Based on multi-type,multi-temporal remote sensing data,we have monitored recent changes in cultivated land use and vegetation,in sandy areas and salinized desertification in the Green Corridor zone of the main channel...Based on multi-type,multi-temporal remote sensing data,we have monitored recent changes in cultivated land use and vegetation,in sandy areas and salinized desertification in the Green Corridor zone of the main channel of the Tarim River Basin.The results of our investigation show that the ecological environment in the Green Corridor of the main channel of the Tarim River Basin has conspicuously improved from 2002 to 2004.These improvements show up largely in such aspects as an increase in the rate of vegetation cover,a reduction in desertification land areas and a weakening in the intensity of sandy and the salinized land.On the other hand,the cultivated area in the Tarim River Basin significantly increased from 2002 to 2004.The rate of growth in cultivated areas during this period was significantly higher than that from 1999 to 2002.The increase in the use of irrigation resulting from the substantial increase in cultivated areas has a long-term potential restraining effect on the restoration of ecological functions of the Tarim River.展开更多
An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally ...An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally weighted quadratic least=squares regression （called as LOESS） method from six-hour satellite surface wind data; the extracted TCW component can then be additionally taken into account or not in ocean modeling, allowing isolation of its effects on the ocean in a clean and clear way. In this paper, seasonally varying TCW fields in year 2008 are extracted from satellite data which are prescribed as a repeated annual cycle over the western Pacific regions off the equator （poleward of 10°N/S）; two long-term OGCM experiments are performed and compared, one with the TCW forcing part included additionally and the other not. Large, persistent thermal perturbations （cooling in the mixed layer （ML） and warming in the thermocline） are induced locally in the western tropical Pacific, which are seen to spread with the mean ocean circulation pathways around the tropical basin. In particular, a remote ocean response emerges in the eastern equatorial Pacific to the prescribed off-equatorial TCW forcing, characterized by a cooling in the mixed layer and a warming in the thermocline. Heat budget analyses indicate that the vertical mixing is a dominant process responsible for the SST cooling in the eastern equatorial Pacific. Further studies are clearly needed to demonstrate the significance of these results in a coupled ocean-atmosphere modeling context.展开更多
Integrating single atoms and clusters into a unified catalytic system represents a novel strategy for enhancing catalytic performance.Compared to single-atom catalysts,those incorporating both single atoms and cluster...Integrating single atoms and clusters into a unified catalytic system represents a novel strategy for enhancing catalytic performance.Compared to single-atom catalysts,those incorporating both single atoms and clusters exhibit superior catalytic activity.However,the co-construction of these systems and the mechanisms of their catalytic efficacy remain challenging and poorly understood.In this study,we synthesized a Mn–N–C catalyst featuring MnY clusters and Mn single atoms via a straightforward two-step sintering method.Y doping facilitated the formation of Mn clusters and optimized the d-band center of Mn through a unique synergy effect,thereby reducing energy barriers and enhancing the reaction kinetics.Additionally,the electron-donating ability of Y single atoms promoted the formation of unsaturated Mn–N_(₃)coordination structures,resulting in excellent oxygen reduction reaction(ORR)performance.Consequently,the MnY/NC catalyst demonstrated a half-wave potential(E_(₁/₂))of 0.90 V and maintained stability in 0.1 M KOH,outperforming both Mn/NC and Pt/C.This work underscores the potential of rare earth metal doping in transition metals to create stable single-atom and cluster systems,effectively leveraging their synergy effect for superior catalytic performance and validating the concept of the“remote synergy effect”in heterogeneous catalysis.展开更多
Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a ...Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a treatment for cerebral palsy and skeletal muscle hypertrophy.In China,Chinese botulinum toxin type A(CBTX-A),a type of BoNT/A,is in widespread clinical use.However,the changes in the morphological and biochemical properties of treated muscles and in remote muscles from the CBTX-A injection site are relatively unknown.Therefore,we investigated the changes in histomorphology and myosin heavy chain(MyHC)isoform composition and distribution in rat gastrocnemius muscles after intramuscular injection of CBTX-A.Methods:The weakness of the injected muscles was assessed periodically to identify their functional deficiency.Muscle slices were stained with hematoxylin-eosin(HE)and adenosine triphosphatase(ATPase).MyHC isoform composition was analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis(SDS-PAGE)to uncover changes in morphological and biochemical properties.Results:Our findings demonstrate that following injection of CBTX-A 5 U into rat gastrocnemius muscles,shifts in MyHC isoform composition emerged on the third day after injection and peaked in the fourth week.The composition remained distinctly different from that of the control group after the twelfth week.More specifically,there was a decrease in the proportion of the type IIb isoform and an increase in the proportions of type IIx,type IIa,and type I isoforms.Conclusions:Data revealed that CBTX-A led to a shift in MyHC composition towards slower isoforms and that the MyHC composition remained far from normal six months after a single injection.However,no noticeable remote muscle weakness was induced.展开更多
The relationship between vegetation greening and climate change remains unclear due to its complexity, especially in drylands. Against the background of global warming, arid and semi-arid areas, including mid-latitude...The relationship between vegetation greening and climate change remains unclear due to its complexity, especially in drylands. Against the background of global warming, arid and semi-arid areas, including mid-latitude deserts, are most sensitive to climate change. In recent decades, the mechanisms underlying the relationship between vegetation greening and climate change have been widely discussed in the literature. However, the influence of vegetation greening in high latitudes on regional climate has not been fully studied. In this paper, a two-dimensional energy balance model was used to study the influence of greening in high latitudes on mid-latitude deserts. The authors found that when greening occurs in high latitudes, the mid-latitude desert recedes at the south boundary, while the polar ice belt and low-latitude vegetation belt both expand. Simultaneously, greening in high latitudes can induce a negative temperature anomaly in northern latitudes and a positive temperature anomaly in southern latitudes. The mid-latitude desert expands at its north and south boundaries until the CO2 concentration reaches 600 ppm(saturated state). The greening in high latitudes could result in a lower global-mean temperature in the ‘saturated’ state, due to the stronger cooling in high latitudes.展开更多
The leaf area index(LAI) is a critical biophysical variable that describes canopy geometric structures and growth conditions.It is also an important input parameter for climate,energy and carbon cycle models.The scali...The leaf area index(LAI) is a critical biophysical variable that describes canopy geometric structures and growth conditions.It is also an important input parameter for climate,energy and carbon cycle models.The scaling effect of the LAI has always been of concern.Considering the effects of the clumping indices on the BRDF models of discrete canopies,an effective LAI is defined.The effective LAI has the same function of describing the leaf density as does the traditional LAI.Therefore,our study was based on the effective LAI.The spatial scaling effect of discrete canopies significantly differed from that of continuous canopies.Based on the directional second-derivative method of effective LAI retrieval,the mechanism responsible for the spatial scaling effect of the discrete-canopy LAI is discussed and a scaling transformation formula for the effective LAI is suggested in this paper.Theoretical analysis shows that the mean values of effective LAIs retrieved from high-resolution pixels were always equal to or larger than the effective LAIs retrieved from corresponding coarse-resolution pixels.Both the conclusions and the scaling transformation formula were validated with airborne hyperspectral remote sensing imagery obtained in Huailai County,Zhangjiakou,Hebei Province,China.The scaling transformation formula agreed well with the effective LAI retrieved from hyperspectral remote sensing imagery.展开更多
To confirm and compare the therapeutic efficacies and remote effects of a Chinese type A botulinum toxin (CBTX-A, Lanzhou Biological Products Institute, China) and Botox (Allergan Inc , USA) for focal dystonia and mu...To confirm and compare the therapeutic efficacies and remote effects of a Chinese type A botulinum toxin (CBTX-A, Lanzhou Biological Products Institute, China) and Botox (Allergan Inc , USA) for focal dystonia and muscle spasm Methods Prospective open study was conducted over 4 years for focal dystonia and muscle spasm We enrolled 785 patients: 192 were injected with Botox and 593 with CBTX-A They were followed for 3 to 48 months Meanwhile single fiber electromyography (SFEMG) was performed in a subset of 40 patients before, 2-3 weeks, 5-8 weeks and 4-5 months after injection of Botox or CBTX-A Results There were no significant differences in clinical effects from two preparations, including the latency of response, maximal benefit and duration of improvement The dose of the Chinese preparation which produced effects similar to Botox was higher A significant increase in jitter was demonstrated 2-3 weeks after injection in both groups and fiber density values increased at the same time or later and remained 4-5 months after injections Conclusion Both preparation are safe and effective treatments for patients with focal dystonia and muscle spasm They both have subclinical effects on neuromuscular transmission of remote uninjected muscles The Chinese preparation is a little less powerful but much cheaper than Botox展开更多
基金Financial support for this work was provided by the National Natural Science Foundation of China (No. 41040011)the Fun-damental Research Funds for the Central Universities (No.CHD2010JC103)
文摘Based on multi-type,multi-temporal remote sensing data,we have monitored recent changes in cultivated land use and vegetation,in sandy areas and salinized desertification in the Green Corridor zone of the main channel of the Tarim River Basin.The results of our investigation show that the ecological environment in the Green Corridor of the main channel of the Tarim River Basin has conspicuously improved from 2002 to 2004.These improvements show up largely in such aspects as an increase in the rate of vegetation cover,a reduction in desertification land areas and a weakening in the intensity of sandy and the salinized land.On the other hand,the cultivated area in the Tarim River Basin significantly increased from 2002 to 2004.The rate of growth in cultivated areas during this period was significantly higher than that from 1999 to 2002.The increase in the use of irrigation resulting from the substantial increase in cultivated areas has a long-term potential restraining effect on the restoration of ecological functions of the Tarim River.
基金supported in part by NSF Grant(Grant No.AGS-1061998)NOAA Grant(Grant No.NA08OAR4310885)+3 种基金NASA Grants(Grant Nos.NNX08AT50G and NNX09AF41G)supportedby the National Basic Research Program of China(Grant No.2013CB430302)the Public Science and Technology Research Funds of Ocean(Grant No.201105018)additionally supported by China Scholarship Council(CSC)with The Ocean University of China,Qingdao,China
文摘An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally weighted quadratic least=squares regression （called as LOESS） method from six-hour satellite surface wind data; the extracted TCW component can then be additionally taken into account or not in ocean modeling, allowing isolation of its effects on the ocean in a clean and clear way. In this paper, seasonally varying TCW fields in year 2008 are extracted from satellite data which are prescribed as a repeated annual cycle over the western Pacific regions off the equator （poleward of 10°N/S）; two long-term OGCM experiments are performed and compared, one with the TCW forcing part included additionally and the other not. Large, persistent thermal perturbations （cooling in the mixed layer （ML） and warming in the thermocline） are induced locally in the western tropical Pacific, which are seen to spread with the mean ocean circulation pathways around the tropical basin. In particular, a remote ocean response emerges in the eastern equatorial Pacific to the prescribed off-equatorial TCW forcing, characterized by a cooling in the mixed layer and a warming in the thermocline. Heat budget analyses indicate that the vertical mixing is a dominant process responsible for the SST cooling in the eastern equatorial Pacific. Further studies are clearly needed to demonstrate the significance of these results in a coupled ocean-atmosphere modeling context.
基金supported by the National Natural Science Foundation of China(Youth Program,No.22309209)the Key Research and Development Program of Hunan Province(Grant No.2023GK2015)+3 种基金the Leading Telant in Science and Technological Innovation Program of Hunan Province,China(No.2022RC3049)the Tianshan Innovation Team Program of Xinjiang,China(No.2024D14001)the Natural Science Foundation of Hunan Province China(Grant No.2023JJ40709)This project was also supported by the State Key Laboratory of Powder Metallurgy,Central South University.
文摘Integrating single atoms and clusters into a unified catalytic system represents a novel strategy for enhancing catalytic performance.Compared to single-atom catalysts,those incorporating both single atoms and clusters exhibit superior catalytic activity.However,the co-construction of these systems and the mechanisms of their catalytic efficacy remain challenging and poorly understood.In this study,we synthesized a Mn–N–C catalyst featuring MnY clusters and Mn single atoms via a straightforward two-step sintering method.Y doping facilitated the formation of Mn clusters and optimized the d-band center of Mn through a unique synergy effect,thereby reducing energy barriers and enhancing the reaction kinetics.Additionally,the electron-donating ability of Y single atoms promoted the formation of unsaturated Mn–N_(₃)coordination structures,resulting in excellent oxygen reduction reaction(ORR)performance.Consequently,the MnY/NC catalyst demonstrated a half-wave potential(E_(₁/₂))of 0.90 V and maintained stability in 0.1 M KOH,outperforming both Mn/NC and Pt/C.This work underscores the potential of rare earth metal doping in transition metals to create stable single-atom and cluster systems,effectively leveraging their synergy effect for superior catalytic performance and validating the concept of the“remote synergy effect”in heterogeneous catalysis.
基金Project (No.491030-w10011) supported by the Zhejiang Provincial Natural Science Foundation of China
文摘Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a treatment for cerebral palsy and skeletal muscle hypertrophy.In China,Chinese botulinum toxin type A(CBTX-A),a type of BoNT/A,is in widespread clinical use.However,the changes in the morphological and biochemical properties of treated muscles and in remote muscles from the CBTX-A injection site are relatively unknown.Therefore,we investigated the changes in histomorphology and myosin heavy chain(MyHC)isoform composition and distribution in rat gastrocnemius muscles after intramuscular injection of CBTX-A.Methods:The weakness of the injected muscles was assessed periodically to identify their functional deficiency.Muscle slices were stained with hematoxylin-eosin(HE)and adenosine triphosphatase(ATPase).MyHC isoform composition was analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis(SDS-PAGE)to uncover changes in morphological and biochemical properties.Results:Our findings demonstrate that following injection of CBTX-A 5 U into rat gastrocnemius muscles,shifts in MyHC isoform composition emerged on the third day after injection and peaked in the fourth week.The composition remained distinctly different from that of the control group after the twelfth week.More specifically,there was a decrease in the proportion of the type IIb isoform and an increase in the proportions of type IIx,type IIa,and type I isoforms.Conclusions:Data revealed that CBTX-A led to a shift in MyHC composition towards slower isoforms and that the MyHC composition remained far from normal six months after a single injection.However,no noticeable remote muscle weakness was induced.
基金This work was jointly supported by the Strategic Priority Research Program of the Chinese Academy of Sciences[grant number XDA2006010301]the National Natural Science Foundation of China[grant numbers 41521004,41705047,and 41875083]+1 种基金the Foundation of the Key Laboratory for Semi-Arid Climate Change of the Ministry of Education in Lanzhou University from the Fundamental Research Funds for the Central Universities[grant numbers lzujbky-2017-bt04 and lzujbky-2017-70]the China 111 Project[grant number B13045].
文摘The relationship between vegetation greening and climate change remains unclear due to its complexity, especially in drylands. Against the background of global warming, arid and semi-arid areas, including mid-latitude deserts, are most sensitive to climate change. In recent decades, the mechanisms underlying the relationship between vegetation greening and climate change have been widely discussed in the literature. However, the influence of vegetation greening in high latitudes on regional climate has not been fully studied. In this paper, a two-dimensional energy balance model was used to study the influence of greening in high latitudes on mid-latitude deserts. The authors found that when greening occurs in high latitudes, the mid-latitude desert recedes at the south boundary, while the polar ice belt and low-latitude vegetation belt both expand. Simultaneously, greening in high latitudes can induce a negative temperature anomaly in northern latitudes and a positive temperature anomaly in southern latitudes. The mid-latitude desert expands at its north and south boundaries until the CO2 concentration reaches 600 ppm(saturated state). The greening in high latitudes could result in a lower global-mean temperature in the ‘saturated’ state, due to the stronger cooling in high latitudes.
基金supported by the National Natural Science Foundation of China(Grant Nos.91025006,40871186,40730525)National Basic Research Program of China(Grant No.2007CB714402)National High Technology Research and Development Program of China(Grant Nos.2009AA12Z143,2009AA122103)
文摘The leaf area index(LAI) is a critical biophysical variable that describes canopy geometric structures and growth conditions.It is also an important input parameter for climate,energy and carbon cycle models.The scaling effect of the LAI has always been of concern.Considering the effects of the clumping indices on the BRDF models of discrete canopies,an effective LAI is defined.The effective LAI has the same function of describing the leaf density as does the traditional LAI.Therefore,our study was based on the effective LAI.The spatial scaling effect of discrete canopies significantly differed from that of continuous canopies.Based on the directional second-derivative method of effective LAI retrieval,the mechanism responsible for the spatial scaling effect of the discrete-canopy LAI is discussed and a scaling transformation formula for the effective LAI is suggested in this paper.Theoretical analysis shows that the mean values of effective LAIs retrieved from high-resolution pixels were always equal to or larger than the effective LAIs retrieved from corresponding coarse-resolution pixels.Both the conclusions and the scaling transformation formula were validated with airborne hyperspectral remote sensing imagery obtained in Huailai County,Zhangjiakou,Hebei Province,China.The scaling transformation formula agreed well with the effective LAI retrieved from hyperspectral remote sensing imagery.
文摘To confirm and compare the therapeutic efficacies and remote effects of a Chinese type A botulinum toxin (CBTX-A, Lanzhou Biological Products Institute, China) and Botox (Allergan Inc , USA) for focal dystonia and muscle spasm Methods Prospective open study was conducted over 4 years for focal dystonia and muscle spasm We enrolled 785 patients: 192 were injected with Botox and 593 with CBTX-A They were followed for 3 to 48 months Meanwhile single fiber electromyography (SFEMG) was performed in a subset of 40 patients before, 2-3 weeks, 5-8 weeks and 4-5 months after injection of Botox or CBTX-A Results There were no significant differences in clinical effects from two preparations, including the latency of response, maximal benefit and duration of improvement The dose of the Chinese preparation which produced effects similar to Botox was higher A significant increase in jitter was demonstrated 2-3 weeks after injection in both groups and fiber density values increased at the same time or later and remained 4-5 months after injections Conclusion Both preparation are safe and effective treatments for patients with focal dystonia and muscle spasm They both have subclinical effects on neuromuscular transmission of remote uninjected muscles The Chinese preparation is a little less powerful but much cheaper than Botox
