young people by exploring the attitudes and perceptions of university students in Shanghai, China, toward reproductive health. Methods： From July 2004 to May 2006, 5 243 students from 14 universities in Shanghai took part in our survey. Topics covered the demands of reproductive health-care services, attitudes towards and experience with sex, exposure to pornographic material, and knowledge on sexual health and sexually transmitted infections （STIs）/AIDS. Results： Of the 5 067 students who provided valid answer sheets, 50.05% were female and 49.95% were male, 14.86% were medical students, and 85.14% had non-medical backgrounds. A total of 38.4% of respondents had received reproductive health education previously. The majority of students supported school-based reproductive health education, and also acquired information about sex predominantly from books, schoolmates, and the Internet. Premarital sexual behavior was opposed by 17.7% of survey participants, and 37.5% could identify all the three types of STIs listed in the questionnaire. Although 83.7% knew how HIV is transmitted, only 55.7% knew when to use a condom and 57.8% knew that the use of condoms could reduce the risk of HIV infection. Conclusion： The reproductive health service is lagging behind current attitudes and demands of university students. Although students＇ attitudes towards sexual matters are liberal, their knowledge about reproductive health and STIs/AIDS is still limited. It is therefore necessary to provide effective and confidential reproductive health services to young people.展开更多
Objective To investigate the attitudes, behaviours and reflections of the university students, on sexuality, reproductive health, violence, smoking, alcohol and drug use, and to find out their expectations from a yout...Objective To investigate the attitudes, behaviours and reflections of the university students, on sexuality, reproductive health, violence, smoking, alcohol and drug use, and to find out their expectations from a youth health service. Methods A total of 5 300 students （1 880 girls, 3 420 boys）from various Jaculties of Kyrykkale University were enrolled into this cross-sectional study. Students completed the self-administered questionnaire as one of the researchers was present at the classroom. Research monitors five categories of priority health-risk behaviours among youth and young adults. Results Mean age of 3 420 male （64.5%） and 1 880female （35.5%） students were 20.3 years. Among all 4 380 （82,9%） students [1 350 girls （71.8%）, 3 030 boys （88.5%）] had some kinds of information about sexuality, however this dropped to 2 730 students （51.5%） within the context of adequacy. Friends were the major source （34%） for the first information on sexuality. Using a condom was the mostly heard method of contraception （46.9%） and interestingly 1.1% of the students had no knowledge on any of the protection methods. Among all 25.3% of the students （33.0% boys, 11.4% girls） had some kind of sexual intercourse, and within this group 58.8% experienced his/her first sexual relationship at 18 years of age and over; 53.9% were protected in all intercourses. Using a condom was the main way of protection for boys （63.7%） and pills were for the girls （73.9%）. None of the female students mentioned having an abortion but 8% had friends who had undergone abortion. Tobacco use was 35.1% among the group, and 8. 7% of the male and 3.6% of the female students were using drugs. Although 67. 4% students claimed they never witnessed violence between their parents, 43.2% witnessed violence among their siblings, 67.0% beween friends, 72.6% in the streets and 64.2% in the school. About 30.0% of the students reported having weight problems, and 14.7% admitted visiting a doctor for that problem. If there would be a service providedfor the adolescents in the university, 67% of the students would attend in case of a problem. Past experiences were important for us and we saw that among all 8% of the participants had some kind of sexual problem, within this group 50.7% felt uncomfortable during the visit and only 60.4% were satisfied with the care of the physician. Conclusion Our study results show the current situation of adolescents in Kyrykkale University and will be used to improve policies and programs to reduce priority healthrisk behaviours among youth of our and surrounding provinces and establish a youth friendly service in Kyrykkale University within this purposes.展开更多
Objective To understand the status of reproductive health knowledge for junior high school students in Guangzhou city and provide the base data for reproductive health education. Methods A total of l 210 students in...Objective To understand the status of reproductive health knowledge for junior high school students in Guangzhou city and provide the base data for reproductive health education. Methods A total of l 210 students including 657 boys and 553 girls aged 12 ~15 years were surveyed with anonymous self-administrated questionnaire. The students were from a middle school in suburb of Guangzhou city. The questionnaire contained basic concepts of reproduction, love, sex, contraceptives, abortion and sexually transmitted diseases （STDs）. Analysis consisted of descriptive statistics and Chi square tests for differences between boys and girls. Results The students mostly had experienced menarche （94%） or first spermatorrhea （83.6%）. About 58. 4% of students just knew little about process of puberty, fertilization, and contraception. Far more boys than girls considered that the effect of abortion on physical injury was harmless （30.4% and 9.6%, P〈O.O01）. More than 60% of respon- dents knew the route of transmission of STDs well but were poor understanding of adverse impact of STDs. The majority of the students did not consider sexual relation- ship acceptable at their age, a viewpoint that was more strongly held by girls （61.6%） than boys （45.1%） （P〈0.001）. Just 35.5% of boys would refuse when the lovers required to have a sex activity, far less than girls （76.1%） （P〈0.001）. The rate of sex intercourses among students was 5%, and a slightly higher proportion （46%） had never used contraception among those who had sexual activity. The demands of students on reproductive health were mainly on how to deal with the relationship with lovers （56. 0%）, knowledge on sexual health and menses （41.7%）, sex moral knowledge （48.3%）, contraception （45.0%）, and preventive measures of STDs/acquired immune deficiency syndrome （AIDS） （47. 0%）. Conclusion The reproductive health knowledge for the students was at very low level There were some differences on the knowledge mastered by boys and girls while the sexual opinion of boys was more open than girls. It was urgent to carry out education among junior high school students to promote their reproductive health.展开更多
Objective:This study aims to examine the effects of a community-based friendly health clinic(CFHC)program that adopts manual participatory learning(MPL)intervention on the adolescents living in the rural and urban are...Objective:This study aims to examine the effects of a community-based friendly health clinic(CFHC)program that adopts manual participatory learning(MPL)intervention on the adolescents living in the rural and urban areas of Indonesia to gain further insights into their knowledge,attitudes,and skills related to adolescent reproductive health(ARH).Methods:A quasi-experimental design was used to obtain information on the ARH knowledge,attitudes,and skills of adolescents.Two intervention studies that used similar protocols and measures were conducted.A total of 192 adolescents(96 adolescents from urban and rural areas)participated in the project,and the participants from each area were divided into eight groups.A questionairre was adopted to measure the ARH knowledge,attitudes,and skills of these participants.A content analysis of the logbook entries of these respondents was conducted to identify their ARH-related problems.The questionnairre and self-reported ARH data were collected before and after the eight-week program.Results:The CFHC program significantly increased the ARH attitudes(p=0.045)and skills(p=0.009)of adolescents in the rural area,but only improved the ARH knowledge(p<0.001)of adolescents in both rural and urban areas.Fourteen themes were identified in three dominant categories,namely,schools,families,and communities.Conclusions:The CFHC with MPL intervention can improve the ARH knowledge,attitudes,and skills of adolescents in the rural area,but can only improve the ARH knowledge of adolescents in the urban area.The ARH program must be designed based on the characterictics of these adolescents to improve their life skills during puberty.展开更多
Objective To understand the reproductive health needs of unmarried youth so as to provide them better quality services. Method Data were drawn from a baseline questionnaire survey of provision of reproductive health i...Objective To understand the reproductive health needs of unmarried youth so as to provide them better quality services. Method Data were drawn from a baseline questionnaire survey of provision of reproductive health information and services for unmarried youth aged 16-20 years in rural areas of Chengdu, Southwest China in 2001-2002. Results The study comprised of 1 895 valid subjects. More than 70% subjects felt that the knowledge, information and services in relation to sexual and reproductive health provided by the society were rather insufficient. Near 95% thought that unmarried young people seeking sexual and reproductive health counseling and services were quite normal, although some of them had different misgivings. Their preferred services in reproductive health included： counseling in relation to sexual and reproductive health, how to cope with unexpected sex and unwanted pregnancy, how to select the appropriate contraceptives for unmarried youth, etc. About 2/3 subjects agreed to provide contraceptive services to unmarried youth actively, by the society. A. nd they thought the difficulties and obstacles in provision of contraceptive services for un- married youth were in the following order.＂ restriction of the traditional conceptions, shyness of unmarried youth in accept of such services, disapproval of parents/school teachers, and so forth. Conclusion To improve reproductive health status of unmarried youth and meet their needs is a challenge to quality service of family planning/reproductive health program in China, The related departments and service providers should pay attention to this matter and take the strategies and measures to provide appropriate, specific, friendly and accessibly services for unmarried young people.展开更多
Objective To understand the sexual and reproductive health knowledge level of high school and university students in Shanghai. Methods A total of 628 high school students and 709 college students were surveyed with an...Objective To understand the sexual and reproductive health knowledge level of high school and university students in Shanghai. Methods A total of 628 high school students and 709 college students were surveyed with anonymous self-administrated questionnaire in Shanghai. Results The median knowledge scores of students from colleges and high schools were 58 and 39, respectively. Those who had surfed the Internet, had browsed websites on reproductive health, or had communicated sex-related issues with fathers/classmates/friends had more reproductive health knowledge. In addition, the percentage of college students who had surfed the Internet, had browsed websites on reproductive health or had communicated sex-related issues with classmates/friends was higher than that of high school students. Conclusion The knowledge scores of respondents were rather low. Compared with the high school students, the college students had more reproductive health knowledge and sought the knowledge more actively.展开更多
There has been little focus on men＇s reproductive health （RH） in China. This descriptive study conducted in Yiling District, Yichang, China, surveyed male knowledge of sexual physiology and RH to assess levels of k...There has been little focus on men＇s reproductive health （RH） in China. This descriptive study conducted in Yiling District, Yichang, China, surveyed male knowledge of sexual physiology and RH to assess levels of knowledge, attitudes and practices （KAPs） regarding prevention of sexually transmitted diseases （STDs）. A total of 3933 men, aged 18-59 years （mean, 40.3 years）, were recruited by cluster random sampling. They completed a questionnaire in the presence of an interviewer, with items related to subject characteristics, RH knowledge, and subjective symptoms of the reproductive system. Physical examination and reproductive system disease diagnosis were performed. Participants＇ occupations were predominantly skilled labor （80.5%）. Nearly four-fifths （78.5%） respondents had at least one reproductive disease. Over half of respondents were aware of and declared a positive attitude about sexual physiology and safe sex, and 70% of them selected to visit a doctor when they had a reproductive disorder. However, only 41.9% believed human immunodeficiency virus/acquired immunodeficiency syndrome could be transmitted through breastfeeding, and 64.6% incorrectly thought they could avoid contracting STDs by cleaning their genitals after intercourse. In addition, 45% discriminated against and were unwilling to be friends with infected persons. Nearly 45% of those with a reproductive system disorder refused to discuss it with friends or family members. These results indicate that this cohort of Chinese men had a certain degree of KAP about RH, whereas some aspects require further public health education in the general population. It is necessary to disseminate accurate knowledge of STD risk in China based on sociodemographic characteristics.展开更多
Objective To get a general picture of the attitudes of middle school educators on sex and reproductive health education. Methods A cross-sectional survey was carried out among 144 middle school educators in three dist...Objective To get a general picture of the attitudes of middle school educators on sex and reproductive health education. Methods A cross-sectional survey was carried out among 144 middle school educators in three districts of Shanghai from September to October 2005 using anonymous self-administered questionnaire. Results The majority of the educators thought that it was necessary to launch the sex and reproductive health education in all of the middle schools in Shanghai （97. 02%）. They were aware that the age of the students＇puberty were earlier now than before （94.41%）, but the reproductive health knowledge of students was neither sufficient nor correct （78.34%）. The sex and reproductive health education had been involved in the curriculum of many middle schools （66.11%）. Lacking of qualified education staffs contributed most （90. 71%） in the schools which had not launched the sex and reproductive health education. Lacking of qualified education staffs （90.91%） challenged most in the schools which had carried the education. Conclusion The middle school educators thought it was necessary to carry the sex and reproductive health education in all of the middle schools in Shanghai while the major challenges were lacking of qualified education staffs and sufficient teaching time.展开更多
At the beginning of my speech, I would like to thank the Partners in Population and Development for offering us an ideal forum to share experience and discuss ways to move forward concepts prompted by ICPD Cairo confe...At the beginning of my speech, I would like to thank the Partners in Population and Development for offering us an ideal forum to share experience and discuss ways to move forward concepts prompted by ICPD Cairo conference.展开更多
Caretaker-adolescent communication is an appealing source for influencing adolescents’ knowledge, attitudes and behavior, because caretakers are an accessible and often willing source of information for their childre...Caretaker-adolescent communication is an appealing source for influencing adolescents’ knowledge, attitudes and behavior, because caretakers are an accessible and often willing source of information for their children. With the realization of the importance of caretakers in influencing adolescent behaviours, it becomes interesting to explore their perceptions about caretaker-adolescent communication on Sexual and Reproductive Health (SRH). An exploratory qualitative research design was conducted in all six districts of Unguja-Zanzibar. Twelve focus group discussions (FGDs) with caretakers who were purposively selected were conducted. Thematic analysis guided the interpretation of the data. The main themes that were identified are perceived the risk of adolescents;style, time and content of communication;barriers to parent-child communication on SRH;and helping our children pass through adolescence safely. The findings show that participants have acknowledged the apparent risky sexual behaviors of their adolescents, and that information on SRH should be offered to children before they reach puberty. Participants had the opinion that communication on SRH should be in the form of warning, threat and unidirectional. Topics such as teenage pregnancy, STIs and HIV, and drug and alcohol were proposed to be openly discussed. However, topics on condom and contraceptives use faced strong opposition. Lack of favorable time, caretakers’ limited knowledge and skills, myth on SRH communication, and being uncomfortable were among the caretaker-adolescent communication barriers identified by caretakers. The findings suggest that participants are keen to help their adolescents to avoid SRH problems, most importantly they emphasised on the need to empower caretakers by equipping them with knowledge of SRH, good communication skills and religious knowledge. Communal parenting on the other hand has been identified as the major weapon in shaping adolescents’ behaviour. This information provides insight in designing family-based intervention aiming at increasing communication about SRH between caretakers and adolescents.展开更多
Adolescent/youth-friendly sexual and reproductive health services(SRHS)play a vital role in reducing morbidity and mortality associated with adolescent SRH.This review examined studies carried out on adolescent/youth-...Adolescent/youth-friendly sexual and reproductive health services(SRHS)play a vital role in reducing morbidity and mortality associated with adolescent SRH.This review examined studies carried out on adolescent/youth-friendly SRHS with focus on availability,accessibility,utilization as well as perception of health care providers,and adolescents about the services.The study design was systematic review of empirical studies using a well-defined strategy.Online journal was searched comprehensively using Web of Science,Google Scholars databases,PubMed,Medline,and EMBASE.Other sources were identified through the scanning of references of selected sources.The articles selected were between 2016 and 2022 and had qualitative/quantitative and mixed methods.The articles that met the selection criteria were also screened using PRISMA-P guidelines and SPIDER framework for systematic review was further used for inclusion criteria based on the following concepts:sample,phenomenon of interest,design,evaluation and research type.A total number of 32 studies were included in the study and findings were reported based on the five emerging themes.The review showed that majority of the adolescents were not aware of adolescent/youth-friendly SRHS,some health care providers were not also in support of the services which accounted for low utilization of the services among adolescents.The review further showed poor accessibility and nonavailability of AYFSRHS as the only available SRHS were meant for married adults.Therefore,these findings serve as evidence for policy-makers at all the levels of healthcare delivery system to considered all the factors observed in this review and develop strategies that will make adolescent/youth-friendly SRHS available and accessible to adolescents.More so,other stakeholders,especially health care providers must improve their attitude toward provision of adolescent/youth-friendly SRHS.展开更多
Objective To analyze and evaluate the impact of adolescents’ sexual and reproductive health education on students’ sexual knowledge,attitude and behavior.Methods A short term intervention was conducted among high sc...Objective To analyze and evaluate the impact of adolescents’ sexual and reproductive health education on students’ sexual knowledge,attitude and behavior.Methods A short term intervention was conducted among high school students in two schools in Xixiang county,Shaanxi Province.The intervention was carried out in the forms of manual,video,discussion,consultation,and so on .The contents of intervention consisted of the knowledge about adolescent physiology,care,conception,STD/HIV, and so on. Results The results showed that students’ knowledge increased significantly(11.92±4.61 before intervention vs 19.81±4.8 after intervention, P =0.000).The sexual attitude and behavior changed insignificantly,especially the change of behavior.Conclusion The intervention is significantly effective in increasing knowledge,but less effective in the change of attitude and almost ineffective in the behavior change.展开更多
The field of reproductive health has had long ronnaents in ways that other health fields have not experience negotiating challenging enviperhaps because other health fields usually deal with illness which everyone agr...The field of reproductive health has had long ronnaents in ways that other health fields have not experience negotiating challenging enviperhaps because other health fields usually deal with illness which everyone agrees is not a good thing. Or maybe because we have all been born, we all think we know something about reproduction. Whatever the reason, we have over the years seen bitter political and ideological debates over population and family planning, abortion, the treatment of HIV/AIDS, in vitro fertilization, new contraceptive technologies--and now adolescent reproductive health. We shouldn＇t be surprised. But just as we have had to prevail in those debates in the past, they are crucial today： the numbers of young people entering their reproductive years throughout the world, especially the developing world, make it essential that youth be reached not only with messages and services crafted in the last 40 years but also with new messages, new ideas and new services.展开更多
Most young person will become sexually active before their 20<sup>th</sup> birthday having to battle with early and unplanned pregnancies, unsafe abortions, maternal deaths and injuries. This study examine...Most young person will become sexually active before their 20<sup>th</sup> birthday having to battle with early and unplanned pregnancies, unsafe abortions, maternal deaths and injuries. This study examined young person’s sexual knowledge, attitudes and practices and their levels of utilization of sexual reproductive health. Our study progresses beyond current research of reporting only sexual behaviour among youth to have insight into sexual and reproductive health update drivers yielding new empirically robust results for the Ghanaian case for sexual and reproductive health service uptake. The descriptively cross sectional design was employed in sampling 170 youth (150 surveyed and 20 Interviewed) using the stratified sampling technique together with a purposive selection of one key informant. Test of significance and associations were performed with the Chisquare test. In all 45.2% (77/170) of youth (10 - 24) had had sexual experience in life time. In respect of in-school youth, 42% (63/150) had had sexual experience whiles 70% (14/20) out-of-school youth had had sexual intercourse in life time. A total of 28.8% (49/170) of all the youth had sexual intercourse in the last six months with only 40.1 (20/49) using condom for protection. Parental discussion of contraceptive methods (29.3%) and sexual and romantic relationship (28.0%) was the least sexual and reproductive health area discussed among in-school youth. Youth knowledge of the available sexual reproductive health service was statistically associated with reproductive health service utilization (X<sup>2</sup> = 0.00, P ≤ 0.05). A concerted effort is required from government, NGO, Civil society organizations and religious bodies to help translate youth knowledge about sexual health into responsible sexual life and protective sex.展开更多
Objectives:We aim to explore the factors related to the health promotion behavior of reproductive health(RH)among Indonesian adolescents via structural equation modeling.Methods:A cross-sectional quantitative study wa...Objectives:We aim to explore the factors related to the health promotion behavior of reproductive health(RH)among Indonesian adolescents via structural equation modeling.Methods:A cross-sectional quantitative study was used to measure 108 adolescents aged 12-16 years.We employed a self-administered questionnaire developed from the health promotion model(HPM)and the empowerment model(EM)on the basis of self-efficacy to determine the factors related to health promotion in maintaining RH behavior.Structural equation modeling(SEM)was used to examine re-lationships among the variables.The Analysis of Moment Structures(AMOS)approach was used to evaluate if the proposed model is suitable for the data based on goodness-of-fit indices.Results:The model is appropriate for the data.Three interrelationships emerge among independent variables(P>0.05),namely,personal and cognitive behaviors(r=-0.01),cognitive and health pro-motion behaviors(r=0.09),and affective and health promotion behaviors(r=-0.17).The strongest relationship is between empowerment and health promotion behavior(r=0.72).Affection(interper-sonal and situational influences),immediate competing demands and preferences,and empowerment(participation and control)are directly related to RH behavior maintenance.Meanwhile,willingness of adolescents,prior related behavior,personal factor,and commitment to a plan of action are indirectly related to RH behavior maintenance.The model explains 43.9%of the variance in maintaining RH behavior.Conclusions:The HPM and EM models help determine the factors related to RH behavior maintenance among adolescents.Intervention to promote RH among Indonesian adolescents should begin from the level of child-parent-health care professional encounter for empowering the RH of adolescents.展开更多
The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integrati...The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in展开更多
Objective To disseminate the knowledge of contraception and STD/AIDS prevention to unmarried young adults.Methods A peer-led 8-month intervention on reproductive health promotion and STD/ AIDS preve,tion was conducted...Objective To disseminate the knowledge of contraception and STD/AIDS prevention to unmarried young adults.Methods A peer-led 8-month intervention on reproductive health promotion and STD/ AIDS preve,tion was conducted in joint venture factories in Kunshan County through existing famity planning service network. A quasi-experimental design was used. Results The contraception. STD/AIDS related knowledge and attitudes improved significantly, and the use of condom also increased significantly in experimental group after the intervention. No such changes occurred in control group. Conclusion This study demonstrates that the peer-led education is an effective approvach of expanding reproductive health and AIDS prevention services to unmarried young adults in the joint venture factories.展开更多
基金supported by University Technology Mara(UiTM)under grant number 600-IRMI/FRGS 5/3(273/2019).
文摘Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)were followed to conduct this systematic review.Studies published until August 2024 in PubMed,Web of Science,and Scopus databases were searched,identified,screened,and selected for a detailed review.The keywords included metformin,diabetes,reproduction,glutathione,and rodent models.Results:A total of 166 studies were identified,of which 11 met the inclusion criteria and were included in the qualitative synthesis.One additional study was identified through snowballing and citation tracking,bringing the total to 12 studies.The findings indicate that metformin and glutathione,administered alone or in combination with other compounds,improved sperm count,motility,and morphology;restored reproductive hormone levels;reduced oxidative stress markers;and improved testicular histopathology in diabetic male rodents.Conclusions:Coformulation of metformin and glutathione with other compounds was found to be more effective in improving fertility and reproductive parameters in diabetic male rodents compared to mono-administration.However,further studies on the coformulation of metformin and glutathione are needed to confirm their efficacy and elucidate the underlying mechanisms.Study registration:The study protocol was registered in the International Prospective Register of Systematic Reviews(PROSPERO)with registration number CRD42024561820.
基金supported by the National Natural Science Foundation of China(No.82374510)the General Scientific Research Project of the Education Department of Zhejiang Province(No.Y202455593),China.
文摘Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely associated with female reproductive health.Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2(Nrf2)and Sirtuin 1(SIRT1),and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptorα(PPARα).This review focuses on the effects of Citrus on oxidative stress and lipid metabolism,aiming to provide new insights for promoting female reproductive health;however,further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.
文摘Aim： To promote the provision of reproductive health services to young people by exploring the attitudes and perceptions of university students in Shanghai, China, toward reproductive health. Methods： From July 2004 to May 2006, 5 243 students from 14 universities in Shanghai took part in our survey. Topics covered the demands of reproductive health-care services, attitudes towards and experience with sex, exposure to pornographic material, and knowledge on sexual health and sexually transmitted infections （STIs）/AIDS. Results： Of the 5 067 students who provided valid answer sheets, 50.05% were female and 49.95% were male, 14.86% were medical students, and 85.14% had non-medical backgrounds. A total of 38.4% of respondents had received reproductive health education previously. The majority of students supported school-based reproductive health education, and also acquired information about sex predominantly from books, schoolmates, and the Internet. Premarital sexual behavior was opposed by 17.7% of survey participants, and 37.5% could identify all the three types of STIs listed in the questionnaire. Although 83.7% knew how HIV is transmitted, only 55.7% knew when to use a condom and 57.8% knew that the use of condoms could reduce the risk of HIV infection. Conclusion： The reproductive health service is lagging behind current attitudes and demands of university students. Although students＇ attitudes towards sexual matters are liberal, their knowledge about reproductive health and STIs/AIDS is still limited. It is therefore necessary to provide effective and confidential reproductive health services to young people.
文摘Objective To investigate the attitudes, behaviours and reflections of the university students, on sexuality, reproductive health, violence, smoking, alcohol and drug use, and to find out their expectations from a youth health service. Methods A total of 5 300 students （1 880 girls, 3 420 boys）from various Jaculties of Kyrykkale University were enrolled into this cross-sectional study. Students completed the self-administered questionnaire as one of the researchers was present at the classroom. Research monitors five categories of priority health-risk behaviours among youth and young adults. Results Mean age of 3 420 male （64.5%） and 1 880female （35.5%） students were 20.3 years. Among all 4 380 （82,9%） students [1 350 girls （71.8%）, 3 030 boys （88.5%）] had some kinds of information about sexuality, however this dropped to 2 730 students （51.5%） within the context of adequacy. Friends were the major source （34%） for the first information on sexuality. Using a condom was the mostly heard method of contraception （46.9%） and interestingly 1.1% of the students had no knowledge on any of the protection methods. Among all 25.3% of the students （33.0% boys, 11.4% girls） had some kind of sexual intercourse, and within this group 58.8% experienced his/her first sexual relationship at 18 years of age and over; 53.9% were protected in all intercourses. Using a condom was the main way of protection for boys （63.7%） and pills were for the girls （73.9%）. None of the female students mentioned having an abortion but 8% had friends who had undergone abortion. Tobacco use was 35.1% among the group, and 8. 7% of the male and 3.6% of the female students were using drugs. Although 67. 4% students claimed they never witnessed violence between their parents, 43.2% witnessed violence among their siblings, 67.0% beween friends, 72.6% in the streets and 64.2% in the school. About 30.0% of the students reported having weight problems, and 14.7% admitted visiting a doctor for that problem. If there would be a service providedfor the adolescents in the university, 67% of the students would attend in case of a problem. Past experiences were important for us and we saw that among all 8% of the participants had some kind of sexual problem, within this group 50.7% felt uncomfortable during the visit and only 60.4% were satisfied with the care of the physician. Conclusion Our study results show the current situation of adolescents in Kyrykkale University and will be used to improve policies and programs to reduce priority healthrisk behaviours among youth of our and surrounding provinces and establish a youth friendly service in Kyrykkale University within this purposes.
基金supported by Science Popularization and Soft Science Program,Science and Technology Planning Project of Guangzhou City,China(No.1515000221)
文摘Objective To understand the status of reproductive health knowledge for junior high school students in Guangzhou city and provide the base data for reproductive health education. Methods A total of l 210 students including 657 boys and 553 girls aged 12 ~15 years were surveyed with anonymous self-administrated questionnaire. The students were from a middle school in suburb of Guangzhou city. The questionnaire contained basic concepts of reproduction, love, sex, contraceptives, abortion and sexually transmitted diseases （STDs）. Analysis consisted of descriptive statistics and Chi square tests for differences between boys and girls. Results The students mostly had experienced menarche （94%） or first spermatorrhea （83.6%）. About 58. 4% of students just knew little about process of puberty, fertilization, and contraception. Far more boys than girls considered that the effect of abortion on physical injury was harmless （30.4% and 9.6%, P〈O.O01）. More than 60% of respon- dents knew the route of transmission of STDs well but were poor understanding of adverse impact of STDs. The majority of the students did not consider sexual relation- ship acceptable at their age, a viewpoint that was more strongly held by girls （61.6%） than boys （45.1%） （P〈0.001）. Just 35.5% of boys would refuse when the lovers required to have a sex activity, far less than girls （76.1%） （P〈0.001）. The rate of sex intercourses among students was 5%, and a slightly higher proportion （46%） had never used contraception among those who had sexual activity. The demands of students on reproductive health were mainly on how to deal with the relationship with lovers （56. 0%）, knowledge on sexual health and menses （41.7%）, sex moral knowledge （48.3%）, contraception （45.0%）, and preventive measures of STDs/acquired immune deficiency syndrome （AIDS） （47. 0%）. Conclusion The reproductive health knowledge for the students was at very low level There were some differences on the knowledge mastered by boys and girls while the sexual opinion of boys was more open than girls. It was urgent to carry out education among junior high school students to promote their reproductive health.
基金The author(s)would like to thank the grant is provided by the Ministry of Research,Technology,and Higher Education,Directorate General of Resources for Research,Technology and Higher Education of Indonesia for providing this research,School of Nursing,University of Jember,and Research Center Department(Lembaga Penelitian)of University of Jember.
文摘Objective:This study aims to examine the effects of a community-based friendly health clinic(CFHC)program that adopts manual participatory learning(MPL)intervention on the adolescents living in the rural and urban areas of Indonesia to gain further insights into their knowledge,attitudes,and skills related to adolescent reproductive health(ARH).Methods:A quasi-experimental design was used to obtain information on the ARH knowledge,attitudes,and skills of adolescents.Two intervention studies that used similar protocols and measures were conducted.A total of 192 adolescents(96 adolescents from urban and rural areas)participated in the project,and the participants from each area were divided into eight groups.A questionairre was adopted to measure the ARH knowledge,attitudes,and skills of these participants.A content analysis of the logbook entries of these respondents was conducted to identify their ARH-related problems.The questionnairre and self-reported ARH data were collected before and after the eight-week program.Results:The CFHC program significantly increased the ARH attitudes(p=0.045)and skills(p=0.009)of adolescents in the rural area,but only improved the ARH knowledge(p<0.001)of adolescents in both rural and urban areas.Fourteen themes were identified in three dominant categories,namely,schools,families,and communities.Conclusions:The CFHC with MPL intervention can improve the ARH knowledge,attitudes,and skills of adolescents in the rural area,but can only improve the ARH knowledge of adolescents in the urban area.The ARH program must be designed based on the characterictics of these adolescents to improve their life skills during puberty.
文摘Objective To understand the reproductive health needs of unmarried youth so as to provide them better quality services. Method Data were drawn from a baseline questionnaire survey of provision of reproductive health information and services for unmarried youth aged 16-20 years in rural areas of Chengdu, Southwest China in 2001-2002. Results The study comprised of 1 895 valid subjects. More than 70% subjects felt that the knowledge, information and services in relation to sexual and reproductive health provided by the society were rather insufficient. Near 95% thought that unmarried young people seeking sexual and reproductive health counseling and services were quite normal, although some of them had different misgivings. Their preferred services in reproductive health included： counseling in relation to sexual and reproductive health, how to cope with unexpected sex and unwanted pregnancy, how to select the appropriate contraceptives for unmarried youth, etc. About 2/3 subjects agreed to provide contraceptive services to unmarried youth actively, by the society. A. nd they thought the difficulties and obstacles in provision of contraceptive services for un- married youth were in the following order.＂ restriction of the traditional conceptions, shyness of unmarried youth in accept of such services, disapproval of parents/school teachers, and so forth. Conclusion To improve reproductive health status of unmarried youth and meet their needs is a challenge to quality service of family planning/reproductive health program in China, The related departments and service providers should pay attention to this matter and take the strategies and measures to provide appropriate, specific, friendly and accessibly services for unmarried young people.
文摘Objective To understand the sexual and reproductive health knowledge level of high school and university students in Shanghai. Methods A total of 628 high school students and 709 college students were surveyed with anonymous self-administrated questionnaire in Shanghai. Results The median knowledge scores of students from colleges and high schools were 58 and 39, respectively. Those who had surfed the Internet, had browsed websites on reproductive health, or had communicated sex-related issues with fathers/classmates/friends had more reproductive health knowledge. In addition, the percentage of college students who had surfed the Internet, had browsed websites on reproductive health or had communicated sex-related issues with classmates/friends was higher than that of high school students. Conclusion The knowledge scores of respondents were rather low. Compared with the high school students, the college students had more reproductive health knowledge and sought the knowledge more actively.
文摘There has been little focus on men＇s reproductive health （RH） in China. This descriptive study conducted in Yiling District, Yichang, China, surveyed male knowledge of sexual physiology and RH to assess levels of knowledge, attitudes and practices （KAPs） regarding prevention of sexually transmitted diseases （STDs）. A total of 3933 men, aged 18-59 years （mean, 40.3 years）, were recruited by cluster random sampling. They completed a questionnaire in the presence of an interviewer, with items related to subject characteristics, RH knowledge, and subjective symptoms of the reproductive system. Physical examination and reproductive system disease diagnosis were performed. Participants＇ occupations were predominantly skilled labor （80.5%）. Nearly four-fifths （78.5%） respondents had at least one reproductive disease. Over half of respondents were aware of and declared a positive attitude about sexual physiology and safe sex, and 70% of them selected to visit a doctor when they had a reproductive disorder. However, only 41.9% believed human immunodeficiency virus/acquired immunodeficiency syndrome could be transmitted through breastfeeding, and 64.6% incorrectly thought they could avoid contracting STDs by cleaning their genitals after intercourse. In addition, 45% discriminated against and were unwilling to be friends with infected persons. Nearly 45% of those with a reproductive system disorder refused to discuss it with friends or family members. These results indicate that this cohort of Chinese men had a certain degree of KAP about RH, whereas some aspects require further public health education in the general population. It is necessary to disseminate accurate knowledge of STD risk in China based on sociodemographic characteristics.
文摘Objective To get a general picture of the attitudes of middle school educators on sex and reproductive health education. Methods A cross-sectional survey was carried out among 144 middle school educators in three districts of Shanghai from September to October 2005 using anonymous self-administered questionnaire. Results The majority of the educators thought that it was necessary to launch the sex and reproductive health education in all of the middle schools in Shanghai （97. 02%）. They were aware that the age of the students＇puberty were earlier now than before （94.41%）, but the reproductive health knowledge of students was neither sufficient nor correct （78.34%）. The sex and reproductive health education had been involved in the curriculum of many middle schools （66.11%）. Lacking of qualified education staffs contributed most （90. 71%） in the schools which had not launched the sex and reproductive health education. Lacking of qualified education staffs （90.91%） challenged most in the schools which had carried the education. Conclusion The middle school educators thought it was necessary to carry the sex and reproductive health education in all of the middle schools in Shanghai while the major challenges were lacking of qualified education staffs and sufficient teaching time.
文摘At the beginning of my speech, I would like to thank the Partners in Population and Development for offering us an ideal forum to share experience and discuss ways to move forward concepts prompted by ICPD Cairo conference.
文摘Caretaker-adolescent communication is an appealing source for influencing adolescents’ knowledge, attitudes and behavior, because caretakers are an accessible and often willing source of information for their children. With the realization of the importance of caretakers in influencing adolescent behaviours, it becomes interesting to explore their perceptions about caretaker-adolescent communication on Sexual and Reproductive Health (SRH). An exploratory qualitative research design was conducted in all six districts of Unguja-Zanzibar. Twelve focus group discussions (FGDs) with caretakers who were purposively selected were conducted. Thematic analysis guided the interpretation of the data. The main themes that were identified are perceived the risk of adolescents;style, time and content of communication;barriers to parent-child communication on SRH;and helping our children pass through adolescence safely. The findings show that participants have acknowledged the apparent risky sexual behaviors of their adolescents, and that information on SRH should be offered to children before they reach puberty. Participants had the opinion that communication on SRH should be in the form of warning, threat and unidirectional. Topics such as teenage pregnancy, STIs and HIV, and drug and alcohol were proposed to be openly discussed. However, topics on condom and contraceptives use faced strong opposition. Lack of favorable time, caretakers’ limited knowledge and skills, myth on SRH communication, and being uncomfortable were among the caretaker-adolescent communication barriers identified by caretakers. The findings suggest that participants are keen to help their adolescents to avoid SRH problems, most importantly they emphasised on the need to empower caretakers by equipping them with knowledge of SRH, good communication skills and religious knowledge. Communal parenting on the other hand has been identified as the major weapon in shaping adolescents’ behaviour. This information provides insight in designing family-based intervention aiming at increasing communication about SRH between caretakers and adolescents.
文摘Adolescent/youth-friendly sexual and reproductive health services(SRHS)play a vital role in reducing morbidity and mortality associated with adolescent SRH.This review examined studies carried out on adolescent/youth-friendly SRHS with focus on availability,accessibility,utilization as well as perception of health care providers,and adolescents about the services.The study design was systematic review of empirical studies using a well-defined strategy.Online journal was searched comprehensively using Web of Science,Google Scholars databases,PubMed,Medline,and EMBASE.Other sources were identified through the scanning of references of selected sources.The articles selected were between 2016 and 2022 and had qualitative/quantitative and mixed methods.The articles that met the selection criteria were also screened using PRISMA-P guidelines and SPIDER framework for systematic review was further used for inclusion criteria based on the following concepts:sample,phenomenon of interest,design,evaluation and research type.A total number of 32 studies were included in the study and findings were reported based on the five emerging themes.The review showed that majority of the adolescents were not aware of adolescent/youth-friendly SRHS,some health care providers were not also in support of the services which accounted for low utilization of the services among adolescents.The review further showed poor accessibility and nonavailability of AYFSRHS as the only available SRHS were meant for married adults.Therefore,these findings serve as evidence for policy-makers at all the levels of healthcare delivery system to considered all the factors observed in this review and develop strategies that will make adolescent/youth-friendly SRHS available and accessible to adolescents.More so,other stakeholders,especially health care providers must improve their attitude toward provision of adolescent/youth-friendly SRHS.
基金theMinistryofChinesePublicHealthandUNFPA(No .99 z 0 7)
文摘Objective To analyze and evaluate the impact of adolescents’ sexual and reproductive health education on students’ sexual knowledge,attitude and behavior.Methods A short term intervention was conducted among high school students in two schools in Xixiang county,Shaanxi Province.The intervention was carried out in the forms of manual,video,discussion,consultation,and so on .The contents of intervention consisted of the knowledge about adolescent physiology,care,conception,STD/HIV, and so on. Results The results showed that students’ knowledge increased significantly(11.92±4.61 before intervention vs 19.81±4.8 after intervention, P =0.000).The sexual attitude and behavior changed insignificantly,especially the change of behavior.Conclusion The intervention is significantly effective in increasing knowledge,but less effective in the change of attitude and almost ineffective in the behavior change.
文摘The field of reproductive health has had long ronnaents in ways that other health fields have not experience negotiating challenging enviperhaps because other health fields usually deal with illness which everyone agrees is not a good thing. Or maybe because we have all been born, we all think we know something about reproduction. Whatever the reason, we have over the years seen bitter political and ideological debates over population and family planning, abortion, the treatment of HIV/AIDS, in vitro fertilization, new contraceptive technologies--and now adolescent reproductive health. We shouldn＇t be surprised. But just as we have had to prevail in those debates in the past, they are crucial today： the numbers of young people entering their reproductive years throughout the world, especially the developing world, make it essential that youth be reached not only with messages and services crafted in the last 40 years but also with new messages, new ideas and new services.
文摘Most young person will become sexually active before their 20<sup>th</sup> birthday having to battle with early and unplanned pregnancies, unsafe abortions, maternal deaths and injuries. This study examined young person’s sexual knowledge, attitudes and practices and their levels of utilization of sexual reproductive health. Our study progresses beyond current research of reporting only sexual behaviour among youth to have insight into sexual and reproductive health update drivers yielding new empirically robust results for the Ghanaian case for sexual and reproductive health service uptake. The descriptively cross sectional design was employed in sampling 170 youth (150 surveyed and 20 Interviewed) using the stratified sampling technique together with a purposive selection of one key informant. Test of significance and associations were performed with the Chisquare test. In all 45.2% (77/170) of youth (10 - 24) had had sexual experience in life time. In respect of in-school youth, 42% (63/150) had had sexual experience whiles 70% (14/20) out-of-school youth had had sexual intercourse in life time. A total of 28.8% (49/170) of all the youth had sexual intercourse in the last six months with only 40.1 (20/49) using condom for protection. Parental discussion of contraceptive methods (29.3%) and sexual and romantic relationship (28.0%) was the least sexual and reproductive health area discussed among in-school youth. Youth knowledge of the available sexual reproductive health service was statistically associated with reproductive health service utilization (X<sup>2</sup> = 0.00, P ≤ 0.05). A concerted effort is required from government, NGO, Civil society organizations and religious bodies to help translate youth knowledge about sexual health into responsible sexual life and protective sex.
基金The author(s)received financial support for the research from the Ministry of Health of Indonesia No.LB.02.01/I.5/412/2016 as the funder of the research
文摘Objectives:We aim to explore the factors related to the health promotion behavior of reproductive health(RH)among Indonesian adolescents via structural equation modeling.Methods:A cross-sectional quantitative study was used to measure 108 adolescents aged 12-16 years.We employed a self-administered questionnaire developed from the health promotion model(HPM)and the empowerment model(EM)on the basis of self-efficacy to determine the factors related to health promotion in maintaining RH behavior.Structural equation modeling(SEM)was used to examine re-lationships among the variables.The Analysis of Moment Structures(AMOS)approach was used to evaluate if the proposed model is suitable for the data based on goodness-of-fit indices.Results:The model is appropriate for the data.Three interrelationships emerge among independent variables(P>0.05),namely,personal and cognitive behaviors(r=-0.01),cognitive and health pro-motion behaviors(r=0.09),and affective and health promotion behaviors(r=-0.17).The strongest relationship is between empowerment and health promotion behavior(r=0.72).Affection(interper-sonal and situational influences),immediate competing demands and preferences,and empowerment(participation and control)are directly related to RH behavior maintenance.Meanwhile,willingness of adolescents,prior related behavior,personal factor,and commitment to a plan of action are indirectly related to RH behavior maintenance.The model explains 43.9%of the variance in maintaining RH behavior.Conclusions:The HPM and EM models help determine the factors related to RH behavior maintenance among adolescents.Intervention to promote RH among Indonesian adolescents should begin from the level of child-parent-health care professional encounter for empowering the RH of adolescents.
文摘The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in
文摘Objective To disseminate the knowledge of contraception and STD/AIDS prevention to unmarried young adults.Methods A peer-led 8-month intervention on reproductive health promotion and STD/ AIDS preve,tion was conducted in joint venture factories in Kunshan County through existing famity planning service network. A quasi-experimental design was used. Results The contraception. STD/AIDS related knowledge and attitudes improved significantly, and the use of condom also increased significantly in experimental group after the intervention. No such changes occurred in control group. Conclusion This study demonstrates that the peer-led education is an effective approvach of expanding reproductive health and AIDS prevention services to unmarried young adults in the joint venture factories.
