Mountainous areas are the priority for forest restoration in semiarid regions,with hillslopes serving as the basic units of mountains.Precipitation is the only water source in these regions,and the uneven distribution...Mountainous areas are the priority for forest restoration in semiarid regions,with hillslopes serving as the basic units of mountains.Precipitation is the only water source in these regions,and the uneven distribution of hillslope soil moisture replenishment after precipitation determines vegetation survival and growth.Therefore,in this study experiments were performed on a hillslope in the Liupan Mountains,Ningxia Hui Autonomous Region,China,to quantify the unevenness of soil moisture replenishment.Soil water content(SWC)in the 0–60 cm layer and precipitation were monitored throughout the growing season in 2020 and 2021.The results showed that(1)Annual soil moisture replenishment was the highest at the mid-slope position,with an average of 309.9 mm,especially under moderate and heavy rain grade conditions,reaching 38.7% and 30.8% of the total replenishment,respectively;(2)Vertical replenishment played a dominant role in the total replenishment,accounting for 82.8%;lateral replenishment played an important but lesser role,accounting for up to 17.2% of the total replenishment;(3)Based on a soil moisture replenishment model established in this study,the maximal replenishment occurred at 90 m from the top of the slope;(4)The dominant factors contributing to the soil moisture replenishment were rainfall amount and saturated hydraulic conductivity(Ks).These findings suggest that attention should be given to both vertical and lateral soil moisture replenishment,and the mid-slope position could be preferred for site selection to achieve precise and integrated forest-water management on hillslopes in semi-arid mountainous regions.展开更多
The rapid advancement of electric vehicles(EVs) has led to a substantial increase in spent lithium-ion batteries(LIBs),necessitating effective recycling pathways to recover the reusable battery components.Traditional ...The rapid advancement of electric vehicles(EVs) has led to a substantial increase in spent lithium-ion batteries(LIBs),necessitating effective recycling pathways to recover the reusable battery components.Traditional recycling methods,such as pyrometallurgy and hydro metallurgy,represent batterycomponent destructive pathways with high energy consumption and substantial waste emissions,leading to considerable environmental issues.In contrast,direct regeneration technologies preserve the integrity of battery components on certain levels,offering a more sustainable and energy-efficient approach.However,these technologies are hindered by complex pre-treatment procedu res,underscoring the need for a simplified route to effectively restore battery performance.This Review categorizes recent advancements in direct regeneration strategies at three levels-powder,electrode,and cell-focusing on their fundamental mechanisms,technological pathways,and socioeconomic sustainability.Among these,cell-level direct regeneration technologies exhibit the highest economic benefits and the lowest waste emissions,positioning them as a promising solution for large-scale battery recovery.By highlighting the potential of cell-level direct regeneration,this review aims to drive further research and development toward scalable and simplified strategies for the efficient reuse of spent LIBs.展开更多
Proton exchange membrane(PEM)water electrolysis presents considerable advantages in green hydrogen production.Nevertheless,oxygen evolution reaction(OER)catalysts in PEM water electrolysis currently encounter several ...Proton exchange membrane(PEM)water electrolysis presents considerable advantages in green hydrogen production.Nevertheless,oxygen evolution reaction(OER)catalysts in PEM water electrolysis currently encounter several pressing challenges,including high noble metal loading,low mass activity,and inadequate durability,which impede their practical application and commercialization.Here we report a self-constructed layered catalyst for acidic OER by directly using an Ir–Ta-based metallic glass as the matrix,featuring a nanoporous IrO_(2) surface formed in situ on the amorphous IrTaO_(x) nanostructure during OER.This distinctive architecture significantly enhances the accessibility and utilization of Ir,achieving a high mass activity of 1.06 A mg_(Ir)^(−1) at a 300 mV overpotential,13.6 and 31.2 times greater than commercial Ir/C and IrO_(2),respectively.The catalyst also exhibits superb stability under industrial-relevant current densities in acid,indicating its potential for practical uses.Our analyses reveal that the coordinated nature of the surface-active Ir species is effectively modulated through electronic interaction between Ir and Ta,preventing them from rapidly evolving into high valence states and suppressing the lattice oxygen participation.Furthermore,the underlying IrTaO_(x) dynamically replenishes the depletion of surface-active sites through inward crystallization and selective dissolution,thereby ensuring the catalyst’s long-term durability.展开更多
Genale-Dawa River Basin is one of the largest and most drought prone re-gions in Ethiopia. As a result a search for alternative source of water has always been a major issue in the region. This study therefore, aims a...Genale-Dawa River Basin is one of the largest and most drought prone re-gions in Ethiopia. As a result a search for alternative source of water has always been a major issue in the region. This study therefore, aims at characterizing and evaluating the ground water potential resource of the river basin. The delineation and numerical discretization of the river basin were primarily done for the proper development of the problem domain. And the groundwater governing equation was solved at individual nodal points of the discretized region using a 3-D numerical ground water model called TAGSAC. This resulted in monthly average groundwater table fluctuation and replenishable ground water potential estimation. Hydrogeological classification was also done based on hydraulic conductivity values obtained from model calibration.展开更多
In order to let the supplier make more reasonable supply decisions,an integrated continuous replenishment policy for the vendor-managed inventory system is presented,which considers the quantity-based shipment consoli...In order to let the supplier make more reasonable supply decisions,an integrated continuous replenishment policy for the vendor-managed inventory system is presented,which considers the quantity-based shipment consolidation and stock replenishment with lead time.Then the system cost is analyzed and a mathematical model is built.Since the model is rather complex,the bounds of the optimal policy are first attained,then the problem is solved by a heuristic algorithm.Through experiments the relationship between the order lead time and the corresponding integrated policy is discussed,and the influence on the system cost is also analyzed.The results reveal that the lead time's influence on the system is more serious with the increase of the order lead time,the integrated policy with the order lead time is more reasonable and the optimal policy can minimize the total system cost.Finally,the parameter sensitivity of the model is analyzed.展开更多
In order to minimize the total cost of the retailer, an optimal replenishment cycle is studied by considering the deteriorating product, two-level trade credits, the limited storage capacity of their own warehouse and...In order to minimize the total cost of the retailer, an optimal replenishment cycle is studied by considering the deteriorating product, two-level trade credits, the limited storage capacity of their own warehouse and credit-linked order quantity simultaneously. A two-echelon supply chain model, which consists of a supplier and a retailer, is established. Then, the retailer＇s optimal replenishment cycle under all the cases are derived by using the optimization theory and method. On the basis of these, the effects of system parameters on the optimal replenishment cycle are examined by using the numerical studies. The results show that, when the retailer＇s trade credit period is longer （shorter） than the customer＇s trade credit period, the optimal replenishment cycle should he increased （decreased） as the retailer＇s trade credit period increases; if the minimum order quantity is high （low）, the optimal replenishment cycle should be increased （not changed） as the minimum order quantity increases.展开更多
In order to let suppliers monitor customers＇ inventory levels and make supply decisions regarding order quantities and delivery time, an integrated continuous replenishment planning （CRP） strategy of fresh food ori...In order to let suppliers monitor customers＇ inventory levels and make supply decisions regarding order quantities and delivery time, an integrated continuous replenishment planning （CRP） strategy of fresh food oriented to retail industry is presented, which integrates the consolidation of shipment and inventory replenishment considering the deterioration of items to guarantee the quality safety of fresh food during the replenishment cycle. A vendor managed inventory （VMI） mathematical model to compute upper-level inventory and delivery cycle is built. Based on the real-time sales data exchange, it enables suppliers to make the decision of the optimal time and the quantities of replenishment for retailers during a delivery cycle, in order to replenish the consumers＇ stock initiatively and minimize the long-run average cost.展开更多
Precipitation plays an important role in the water supplies that support ecological restoration by sustaining large-scale artificial plantations in arid and semiarid regions, especially black locust(Robinia pseudoacac...Precipitation plays an important role in the water supplies that support ecological restoration by sustaining large-scale artificial plantations in arid and semiarid regions, especially black locust(Robinia pseudoacacia) plantations(RP plantations), which are widely planted due to R. pseudoacacia being an excellent pioneer species. Characterizing the response of soil moisture to rainfall events at different stages of restoration is important for assessing the sustainability of restoration in RP plantations. In this study, we quantified the response of soil moisture to rainfall events at different years of restoration(15, 20 and 30 yr) representing different restoration stages in RP plantations in a typical hilly-gully area, i.e., the Yangjuangou Catchment, of the Loess Plateau, China. Over the growing season(June to September) of 2017, smart probes were placed at nine depths(10, 20, 40, 60, 80, 100, 120, 150, and 180 cm below the soil surface) to obtain volumetric soil water information at 30-min intervals in the three RP plantations. The advance of the wetting front was depicted, and the total cumulative water infiltration was measured. Soil moisture was mainly replenished by eight heavy rainfall events(mean rainfall amount = 46.3 mm), accounting for 88.7% of the rainfall during the growing season. The mean soil moisture content profiles of RP plantations at the three restoration stages were ordered as 30-yr(14.07%) > 20-yr(10.12%) > 15-yr(8.03%), and this relationship displayed temporal stability. Soil moisture was primarily replenished by rainfall at the 0-60 cm soil depth, and soil moisture remained stable below the 100-cm soil depth. The rainfall regime influenced the advancement of the wetting front. Here, a single rainfall event of 30 mm was the rainfall threshold for infiltration into the 60-cm soil layer. The total infiltration time ranged from 310.5-322.0 h, but no significant differences were found among RP plantations at different restoration stages. Young and old RP plantations had more total infiltration(more than 228.2 mm) and deeper infiltration depths(80-100 cm) than middle-aged plantations. The RP plantation at the intermediate restoration stage exhibited minimal total infiltration(174.2 mm) and a shallow infiltration depth(60 cm) due to the soil physical structure of the plot, which may have limited rain infiltration. More stand conditions that may affect infiltration should be considered for priority afforestation areas.展开更多
Objective: To explore the mechanism of action of Juanbi Capsules (蠲痹胶囊), a Chinese medicine for invigorating the kidney and replenishing qi, in preventing osteoarthritis of the knee in rabbits. Methods: Seventy-tw...Objective: To explore the mechanism of action of Juanbi Capsules (蠲痹胶囊), a Chinese medicine for invigorating the kidney and replenishing qi, in preventing osteoarthritis of the knee in rabbits. Methods: Seventy-two 4-month-old, Japanese long-eared white rabbits were randomly divided into 6 groups: control (group A), model (group B), Chinese drug; high-dose (group C), Chinese drug; mid-dose (group D), Chinese drug; low-dose (group E), and drug control (group F). With the exception of the rabbits in group A, each rabbit was subjected to plaster cast fixation for 6 weeks to induce osteoarthritis. In addition, rabbits were administrated with an intragastric injection of the Chinese drug (groups C, D and E) or an aminoglucose hydrochloride capsule (group F) for 4 weeks. Blood was drawn from the central ear artery for serum MMP-2 and MMP-9 concentrations, and the knee joint cartilage was harvested for gross observation and light microscopy. Results: There were significant differences in serum MMP-2 and MMP-9 concentrations between group B and groups C, D and E (P<0.05), with no significant differences between groups D and F. Histological results showed various changes in tissue staining with treatment, with osteophyte and bone cyst formation, and superficial erosion in the articular surface of the cartilage; in some cases, the defect reached the mid-layer of the cartilage, and these changes were lower than those in the model group. Conclusion: Juanbi Capsules assist in preventing osteoarthritis in the rabbit, possibly by decreasing serum MMP-2 and MMP-9 levels.展开更多
To investigate highway petrol station replenishment in initiative distribution mode,this paper develops a mixed-integer linear programming(MILP)model with minimal operational costs that includes loading costs,unloadin...To investigate highway petrol station replenishment in initiative distribution mode,this paper develops a mixed-integer linear programming(MILP)model with minimal operational costs that includes loading costs,unloading costs,transport costs and the costs caused by unpunctual distribution.Based on discrete representation,the working day is divided into equal time intervals,and the truck distribution process is decomposed into a pair of tasks including driving,standby,rest,loading and unloading.Each truck must execute one task during a single interval,and the currently executing task is closely related to the preceding and subsequent tasks.By accounting for predictive time-varying sales at petrol stations,real-time road congestion and a series of operational constraints,the proposed model produces the optimal truck dispatch,namely,a detailed task assignment for all trucks during each time interval.The model is tested on a real-world case of a replenishment system comprising eight highway petrol stations,one depot,one garage and eight trucks to demonstrate its applicability and accuracy.展开更多
Striga hermonthica is a major constraint to smallholder sub-sistence agriculture production in the sub-Saharan African region. Low soil fertility and overall environmental degradation has contributed to the build-up o...Striga hermonthica is a major constraint to smallholder sub-sistence agriculture production in the sub-Saharan African region. Low soil fertility and overall environmental degradation has contributed to the build-up of the parasitic weed infestation. Improved cropping systems have to be introduced to address the interrelated problems of S. her-monthica and soil fertility decline. Thus, the effects of improved fallow with leguminous shrub Sesbania sesban on maize yields and levels of S. hermonthica infestation on farm land in the bimodal highlands of western Kenya were investigated. The experimental treatments were arranged in a phased entry, and randomized complete block scheme were six months Sesbania fallow, 18 months Sesbania fallow, six months natural fallow consisting of regrowth of natural vegetation without cultivation, 18 months natural fallow, continuous maize cropping without fertilizer application, and continuous maize cropping with P and N fertilization. Results show that Sesbania fallows significantly （p0.05） increase maize yield relative to continuous unfertilized maize. S. hermonthica plant populations decrease in continuous maize between the first season （mean = 428 000 ± 63 000 ha-1） and second season （mean=51 000 ± 15 000 ha-1）, presumably in response to good weed management. S. hermonthica seed populations in the soil decrease throughout the duration of the experi-ment in the continuous maize treatments. Short-duration Sesbania fal-lows can provide modest yield improvements relative to continuous unfertilized maize, but short-duration weedy fallows are ineffective. Continuous maize cultivation with good weed control may provide more effective S. hermonthica control than fallowing.展开更多
Aiming at the four issues of underground storage state,exploitation mechanism,crude oil flow and efficient recovery,the key theoretical and technical issues and countermeasures for effective development of Gulong shal...Aiming at the four issues of underground storage state,exploitation mechanism,crude oil flow and efficient recovery,the key theoretical and technical issues and countermeasures for effective development of Gulong shale oil are put forward.Through key exploration and research on fluid occurrence,fluid phase change,exploitation mechanism,oil start-up mechanism,flow regime/pattern,exploitation mode and enhanced oil recovery(EOR)of shale reservoirs with different storage spaces,multi-scale occurrence states of shale oil and phase behavior of fluid in nano confined space were provided,the multi-phase,multi-scale flow mode and production mechanism with hydraulic fracture-shale bedding fracture-matrix infiltration as the core was clarified,and a multi-scale flow mathematical model and recoverable reserves evaluation method were preliminarily established.The feasibility of development mode with early energy replenishment and recovery factor of 3o%was discussed.Based on these,the researches of key theories and technologies for effective development of Gulong shale oil are proposed to focus on:(1)in-situ sampling and non-destructive testing of core and fluid;(2)high-temperature,high-pressure,nano-scale laboratory simulation experiment;(3)fusion of multi-scale multi-flow regime numerical simulation technology and large-scale application software;(4)waterless(CO_(2))fracturing technique and the fracturing technique for increasing the vertical fracture height;(5)early energy replenishment to enhance oil recovery;(6)lifecycle technical and economic evaluation.Moreover,a series of exploitation tests should be performed on site as soon as possible to verify the theoretical understanding,optimize the exploitation mode,form supporting technologies,and provide a generalizable development model,thereby supporting and guiding the effective development and production of Gulong shale oil.展开更多
Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disabili...Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disability in young people.Currently available treatments for BD are still fairly limited in terms of efficacy,with high rates of non-adherence,non-response,and undesirable side effects.Traditional Chinese medicine(TCM) has a long history and rich experience in stabilizing mania and improving quality of life.Aiming at rebalancing Yin and Yang in BD,therapy of replenishing Yin and regulating Yang(RYRY therapy) has been in clinical use for years in China.The present prospective,double-blind,randomized controlled trial is designed to investigate the efficacy and safety of RYRY therapy for bipolar mania and its possible mechanism from the point of regulating gut microbiota and anti-inflammation.A total of 60 eligible participants will be recruited from Beijing Anding Hospital.They will be randomized to either the study group or the control group in a ratio of 1∶1.Participants allocated to the study group will receive RYRY granule,while placebo granule will be applied in the control group.Participants in both groups will be prescribed conventional therapy for manic episode in BD.Four scheduled visits will be conducted over 4 weeks.Outcome measurements include Young Mania Rating Scale,TCM Symptom Pattern Rating Scale,Treatment Emergent Symptom Scale,levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α and the gut microbial community profile of stool samples.Safety outcomes and adverse events will also be recorded.In this study,we set a number of scientific and objective assessments to evaluate the efficacy of RYRY therapy and study into its possible mechanism,hopefully offering clinicians an alternative approach to BD.展开更多
OBJECTIVE:To discuss the influence of Sailuotong(塞络通,SLT)on the Neurovascular Unit(NVUs)of amyloid precursor protein(APP)/presenilin-1(PS1)mice and evaluate the role of gas supplementation in activating blood circu...OBJECTIVE:To discuss the influence of Sailuotong(塞络通,SLT)on the Neurovascular Unit(NVUs)of amyloid precursor protein(APP)/presenilin-1(PS1)mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease(AD).METHODS:The mice were allocated into the following nine groups:(a)the C57 Black(C57BL)sham-operated group(control group),(b)ischaemic treatment in C57BL mice(the C57 ischaemic group),(c)the APP/PS1 sham surgery group(APP/PS1 model group),(d)ischaemic treatment in APP/PS1 mice(APP/PS1 ischaemic group),(e)C57BL mice treated with aspirin following ischaemic treatment(C57BL ischaemic+aspirin group),(f)C57BL mice treated with SLT following ischaemic treatment(C57BL ischaemic+SLT group),(g)APP/PS1 mice treated with SLT(APP/PS1+SLT group),(h)APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment(APP/PS1 ischaemic+donepezil hydrochloride group)and(i)APP/PS1 mice treated with SLT following ischaemic treatment(APP/PS1 ischaemic+SLT group).The ischaemic model was established by operating on the bilateral common carotid arteries and creating a microembolism.The Morris water maze and step-down tests were used to detect the spatial behaviour and memory ability of mice.The hippocampus of each mouse was observed by haematoxylin and eosin(HE)and Congo red staining.The ultrastructure of NVUs in each group was observed by electron microscopy,and various biochemical indicators were detected by enzymelinked immunosorbent assay(ELISA).The protein expression level was detected by Western blot.The mRNA expression was detected by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The results of the Morris water maze and step-down tests showed that ischemia reduced learning and memory in the mice,which were restored by SLT.The results of HE staining showed that SLT restored the pathological changes of the NVUs.The Congo red staining results revealed that SLT also improved the scattered orange-red sediments in the upper cortex and hippocampus of the APP/PS1 and APP/PS1 ischaemic mice.Furthermore,SLT significantly reduced the content of Aβ,improved the vascular endothelium and repaired the mitochondrial structures.The ELISA detection,western blot detection and qRT-PCR showed that SLT significantly increased the vascular endothelial growth factor(VEGF),angiopoietin and basic fibroblast growth factor,as well as the levels of gene and protein expression of low-density lipoprotein receptor-related protein-1(LRP-1)and VEGF in brain tissue.CONCLUSIONS:By increasing the expression of VEGF,SLT can promote vascular proliferation,up-regulate the expression of LRP-1,promote the clearance of Aβand improve the cognitive impairment of APP/PS1 mice.These results confirm that SLT can improve AD by promoting vascular proliferation and Aβclearance to protect the function of NVUs.展开更多
Objective: To observe the effects of Bushenyiqihexue Formula (补肾益气和血方 Formula for Tonifying the Kidney, Replenishing qi and Harmonizing Blood, FTKRQHB) on the endometrial gland apoptosis in the mice with blasto...Objective: To observe the effects of Bushenyiqihexue Formula (补肾益气和血方 Formula for Tonifying the Kidney, Replenishing qi and Harmonizing Blood, FTKRQHB) on the endometrial gland apoptosis in the mice with blastocyst implantation dysfunction. Methods: The mice with the first-day pregnancy were divided into the control, model and treatment groups, with 30 in each group, and blastocyst implantation dysfunction was induced by subcutaneous injection of mifepristone in the mice of the model and treatment groups. The pregnancy rate and implantation number of blastocysts were measured and the expressions of proliferating cell nuclear antigen (PCNA), Bax, Bcl-2, and activated caspase-3 were detected in all the three groups. Results: The model group had significantly depressed pregnancy rate, implantation number of blastocysts and apoptosis index, and elevated proliferation index of endometrial gland as compared with the control group (P<0.05 or P<0.01). Administration of FTKRQHB (the treatment group) resulted in significant increases in pregnancy rate, implantation number of blastocysts and apoptosis index of the endometrial gland, and a significant decrease in the proliferation index of the endometrial gland as compared with the model group (P<0.05 or P<0.01). The differences in the four indexes between the treatment group and control group were not significant statistically. The Bax and activated caspase-3 expressions in endometrial gland in the model group became significantly lower than that of the control group (P<0.01), whereas those in the treatment group were significant higher than that of the model group (P<0.01). However, the Bax and activated caspase-3 expressions in endometrial gland were similar in both treatment and control groups. Conclusion: Promoting the increases in Bax and activated caspase-3 expressions in the endometrial gland and bringing into balance between apoptosis and proliferation of the glandular cells at the implantation window phase by FTKRQHB may contribute to the effects of promoting the establishment of endometrial receptivity and improving blastocyst implantation dysfunction.展开更多
A replenishment decision-making model for supply-hub is firstly established from the angle of supplier, and optimal replenishment decision of the supplier is analyzed. Then, inventory optimization model for supply-hub...A replenishment decision-making model for supply-hub is firstly established from the angle of supplier, and optimal replenishment decision of the supplier is analyzed. Then, inventory optimization model for supply-hub is formulated from the angle of the manufacturer, and the optimization algorithm for obtaining optimal inventory levels is given. The result shows that liability period decides the share of the inventory cost between two sides in supply chain. With the increase of liability period, the service level has been quickly reduced even though the manufacturer's cost has been cut down by transferring the inventory cost to the supplier. As to the safety inventory, if the lower bound of components safety inventory increases, the supplier's cost will rise up more slowly than the liability period does, while the service levels increases as the safety inventory's lower bound is raised.展开更多
Various petrographic features and geochemical characteristics indicative of disequilibrium are preserved in plagioclase phenocrysts from basaltic to andesitic lavas in East Junggar, northwest China. These characterist...Various petrographic features and geochemical characteristics indicative of disequilibrium are preserved in plagioclase phenocrysts from basaltic to andesitic lavas in East Junggar, northwest China. These characteristics indicate that they crystallized in a magma chamber, which was replenished by less differentiated and high-temperature magmas. The petrographic and geochemical features of the plagioclase phenocrysts are interpreted to record responses to changes in temperature, composition and mechanical effect during magma replenishment. Distinct rare earth element(REE) patterns between cores and rims of the same plagioclase crystal suggest derivation from two end-member magmas. From core to rim, plagioclase phenocrysts commonly display sharp fluctuations of anorthite(An) content up to 20, which either correspond to reverse zoning associated with ovoidal cores and resorption surface(PI), or normal zoning with euhedral form and no resorption surface(P2). Plagioclase crystals with diverse textures and remarkably different An content coexist on the scale of a thin-section. Cores of these plagioclases in each sample display a bimodal distribution of An content. From core to rim in PI, concentrations o f FeOT and Sr increase remarkably as An content increases. During magma replenishment, pre-existing plagioclase phenocrysts in the andesitic magma, which were immersed into hotter and less differentiated magmas, were heated and resorbed to form ovoidal cores, and then were overgrown by a thin rim with much higher contents of An, FeO^T and Sr. However, pre-existing plagioclase phenocrysts in the basaltic magma were injected into cooler and more evolved magmas, and were remained as euhedral cores, which were later enclosed by oscillatory zoned rims with much lower contents of An, Sr and Ba.展开更多
A frequency domain analysis method based on the three-dimensional translating-pulsating （3DTP） source Green function is developed to investigate wave loads and free motions of two ships advancing on parallel course ...A frequency domain analysis method based on the three-dimensional translating-pulsating （3DTP） source Green function is developed to investigate wave loads and free motions of two ships advancing on parallel course in waves. Two experiments are carried out respectively to mea- sure the wave loads and the free motions for a pair of side-by- side arranged ship models advancing with an identical speed in head regular waves. For comparison, each model is also tested alone. Predictions obtained by the present solution are found in favorable agreement with the model tests and are more accurate than the traditional method based on the three dimensional pulsating （3DP） source Green function. Numer- ical resonances and peak shift can be found in the 3DP pre- dictions, which result from the wave energy trapped in the gap between two ships and the extremely inhomogeneous wave load distribution on each hull. However, they can be eliminated by 3DTP, in which the speed affects the free sur- face and most of the wave energy can be escaped from the gap. Both the experiment and the present prediction show that hydrodynamic interaction effects on wave loads and free motions are significant. The present solver may serve as a validated tool to predict wave loads and motions of two ves- sels under replenishment at sea, and may help to evaluate the hydrodynamic interaction effects on the ships safety in replenishment operation.展开更多
Missing early aftershocks following relatively large or moderate earthquakes can cause significant bias in the analysis of seismic catalogs.In this paper,we systematically address the aftershock missing problem for fi...Missing early aftershocks following relatively large or moderate earthquakes can cause significant bias in the analysis of seismic catalogs.In this paper,we systematically address the aftershock missing problem for five earthquake sequences associated with moderate-size events that occurred inland Japan,by using a stochastic replenishing method.The method is based on the notion that if a point process(e.g.,earthquake sequence)with timeindependent marks(e.g.,magnitudes)is completely observed,it can be transformed into a homogeneous Poisson process by a bi-scale empirical transformation.We use the Japan Meteorological Agency(JMA)earthquake catalog to select the aftershock data and replenish the missing early events using the later complete part of each aftershock sequence.The time windows for each sequence span from 6 months before the mainshock to three months after.The semi-automatic spatial selection uses a clustering method for the epicentral selection of earthquakes.The results obtained for the original JMA catalog and replenished datasets are compared to get insight into the biases that the missing early aftershocks may cause on the Omori-Utsu law parameters’estimation,characterizing the aftershock decay with time from the mainshock.We have also compared the Omori-Utsu law parameter estimates for two datasets following the same mainshock;the first dataset is the replenished sequence,while the second dataset has been obtained by waveform-based analysis to detect early aftershocks that are not recorded in the JMA catalog.Our results demonstrate that the Omori-Utsu law parameters estimated for the replenished datasets are robust with respect to the threshold magnitude used for the analyzed datasets.Even when using aftershock time windows as short as three days,the replenished datasets provide stable Omori-Utsu law parameter estimations.The p-values for all the analyzed sequences are about 1.1 and c-values are significantly smaller compared to those of original datasets.Our findings prove that the replenishment method is a fast,reliable approach to address the missing aftershock problem.展开更多
In this paper, a 3D time domain technique is adopted to calculate the coupled hydrodynamic interaction between two bodies without flare in waves. For verifying the code, two same cylinders are selected to calculate co...In this paper, a 3D time domain technique is adopted to calculate the coupled hydrodynamic interaction between two bodies without flare in waves. For verifying the code, two same cylinders are selected to calculate coupled hydrodynamic effects by comparison with the results obtained by 3D frequency method which has been proved to be efficient for solving such problems. In order to improve efficiency of calculation, the effect of history time has been discussed, and an improved method is presented. Moreover, the effect of lateral separation distance is also discussed in detail. The technique developed here may serve as a more rigorous tool to analyze the related transient problems of two ships doing underway replenishment in waves.展开更多
基金financially supported by the Central Public-Interest Scientific Institution Basal Research Fund of Chinese Academy of Forestry(CAFYBB2021ZW002)the National Key Research and Development Program of China(2022YFF1300404)the National Natural Science Foundation of China(U21A2005)。
文摘Mountainous areas are the priority for forest restoration in semiarid regions,with hillslopes serving as the basic units of mountains.Precipitation is the only water source in these regions,and the uneven distribution of hillslope soil moisture replenishment after precipitation determines vegetation survival and growth.Therefore,in this study experiments were performed on a hillslope in the Liupan Mountains,Ningxia Hui Autonomous Region,China,to quantify the unevenness of soil moisture replenishment.Soil water content(SWC)in the 0–60 cm layer and precipitation were monitored throughout the growing season in 2020 and 2021.The results showed that(1)Annual soil moisture replenishment was the highest at the mid-slope position,with an average of 309.9 mm,especially under moderate and heavy rain grade conditions,reaching 38.7% and 30.8% of the total replenishment,respectively;(2)Vertical replenishment played a dominant role in the total replenishment,accounting for 82.8%;lateral replenishment played an important but lesser role,accounting for up to 17.2% of the total replenishment;(3)Based on a soil moisture replenishment model established in this study,the maximal replenishment occurred at 90 m from the top of the slope;(4)The dominant factors contributing to the soil moisture replenishment were rainfall amount and saturated hydraulic conductivity(Ks).These findings suggest that attention should be given to both vertical and lateral soil moisture replenishment,and the mid-slope position could be preferred for site selection to achieve precise and integrated forest-water management on hillslopes in semi-arid mountainous regions.
基金supported by the National Key R&D Program of China (No.2023YFB3809300)financially supported by the Project of National Natural Science Foundation of China (No.22405297)+2 种基金the Talent Recruitment Project of Guangdong (No.2023QN10C330)the joint Project of National Natural Science Foundation of China (NSFC) and Guangdong Province (No.U1801251)the Science and Technology Planning Project of Guangzhou City for International Cooperation Program (No. 201704030020)。
文摘The rapid advancement of electric vehicles(EVs) has led to a substantial increase in spent lithium-ion batteries(LIBs),necessitating effective recycling pathways to recover the reusable battery components.Traditional recycling methods,such as pyrometallurgy and hydro metallurgy,represent batterycomponent destructive pathways with high energy consumption and substantial waste emissions,leading to considerable environmental issues.In contrast,direct regeneration technologies preserve the integrity of battery components on certain levels,offering a more sustainable and energy-efficient approach.However,these technologies are hindered by complex pre-treatment procedu res,underscoring the need for a simplified route to effectively restore battery performance.This Review categorizes recent advancements in direct regeneration strategies at three levels-powder,electrode,and cell-focusing on their fundamental mechanisms,technological pathways,and socioeconomic sustainability.Among these,cell-level direct regeneration technologies exhibit the highest economic benefits and the lowest waste emissions,positioning them as a promising solution for large-scale battery recovery.By highlighting the potential of cell-level direct regeneration,this review aims to drive further research and development toward scalable and simplified strategies for the efficient reuse of spent LIBs.
基金financially supported by the National Natural Science Foundation of China(Nos.52101202,52071024)the Funds for Creative Research Groups of China(No.51921001)+3 种基金the National Key Research and Development Program of China(No.2022YFB3707103)the Gusu Leading Talents Program(No.ZXL2021206)the Basic Research Program of Taicang(No.TC2023JC29)the Fundamental Research Fund for the Central Universities of China,GuangDong Basic and Applied Basic Research Foundation,and State Key Lab for Advanced Metals and Materials(No.2024-Z11).
文摘Proton exchange membrane(PEM)water electrolysis presents considerable advantages in green hydrogen production.Nevertheless,oxygen evolution reaction(OER)catalysts in PEM water electrolysis currently encounter several pressing challenges,including high noble metal loading,low mass activity,and inadequate durability,which impede their practical application and commercialization.Here we report a self-constructed layered catalyst for acidic OER by directly using an Ir–Ta-based metallic glass as the matrix,featuring a nanoporous IrO_(2) surface formed in situ on the amorphous IrTaO_(x) nanostructure during OER.This distinctive architecture significantly enhances the accessibility and utilization of Ir,achieving a high mass activity of 1.06 A mg_(Ir)^(−1) at a 300 mV overpotential,13.6 and 31.2 times greater than commercial Ir/C and IrO_(2),respectively.The catalyst also exhibits superb stability under industrial-relevant current densities in acid,indicating its potential for practical uses.Our analyses reveal that the coordinated nature of the surface-active Ir species is effectively modulated through electronic interaction between Ir and Ta,preventing them from rapidly evolving into high valence states and suppressing the lattice oxygen participation.Furthermore,the underlying IrTaO_(x) dynamically replenishes the depletion of surface-active sites through inward crystallization and selective dissolution,thereby ensuring the catalyst’s long-term durability.
文摘Genale-Dawa River Basin is one of the largest and most drought prone re-gions in Ethiopia. As a result a search for alternative source of water has always been a major issue in the region. This study therefore, aims at characterizing and evaluating the ground water potential resource of the river basin. The delineation and numerical discretization of the river basin were primarily done for the proper development of the problem domain. And the groundwater governing equation was solved at individual nodal points of the discretized region using a 3-D numerical ground water model called TAGSAC. This resulted in monthly average groundwater table fluctuation and replenishable ground water potential estimation. Hydrogeological classification was also done based on hydraulic conductivity values obtained from model calibration.
基金The National Key Technology R&D Program of China during the 11 th Five-Year Plan Period(No.2006BAH02A06)
文摘In order to let the supplier make more reasonable supply decisions,an integrated continuous replenishment policy for the vendor-managed inventory system is presented,which considers the quantity-based shipment consolidation and stock replenishment with lead time.Then the system cost is analyzed and a mathematical model is built.Since the model is rather complex,the bounds of the optimal policy are first attained,then the problem is solved by a heuristic algorithm.Through experiments the relationship between the order lead time and the corresponding integrated policy is discussed,and the influence on the system cost is also analyzed.The results reveal that the lead time's influence on the system is more serious with the increase of the order lead time,the integrated policy with the order lead time is more reasonable and the optimal policy can minimize the total system cost.Finally,the parameter sensitivity of the model is analyzed.
基金The National Natural Science Foundation of China(No.71371003,71001025,71390333)
文摘In order to minimize the total cost of the retailer, an optimal replenishment cycle is studied by considering the deteriorating product, two-level trade credits, the limited storage capacity of their own warehouse and credit-linked order quantity simultaneously. A two-echelon supply chain model, which consists of a supplier and a retailer, is established. Then, the retailer＇s optimal replenishment cycle under all the cases are derived by using the optimization theory and method. On the basis of these, the effects of system parameters on the optimal replenishment cycle are examined by using the numerical studies. The results show that, when the retailer＇s trade credit period is longer （shorter） than the customer＇s trade credit period, the optimal replenishment cycle should he increased （decreased） as the retailer＇s trade credit period increases; if the minimum order quantity is high （low）, the optimal replenishment cycle should be increased （not changed） as the minimum order quantity increases.
文摘In order to let suppliers monitor customers＇ inventory levels and make supply decisions regarding order quantities and delivery time, an integrated continuous replenishment planning （CRP） strategy of fresh food oriented to retail industry is presented, which integrates the consolidation of shipment and inventory replenishment considering the deterioration of items to guarantee the quality safety of fresh food during the replenishment cycle. A vendor managed inventory （VMI） mathematical model to compute upper-level inventory and delivery cycle is built. Based on the real-time sales data exchange, it enables suppliers to make the decision of the optimal time and the quantities of replenishment for retailers during a delivery cycle, in order to replenish the consumers＇ stock initiatively and minimize the long-run average cost.
基金Under the auspices of the National Key Research and Development Program of China(No.2016YFC0501602,2017YFC0504701)National Natural Science Foundation of China(No.41877539)。
文摘Precipitation plays an important role in the water supplies that support ecological restoration by sustaining large-scale artificial plantations in arid and semiarid regions, especially black locust(Robinia pseudoacacia) plantations(RP plantations), which are widely planted due to R. pseudoacacia being an excellent pioneer species. Characterizing the response of soil moisture to rainfall events at different stages of restoration is important for assessing the sustainability of restoration in RP plantations. In this study, we quantified the response of soil moisture to rainfall events at different years of restoration(15, 20 and 30 yr) representing different restoration stages in RP plantations in a typical hilly-gully area, i.e., the Yangjuangou Catchment, of the Loess Plateau, China. Over the growing season(June to September) of 2017, smart probes were placed at nine depths(10, 20, 40, 60, 80, 100, 120, 150, and 180 cm below the soil surface) to obtain volumetric soil water information at 30-min intervals in the three RP plantations. The advance of the wetting front was depicted, and the total cumulative water infiltration was measured. Soil moisture was mainly replenished by eight heavy rainfall events(mean rainfall amount = 46.3 mm), accounting for 88.7% of the rainfall during the growing season. The mean soil moisture content profiles of RP plantations at the three restoration stages were ordered as 30-yr(14.07%) > 20-yr(10.12%) > 15-yr(8.03%), and this relationship displayed temporal stability. Soil moisture was primarily replenished by rainfall at the 0-60 cm soil depth, and soil moisture remained stable below the 100-cm soil depth. The rainfall regime influenced the advancement of the wetting front. Here, a single rainfall event of 30 mm was the rainfall threshold for infiltration into the 60-cm soil layer. The total infiltration time ranged from 310.5-322.0 h, but no significant differences were found among RP plantations at different restoration stages. Young and old RP plantations had more total infiltration(more than 228.2 mm) and deeper infiltration depths(80-100 cm) than middle-aged plantations. The RP plantation at the intermediate restoration stage exhibited minimal total infiltration(174.2 mm) and a shallow infiltration depth(60 cm) due to the soil physical structure of the plot, which may have limited rain infiltration. More stand conditions that may affect infiltration should be considered for priority afforestation areas.
基金supported by special-purpose scientific research plan of the Education Department of Shaanxi Province (09JK411)the foundation of the Education Department of Shaanxi Province for Key Discipline and The State Administration of TCM for Key Specialized Subject Construction
文摘Objective: To explore the mechanism of action of Juanbi Capsules (蠲痹胶囊), a Chinese medicine for invigorating the kidney and replenishing qi, in preventing osteoarthritis of the knee in rabbits. Methods: Seventy-two 4-month-old, Japanese long-eared white rabbits were randomly divided into 6 groups: control (group A), model (group B), Chinese drug; high-dose (group C), Chinese drug; mid-dose (group D), Chinese drug; low-dose (group E), and drug control (group F). With the exception of the rabbits in group A, each rabbit was subjected to plaster cast fixation for 6 weeks to induce osteoarthritis. In addition, rabbits were administrated with an intragastric injection of the Chinese drug (groups C, D and E) or an aminoglucose hydrochloride capsule (group F) for 4 weeks. Blood was drawn from the central ear artery for serum MMP-2 and MMP-9 concentrations, and the knee joint cartilage was harvested for gross observation and light microscopy. Results: There were significant differences in serum MMP-2 and MMP-9 concentrations between group B and groups C, D and E (P<0.05), with no significant differences between groups D and F. Histological results showed various changes in tissue staining with treatment, with osteophyte and bone cyst formation, and superficial erosion in the articular surface of the cartilage; in some cases, the defect reached the mid-layer of the cartilage, and these changes were lower than those in the model group. Conclusion: Juanbi Capsules assist in preventing osteoarthritis in the rabbit, possibly by decreasing serum MMP-2 and MMP-9 levels.
基金This work was part of the Program of“Study on Optimization and Supply side Reliability of Oil Product Supply Chain Logistics System”funded under the National Natural Science Foundation of China,grant number 51874325.The authors are grateful to all study participants.
文摘To investigate highway petrol station replenishment in initiative distribution mode,this paper develops a mixed-integer linear programming(MILP)model with minimal operational costs that includes loading costs,unloading costs,transport costs and the costs caused by unpunctual distribution.Based on discrete representation,the working day is divided into equal time intervals,and the truck distribution process is decomposed into a pair of tasks including driving,standby,rest,loading and unloading.Each truck must execute one task during a single interval,and the currently executing task is closely related to the preceding and subsequent tasks.By accounting for predictive time-varying sales at petrol stations,real-time road congestion and a series of operational constraints,the proposed model produces the optimal truck dispatch,namely,a detailed task assignment for all trucks during each time interval.The model is tested on a real-world case of a replenishment system comprising eight highway petrol stations,one depot,one garage and eight trucks to demonstrate its applicability and accuracy.
基金supported by Swedish International Development Cooperation Agency (Sida)
文摘Striga hermonthica is a major constraint to smallholder sub-sistence agriculture production in the sub-Saharan African region. Low soil fertility and overall environmental degradation has contributed to the build-up of the parasitic weed infestation. Improved cropping systems have to be introduced to address the interrelated problems of S. her-monthica and soil fertility decline. Thus, the effects of improved fallow with leguminous shrub Sesbania sesban on maize yields and levels of S. hermonthica infestation on farm land in the bimodal highlands of western Kenya were investigated. The experimental treatments were arranged in a phased entry, and randomized complete block scheme were six months Sesbania fallow, 18 months Sesbania fallow, six months natural fallow consisting of regrowth of natural vegetation without cultivation, 18 months natural fallow, continuous maize cropping without fertilizer application, and continuous maize cropping with P and N fertilization. Results show that Sesbania fallows significantly （p0.05） increase maize yield relative to continuous unfertilized maize. S. hermonthica plant populations decrease in continuous maize between the first season （mean = 428 000 ± 63 000 ha-1） and second season （mean=51 000 ± 15 000 ha-1）, presumably in response to good weed management. S. hermonthica seed populations in the soil decrease throughout the duration of the experi-ment in the continuous maize treatments. Short-duration Sesbania fal-lows can provide modest yield improvements relative to continuous unfertilized maize, but short-duration weedy fallows are ineffective. Continuous maize cultivation with good weed control may provide more effective S. hermonthica control than fallowing.
基金Supported by the National Natural Science Foundation of China(U22B2075).
文摘Aiming at the four issues of underground storage state,exploitation mechanism,crude oil flow and efficient recovery,the key theoretical and technical issues and countermeasures for effective development of Gulong shale oil are put forward.Through key exploration and research on fluid occurrence,fluid phase change,exploitation mechanism,oil start-up mechanism,flow regime/pattern,exploitation mode and enhanced oil recovery(EOR)of shale reservoirs with different storage spaces,multi-scale occurrence states of shale oil and phase behavior of fluid in nano confined space were provided,the multi-phase,multi-scale flow mode and production mechanism with hydraulic fracture-shale bedding fracture-matrix infiltration as the core was clarified,and a multi-scale flow mathematical model and recoverable reserves evaluation method were preliminarily established.The feasibility of development mode with early energy replenishment and recovery factor of 3o%was discussed.Based on these,the researches of key theories and technologies for effective development of Gulong shale oil are proposed to focus on:(1)in-situ sampling and non-destructive testing of core and fluid;(2)high-temperature,high-pressure,nano-scale laboratory simulation experiment;(3)fusion of multi-scale multi-flow regime numerical simulation technology and large-scale application software;(4)waterless(CO_(2))fracturing technique and the fracturing technique for increasing the vertical fracture height;(5)early energy replenishment to enhance oil recovery;(6)lifecycle technical and economic evaluation.Moreover,a series of exploitation tests should be performed on site as soon as possible to verify the theoretical understanding,optimize the exploitation mode,form supporting technologies,and provide a generalizable development model,thereby supporting and guiding the effective development and production of Gulong shale oil.
基金Supported by Beijing Municipal Administration of Hospitals Incubating Program(No.PZ2021031),which plays no role in the design of the studycollection,analysis,and interpretation of data,and in writing the manuscript。
文摘Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disability in young people.Currently available treatments for BD are still fairly limited in terms of efficacy,with high rates of non-adherence,non-response,and undesirable side effects.Traditional Chinese medicine(TCM) has a long history and rich experience in stabilizing mania and improving quality of life.Aiming at rebalancing Yin and Yang in BD,therapy of replenishing Yin and regulating Yang(RYRY therapy) has been in clinical use for years in China.The present prospective,double-blind,randomized controlled trial is designed to investigate the efficacy and safety of RYRY therapy for bipolar mania and its possible mechanism from the point of regulating gut microbiota and anti-inflammation.A total of 60 eligible participants will be recruited from Beijing Anding Hospital.They will be randomized to either the study group or the control group in a ratio of 1∶1.Participants allocated to the study group will receive RYRY granule,while placebo granule will be applied in the control group.Participants in both groups will be prescribed conventional therapy for manic episode in BD.Four scheduled visits will be conducted over 4 weeks.Outcome measurements include Young Mania Rating Scale,TCM Symptom Pattern Rating Scale,Treatment Emergent Symptom Scale,levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α and the gut microbial community profile of stool samples.Safety outcomes and adverse events will also be recorded.In this study,we set a number of scientific and objective assessments to evaluate the efficacy of RYRY therapy and study into its possible mechanism,hopefully offering clinicians an alternative approach to BD.
基金National Natural Science Foundation of China(81503450):Experimental study on the treatment of transgenic mice with Alzheimer's disease by protecting neurovascular unit by supplementing Qi and activating blood circulation investigate。
文摘OBJECTIVE:To discuss the influence of Sailuotong(塞络通,SLT)on the Neurovascular Unit(NVUs)of amyloid precursor protein(APP)/presenilin-1(PS1)mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease(AD).METHODS:The mice were allocated into the following nine groups:(a)the C57 Black(C57BL)sham-operated group(control group),(b)ischaemic treatment in C57BL mice(the C57 ischaemic group),(c)the APP/PS1 sham surgery group(APP/PS1 model group),(d)ischaemic treatment in APP/PS1 mice(APP/PS1 ischaemic group),(e)C57BL mice treated with aspirin following ischaemic treatment(C57BL ischaemic+aspirin group),(f)C57BL mice treated with SLT following ischaemic treatment(C57BL ischaemic+SLT group),(g)APP/PS1 mice treated with SLT(APP/PS1+SLT group),(h)APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment(APP/PS1 ischaemic+donepezil hydrochloride group)and(i)APP/PS1 mice treated with SLT following ischaemic treatment(APP/PS1 ischaemic+SLT group).The ischaemic model was established by operating on the bilateral common carotid arteries and creating a microembolism.The Morris water maze and step-down tests were used to detect the spatial behaviour and memory ability of mice.The hippocampus of each mouse was observed by haematoxylin and eosin(HE)and Congo red staining.The ultrastructure of NVUs in each group was observed by electron microscopy,and various biochemical indicators were detected by enzymelinked immunosorbent assay(ELISA).The protein expression level was detected by Western blot.The mRNA expression was detected by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The results of the Morris water maze and step-down tests showed that ischemia reduced learning and memory in the mice,which were restored by SLT.The results of HE staining showed that SLT restored the pathological changes of the NVUs.The Congo red staining results revealed that SLT also improved the scattered orange-red sediments in the upper cortex and hippocampus of the APP/PS1 and APP/PS1 ischaemic mice.Furthermore,SLT significantly reduced the content of Aβ,improved the vascular endothelium and repaired the mitochondrial structures.The ELISA detection,western blot detection and qRT-PCR showed that SLT significantly increased the vascular endothelial growth factor(VEGF),angiopoietin and basic fibroblast growth factor,as well as the levels of gene and protein expression of low-density lipoprotein receptor-related protein-1(LRP-1)and VEGF in brain tissue.CONCLUSIONS:By increasing the expression of VEGF,SLT can promote vascular proliferation,up-regulate the expression of LRP-1,promote the clearance of Aβand improve the cognitive impairment of APP/PS1 mice.These results confirm that SLT can improve AD by promoting vascular proliferation and Aβclearance to protect the function of NVUs.
基金supported by the National Natural Science Foundation of China (No. 30171193)
文摘Objective: To observe the effects of Bushenyiqihexue Formula (补肾益气和血方 Formula for Tonifying the Kidney, Replenishing qi and Harmonizing Blood, FTKRQHB) on the endometrial gland apoptosis in the mice with blastocyst implantation dysfunction. Methods: The mice with the first-day pregnancy were divided into the control, model and treatment groups, with 30 in each group, and blastocyst implantation dysfunction was induced by subcutaneous injection of mifepristone in the mice of the model and treatment groups. The pregnancy rate and implantation number of blastocysts were measured and the expressions of proliferating cell nuclear antigen (PCNA), Bax, Bcl-2, and activated caspase-3 were detected in all the three groups. Results: The model group had significantly depressed pregnancy rate, implantation number of blastocysts and apoptosis index, and elevated proliferation index of endometrial gland as compared with the control group (P<0.05 or P<0.01). Administration of FTKRQHB (the treatment group) resulted in significant increases in pregnancy rate, implantation number of blastocysts and apoptosis index of the endometrial gland, and a significant decrease in the proliferation index of the endometrial gland as compared with the model group (P<0.05 or P<0.01). The differences in the four indexes between the treatment group and control group were not significant statistically. The Bax and activated caspase-3 expressions in endometrial gland in the model group became significantly lower than that of the control group (P<0.01), whereas those in the treatment group were significant higher than that of the model group (P<0.01). However, the Bax and activated caspase-3 expressions in endometrial gland were similar in both treatment and control groups. Conclusion: Promoting the increases in Bax and activated caspase-3 expressions in the endometrial gland and bringing into balance between apoptosis and proliferation of the glandular cells at the implantation window phase by FTKRQHB may contribute to the effects of promoting the establishment of endometrial receptivity and improving blastocyst implantation dysfunction.
基金Projects(71102174,70971036) supported by the National Natural Science Foundation of ChinaProject(9123028) supported by the Beijing Natural Science Foundation,China+3 种基金Project(20111101120019) supported by the Specialized Research Fund for Doctoral Program of Higher Education of ChinaProject(11JGC106) supported by the Beijing Philosophy&Social Science Foundation of ChinaProjects(NCET-10-0048,NCET-10-0043) supported by the Program for New Century Excellent Talents in Universities of ChinaProject(2010YC1307) supported by the Excellent Young Teacher in Beijing Institute of Technology of China
文摘A replenishment decision-making model for supply-hub is firstly established from the angle of supplier, and optimal replenishment decision of the supplier is analyzed. Then, inventory optimization model for supply-hub is formulated from the angle of the manufacturer, and the optimization algorithm for obtaining optimal inventory levels is given. The result shows that liability period decides the share of the inventory cost between two sides in supply chain. With the increase of liability period, the service level has been quickly reduced even though the manufacturer's cost has been cut down by transferring the inventory cost to the supplier. As to the safety inventory, if the lower bound of components safety inventory increases, the supplier's cost will rise up more slowly than the liability period does, while the service levels increases as the safety inventory's lower bound is raised.
基金financial support by the Natural Science Foundation of China (41573030, 41503024)the Geological Survey Program from China Geological Survey (No. DD20190518)
文摘Various petrographic features and geochemical characteristics indicative of disequilibrium are preserved in plagioclase phenocrysts from basaltic to andesitic lavas in East Junggar, northwest China. These characteristics indicate that they crystallized in a magma chamber, which was replenished by less differentiated and high-temperature magmas. The petrographic and geochemical features of the plagioclase phenocrysts are interpreted to record responses to changes in temperature, composition and mechanical effect during magma replenishment. Distinct rare earth element(REE) patterns between cores and rims of the same plagioclase crystal suggest derivation from two end-member magmas. From core to rim, plagioclase phenocrysts commonly display sharp fluctuations of anorthite(An) content up to 20, which either correspond to reverse zoning associated with ovoidal cores and resorption surface(PI), or normal zoning with euhedral form and no resorption surface(P2). Plagioclase crystals with diverse textures and remarkably different An content coexist on the scale of a thin-section. Cores of these plagioclases in each sample display a bimodal distribution of An content. From core to rim in PI, concentrations o f FeOT and Sr increase remarkably as An content increases. During magma replenishment, pre-existing plagioclase phenocrysts in the andesitic magma, which were immersed into hotter and less differentiated magmas, were heated and resorbed to form ovoidal cores, and then were overgrown by a thin rim with much higher contents of An, FeO^T and Sr. However, pre-existing plagioclase phenocrysts in the basaltic magma were injected into cooler and more evolved magmas, and were remained as euhedral cores, which were later enclosed by oscillatory zoned rims with much lower contents of An, Sr and Ba.
基金supported by the National Natural Science Foundation of China(50879090)the Key Research Program of Hydrodynamics of China(9140A14030712JB11044)
文摘A frequency domain analysis method based on the three-dimensional translating-pulsating （3DTP） source Green function is developed to investigate wave loads and free motions of two ships advancing on parallel course in waves. Two experiments are carried out respectively to mea- sure the wave loads and the free motions for a pair of side-by- side arranged ship models advancing with an identical speed in head regular waves. For comparison, each model is also tested alone. Predictions obtained by the present solution are found in favorable agreement with the model tests and are more accurate than the traditional method based on the three dimensional pulsating （3DP） source Green function. Numer- ical resonances and peak shift can be found in the 3DP pre- dictions, which result from the wave energy trapped in the gap between two ships and the extremely inhomogeneous wave load distribution on each hull. However, they can be eliminated by 3DTP, in which the speed affects the free sur- face and most of the wave energy can be escaped from the gap. Both the experiment and the present prediction show that hydrodynamic interaction effects on wave loads and free motions are significant. The present solver may serve as a validated tool to predict wave loads and motions of two ves- sels under replenishment at sea, and may help to evaluate the hydrodynamic interaction effects on the ships safety in replenishment operation.
基金Bogdan Enescu is grateful to the Executive Agency for Higher Education,Research,Development and Innovation Funding(UEFISCDI),Romania,through the project PNIII-P4-ID-PCE-2020-1361,119 PCE/2021(AFROS)for support.Jiancang Zhuang was supported by MEXT Project for Seismology toward Research Innovation with Data of Earthquake(STAR-E)Grant Number JPJ010217.
文摘Missing early aftershocks following relatively large or moderate earthquakes can cause significant bias in the analysis of seismic catalogs.In this paper,we systematically address the aftershock missing problem for five earthquake sequences associated with moderate-size events that occurred inland Japan,by using a stochastic replenishing method.The method is based on the notion that if a point process(e.g.,earthquake sequence)with timeindependent marks(e.g.,magnitudes)is completely observed,it can be transformed into a homogeneous Poisson process by a bi-scale empirical transformation.We use the Japan Meteorological Agency(JMA)earthquake catalog to select the aftershock data and replenish the missing early events using the later complete part of each aftershock sequence.The time windows for each sequence span from 6 months before the mainshock to three months after.The semi-automatic spatial selection uses a clustering method for the epicentral selection of earthquakes.The results obtained for the original JMA catalog and replenished datasets are compared to get insight into the biases that the missing early aftershocks may cause on the Omori-Utsu law parameters’estimation,characterizing the aftershock decay with time from the mainshock.We have also compared the Omori-Utsu law parameter estimates for two datasets following the same mainshock;the first dataset is the replenished sequence,while the second dataset has been obtained by waveform-based analysis to detect early aftershocks that are not recorded in the JMA catalog.Our results demonstrate that the Omori-Utsu law parameters estimated for the replenished datasets are robust with respect to the threshold magnitude used for the analyzed datasets.Even when using aftershock time windows as short as three days,the replenished datasets provide stable Omori-Utsu law parameter estimations.The p-values for all the analyzed sequences are about 1.1 and c-values are significantly smaller compared to those of original datasets.Our findings prove that the replenishment method is a fast,reliable approach to address the missing aftershock problem.
文摘In this paper, a 3D time domain technique is adopted to calculate the coupled hydrodynamic interaction between two bodies without flare in waves. For verifying the code, two same cylinders are selected to calculate coupled hydrodynamic effects by comparison with the results obtained by 3D frequency method which has been proved to be efficient for solving such problems. In order to improve efficiency of calculation, the effect of history time has been discussed, and an improved method is presented. Moreover, the effect of lateral separation distance is also discussed in detail. The technique developed here may serve as a more rigorous tool to analyze the related transient problems of two ships doing underway replenishment in waves.
