Based on the seismic observation report data provided by the Xinjiang Digital Seismic Network from 2009 to 2014,we calculate the wave velocity ratio and its background value for medium and small earthquakes by using t...Based on the seismic observation report data provided by the Xinjiang Digital Seismic Network from 2009 to 2014,we calculate the wave velocity ratio and its background value for medium and small earthquakes by using the multi-station method in Tianshan,Xinjiang.This paper analyzes the variation of the wave velocity ratio disturbance value to highlight the abnormal,and also back-traces 7 moderate earthquakes at the research area.The results show that:(1)the background value of the wave velocity ratio is almost 1.70,the wave velocity ratio obviously decreases in the middle-eastern part of Tianshan and the region near the Puchang fault;(2)the wave velocity ratio disturbance value is mostly low in the epicenter before four earthquakes of M≥5.0 from 2011 to 2013 in the study area;(3)before 7 moderate strong earthquakes,the earthquake events with low value of the wave velocity ratio account for over 60% of corresponding total events near the epicenters,and the low value of the wave velocity ratio is relatively obvious before moderate earthquakes.展开更多
Spontaneous reporting system(SRS) is an important way to monitor the adverse drug reaction(ADR) and discover the ADR signal for marketed drugs. It can detect adverse reaction signals timely and effectively, and preven...Spontaneous reporting system(SRS) is an important way to monitor the adverse drug reaction(ADR) and discover the ADR signal for marketed drugs. It can detect adverse reaction signals timely and effectively, and prevent the occurrence of drug damage. Runzao Zhiyang Capsule is mainly composed of Radix Polygoni Multiflor, Radix Polygoni Multiflori Preparata, Radix Rehmanniae Recens, Radix Sophorae Flavescentis, Folium Mori and Urtica dentata Hand.-Mazz. It has the functions of nourishing blood, nourishing yin, expelling wind to relieve itching and moistening the intestines to relieve constipation. It is mainly used for skin itching, acne, constipation and other diseases caused by blood deficiency and wind dryness. The large, national SRS database of ADRs needs effective evaluation methods. We reported on the use of Bayesian confidence propagation neural network method(BCPNN) and reporting rate ratio method(PRR) with propensity score to control confounding variables. The tendency score method was used to control the hybrid bias produced by SRS data analysis. After the calculation of PRR and BCPNN, the score of "diarrhea", "rash" and "gastric dysfunction" showed that there was an early warning before and after matching. To sum up, it indicated that diarrhea, rash and gastric dysfunction were early warning signs.展开更多
目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从200...目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从2004年第1季度至2024年第1季度的药品不良事件(ADE)报告,采用计算报告比值比(ROR)法以及英国药品和健康产品管理局(Medicines and Healthcare Products Regulatory Agency,MHRA)的综合标准法来挖掘两药的ADE信号并进行分析。结果共收集到奥马环素和莫西沙星的ADE报告分别为527、16614份,性别构成比均为男性多于女性。经信号筛选,得到奥马环素45个ADE信号、莫西沙星607个ADE信号。药物发生频次最多的3个ADE信号奥马环素为恶心、呕吐、腹泻(分别为108、61、37例),在其药品说明书中均有记载,而莫西沙星分别为皮疹、头晕、超敏反应(分别为1198、1157、945例),其中头晕未在说明书中记载。按信号强度排序,奥马环素的输液部位静脉炎(ROR值为635.83)和莫西沙星的虹膜缺失检测阳性(ROR值为3478.69)位列第一,奥马环素被其药品说明书记载,而莫西沙星说明书中未被记载。结论奥马环素ADE主要累及到各类损伤、中毒及操作并发症和胃肠系统疾病;而莫西沙星主要累及神经系统疾病和全身性疾病及给药部位各种反应,且新的可疑风险信号较多。展开更多
基金funded by the Earthquake Science Fund of Xinjiang (201404)Seismic Tracing Oriented Task of China Earthquake Administration(2015010122)
文摘Based on the seismic observation report data provided by the Xinjiang Digital Seismic Network from 2009 to 2014,we calculate the wave velocity ratio and its background value for medium and small earthquakes by using the multi-station method in Tianshan,Xinjiang.This paper analyzes the variation of the wave velocity ratio disturbance value to highlight the abnormal,and also back-traces 7 moderate earthquakes at the research area.The results show that:(1)the background value of the wave velocity ratio is almost 1.70,the wave velocity ratio obviously decreases in the middle-eastern part of Tianshan and the region near the Puchang fault;(2)the wave velocity ratio disturbance value is mostly low in the epicenter before four earthquakes of M≥5.0 from 2011 to 2013 in the study area;(3)before 7 moderate strong earthquakes,the earthquake events with low value of the wave velocity ratio account for over 60% of corresponding total events near the epicenters,and the low value of the wave velocity ratio is relatively obvious before moderate earthquakes.
基金funded by National Science and Technology Major Project of New Important Drug Creation (2015ZX09501004-001-002)The National Natural Science Foundation of China (81473798):Study on allergic reaction mechanism of Chinese medicine injections with active monitoring and network target monitoring+1 种基金Project of "One Belt, One Road" for Traditional Chinese Medicine of China Academy of Chinese Medical Sciences (GH2017-04)Construction of China-US Major Disease Clinical Research Center (GH2017-04-01)
文摘Spontaneous reporting system(SRS) is an important way to monitor the adverse drug reaction(ADR) and discover the ADR signal for marketed drugs. It can detect adverse reaction signals timely and effectively, and prevent the occurrence of drug damage. Runzao Zhiyang Capsule is mainly composed of Radix Polygoni Multiflor, Radix Polygoni Multiflori Preparata, Radix Rehmanniae Recens, Radix Sophorae Flavescentis, Folium Mori and Urtica dentata Hand.-Mazz. It has the functions of nourishing blood, nourishing yin, expelling wind to relieve itching and moistening the intestines to relieve constipation. It is mainly used for skin itching, acne, constipation and other diseases caused by blood deficiency and wind dryness. The large, national SRS database of ADRs needs effective evaluation methods. We reported on the use of Bayesian confidence propagation neural network method(BCPNN) and reporting rate ratio method(PRR) with propensity score to control confounding variables. The tendency score method was used to control the hybrid bias produced by SRS data analysis. After the calculation of PRR and BCPNN, the score of "diarrhea", "rash" and "gastric dysfunction" showed that there was an early warning before and after matching. To sum up, it indicated that diarrhea, rash and gastric dysfunction were early warning signs.
文摘目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从2004年第1季度至2024年第1季度的药品不良事件(ADE)报告,采用计算报告比值比(ROR)法以及英国药品和健康产品管理局(Medicines and Healthcare Products Regulatory Agency,MHRA)的综合标准法来挖掘两药的ADE信号并进行分析。结果共收集到奥马环素和莫西沙星的ADE报告分别为527、16614份,性别构成比均为男性多于女性。经信号筛选,得到奥马环素45个ADE信号、莫西沙星607个ADE信号。药物发生频次最多的3个ADE信号奥马环素为恶心、呕吐、腹泻(分别为108、61、37例),在其药品说明书中均有记载,而莫西沙星分别为皮疹、头晕、超敏反应(分别为1198、1157、945例),其中头晕未在说明书中记载。按信号强度排序,奥马环素的输液部位静脉炎(ROR值为635.83)和莫西沙星的虹膜缺失检测阳性(ROR值为3478.69)位列第一,奥马环素被其药品说明书记载,而莫西沙星说明书中未被记载。结论奥马环素ADE主要累及到各类损伤、中毒及操作并发症和胃肠系统疾病;而莫西沙星主要累及神经系统疾病和全身性疾病及给药部位各种反应,且新的可疑风险信号较多。
