The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front...The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front end.Traditional Chinese Medicine(TCM)practitioners analyze and diagnose the pulse patterns at the replication end.Meanwhile,the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking,which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking.With the support of clinical samples,an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.展开更多
Insulin-like growth factor-I （IGF-I） plays a key role in female reproduction, because it has the effect of anti-apoptosis improving cell proliferation, transformation and differentiation. This paper reviewed the eff...Insulin-like growth factor-I （IGF-I） plays a key role in female reproduction, because it has the effect of anti-apoptosis improving cell proliferation, transformation and differentiation. This paper reviewed the effects of IGF-I on ovary, follicle growth, acquisition of oocyte competence and preimplantation embryo viability, and then summarized different points about IGF-1 for reproduction system展开更多
Human safety is the most important issue in disaster management. Speech is a sound signal containing information that is easily and quickly understood by humans. Using speech as sound signage in emergency systems can ...Human safety is the most important issue in disaster management. Speech is a sound signal containing information that is easily and quickly understood by humans. Using speech as sound signage in emergency systems can effectively increase human safety in low or poor visibility conditions such as in smoke-filled situations. However, reflections of sound through walls, floor surfaces, and ceilings will affect clarity of speech. Unfortunately, because of the characteristics of sound reproduction systems, a single loudspeaker propagates sound waves omni-directionally at low frequencies. This paper proposes a simple multiple-loudspeaker system for reproducing sound with uni-directional characteristics. The proposed system consists mainly of a primary loudspeaker for introducing sound in the desired beam, a secondary loudspeaker for reducing gain in the undesired direction, and digital filters. An adaptive finite-impulse-response (FIR) filter is used to produce the controlling sound by implementing a filtered-x least-mean-square algorithm, and a delay filter for adjusting the time alignment of sound propagation between primary and secondary sources at the control point. Several operational conditions for illustrating real situations and reflections were considered in an anechoic chamber. Experimental results show the directivity patterns of the proposed multiple-loudspeaker system for the required conditions. In a low frequency range, the system is able to control unidirectional propagation;there is a sound beam in the desired direction and, conversely, reduction of gain in the undesired direction around the control point.展开更多
Objective:To evaluate mobile applications available for patients undergoing assisted reproduction and assess the extent of their clinical validation.Methods:A systematic search was conducted in the Apple App Store and...Objective:To evaluate mobile applications available for patients undergoing assisted reproduction and assess the extent of their clinical validation.Methods:A systematic search was conducted in the Apple App Store and Google Play between September 1,2023 and September 30,2023 to identify mobile applications related to assisted reproduction.Apps were evaluated using the mobile app rating scale(MARS).In parallel,a literature search of PubMed,Scopus,Embase,and Web of Science was performed to identify clinical studies related to mobile applications in assisted reproduction.Clinical validation status and MARS scores were recorded,and findings were synthesized to highlight the gap between commercially available apps and research-based evidence.Results:From 1143 apps screened,11 met the inclusion criteria.Mean MARS score across apps was 3.63,with Leeaf scoring the highest(4.60).However,only one application(Embie)was supported by published research.The literature research identified 13 relevant studies,mostly randomized controlled trials,cohort studies,or usability studies.While research-based apps demonstrated clinical utility(e.g.,MediEmo,PreLiFe,Patient Journey App),most were unavailable on app stores.This revealed a disconnect between research-backed applications and those accessible to patients.Conclusions:Although several mobile apps for assisted reproduction demonstrate high usability and quality,few are clinically validated.The lack of integration between research and practice highlights the need for stronger collaboration between researchers,developers,and policymakers to ensure that patients access safe and effective tools.展开更多
Hybrid-sterility-mediated reproductive isolation is pivotal for speciation,yet the underlying molecular mechanisms and environmental responses remain unclear.Here,we report a temperature-sensitive pollen killer-protec...Hybrid-sterility-mediated reproductive isolation is pivotal for speciation,yet the underlying molecular mechanisms and environmental responses remain unclear.Here,we report a temperature-sensitive pollen killer-protector system at a three-gene Sa locus for indica-japonica rice hybrid sterility.Genetic analyses identified SaFL^(+),a strong pollen protector from Sa-i(indica allele),and SaFL^(-),a weak japonica allele from Sa-j,which is exclusively functional under high temperatures.Protein interaction,ubiquitination,and degradation assays showed that SaF^(+)and SaM^(+)from Sa-i form a pollen-killer complex to bind and ubiquitinate the reactive oxygen species scavenger COX11 for degradation in mitochondria,causing male sterility of the Sa-j pollen.Protein affinity and competitive binding assays indicated that in the Sa-i pollen,SaFL^(+)binds SaM^(+)to disrupt the killer complex and restore fertility.However,the weak protector SaFL^(-)can bind SaM^(+)under high temperatures,sparing the Sa-j pollen from sterility.Synteny comparisons and haplotype analyses showed that the Sa locus originated in ancient wild rice and underwent divergence within the Oryza genus during expansion from tropical to temperate environments,which might have driven latitudinal adaptation and reproductive isolation in rice populations.Thus,Sa represents a temperature-sensitive reproductive-isolation system associated with domestication and environmental adaptation in rice.展开更多
Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive stra...Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive strategies responsible for cushion species reproductive success and maintenance in severe alpine habitats remain largely unclear. In this study, we reviewed the current understanding of reproductive strategies and population persistence in alpine cushion species. We then present a preliminary case study on the sexual reproduction of Arenaria polytrichoides(Caryophyllaceae), a typical cushion species inhabiting high elevations of the Himalaya Hengduan Mountains, which is a hotspot for diversification of cushion species. Finally, we highlight the limitations of our current understanding of alpine cushion species reproduction and propose future directions for study.展开更多
Illustrated with the Rossler and Lorenz systems, the topological structure is reproduced using univariable temporal series. The study shows that there are a number of principal vectors reproduced withone-dimensional t...Illustrated with the Rossler and Lorenz systems, the topological structure is reproduced using univariable temporal series. The study shows that there are a number of principal vectors reproduced withone-dimensional temporal series,which reflect from a certain aspect the topological structure for the system attractors.展开更多
The 22.2 multichannel system and its simplified system with 10-channel and 8-channel have been proposed, which brings people 3 D listening experience. But these systems could only accurately reproduce sound field at a...The 22.2 multichannel system and its simplified system with 10-channel and 8-channel have been proposed, which brings people 3 D listening experience. But these systems could only accurately reproduce sound field at a central listening point which is called sweetspot. In order to solve this problem, this paper proposes a non-central zone sound field reproduction method PVMDZ（particle velocity matching between different zones） based on the physical property of sound. The proposed method matches the physical property of sound of non-central zone in reconstructed sound field with that of central zone in original sound field, so the reproduced non-central zone would produce the same listening experience as the central zone of the original system does. By experiments, we compare the performances of the proposed method with the traditional one, and the result proves that the sound field error of proposed method is reduced.展开更多
Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research a...Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.展开更多
Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L...Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.展开更多
Cytokinins are ancient hormones present across all kingdoms of life except archaea,although functional biosynthesis pathways have yet to be identified in animalia.Known for their roles in cell division and proliferati...Cytokinins are ancient hormones present across all kingdoms of life except archaea,although functional biosynthesis pathways have yet to be identified in animalia.Known for their roles in cell division and proliferation,cytokinins are critical to plant life,as they regulate various aspects of vegetative growth,stress response,and reproduction.In this review,we summarize literature from 2020 to 2025 pertaining to the cytokinin functions in plant reproduction.While general aspects of cytokinin’s role in plant reproduction have been addressed,we particularly focus on the role of cytokinin in reproductive systems due to recent work identifying their role as sex-determining factors in dioecious species in Salicaceae and other families,their role in determining flower sex in monoecious species,and their involvement in self-incompatibility response and asexual reproduction.展开更多
Elaeagnaceae Juss. belongs to the family Elaeagnus L. and Shepherdia Nutt. This study aims at the significance and vegetative reproduction of species of the family (Elaeagnus macrophylla Thunb. and Shepherdia canadens...Elaeagnaceae Juss. belongs to the family Elaeagnus L. and Shepherdia Nutt. This study aims at the significance and vegetative reproduction of species of the family (Elaeagnus macrophylla Thunb. and Shepherdia canadensis (L.) Nutt.) in the national economy. The trials were carried out in the experimental site of SamSU’s Botanic Garden, which is named after Sharof Rashidov. The study’s findings are based on the results obtained by planting cuttings of S. canadensis and E. macrophylla species of varying sizes and durations, as well as the cuttings’ roots and the impacts of growth chemicals.展开更多
In this paper,the author follows the trail of C.Malabou,Q.Meillassoux,and G.Deleuze and tries to test three philosophical concepts that seem to be particularly threatened in the era of automatic digital reproduction.T...In this paper,the author follows the trail of C.Malabou,Q.Meillassoux,and G.Deleuze and tries to test three philosophical concepts that seem to be particularly threatened in the era of automatic digital reproduction.These three concepts are plasticity(defended for many years by C.Malabou),contingency(reconstructed by Q.Meillassoux),and virtuality(developed by G.Deleuze).The main task of the text will be to reflect on which of these three concepts better protects our thinking against automation and stays faithful to the ideal of creativity.In what sense are plasticity,contingency,and the possibility of virtualization the a priori condition of any transformation,physical or intellectual,affective or conceptual metamorphosis?In what sense are these three concepts the only conditions for the survival of every living being?Would a being without contingency,plasticity,and disposition to virtualization simply be a dead being?展开更多
Environmental fluctuations are a pervasive natural phenomenon that typically favor diverse maternal investment strategies.Organisms across various evolutionary lineages have acquired the ability to enter the dormancy ...Environmental fluctuations are a pervasive natural phenomenon that typically favor diverse maternal investment strategies.Organisms across various evolutionary lineages have acquired the ability to enter the dormancy state to tolerate conditions that are unsuitable for normal life activities.In cyclical parthenogenesis,sexual reproduction is generally linked with dormancy,thereby enhancing the long-term fitness of populations through positive feedback mechanisms.This study evaluates the impact of environmental variability on offspring population dynamics through sexual reproduction in the rotifer Brachionus calyciflorus.We found that mictic females(sexual females)exposed to low-predictability environments produced resting eggs with a sporadic hatching pattern,reduced hatching rate,and smaller sizes of resting egg,embryo,and stem females,while increasing variations in fertilization among individuals to maximize population fitness.Variations in population growth could be manifested in enhanced reproductive capacity 2–3 d post-hatching,along with differences in fecundity among individuals.This suggests that dormant eggs from unstable environments may prioritize offspring survival and adjust to increased fertilization among individuals.This adaptive strategy enables rotifer populations to rapidly adjust to environmental changes,thus avoiding extinction and thriving in diverse habitats.Our systematic study enhances the understanding of how environmental stability affects long-term population fitness in cyclical parthenogens.展开更多
In this comprehensive review,we delve into the evolution of drug delivery systems in reproductive medicine with a focus on the emerging role of exosomes,a class of extracellular vesicles.Exosomes offer unique advantag...In this comprehensive review,we delve into the evolution of drug delivery systems in reproductive medicine with a focus on the emerging role of exosomes,a class of extracellular vesicles.Exosomes offer unique advantages in overcoming these challenges due to their inherent biocompatibility,stability,and ability to facilitate targeted delivery.This review provides a detailed examination of exosome biogenesis and their function in cellular communication,setting the stage for understanding their potential as drug delivery vehicles.We explore the mechanisms through which exosomes can be loaded with small molecule drugs and the benefits they offer over synthetic nanoparticles.The review highlights groundbreaking case studies that illustrate the successful application of exosome-mediated drug delivery in reproductive health,including enhancing fertility treatments,supporting gamete and embryo development,and facilitating maternal-fetal communication.This study aims to provide a precise un-derstanding of how exosomal drug delivery can revolutionize treatments for reproductive health dis-orders,paving the way for future therapeutic applications.Lastly,we touch upon the promising therapeutic implications of exosomal delivery for proteins and genes,offering a window into future treatments for reproductive health disorders.展开更多
This paper defines and explores the concept of social reproduction work,highlighting its significance and the fact that women are its primary contributors.It identifies key social issues faced by social reproduction w...This paper defines and explores the concept of social reproduction work,highlighting its significance and the fact that women are its primary contributors.It identifies key social issues faced by social reproduction workers,including marginalization,neglect,and unequal access to resources.Additionally,the study examines the primary challenges encountered by these workers:the lack of direct economic benefits,difficulty in balancing work and family responsibilities,and the significant physical and mental strain associated with unpaid labor.Using the theoretical framework of the capitalist economic system,the paper delves into the root causes of the caregiving crisis.Furthermore,it critiques the applicability of reproduction work theories in explaining unpaid care work in the Global South.Three key limitations are outlined:the neglect of informal economic systems in the Global South,persistent gender inequality,and the dynamic nature of global economic migration.展开更多
Objective: Adolescent reproduction health (ARH) differs greatly based on religions, religious norms, culture, and ethnicities in the Indonesian context. The value of local wisdom was considered too binding, traditiona...Objective: Adolescent reproduction health (ARH) differs greatly based on religions, religious norms, culture, and ethnicities in the Indonesian context. The value of local wisdom was considered too binding, traditional, and outdated, particularly on ARH in agricultural areas. The purpose of the study was to identify the problems, challenges, and needs, specifically for ARH, in the agricultural area of Indonesia. Methods: A qualitative study was performed among 41 communities, including 28 village officials (VOs), 9 community health volunteers (CHVs), and 9 adolescents. The data were collected through in-depth interviews and FGD. An thematic analysis was used to describe the phenomena. Results: This research obtained results regarding ARH in terms of communication patterns, daily behavior, reproductive practices, and hygiene of adolescent reproductive organs, especially in agricultural areas. Conclusions: The differences in the perspective of ARH are influenced by environment, parental roles, religion, ethnicity, and knowledge.展开更多
Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their...Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their functioning,such as biomimetic sperms and flagellate microorganisms.The success rates of assisted reproductive technology techniques like in vitro fertilisation(IVF)and intracytoplasmic sperm injection(ICSI)may increase as a result of these developments.Furthermore,the incorporation of artificial intelligence(AI)into spermbots has the potential to optimize reproductive therapies by reducing inherited illnesses through genetic screening and editing.However,before the widespread implementation of spermbots in clinical practice,several critical aspects must be addressed.Thorough investigations into biocompatibility,ethical considerations,and long-term safety are necessary to ensure that these technologies are safe and effective for in vivo applications.展开更多
Morphology of the male reproductive system, chromosome behaviors during meiosis and spem tail structures in Homoptera and Heteroptera are compared in this paper. The sheathed testis is found in Fulgoroidea and Heterop...Morphology of the male reproductive system, chromosome behaviors during meiosis and spem tail structures in Homoptera and Heteroptera are compared in this paper. The sheathed testis is found in Fulgoroidea and Heteroptera, and unsheathed testis occurs in Cicadoidea, Cicadelloidea, Cercopoidea, Membracoidea, Psyloidea, Aphidoidea, Aleyrodoidea and Coccoidea. The testis also can be divide into three types by the shape of testicular follicles. The sphere-shaped type is found in Cicadoidea, Cicadelloidea, Cercopoidea, Membracoidea, Aphidoidea and Aleyrodoidea, the tube-shaped type observed in Fulgoroidea, Psyloidea and Coccoidea, and the lamella-shaped type represented by Heteroptera. It is suggested the unsheathed testis may be the primitive type in Homoptera. Meiosis can be divided into 6 type at least, i.e. 1） Cicadoid type; 2） Fulgoroid type; 3） Psyloid type; 4） Aphidoid type; 5） Aleyrodoid type; and 6） Coccoid type. At least four groups exhibit a diffuse stage during meiosis prophase l, they are Psyloidea, Fulgoroidea, Coccoidea and Heteroptera. Sperm tail structures are similar to those reported from other insects with a typical 9＋9＋2 axoneme except that in Aleyrodoidea and Coccoidea whose sperm tail is degenerated.展开更多
As the application of acupuncture has been increased year by year in the field of overseas reproduction, it has become crucial to give a scientific and objective evaluation of the safety and efficacy of acupuncture in...As the application of acupuncture has been increased year by year in the field of overseas reproduction, it has become crucial to give a scientific and objective evaluation of the safety and efficacy of acupuncture in the field of assisted reproduction, which attaches great importance to the sustainable development of acupuncture in the field of reproduction. This article aims to introduce the current situation of overseas clinical study in the field of assisted reproduction, analyze the existing issues profoundly and put forward measures to solve them, in order to enhance the level of international clinical study of acupuncture.展开更多
基金Key R&D Plan of Liaoning Province(No.202000357-JH13/103):Construction of Liaoning Traditional Chinese Medicine Industry Technology Innovation Research InstituteNational Key Research and Development Plan Special Project(No.2019JH2/10300040)。
文摘The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front end.Traditional Chinese Medicine(TCM)practitioners analyze and diagnose the pulse patterns at the replication end.Meanwhile,the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking,which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking.With the support of clinical samples,an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.
文摘Insulin-like growth factor-I （IGF-I） plays a key role in female reproduction, because it has the effect of anti-apoptosis improving cell proliferation, transformation and differentiation. This paper reviewed the effects of IGF-I on ovary, follicle growth, acquisition of oocyte competence and preimplantation embryo viability, and then summarized different points about IGF-1 for reproduction system
文摘Human safety is the most important issue in disaster management. Speech is a sound signal containing information that is easily and quickly understood by humans. Using speech as sound signage in emergency systems can effectively increase human safety in low or poor visibility conditions such as in smoke-filled situations. However, reflections of sound through walls, floor surfaces, and ceilings will affect clarity of speech. Unfortunately, because of the characteristics of sound reproduction systems, a single loudspeaker propagates sound waves omni-directionally at low frequencies. This paper proposes a simple multiple-loudspeaker system for reproducing sound with uni-directional characteristics. The proposed system consists mainly of a primary loudspeaker for introducing sound in the desired beam, a secondary loudspeaker for reducing gain in the undesired direction, and digital filters. An adaptive finite-impulse-response (FIR) filter is used to produce the controlling sound by implementing a filtered-x least-mean-square algorithm, and a delay filter for adjusting the time alignment of sound propagation between primary and secondary sources at the control point. Several operational conditions for illustrating real situations and reflections were considered in an anechoic chamber. Experimental results show the directivity patterns of the proposed multiple-loudspeaker system for the required conditions. In a low frequency range, the system is able to control unidirectional propagation;there is a sound beam in the desired direction and, conversely, reduction of gain in the undesired direction around the control point.
基金funded by Vietnam National University Ho Chi Minh City(VNU-HCM)under grant number NCM2020-28-01.
文摘Objective:To evaluate mobile applications available for patients undergoing assisted reproduction and assess the extent of their clinical validation.Methods:A systematic search was conducted in the Apple App Store and Google Play between September 1,2023 and September 30,2023 to identify mobile applications related to assisted reproduction.Apps were evaluated using the mobile app rating scale(MARS).In parallel,a literature search of PubMed,Scopus,Embase,and Web of Science was performed to identify clinical studies related to mobile applications in assisted reproduction.Clinical validation status and MARS scores were recorded,and findings were synthesized to highlight the gap between commercially available apps and research-based evidence.Results:From 1143 apps screened,11 met the inclusion criteria.Mean MARS score across apps was 3.63,with Leeaf scoring the highest(4.60).However,only one application(Embie)was supported by published research.The literature research identified 13 relevant studies,mostly randomized controlled trials,cohort studies,or usability studies.While research-based apps demonstrated clinical utility(e.g.,MediEmo,PreLiFe,Patient Journey App),most were unavailable on app stores.This revealed a disconnect between research-backed applications and those accessible to patients.Conclusions:Although several mobile apps for assisted reproduction demonstrate high usability and quality,few are clinically validated.The lack of integration between research and practice highlights the need for stronger collaboration between researchers,developers,and policymakers to ensure that patients access safe and effective tools.
基金supported by the National Natural Science Foundation of China(32030080 to L.C.and 31991222 to Y.-G.L.)the Open Competition Program of the Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG05 to L.C.)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(2022A1515110431 to G.L.and 2019B030302006 to Y.-G.L.)the Invigorate the Seed Industry of Guangdong Province(2024-NPY-00-044 to L.C.).
文摘Hybrid-sterility-mediated reproductive isolation is pivotal for speciation,yet the underlying molecular mechanisms and environmental responses remain unclear.Here,we report a temperature-sensitive pollen killer-protector system at a three-gene Sa locus for indica-japonica rice hybrid sterility.Genetic analyses identified SaFL^(+),a strong pollen protector from Sa-i(indica allele),and SaFL^(-),a weak japonica allele from Sa-j,which is exclusively functional under high temperatures.Protein interaction,ubiquitination,and degradation assays showed that SaF^(+)and SaM^(+)from Sa-i form a pollen-killer complex to bind and ubiquitinate the reactive oxygen species scavenger COX11 for degradation in mitochondria,causing male sterility of the Sa-j pollen.Protein affinity and competitive binding assays indicated that in the Sa-i pollen,SaFL^(+)binds SaM^(+)to disrupt the killer complex and restore fertility.However,the weak protector SaFL^(-)can bind SaM^(+)under high temperatures,sparing the Sa-j pollen from sterility.Synteny comparisons and haplotype analyses showed that the Sa locus originated in ancient wild rice and underwent divergence within the Oryza genus during expansion from tropical to temperate environments,which might have driven latitudinal adaptation and reproductive isolation in rice populations.Thus,Sa represents a temperature-sensitive reproductive-isolation system associated with domestication and environmental adaptation in rice.
基金supported by grants from the National Key Research and Development Program of China (grant no. 2017YFC0505200)the Major Program of National Natural Science Foundation of China (grant no. 31590823) to H Sunthe Natural Science Foundation of China (Grant no. 31500185 to JG Chen, 31470321 to Y Yang)
文摘Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive strategies responsible for cushion species reproductive success and maintenance in severe alpine habitats remain largely unclear. In this study, we reviewed the current understanding of reproductive strategies and population persistence in alpine cushion species. We then present a preliminary case study on the sexual reproduction of Arenaria polytrichoides(Caryophyllaceae), a typical cushion species inhabiting high elevations of the Himalaya Hengduan Mountains, which is a hotspot for diversification of cushion species. Finally, we highlight the limitations of our current understanding of alpine cushion species reproduction and propose future directions for study.
文摘Illustrated with the Rossler and Lorenz systems, the topological structure is reproduced using univariable temporal series. The study shows that there are a number of principal vectors reproduced withone-dimensional temporal series,which reflect from a certain aspect the topological structure for the system attractors.
基金Supported by the National Natural Science Foundation of China(61231015,61401319)the Natural Science Foundation of Hubei Province(2015CFA061)
文摘The 22.2 multichannel system and its simplified system with 10-channel and 8-channel have been proposed, which brings people 3 D listening experience. But these systems could only accurately reproduce sound field at a central listening point which is called sweetspot. In order to solve this problem, this paper proposes a non-central zone sound field reproduction method PVMDZ（particle velocity matching between different zones） based on the physical property of sound. The proposed method matches the physical property of sound of non-central zone in reconstructed sound field with that of central zone in original sound field, so the reproduced non-central zone would produce the same listening experience as the central zone of the original system does. By experiments, we compare the performances of the proposed method with the traditional one, and the result proves that the sound field error of proposed method is reduced.
基金supported by the National Nature Science Foundation of China(NSFC,No.31960156,No.31660338,No.31760627,and No.32270848)Collaborative Innovation Center of Chinese Ministry of Education(2020-39),Science and Technology Support Program of Guizhou Province(QKH[2021]111,QKH[2020]4Y192,QKH[2018]5772-006,and QKH[2019]5406)Science and Technology Fund of Guizhou Provincial Health Commission(gzwkj2022-019).
文摘Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.
文摘Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.
基金funded by a National Science Foundation award to Henning PM(no.2208975).
文摘Cytokinins are ancient hormones present across all kingdoms of life except archaea,although functional biosynthesis pathways have yet to be identified in animalia.Known for their roles in cell division and proliferation,cytokinins are critical to plant life,as they regulate various aspects of vegetative growth,stress response,and reproduction.In this review,we summarize literature from 2020 to 2025 pertaining to the cytokinin functions in plant reproduction.While general aspects of cytokinin’s role in plant reproduction have been addressed,we particularly focus on the role of cytokinin in reproductive systems due to recent work identifying their role as sex-determining factors in dioecious species in Salicaceae and other families,their role in determining flower sex in monoecious species,and their involvement in self-incompatibility response and asexual reproduction.
文摘Elaeagnaceae Juss. belongs to the family Elaeagnus L. and Shepherdia Nutt. This study aims at the significance and vegetative reproduction of species of the family (Elaeagnus macrophylla Thunb. and Shepherdia canadensis (L.) Nutt.) in the national economy. The trials were carried out in the experimental site of SamSU’s Botanic Garden, which is named after Sharof Rashidov. The study’s findings are based on the results obtained by planting cuttings of S. canadensis and E. macrophylla species of varying sizes and durations, as well as the cuttings’ roots and the impacts of growth chemicals.
文摘In this paper,the author follows the trail of C.Malabou,Q.Meillassoux,and G.Deleuze and tries to test three philosophical concepts that seem to be particularly threatened in the era of automatic digital reproduction.These three concepts are plasticity(defended for many years by C.Malabou),contingency(reconstructed by Q.Meillassoux),and virtuality(developed by G.Deleuze).The main task of the text will be to reflect on which of these three concepts better protects our thinking against automation and stays faithful to the ideal of creativity.In what sense are plasticity,contingency,and the possibility of virtualization the a priori condition of any transformation,physical or intellectual,affective or conceptual metamorphosis?In what sense are these three concepts the only conditions for the survival of every living being?Would a being without contingency,plasticity,and disposition to virtualization simply be a dead being?
基金Supported by the National Natural Science Foundation of China(No.32071528)。
文摘Environmental fluctuations are a pervasive natural phenomenon that typically favor diverse maternal investment strategies.Organisms across various evolutionary lineages have acquired the ability to enter the dormancy state to tolerate conditions that are unsuitable for normal life activities.In cyclical parthenogenesis,sexual reproduction is generally linked with dormancy,thereby enhancing the long-term fitness of populations through positive feedback mechanisms.This study evaluates the impact of environmental variability on offspring population dynamics through sexual reproduction in the rotifer Brachionus calyciflorus.We found that mictic females(sexual females)exposed to low-predictability environments produced resting eggs with a sporadic hatching pattern,reduced hatching rate,and smaller sizes of resting egg,embryo,and stem females,while increasing variations in fertilization among individuals to maximize population fitness.Variations in population growth could be manifested in enhanced reproductive capacity 2–3 d post-hatching,along with differences in fecundity among individuals.This suggests that dormant eggs from unstable environments may prioritize offspring survival and adjust to increased fertilization among individuals.This adaptive strategy enables rotifer populations to rapidly adjust to environmental changes,thus avoiding extinction and thriving in diverse habitats.Our systematic study enhances the understanding of how environmental stability affects long-term population fitness in cyclical parthenogens.
基金NGS assistant and Beijing Chipstone co.for their copy editing service.
文摘In this comprehensive review,we delve into the evolution of drug delivery systems in reproductive medicine with a focus on the emerging role of exosomes,a class of extracellular vesicles.Exosomes offer unique advantages in overcoming these challenges due to their inherent biocompatibility,stability,and ability to facilitate targeted delivery.This review provides a detailed examination of exosome biogenesis and their function in cellular communication,setting the stage for understanding their potential as drug delivery vehicles.We explore the mechanisms through which exosomes can be loaded with small molecule drugs and the benefits they offer over synthetic nanoparticles.The review highlights groundbreaking case studies that illustrate the successful application of exosome-mediated drug delivery in reproductive health,including enhancing fertility treatments,supporting gamete and embryo development,and facilitating maternal-fetal communication.This study aims to provide a precise un-derstanding of how exosomal drug delivery can revolutionize treatments for reproductive health dis-orders,paving the way for future therapeutic applications.Lastly,we touch upon the promising therapeutic implications of exosomal delivery for proteins and genes,offering a window into future treatments for reproductive health disorders.
文摘This paper defines and explores the concept of social reproduction work,highlighting its significance and the fact that women are its primary contributors.It identifies key social issues faced by social reproduction workers,including marginalization,neglect,and unequal access to resources.Additionally,the study examines the primary challenges encountered by these workers:the lack of direct economic benefits,difficulty in balancing work and family responsibilities,and the significant physical and mental strain associated with unpaid labor.Using the theoretical framework of the capitalist economic system,the paper delves into the root causes of the caregiving crisis.Furthermore,it critiques the applicability of reproduction work theories in explaining unpaid care work in the Global South.Three key limitations are outlined:the neglect of informal economic systems in the Global South,persistent gender inequality,and the dynamic nature of global economic migration.
基金supported by Kementerian RisetTeknologi dan Pendidikan Tinggi (Ministry of Research,Technology&Higher Education (RISTEKDIKTI) for funding International Collaboration Hibah Kerjasama International LP2M Universitas Jember 2021
文摘Objective: Adolescent reproduction health (ARH) differs greatly based on religions, religious norms, culture, and ethnicities in the Indonesian context. The value of local wisdom was considered too binding, traditional, and outdated, particularly on ARH in agricultural areas. The purpose of the study was to identify the problems, challenges, and needs, specifically for ARH, in the agricultural area of Indonesia. Methods: A qualitative study was performed among 41 communities, including 28 village officials (VOs), 9 community health volunteers (CHVs), and 9 adolescents. The data were collected through in-depth interviews and FGD. An thematic analysis was used to describe the phenomena. Results: This research obtained results regarding ARH in terms of communication patterns, daily behavior, reproductive practices, and hygiene of adolescent reproductive organs, especially in agricultural areas. Conclusions: The differences in the perspective of ARH are influenced by environment, parental roles, religion, ethnicity, and knowledge.
文摘Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their functioning,such as biomimetic sperms and flagellate microorganisms.The success rates of assisted reproductive technology techniques like in vitro fertilisation(IVF)and intracytoplasmic sperm injection(ICSI)may increase as a result of these developments.Furthermore,the incorporation of artificial intelligence(AI)into spermbots has the potential to optimize reproductive therapies by reducing inherited illnesses through genetic screening and editing.However,before the widespread implementation of spermbots in clinical practice,several critical aspects must be addressed.Thorough investigations into biocompatibility,ethical considerations,and long-term safety are necessary to ensure that these technologies are safe and effective for in vivo applications.
文摘Morphology of the male reproductive system, chromosome behaviors during meiosis and spem tail structures in Homoptera and Heteroptera are compared in this paper. The sheathed testis is found in Fulgoroidea and Heteroptera, and unsheathed testis occurs in Cicadoidea, Cicadelloidea, Cercopoidea, Membracoidea, Psyloidea, Aphidoidea, Aleyrodoidea and Coccoidea. The testis also can be divide into three types by the shape of testicular follicles. The sphere-shaped type is found in Cicadoidea, Cicadelloidea, Cercopoidea, Membracoidea, Aphidoidea and Aleyrodoidea, the tube-shaped type observed in Fulgoroidea, Psyloidea and Coccoidea, and the lamella-shaped type represented by Heteroptera. It is suggested the unsheathed testis may be the primitive type in Homoptera. Meiosis can be divided into 6 type at least, i.e. 1） Cicadoid type; 2） Fulgoroid type; 3） Psyloid type; 4） Aphidoid type; 5） Aleyrodoid type; and 6） Coccoid type. At least four groups exhibit a diffuse stage during meiosis prophase l, they are Psyloidea, Fulgoroidea, Coccoidea and Heteroptera. Sperm tail structures are similar to those reported from other insects with a typical 9＋9＋2 axoneme except that in Aleyrodoidea and Coccoidea whose sperm tail is degenerated.
文摘As the application of acupuncture has been increased year by year in the field of overseas reproduction, it has become crucial to give a scientific and objective evaluation of the safety and efficacy of acupuncture in the field of assisted reproduction, which attaches great importance to the sustainable development of acupuncture in the field of reproduction. This article aims to introduce the current situation of overseas clinical study in the field of assisted reproduction, analyze the existing issues profoundly and put forward measures to solve them, in order to enhance the level of international clinical study of acupuncture.
